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A study on lipid dynamics during pathogen infection

Research Project

Project/Area Number 19370058
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

MAEHAMA Tomohiko  National Institute of Infectious Diseases, 細胞化学部, 室長 (40322755)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywordsウイルス / 感染症 / 脂質 / シグナル伝達 / イノシトールリン脂質
Research Abstract

Cellular lipids function as building blocks of biomembranes and signaling molecules thereby being fundamental components for all cells. In this study, we analyzed the function of cellular lipids for infection cycle of hepatitis C virus and infectious prion. We found that certain types of phosphoinositide were required for replication process of human hepatitis C virus. In addition, we found that the inhibition of sphingolipid biosynthesis substantially suppressed cell-to-cell transmission of infectious prion using newly developed infectious prion transmission assay system.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] An improved method for cell-to-cell transmission of infectious prion.2010

    • Author(s)
      Tanaka, M., Hara, H., Nishina, H., Hanada, K., Hagiwara, K., Maehama, T.
    • Journal Title

      Biochem. Biophys. Res. Commun. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid-induced migration by isoproterenol in glioma cells.2009

    • Author(s)
      Malchinkhuu, E., Sato, K., Maehama, T., Ishiuchi, S., Yoshimoto, Y., Mogi, C., Kimura, T., Kurose, H., Tomura, H., Okajima, F.
    • Journal Title

      Mol. Biol. Cell 20

      Pages: 5156-5165

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] アミノ酸感知シグナル-mTOR活性化の分子機構-2009

    • Author(s)
      前濱朝彦
    • Journal Title

      アミノ酸研究 3

      Pages: 5-14

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] アミノ酸感知シグナル2009

    • Author(s)
      前濱朝彦
    • Journal Title

      細胞工学 28

      Pages: 760-764

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] アミノ酸感知シグナル -mTOR活性化の分子機構-2009

    • Author(s)
      前濱朝彦
    • Journal Title

      アミノ酸研究 3

      Pages: 5-14

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cell2009

    • Author(s)
      Malchinkmuu, E., 他
    • Journal Title

      Mol.Biol.Cell 20

      Pages: 5156-5165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RalA functions as an indispensable signal mediator for the nutrient-sensing system.2008

    • Author(s)
      Maehama, T., Tanaka, M., Nishina, H., Murakami, M., Kanaho, Y., Hanada, K.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 35053-35059

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] あらたな癌抑制遺伝子PICT-1/GLTSCR22008

    • Author(s)
      前濱朝彦、岡原史明、金保安則
    • Journal Title

      医学のあゆみ 224

      Pages: 172-173

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.2008

    • Author(s)
      Malchinkhuu, E., Sato, K., Maehama, T., Mogi, C., Tomura, H., Ishiuchi, S., Yoshimoto, Y., Kurose, H., Okajima, F.
    • Journal Title

      Biochem. Biophys. Res. Commun. 366

      Pages: 963-968

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RalA functions as an indispensable signal mediator for the nutrient-sensing system2008

    • Author(s)
      Maehama, T.
    • Journal Title

      Journal of Biological Chemistry 283

      Pages: 35053-35059

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN2008

    • Author(s)
      Malchinkhuu, E.
    • Journal Title

      Biochem.Biophys.Res.Commun. 366

      Pages: 963-968

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] あらたな癌抑制遺伝子PICT-1/GLTSCR22008

    • Author(s)
      前濱 朝彦
    • Journal Title

      医学のあゆみ 224

      Pages: 172-173

    • Related Report
      2007 Annual Research Report
  • [Journal Article] PTEN: its deregulation and tumorigenesis.2007

    • Author(s)
      Maehama, T.
    • Journal Title

      Biol. Pharm. Bull. 30

      Pages: 1624-1627

    • NAID

      110006380239

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PTEN:its deregulation and tumorigenesis2007

    • Author(s)
      Maehama, T.
    • Journal Title

      Biol.Pharm.Bull. 30

      Pages: 1624-1627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 共培養系を用いた高効率なPrPSc伝播実験系の確立2009

    • Author(s)
      田中正彦、原英之、萩原健一、花田賢太郎、仁科博史、前濱朝彦
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2009-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 共培養系を用いた高効率なPrPSc伝播実験系の確立2009

    • Author(s)
      田中正彦, 他
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of a Ras-family GTPase as an indispensable signal mediator for nutrient sensing and mTORC1 activation2008

    • Author(s)
      Maehama, T.
    • Organizer
      8th International Conference on Protein Phosphatases
    • Place of Presentation
      群馬県前橋市
    • Year and Date
      2008-11-14
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.nih.go.jp/niid/biochem/4th/research.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.nih.go.jp/niid/reports/index.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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