| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Research Abstract |
Membrane morphology change, such as cell fusion and cell division, is induced by related proteins. The aim of the research here is to develop a coarse-grained simulation model for protein-membrane complex and to apply it to the membrane morphology dynamics. We extended the multiple-basin model for proteins, used Noguchi model for lipids, and proposed the excluded volume and hydrophobic interaction terms for the protein-lipid interaction. By this new model, we successfully simulated vesicle formation, vesicle fusion, phase separation of 2-components vesicle, and budding addressing their mechanisms.
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