Analyses of common structural motif of rhodopsin family

• Project/Area Number: 19370065
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biophysics
• Research Institution: Nagoya University
• Principal Investigator: TSUTOMU Kouyama Nagoya University, 理学研究科, 教授 (30170210)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Midori 名古屋大学, 理学研究科, 助教 (20324387) ; IHARA Kunio 名古屋大学, 遺伝子実験施設, 助教 (90223297)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: 結晶構造解析 / ロドプシン / プロトンポンプ / ハロロドプシン / 視物質 / 古細菌 / バクテリオロドプシン / アーキロドプシン / イカロドプシン / X線結晶構造解析 / イオンポンプ / Gタンパク質共役レセプター / レチナールタンパク質

Research Abstract

高度好塩菌の光駆動プロトン輸送体(バクテリオロドプシン、アーキロドプシン)、光駆動塩素イオン輸送体(ハロロドプシン)、無脊椎動物系の視物質(イカロドプシン)など、異なる機能を有するロドプシン群蛋白質(=7 回膜貫通型レチナール結合蛋白質)を研究対象とし、それらの立体構造ならびに光誘起構造変化を調べ、ロドプシン群蛋白質の機能発現に必須な構造モチーフについての構造学的情報を得ることを目標として研究を展開した。

Research Products

• [Journal Article] 視物質および古細菌型ロドプシンの結晶化 (2009)
  • Author(s): 神山 勉
  • Journal Title: 日本結晶学会誌 51 Pages: 107-111
  • NAID: 10024820477
  • Peer Reviewed
• [Journal Article] 新しい光受容体の作動機構 (2009)
  • Author(s): 神山 勉
  • Journal Title: パリティ 24 Pages: 68-70
• [Journal Article] イカロドプシンの結晶構造と無脊椎動物の視覚 (2009)
  • Author(s): 村上緑
  • Journal Title: 生物物理 49 Pages: 15-16
  • NAID: 110007044738
• [Journal Article] Functionally important structural elements of the cyanobacterial clock-related protein Pex (2009)
  • Author(s): S. Kurosawa, R. Murakami, K. Onai, M. Morishita, D. Hasegawa, R. Iwase, T. Uzumaki, F. Hayashi, T. Kitajima-Ihara, S. Sakata, M. Murakami, T. Kouyama, M. Ishiura
  • Journal Title: Genes Cells 14 Pages: 1-16
  • Peer Reviewed
• [Journal Article] Functionally important structural elements of the cyanobacterial clock-related protein Pex (2009)
  • Author(s): S. Kurosawa, R. Murakami, K. Onai, M. Morishita, D. Hasegawa, R. Iwase, T. Uzumaki, F. Hayashi, T. Kitaima-Ihara, S. Sakata, M. Murakami, T. Kouyama, M. Ishiura
  • Journal Title: Genes Cells 14 Pages: 1-16
  • Peer Reviewed
• [Journal Article] 視物質および古細菌型ロドプシンの結晶化 (2009)
  • Author(s): 神山勉
  • Journal Title: 日本結晶学会誌 51 Pages: 107-111
  • NAID: 10024820477
  • Peer Reviewed
• [Journal Article] 新しい光受容体の作動機構 (2009)
  • Author(s): 神山勉
  • Journal Title: パリティ 24 Pages: 68-70
  • Peer Reviewed
• [Journal Article] Effect of xenon binding to a hydrophobic cavity on the proton pumping cycle in bacteriorhodopsin (2008)
  • Author(s): N. Hayakawa, T. Kasahara, D. Hasegawa, K. Yoshimura, M. Murakami, T. Kouyama
  • Journal Title: J. Mol. Biol 384 Pages: 812-823
  • Peer Reviewed
• [Journal Article] スルメイカロドプシンのX 線結晶構造解析 (2008)
  • Author(s): 村上緑、神山勉
  • Journal Title: 実験医学 26 Pages: 2237-2240
• [Journal Article] Crystal structure of squid rhodopsin (2008)
  • Author(s): M. Murakami and T. Kouyama
  • Journal Title: Nature 453 Pages: 363-367
  • Peer Reviewed
• [Journal Article] Structural role of bacterioruberin in the trimeric structure of archaerhodopsin-2 (2008)
  • Author(s): K. Yoshimura and T. Kouyama
  • Journal Title: J. Mol. Biol 375 Pages: 1267-1281
  • Peer Reviewed
