Structure and function of metal-containing sensor proteins that use gas molecules as physiological effectors

• Project/Area Number: 19370059
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2009); National Institutes of Natural Sciences Okazaki Research Facilities (2007-2008)
• Principal Investigator: AONO Shigetoshi 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (60183729)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: センサータンパク質 / ヘムタンパク質 / 構造機能相関 / シグナル伝達 / 水素結合ネットワーク / 走化性制御系 / ヘム / グロビンドメイン / 気体分子センサー

Research Abstract

I have studied gas sensor proteins using oxygen or carbon monoxide as their physiological effector molecules to elucidate their structure and function relationships. This study has revealed a novel biological function of gas molecules as signal molecules and the molecular mechanism of gas sensor proteins.

Research Products

• [Journal Article] The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii (2010)
  • Author(s): H. Nakajima, N. Takatani, K. Yoshimitsu, M. Ito, S. Aono, Y. Takahashi, Y. Watanabe
  • Journal Title: FEBS J. 277 Pages: 817-832
  • Peer Reviewed
• [Journal Article] Molecular Oxygen regulates the enzymatic activity of a heme-containing diguanylate cyclase (HemDGC) for the synthesis of cyclic di-GMP (2010)
  • Author(s): H. Sawai, S. Yoshioka, T. Uchida, M. Hyodo, Y. Hayakawa, K. Ishimori, S. Aono
  • Journal Title: Biochim. Biophys. Acta-Proteins and Proteomics 1804 Pages: 166-172
  • Peer Reviewed
• [Journal Article] The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii (2010)
  • Author(s): Hiroshi Nakajima
  • Journal Title: FEBS J. 277 Pages: 817-832
  • Peer Reviewed
• [Journal Article] Molecular Oxygen regulates the enzymatic activity of a heme-containing diguanylate cyclase (HemDGC) for the synthesis of cyclic di-GMP (2010)
  • Author(s): Hitomi Sawai
  • Journal Title: Biochim.Biophys.Acta-Proteins & Proteomics 1804 Pages: 166-172
  • Peer Reviewed
• [Journal Article] X-ray crystal structure of Michaelis complex of aldoxime dehydratase (2009)
  • Author(s): H. Sawai, H. Sugimoto, Y. Asano, Y. Kato, Y. Shiro, S. Aono
  • Journal Title: J. Biol. Chem. 284 Pages: 32089-32096
  • Peer Reviewed
• [Journal Article] X-ray crystal structure of Michaelis complex of aldoxime dehydratase (2009)
  • Author(s): Hitomi Sawai
  • Journal Title: J.Biol.Chem. 284 Pages: 32089-32096
  • Peer Reviewed
• [Journal Article] Metal-containing sensor proteins sensing diatomic gas molecules (2008)
  • Author(s): S. Aono
  • Journal Title: Dalton Trans. -24 Pages: 3137-3146
  • Peer Reviewed
• [Journal Article] Hydrogen bonding interaction on the heme-bound ligand in the heme-based O2 sensor protein (2008)
  • Author(s): M. Nishimura, H. Yoshimura, K. Ozawa, S. Yoshioka, M. Kubo, T. Kitagawa, S. Aono
  • Journal Title: J. Porphyrins Phthalocyanines 12 Pages: 142-148
  • Peer Reviewed
• [Journal Article] Protein conformation changes of HemAT-Bs upon ligand binding probed by ultraviolet resonance Raman spectroscopy (2008)
  • Author(s): Samir F. El-Mashtoly, Y. Gu, H. Yoshimura, S. Yoshioka, S. Aono, T. Kitagawa
  • Journal Title: J. Biol. Chem. 283 Pages: 6942-6949
  • Peer Reviewed
• [Journal Article] Hydrogen bonding interaction on the heme-based ligand in The heme-based O_2 sensor protein (2008)
  • Author(s): Muneto Nishimura
  • Journal Title: J.Porphyrins & Phthalocyanines 12 Pages: 142-148
  • Peer Reviewed
• [Journal Article] Metal-containing sensor proteins sensing diatomic gas molecules (2008)
  • Author(s): Shigetoshi Aono
  • Journal Title: Dalton Trans. 24 Pages: 3137-3146
  • Peer Reviewed
• [Journal Article] Protein conformation changes of HemAT-Bs upon ligand binding probed by ultraviolet resonance Raman spectroscopy (2008)
