| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Research Abstract |
Heterochromatin protein 1 (HP1) plays a critical role in heterochromatin formation and mitotic progression through interaction with various proteins. In this study, we tried to identify binding proteins of HP1 subtypes, α, β, γ, by proteomic approach. We revealed that 1) all subtypes binds many kinds of protein through a similar way, 2) a protein newly identified as HP1 binding, POGZ, binds to HP1 and regulates HP1 binding of other protein, 3) there are several proteins those can bind to a specific subtype of HP1, those may provide specific characterization of each HP1 subtype.
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