• [Journal Article] A halorhodopsin-overproducing mutant isolated from an extremely haloalkaliphilic archaeon Natronomonas pharaonis (2008)
  • Author(s): K. Ihara, A. Narusawa, K. Maruyama, M. Takeguchi, T. Kouyama
  • Journal Title: FEBS Lett 582 Pages: 2931-2936
  • Peer Reviewed
• [Journal Article] Salinibacter sensory rhodopsin : sensory rhodopsin I-like protein from a eubacterium (2008)
  • Author(s): T. Kitajima-Ihara, Y. Furutani, D. Suzuki, K. Ihara K, H. Kandori, M. Homma, Y. Sudo
  • Journal Title: J. Biol. Chem 283 Pages: 23533-23541
  • Peer Reviewed
• [Journal Article] Effect of xenon binding to a hydrophobic cavity on the proton pumping cycle in bacteriorhodopsin (2008)
  • Author(s): N. Hayakawa, T. Kasahara, D. Hasegawa, K. Yoshimura, M. Murakami, T. Kouyama
  • Journal Title: J. Mol. Biol. 384 Pages: 812-823
  • Peer Reviewed
• [Journal Article] Crystal structure of squid rhodopsin (2008)
  • Author(s): M. Murakami, T. Kouyama
  • Journal Title: Nature 453 Pages: 363-367
  • Peer Reviewed
• [Journal Article] Structural role of bacterioruberin in the trimeric structure of archaerhodopsin-2 (2008)
  • Author(s): K. Yoshimura, T. Kouyama
  • Journal Title: J. Mol. Biol. 375 Pages: 1267-1281
  • Peer Reviewed
• [Journal Article] A halorhodopsin-overproducing mutant isolated from an extremely haloalkaliphilic archaeon Natronomonas pharaonis (2008)
  • Author(s): K. Ihara, A. Narusawa, K. Maruyama, M. Takeguchi, T. Kouyama
  • Journal Title: FEBS Lett. 582 Pages: 2931-2936
  • Peer Reviewed
• [Journal Article] Structural Role of Bacterioruberin in the Trimeric Structure of Archaerhodopsin-2 (2008)
  • Author(s): K. Yoshimura and T. Kouyama
  • Journal Title: J. Mol. Biol. 375 Pages: 1267-1281
  • Peer Reviewed
• [Journal Article] Crystallization and crystal properties of squid rhodospin (2007)
  • Author(s): M. Murakami, R. Kitahara, T. Gotoh, and T. Kouyama
  • Journal Title: Acta Crystallogr F63 Pages: 475-479
  • Peer Reviewed
• [Journal Article] Halide binding by the D212N mutant of Bacteriorhodopsin affects hydrogen bonding of water in the active site (2007)
  • Author(s): M. Shibata, M Yoshitsugu, N,Mizuide, K. Ihara H,Kandori
  • Journal Title: Biochemistry 46 Pages: 7525-7535
  • Peer Reviewed
• [Journal Article] バクテリオロドプシンのプロトン輸送機構 : 蛋白質中のプロトンと水分子の動き (2007)
  • Author(s): 前田章夫、神山勉
  • Journal Title: 蛋白質・核酸・酵素 9, 52 Pages: 1314-1321
  • NAID: 40015608588
  • Peer Reviewed
• [Journal Article] Crystallization and crystal properties of squid rhodopsin (2007)
  • Author(s): M. Murakami, R. Kitahara, T. Gotoh and T. Kouyama
  • Journal Title: Acta Cryst. F63 Pages: 475-279
  • Peer Reviewed
• [Journal Article] バクテリオロドプシンのプロトン輸送機構:蛋白質中のプロトンと水分子の動き (2007)
  • Author(s): 前田章夫、神山勉
  • Journal Title: 蛋白質・核酸・酵素 52 Pages: 1314-1321
  • NAID: 40015608588
  • Peer Reviewed
• [Journal Article] Halide binding by the D212N mutant of Bacteriorhodopsin affects hydrogen bonding of water in the active site. (2007)
  • Author(s): Shibata M, Yoshitsugu M, Mizaide N, Ihara K, Kandori H.