  • Author(s): Samir F.El-Mashtoly
  • Journal Title: J.Biol.Chem 283 Pages: 6942-6949
  • Peer Reviewed
• [Journal Article] The formation of hydrogen bond in the proximal heme pocket of HemAT-Bs upon ligand binding (2007)
  • Author(s): H. Yoshimura, S. Yoshioka, Y. Mizutani, S. Aono
  • Journal Title: Biochem. Biophys. Res. Commun. 357(4) Pages: 1053-1057
  • Peer Reviewed
• [Journal Article] The formation of hydrogen bond in the proximal heme pocket of Hem AT-Bs upon ligand binding (2007)
  • Author(s): Hideaki Yoshimura
  • Journal Title: Biochem.Biophys.Res.Commun 357 Pages: 1053-1057
  • Peer Reviewed
• [Journal Article] Crystal structure of CO-sensing transcription activator CooA bound to exogenous ligand imidazole (2007)
  • Author(s): Hirofumi Komori
  • Journal Title: J.Mol.Biol 367 Pages: 864-871
  • Peer Reviewed
• [Journal Article] 気体分子をスイッチとする生体機能制御 (2007)
  • Author(s): 青野 重利
  • Journal Title: 化学 62 Pages: 68-69
• [Presentation] 低温X線照射還元によるアルドキシム脱水酵素の結晶内におけるミカエリス複合体の生成およびその構造決定 (2009)
  • Author(s): 澤井仁美
  • Organizer: 日本結晶学会2009年度年会
  • Place of Presentation: 関西学院大学(兵庫)
  • Year and Date: 2009-12-05
• [Presentation] Reaction mechanism of aldoxime dehydration revealed by X-ray crystal structure of the Michaelis complex of aldoxime dehydratase (2009)
  • Author(s): Shigetosi Aono
  • Organizer: 2^<nd> Japan-Korea Seminar on Biomolecular Sciences Experiments and Simulations
  • Place of Presentation: 名古屋大学(愛知)
  • Year and Date: 2009-11-22
• [Presentation] Structure and function of aldoxime dehydratase containing a heme as the active center for dehydration reaction (2009)
  • Author(s): Shigetoshi Aono
  • Organizer: Symposium on Advanced Biological Inorganic Chemistry(SABIC-2009)
  • Place of Presentation: Mumbai, India
  • Year and Date: 2009-11-06
• [Presentation] X-ray crystal structure of the Michaelis complex of a novel heme enzyme, aldoxime dehydratase (2009)
  • Author(s): 澤井仁美
  • Organizer: Symposium on Advanced Biological Inorganic Chemistry(SABIC-2009)
  • Place of Presentation: Mumbai, India
  • Year and Date: 2009-11-06
• [Presentation] Molecular oxygen regulates the enzymatic activity of a heme-containing diguanylate cyclase, HemDGC (2009)
  • Author(s): S. Aono
  • Organizer: 14th International Conference on Biological Inorganic Chemistry (ICBIC-14)
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-30
• [Presentation] Molecular oxygen regulates the enzymatic activity of a heme-containing diguanylate cyclase, HemDGC (2009)
  • Author(s): Shigetoshi Aono
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-30
• [Presentation] Nitrogenase transcriptional activator, VnfA-Identification of signal molecule by using in vivo activity assay system (2009)
  • Author(s): K. Yoshimitsu
  • Organizer: 14th International Conference on Biological Inorganic Chemistry (ICBIC-14)
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-26
• [Presentation] Functional analysis of vanadium nitrogenase regulating protein in Azotobacter vinelandii (2009)
  • Author(s): H. Nakajima
  • Organizer: 14th International Conference on Biological Inorganic Chemistry (ICBIC-14)
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-26
• [Presentation] Crystal structure of the Michaelis complex of aldoxime dehydratase (2009)
  • Author(s): 澤井仁美
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-26
• [Presentation] Functional analysis of vanadium nitrogenase regulating protein in Azotobacter vinelandii (2009)
  • Author(s): Hiroshi Nakajima
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-26
• [Presentation] Nitrogenase transcriptional activator, VnfA -Identification of signal molecule by using in vivo activity assay system (2009)
  • Author(s): Kyohei Yoshimitsu
