A study on lipid dynamics during pathogen infection
| Project/Area Number |
19370058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
MAEHAMA Tomohiko National Institute of Infectious Diseases, 細胞化学部, 室長 (40322755)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | ウイルス / 感染症 / 脂質 / シグナル伝達 / イノシトールリン脂質 |
|---|
| Research Abstract |
Cellular lipids function as building blocks of biomembranes and signaling molecules thereby being fundamental components for all cells. In this study, we analyzed the function of cellular lipids for infection cycle of hepatitis C virus and infectious prion. We found that certain types of phosphoinositide were required for replication process of human hepatitis C virus. In addition, we found that the inhibition of sphingolipid biosynthesis substantially suppressed cell-to-cell transmission of infectious prion using newly developed infectious prion transmission assay system.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] An improved method for cell-to-cell transmission of infectious prion.2010
Author(s)
Tanaka, M., Hara, H., Nishina, H., Hanada, K., Hagiwara, K., Maehama, T.
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Journal Title
Biochem. Biophys. Res. Commun. (in press)
Related Report
Peer Reviewed
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[Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells.2009
Author(s)
Malchinkhuu, E., Sato, K., Maehama, T., Ishiuchi, S., Yoshimoto, Y., Mogi, C., Kimura, T., Kurose, H., Tomura, H., Okajima, F.
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Journal Title
Mol. Biol. Cell 20
Pages: 5156-5165
Related Report
Peer Reviewed
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[Journal Article] RalA functions as an indispensable signal mediator for the nutrient-sensing system.2008
Author(s)
Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., Hanada, K.
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Journal Title
J. Biol. Chem. 283
Pages: 35053-35059
Related Report
Peer Reviewed
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[Journal Article] S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.2008
Author(s)
Malchinkhuu, E., Sato, K., Maehama, T., Mogi, C., Tomura, H., Ishiuchi, S., Yoshimoto, Y., Kurose, H., Okajima, F.
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Journal Title
Biochem. Biophys. Res. Commun. 366
Pages: 963-968
Related Report
Peer Reviewed
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