Molecular simulation study of membrane morphology change induced by proteins
| Project/Area Number |
19370069
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
TAKADA Shoji Kyoto University, 大学院・理学研究科, 准教授 (60304086)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
|---|
| Keywords | ベシクル融合 / ベシクル発芽 / ラフト / 粗視化モデル / シミュレーション / インフルエンザ / SNARE |
|---|
| Research Abstract |
Membrane morphology change, such as cell fusion and cell division, is induced by related proteins. The aim of the research here is to develop a coarse-grained simulation model for protein-membrane complex and to apply it to the membrane morphology dynamics. We extended the multiple-basin model for proteins, used Noguchi model for lipids, and proposed the excluded volume and hydrophobic interaction terms for the protein-lipid interaction. By this new model, we successfully simulated vesicle formation, vesicle fusion, phase separation of 2-components vesicle, and budding addressing their mechanisms.
|
Report
(4 results)
Research Products
(76 results)