  • Organizer: 14th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2009-07-26
• [Presentation] Physiological role of thiolate coordination to the heme in CooA from R. rubrum (2009)
  • Author(s): S. Aono
  • Organizer: 16th International Conference on Cytoshrome P450
  • Place of Presentation: 万国津粱館(沖縄)
  • Year and Date: 2009-06-24
• [Presentation] Physiological role of thiolate coordination to the heme in CooA from R.rubrum (2009)
  • Author(s): Shigetoshi Aono
  • Organizer: 16th International Conference on Cytoshrome P450
  • Place of Presentation: 万国津梁館(沖縄)
  • Year and Date: 2009-06-24
• [Presentation] 新規なヘム酵素(アルドキシム脱水酵素)の酵素基質複合体のX線結晶構造 (2009)
  • Author(s): 澤井仁美
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本全日空ホテル(熊本)
  • Year and Date: 2009-05-21
• [Presentation] 時間分解共鳴ラマン分光法によるガスセンサータンパク質HemATの酸素脱離に伴うダイナミクスの観測 (2009)
  • Author(s): 吉田祐
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-29
• [Presentation] Fe-Sクラスタを有するニトロゲナーゼ転写調節因子VnfAにおけるクラスタの役割 (2009)
  • Author(s): 中島洋
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-29
• [Presentation] 時間分解共鳴ラマと分光法によるガスセンサータンパク質 Hem AT の酸素脱離に伴うダイナミクスの観測 (2009)
  • Author(s): 吉田祐
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 鯨工業大学(神奈川)
  • Year and Date: 2009-03-29
• [Presentation] ニトロゲナーゼ転写調節因子VnfA- in vivoアッセイによる環境因子の同定 (2009)
  • Author(s): 吉満匡平
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-27
• [Presentation] Fe-S クラスタを有するニトロゲナーゼ転写制御因子 VnfA におけるクラスタの役割 (2009)
  • Author(s): 中島洋
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-27
• [Presentation] ニトロゲナーゼ転写調節因子 VnfA-in vivo アッセイによる環境因子の同定 (2009)
  • Author(s): 吉満匡平
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学(千葉)
  • Year and Date: 2009-03-27
• [Presentation] Heme-based gas sensor proteins as a possible material for a bioinorganic device (2008)
  • Author(s): S. Aono
  • Organizer: The IUMRS International Conference in Asia 2008 (IUMRS-ICA 2008)
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2008-12-10
• [Presentation] Heme-based gas sensor proteins as a possible material for a bioinorganic device (2008)
  • Author(s): 青野重利
  • Organizer: The IUMRS International Conference in Asia 2008
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2008-12-10
• [Presentation] Functional analysis of a nitrogenase transcriptional activator, VnfA, from Azotobacter vinelandii (2008)
  • Author(s): Kyohei Yoshimitsu
  • Organizer: The IUMRS International Conference in Asia 2008
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2008-12-10
• [Presentation] A novel globin-coupled oxygen sensor protein responsible for the synthesis of a bacterial second messenger, cyclic di-GMP (2008)
  • Author(s): S. Aono
  • Organizer: 4th Asian Biological Inorganic Chemistry Conference (AsBIC-4)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-13
• [Presentation] Functional analyses of Fe3S4 cluster involved in VnfA, vanadium nitrogenase regulation protein (2008)
  • Author(s): H. Nakajima
  • Organizer: 4th Asian Biological Inorganic Chemistry Conference (AsBIC-4)
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-13
• [Presentation] Functional analyses of Fe3S4 cluster involved in VnfA, vanadium nitrogenase regulation protein (2008)
  • Author(s): 中島洋
  • Organizer: 4^<th> Asian Biological Inorganic Chemistry Conference
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-13
• [Presentation] A novel globin-coupled oxygen sensor protein responsible for the synthesis of a bacterial second messenger, c-di-GMP (2008)
  • Author(s): Hitomi Sawai
  • Organizer: 4^<th> Asian Biological Inorganic Chemistry Conference
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-11-13
• [Presentation] ヘム含有型センサータンパク質によるガス分子センシングとシグナル伝逹 (2008)
  • Author(s): 青野重利
  • Organizer: バイオ分子センサー連携研究プロジェクトレクチャーコース