  • Journal Title: Biochemistry 46 Pages: 7525-7535
  • Peer Reviewed
• [Journal Article] White and H.Stan-Lotter Halorubrum chaoviator sp. Nov., a haloarchaeon isolated from sea salt in Baja California, Mexico, Western Australia and Naxos
  • Author(s): R. L.Mancinelli, R.Landheim, C.Sanchez-Porro, M.Dornmayr-Pfaffenhuemer, C. Gruber, A. Legat, A. Ventosa, C. Radax, K. Ihara, M. R
  • Journal Title: Greece. Int. J. System. Evol. Microbiol (in press)
  • Peer Reviewed
• [Presentation] イカロドプシン光反応初期中間体の構造解析 (2009)
  • Author(s): 村上緑, 神山勉
  • Organizer: 第4回日本生物物理学会中部支部討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-31
• [Presentation] イカロドプシン光異性化反応の構造解析 (2009)
  • Author(s): 村上緑
  • Organizer: シンポジウム : 名大の生物物理の生誕50周年
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-26
• [Presentation] Crystal structures of archaeal and invertebrate rhodopsins (2008)
  • Author(s): T. Kouyama
  • Organizer: Molecular Pharmacology of G Protein-Coupled Receptors 2008
  • Place of Presentation: Sydney
  • Year and Date: 2008-11-15
• [Presentation] Crystal structures of archaeal and invertebrate rhodopsins (2008)
  • Author(s): T. Kouyama
  • Organizer: Molecular Pharmacology of G Protein-Coupled Receptors 2008
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2008-11-15
• [Presentation] X-ray structure of squid rhodopsin (2008)
  • Author(s): M. Murakami
  • Organizer: International symposium on membrane proteins and high resolution X-ray structural analysis
  • Place of Presentation: Hyogo
  • Year and Date: 2008-09-01
• [Presentation] X-ray structure of squid rhodopsin (2008)
  • Author(s): M. Murakami
  • Organizer: International symposium on membrane proteins and high resolution X-ray structural analysis
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 2008-09-01
• [Presentation] Crystallization of visual pigments and archaeal rhodopsins (2008)
  • Author(s): T. Kouyama, M. Murakami, K. Yoshimura and M. Yamamoto
  • Organizer: XXI Congress and General Assembly of the International Union of Crystallography
  • Place of Presentation: Osaka
  • Year and Date: 2008-08-29
• [Presentation] Crystallization of visual pigments and archaeal rhodopsins (2008)
  • Author(s): T. Kouyama, M. Murakami, K. Yoshimura, M. Yamamoto
  • Organizer: XXI Congress and General Assembly of the Interaational Union of Crystallography
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2008-08-29
• [Presentation] Dimeric structure of squid rhodopsin (2008)
  • Author(s): M. Murakami and T. Kouyama
  • Organizer: 13th International conference of retinal proteins
  • Place of Presentation: Barcelona
  • Year and Date: 2008-06-28
• [Presentation] Protein-lipid interactions in 3D crystals of squid rhodopsin and archaeal rhodopsins (2008)
  • Author(s): T. Kouyama, M. Murakami and K. Yoshimura
  • Organizer: 13th International conference of retinal proteins
  • Place of Presentation: Barcelona
  • Year and Date: 2008-06-28
• [Presentation] Dimeric structure of squid rhodopsin (2008)
  • Author(s): M. Murakami, T. Kouyama
  • Organizer: 13th International conference of retinal proteins
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2008-06-18
• [Presentation] Protein-lipid interactions in 3D crystals of squid rhodopsin and archaeal rhodopsins (2008)
  • Author(s): T. Kouyama, M. Murakami, K. Yoshimura
  • Organizer: 13th International conference of retinal proteins
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2008-06-16
• [Presentation] 無脊椎動物のロドプシンおよび古細菌型ロドプシンの構造 (2008)
