Studies of Lipid Droplets : Intracellular Dynamics and Regulatory Mechanisms of Functions
| Project/Area Number |
19370056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | University of Hyogo |
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Principal Investigator |
OSUMI Takashi University of Hyogo, 大学院・生命理学研究科, 教授 (50111787)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Tomohiro 昭和大学, 薬学部, 准教授 (50347530)
OKAMURA Tomoo 兵庫県立大学, 大学院・生命理学研究科, 助教 (90553991)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 脂肪滴 / 心臓 / ノックアウトマウス / 中性脂肪 / 脂肪酸 / 心筋症 / 脂肪滴結合タンパク質 / 脂肪細胞 / MLDP / ペリリピン / 脂質代謝 / 糖尿病 / PATタンパク質 / 脂肪分解 / トリグリセリド |
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| Research Abstract |
Lipid droplets (LDs) are organelles storing neutral lipids. Specific sets of proteins bind to the surface of LDs, probably providing LDs with tissue specificities. We generated and characterized mice lacking MLDP, a LD-binding protein enriched in the heart. These mice completely lacked LDs in the heart, and exhibited higher level of metabolism of fat and carbohydrate. Consequently, they exhibited enhanced resistance to cardiomyopathy due to aberrant accumulation of fat in the heart. We also studied the morphological changes of LDs and redistribution of LD-binding proteins during catecholamine-dependent lipid mobilization in adipocytes.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Target specificities of estrogen receptor-related receptors: Analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene.2008
Author(s)
Akter, Mst. H., Chano, T., Okabe, H., Yamaguchi, T., Hirose, F., Osumi, T.
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Journal Title
J. Biochem. 143
Pages: 395-406
NAID
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[Journal Article] Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells.2007
Author(s)
Tanaka, T., Morishige, J., Iwawaki, D., Fukuhara, T., Hamamura, N., Hirano, K., Osumi, T., Satouchi, K.
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Journal Title
FEBS J. 274
Pages: 2728-2737
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