Roles of hyper-anisotropic dynamics and frustration on protein function investigated in sub-msec order
| Project/Area Number |
19370062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KITAO Akio The University of Tokyo, 分子細胞生物学研究所, 准教授 (30252422)
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| Co-Investigator(Kenkyū-buntansha) |
城地 保昌 東京大学, 分子細胞生物学研究所, 助教 (30360415)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | タンパク質 / 超異方性 / 動態 / 機能 / フラストレーション / 動態. |
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| Research Abstract |
To elucidate the detailed protein functional principle in broad time and space ranges, we focused on the dynamics of nano to sub-milli sec order, observed function relevant protein dynamics by molecular simulation, and studied the hyper anisotropy and frustration of the systems. We also have developed the methods to calculate free energy landscape from massive parallel simulations and to extract correlated motions in high dimensional dynamics and used them to investigate the relation between protein dynamics and function.
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Report
(6 results)
Research Products
(183 results)
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[Presentation] 【ポスター】Dynomics Era:Eortsinconstructinga PDB-commensurate dynamics dataase and web servers-How dynamics data can be of use to gain insights into biomolecular function2007
Author(s)
Yang Lee-Wei, A. J.Rader, EranEyal, Xiong Liu, h.ristopher J. Jursa, Chakra Chemubhotla, .hark Holliman, Shann Ching Chen
Organizer
ISMB/ECCB2007, Vienna Austria, July 2007
Place of Presentation
Vienna,Austria
Year and Date
2007-07-22
Related Report
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