  • Author(s): 神山勉
  • Organizer: 第5回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-09
• [Presentation] Crystal Structure of Squid Rhodopsin (2008)
  • Author(s): M. Murakami
  • Organizer: Gordon Research Conference on "LIGAND RECOGNITION & MOLECULAR GATING"
  • Place of Presentation: Ventura, CA
  • Year and Date: 2008-03-06
• [Presentation] Crystal Structure of Squid Rhodopsin (2008)
  • Author(s): M. Murakami
  • Organizer: Gordon Research Conference on "LIGAND RECO GNITION & MOLECULAR GATING"
  • Place of Presentation: Ventura, CA, USA
  • Year and Date: 2008-03-06
• [Presentation] Crystal Structure of Squid Rhodopsin at 2.5A resolution (2008)
  • Author(s): T. Kouyama and M. Murakami
  • Organizer: GPCR symposium - Frontier on Integral Membrane Proteins in Crystal Structure Determination -
  • Place of Presentation: Hyogo
  • Year and Date: 2008-02-26
• [Presentation] Crystal Structure of Squid Rhodopsin at 2.5A resolution (2008)
  • Author(s): T. Kouyama and M. Murakami
  • Organizer: GPCR symposium - Frontier on Integral Membrane Proteins in Crystal Structure Determination-
  • Place of Presentation: Hyogo
  • Year and Date: 2008-02-26
• [Presentation] Crystallographic studies of squid rhodopsin and archaeal rhodopsins (2008)
  • Author(s): T. Kouyama
  • Organizer: Gordon Research Conference on "PHOTOSENSORY RECEPTORS & SIGNAL TRANSDUCTION"
  • Place of Presentation: Ventura, CA
  • Year and Date: 2008-01-29
• [Presentation] Crystallographic studies of squid rhodopsin and archaeal rhodopsins (2008)
  • Author(s): T. Kouyama
  • Organizer: Gordon Research Conference on "PHOTOSENSORY RECEPTORS & SIGNAL TRANSDUCTION"
  • Place of Presentation: Ventura, CA, USA
  • Year and Date: 2008-01-29
• [Presentation] 好アルカリ性好塩菌由来Natronomonas pharaonisのハロロドプシンの結晶化 (2008)
  • Author(s): 竹口優、成澤明洋、井原邦夫、神山勉
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] 古細菌型ロドプシンと無脊椎動物のロドプシンの構造比較 (2008)
  • Author(s): 神山勉
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] バクテリオロドプシンのアルカリpHでの光誘起構造変化 (2008)
  • Author(s): 山本昌孝、村上緑、神山勉
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] イカロドプシンのX線結晶構造解析 (2008)
  • Author(s): 村上緑、神山勉
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] 古細菌型ロドプシンを発現した大腸菌の膜生理学 (2008)
  • Author(s): 井原邦夫
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] バクテリオロドプシン変異体の二次元結晶構造の高速AFM観察 (2008)
  • Author(s): 柴田幹大、山下隼人、内橋貴之、山田純也、井原邦夫、神取秀樹、安藤敏夫
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] D85N変異体を用いて解析したバクテリオロドプシンのシッフ塩基部位の水素結合構造 (2008)
  • Author(s): 山田純也、柴田幹大、井原邦夫、神取秀樹
  • Organizer: 日本生物物理学会第46回年会
  • Place of Presentation: 福岡
• [Presentation] スルメイカロドプシンのX 線結晶構造解析 (2008)
  • Author(s): 村上緑、神山勉
  • Organizer: 第8回日本蛋白質科学会年会
  • Place of Presentation: 東京
• [Presentation] クライオ原子間力顕微鏡による凍結割断試料の液浸観察 (2007)
  • Author(s): 山川奈津子、真塩海里、山本昌孝、五藤俊明、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-23
• [Presentation] バクテリオロドプシンを発現した大腸菌の光生理反応 (2007)
  • Author(s): 井原 邦夫
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-23
• [Presentation] スルメイカロドプシンのX線結晶構造解析 (2007)
  • Author(s): 村上緑、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-22
• [Presentation] アーキロドプシン-2の3量体におけるバクテリオルベリンの役割 (2007)
  • Author(s): 吉村恵子、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] バクテリオロドプシンの疎水キャビティに結合する希ガスとその効果 (2007)
  • Author(s): 早川直紀、村上緑、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] バクテリオロドプシン3次元結晶のM 中間体寿命に及ぼす格子力の影響 (2007)
  • Author(s): 山本昌孝、早川直紀、村上緑、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] 高度好塩性アルカリ古細菌Natronomonas pharaonis におけるハロロドプシンの解析 (2007)