  • Place of Presentation: 生理学研究所(愛知)
  • Year and Date: 2008-10-07
• [Presentation] ニトロゲナーゼ転写調節因子VnfAに含まれる鉄イオウの役割 (2008)
  • Author(s): 中島洋
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 東京工業大学(神奈川)
  • Year and Date: 2008-09-19
• [Presentation] ニトロゲナーゼ転写活性化因子VnfAに含まれる鉄イオウの役割 (2008)
  • Author(s): 中島洋
  • Organizer: 第3回バイオ関連化学合同シンポジウム
  • Place of Presentation: 東京工業大学(神奈川)
  • Year and Date: 2008-09-19
• [Presentation] HemDGC, a novel globin-coupled O2 sensor, regulates synthesis of a bacterial second messenger (c-di-GMP) (2008)
  • Author(s): H. Sawai
  • Organizer: 4th International Conference on Metals and Genetics (ICMG-13)
  • Place of Presentation: Paris, France
  • Year and Date: 2008-07-22
• [Presentation] HemDGC, a novel globin-coupled O_2 sensor, regulates synthesis of a bacterial second messenger(c-di-GMP) (2008)
  • Author(s): Hitomi Sawai
  • Organizer: 4^<th> International Conference on Metals and Genetics
  • Place of Presentation: Paris, France
  • Year and Date: 2008-07-22
• [Presentation] The molecular mechanism of functional regulation of the heme-based sensor proteins (2008)
  • Author(s): S. Aono
  • Organizer: 5th International Conference on Porphyrins and Phthalocyanines (ICPP-5)
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2008-07-11
• [Presentation] The molecular mechanism of functional regulation of the heme-based sensor proteins (2008)
  • Author(s): 青野重利
  • Organizer: 5^<th> International Conference on Porphyrins and Phthalocyanines
  • Place of Presentation: Moscow, Russia
  • Year and Date: 2008-07-11
• [Presentation] ニトロゲナーゼ転写活性化因子VnfAの転写調節機構の解明 (2008)
  • Author(s): 中島洋
  • Organizer: 第35回生体分子科学討論会
  • Place of Presentation: 兵庫県立大学(兵庫)
  • Year and Date: 2008-06-26
• [Presentation] Structure and function of a globin-coupled enzyme that catalyses the formation of a bacterial seconde messenger, c-di-GMP (2008)
  • Author(s): 青野重利
  • Organizer: 第18回金属の関与する生体関連反応シンポジウム
  • Place of Presentation: 名古屋市立大学(愛知)
  • Year and Date: 2008-06-05
• [Presentation] タコヘモシアニンの構造改変に基づくチロシナーゼアナログの開発 (2008)
  • Author(s): 下川 千寿
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-29
• [Presentation] 鉄硫黄クラスタを有するニトロゲナーゼ転写活性化因子VnfAにおけるクラスタの役割 (2008)
  • Author(s): 中島 洋
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 2008-03-27
• [Presentation] ガスセンサーとして機能するヘムタンパク質の構造と機能 (2008)
  • Author(s): 青野 重利
  • Organizer: 第6回岡崎統合バィオサイエンスセンターシンポジウム
  • Place of Presentation: 岡崎
  • Year and Date: 2008-03-06
• [Presentation] Regulaiton of the enzymatic activity of diguanylate cyclase by a globin-coupled sensor domain (2008)
  • Author(s): 青野重利
  • Organizer: Korea-Japan Seminar on Biomolecular Sciences- Experiments and Simulations
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-02-28
• [Presentation] Sensing of gas molecules and signal transduction in coordinations space of sensor proteins (2007)
  • Author(s): Shigetoshi Aono
  • Organizer: 3rd International Symposium on Chemistry of Coordination Space
  • Place of Presentation: Awaji, Japan
  • Year and Date: 2007-12-11
• [Presentation] Sensing of gas molecules and signal transduction in coordination space of sensor proteins (2007)
  • Author(s): S. Aono
  • Organizer: 3rd International Symposium on Chemistry of Coordination Space (ISCCS 2007)
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)
  • Year and Date: 2007-12-10
• [Presentation] セカンドメッセンジャー(c-di-GMP)合成を制御する新規な酸素センサータンパク質の構造と性質 (2007)
  • Author(s): 吉岡資郎
  • Organizer: 第40回酸化反応討論会
  • Place of Presentation: 奈良女子大学(奈良)
  • Year and Date: 2007-11-17
• [Presentation] セカンドメッセンジャー(c-di-GMP)合成を制御する新規な酸素センサータンパク質の構造と性質 (2007)
  • Author(s): 吉岡 資郎
  • Organizer: 第40回酸化反応討論会
  • Place of Presentation: 奈良
  • Year and Date: 2007-11-17
