| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
Lipid droplets (LDs) are organelles storing neutral lipids. Specific sets of proteins bind to the surface of LDs, probably providing LDs with tissue specificities. We generated and characterized mice lacking MLDP, a LD-binding protein enriched in the heart. These mice completely lacked LDs in the heart, and exhibited higher level of metabolism of fat and carbohydrate. Consequently, they exhibited enhanced resistance to cardiomyopathy due to aberrant accumulation of fat in the heart. We also studied the morphological changes of LDs and redistribution of LD-binding proteins during catecholamine-dependent lipid mobilization in adipocytes.
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