  • Author(s): 成澤明洋、丸山恵太、竹口優、井原邦夫、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] バクテリオロドプシンミュータントL93Aの結晶構造解析 (2007)
  • Author(s): 樋掛雅則、山本昌孝、早川直紀、井原邦夫、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] アーキロドプシン-2のM中間体のX線構造解析 (2007)
  • Author(s): 藤井隆道、吉村恵子、村上緑、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] 高度好塩性アルカリ古細菌Natronomonas pharaonisにおけるハロロドプシンの解析 (2007)
  • Author(s): 成澤明洋、丸山恵太、竹口優、井原邦夫、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] アーキロドプシンー2のM中間体のX線構造解析 (2007)
  • Author(s): 藤井隆道、吉村恵子、村上緑、神山勉
  • Organizer: 日本生物物理学会第45回年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-21
• [Presentation] イカロドプシンの結晶構造 (2007)
  • Author(s): 村上緑、神山勉
  • Organizer: 日本結晶学会2007年度年会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-02
• [Presentation] バクテリオロドプシンの光反応サイクルに及ぼすXeガスの影響 (2007)
  • Author(s): 早川直紀、笠原隆史、長谷川大祐、村上緑、神山勉
  • Organizer: 日本結晶学会2007年度年会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-02
• [Presentation] バクテリオロドプシンの光誘起構造変化に及ぼす結晶格子力の影響 (2007)
  • Author(s): 山本昌孝、早川直紀、村上緑、神山勉
  • Organizer: 日本結晶学会2007年度年会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-02
• [Presentation] アーキロドプシン-2の3量体構造におけるバクテリオルベリンの特異的結合 (2007)
  • Author(s): 吉村恵子、神山勉
  • Organizer: 日本結晶学会2007年度年会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-02
• [Presentation] X-ray crystallographic studies of the reaction intermediates of archaeal proton pumps (2007)
  • Author(s): .T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] Trimeric Structure of Archaerhodopsin-2 at 2.1 A Resolution (2007)
  • Author(s): K. Yoshimura, T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] Binding of xenon to a hydrophobic cavity in the cytoplasmic half of bacteriorhodopsin & its effect to the absorption kinetics (2007)
  • Author(s): N. Hayakawa, M. Murakami, T. Kasahara, D. Hasegawa, T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] Decay kinetics of the M intermediate of bR in 3D crystals : Influence of the crystal lattice force (2007)
  • Author(s): M. Yamamoto, N. Hayakawa, M. Murakami, T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] X-ray crystallographic studies of the reaction intermediates of archaealproton pumps (2007)
  • Author(s): T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] Trimeric Structure of Archaerhodopsin-2 at 2.1 Å Resolution (2007)
  • Author(s): K. Yoshimura and T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] Decay kinetics of the M intermediate of bR in 3D crystals: Influence of the crystal lattice force (2007)
  • Author(s): M. Yamamoto, N. Hayakawa, M. Murakami and T. Kouyama
  • Organizer: Nagoya International Symposium on Science of Molecular Assembly and Biomolecular Systems
  • Place of Presentation: Nagoya
  • Year and Date: 2007-11-30
• [Presentation] Binding of Noble Gases to a Hydrophobic Cavity in the Cytoplasmic Half of Bacteriorhodopsin (2007)
  • Author(s): N. Hayakawa, M. Murakami, T. Kasahara, D. Hasegawa and T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: 東京
  • Year and Date: 2007-11-10
• [Presentation] X-ray crystallographic study of squid rhodopsin (2007)
  • Author(s): M. Murakami and T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: 東京
  • Year and Date: 2007-11-10
• [Presentation] Decay kinetics of the M intermediate of bR in 3D crystals: Influence of the crystal lattice force (2007)
  • Author(s): M. Yamamoto, N. Hayakawa, M. Murakami and T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: 東京