• [Presentation] Molecular mechanism by which heme-based sensor proteins sense their effector gas molecules (2007)
  • Author(s): S. Aono
  • Organizer: 67th Okazaki Conference「Molecular Science and Chemical Biology of Biomolecular Function」
  • Place of Presentation: 岡崎コンファレンスセンター(愛知)
  • Year and Date: 2007-11-11
• [Presentation] Molecular mechanism by which heme-based sensor proteins sense their effector gas molecules (2007)
  • Author(s): Shigetoshi Aono
  • Organizer: 67th Okazaki Conference
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2007-11-11
• [Presentation] 酸素センサータンパク質HemATによるCheAリン酸化反応の制御 (2007)
  • Author(s): 西村宗十
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 東北大学(宮城)
  • Year and Date: 2007-09-28
• [Presentation] 酸素センサータンパク質HemATによるCheAリン酸化反応の制御 (2007)
  • Author(s): 西村 宗十
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-28
• [Presentation] タコヘモシアニン最小活性ユニットの発現系構築とその酸化機能 (2007)
  • Author(s): 下川 千寿
  • Organizer: 第22回生体機能関連化学シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-28
• [Presentation] ニトロゲナーゼ転写調節因子VnfAが有するFe-Sクラスタによる転写調節の仕組み (2007)
  • Author(s): 中島洋
  • Organizer: 第57回錯体化学討論会
  • Place of Presentation: 名古屋工業大学(愛知)
  • Year and Date: 2007-09-25
• [Presentation] 酸素センサータンパク質HemATによる特異的酸素認識とシグナル伝達 (2007)
  • Author(s): 青野重利
  • Organizer: 第100回触媒化学討論会A
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2007-09-19
• [Presentation] 酸素センサータンパク質HemATによる特異的酸素認識とシグナル伝達 (2007)
  • Author(s): 青野 重利
  • Organizer: 第100回触媒化学討論会
  • Place of Presentation: 札幌
  • Year and Date: 2007-09-19
• [Presentation] The mechanism of CO sensing in the heme-based CO sensor CooA revealed by the crystal structure of the exogenous ligand bound form (2007)
  • Author(s): S. Aono
  • Organizer: 13th International Conference on Biological Inorganic Chemistry (ICBIC-13)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-07-17
• [Presentation] Oxygen sensing mechanism of signal transducer protein HemAT (2007)
  • Author(s): M. Nishimura
  • Organizer: 13th International Conference on Biological Inorganic Chemistry (ICBIC-13)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-07-17
• [Presentation] The mechanism of CO sensing in the heme-based CO sensor CooA revealed by the crystal structure of the exogenous ligand bound form (2007)
  • Author(s): Shigetoshi Aono
  • Organizer: 13th Intemational Conference on Biological Inorganic Chemistry
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-07-17
• [Presentation] Oxygen sensing mechanism of signal transducer protein HemAT (2007)
  • Author(s): Muneto Nishimura
  • Organizer: 13th International Conference on Biological Inorganic C
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-07-16
• [Presentation] Isolation,characterization,and monooxygenase activity of the minimal functional unit of octopus hemocyanin (2007)
  • Author(s): Chizu Shimokawa
  • Organizer: 13th International Conference on Biological Inorganic Chemistry
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2007-07-16
• [Presentation] グロビン型センサードメインを有するセカンドメッセンジャー(c-di-GMP)合成酵素の酸素による活性制御 (2007)
  • Author(s): 澤井仁美
  • Organizer: 第34回生体分子科学討論会
  • Place of Presentation: 東北大学(宮城)
  • Year and Date: 2007-06-22
• [Presentation] グロビン型センサードメィンを有するセカンドメッセンジャー(c-di-GMP)合成酵素の酸素による活性制御 (2007)
  • Author(s): 澤井 仁美
  • Organizer: 第34回生体分子科学討論会
  • Place of Presentation: 仙台
  • Year and Date: 2007-06-22
• [Presentation] 気体分子により駆動される生体内シグナル伝達の分子機構 (2007)
  • Author(s): 青野重利
  • Organizer: 第7回日本蛋白質科学会年会
  • Place of Presentation: 仙台国際センター(宮城)
  • Year and Date: 2007-05-26
• [Presentation] 気体分子により駆動される生体内シグナル伝達の分子機構 (2007)
  • Author(s): 青野 重利
  • Organizer: 第7回日本蛋白質科学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-25
• [Remarks]
  • URL: http://www.oib.orion.ac.jp/Lab/aono.html