  • Year and Date: 2007-11-10
• [Presentation] Structures and Dynamics of Archaeal Light-Driven Proton Pumps in 3D Crystals : Effect of Crystal Packing, Lattice Force and Xenon Binding (2007)
  • Author(s): T. Kouyama
  • Organizer: International Symposium on RETINAL PROTEINS : EXPERIMENTS AND THEORY
  • Place of Presentation: Bremen, Germany
  • Year and Date: 2007-09-24
• [Presentation] Trimeric Structure of Archaerhodopsin-2 at 2.1 A Resolution (2007)
  • Author(s): K. Yoshimura, T. Kouyama
  • Organizer: International Symposium on RETINAL PROTEINS : EXPERIMENTS AND THEORY
  • Place of Presentation: Bremen, Germany
  • Year and Date: 2007-09-24
• [Presentation] Crystal Structure of Squid Rhodopsin (2007)
  • Author(s): M. Murakami, T. Kouyama
  • Organizer: International Symposium on RETINAL PROTEINS : EXPERIMENTS AND THEORY
  • Place of Presentation: Bremen, Germany
  • Year and Date: 2007-09-24
• [Presentation] Crystal Structure of Squid Rhodopsin (2007)
  • Author(s): M. Murakami and T. Kouyama
  • Organizer: International Symposium on RETINAL PROTEINS: EXPERIMENTS AND THEORY
  • Place of Presentation: Bremen, Germany
  • Year and Date: 2007-09-24
• [Presentation] Structures and Dynamics of Archaeal Light-Driven Proton Pumps in 3D Crystals: Effect of Crystal Packing, Lattice Force and Xenon Binding (2007)
  • Author(s): T. Kouyama
  • Organizer: International Symposium on RETINAL PROTEINS: EXPERIMENTS AND THEORY
  • Place of Presentation: Bremen, Germany
  • Year and Date: 2007-09-24
• [Presentation] Trimeric Structure of Archaerhodopsin-2 at 2.1 Å Resolution (2007)
  • Author(s): K. Yoshimura and T. Kouyama
  • Organizer: International Symposium on RETINAL PROTEINS: EXPERIMENTS AND THEORY
  • Place of Presentation: Bremen, Germany
  • Year and Date: 2007-09-24
• [Presentation] Importance of bacterioruberin for maintaining the trimer in archaerhodopsin-2 (2007)
  • Author(s): K. Yoshimura, T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-10
• [Presentation] Binding of Noble Gases to a Hydrophobic Cavity in the Cytoplasmic Half of Bacteriorhodopsin (2007)
  • Author(s): N. Hayakawa, M. Murakami, T. Kasahara, D. Hasegawa, T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-10
• [Presentation] X-ray crystallographic study of squid rhodopsin (2007)
  • Author(s): M. Murakami, T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-10
• [Presentation] Decay kinetics of the M intermediate of bR in 3D crystals : Influence of the crystal lattice force (2007)
  • Author(s): M. Yamamoto, N. Hayakawa, M. Murakami, T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: Tokyo
  • Year and Date: 2007-09-10
• [Presentation] Importance of bacterioruberin for maintaining the trimer in archaerhodopsin-2 (2007)
  • Author(s): K. Yoshimura and T. Kouyama
  • Organizer: 2nd International Symposium on Diffraction Structural Biology 2007
  • Place of Presentation: 東京
  • Year and Date: 2007-09-10
• [Book] 生物物理学ハンドブック(石渡信一、桂勲、桐野豊、美宅成樹 編) (2007)
  • Author(s): 神山勉
  • Publisher: 朝倉書店
• [Book] 生物物理学ハンドブック (2007)
  • Author(s): 神山 勉
  • Total Pages: 700
  • Publisher: 朝倉書店
• [Remarks] 新聞報道
• [Remarks] 中日新聞平成20年5月15日朝刊
• [Remarks] 新薬開発への鍵のタンパク、立体構造を初解明、名大教授ら、イカ使い成功
• [Remarks] 日刊工業新聞平成20年5月15日
• [Remarks] 細胞の情報伝達物質、名大、スルメイカで解明
• [Remarks] Nagoya University Topics, No.182, 10-11 (2008)
• [Patent(Industrial Property Rights)] 特許権 (2008)
  • Inventor(s): 神山勉、村上緑
  • Industrial Property Rights Holder: 神山勉、村上緑
  • Industrial Property Number: 2008-058864
  • Filing Date: 2008-03-09