Functional analysis of Notch signaling during development

• Project/Area Number: 19370084
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Nagoya University
• Principal Investigator: ITO Motoyuki Nagoya University, 高等研究院, 特任准教授 (20377906)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 個体発生 / Notch / zebrafish / development / Notch signal / neurogenesis

Research Abstract

NotchリガンドであるJaggedが発生過程でDeltaとは異なる機能を持ち、脊索細胞の発生制御を介して、体軸構造形成に重要な働きをする事が明らかとなった。また、Notchシグナルを調節するタンパク質として、NLKを同定し、NLKがNotchをリン酸化する事で、その活性を抑制し、神経細胞発生を制御する事を明らかにした。

Research Products

• [Journal Article] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex (2010)
  • Author(s): Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M
  • Journal Title: Nat. Cell Biol 12 Pages: 278-285
  • Peer Reviewed
• [Journal Article] Nemo-like kinase suppresses Notch signalling by interfering with for mation of the Notch active transcriptional complex (2010)
  • Author(s): Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M
  • Journal Title: Nat.Cell Biol. 12 Pages: 278-295
  • Peer Reviewed
• [Journal Article] Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin (2009)
  • Author(s): Ishitani T, Ishitani S, Matsumoto K, Itoh M
  • Journal Title: J. Neurochem 111 Pages: 1104-1118
  • Peer Reviewed
• [Journal Article] Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin (2009)
  • Author(s): Ishitani T, Ishitani S, Matsumoto K, Itoh M.
  • Journal Title: J.Neurochem. 111 Pages: 1104-1118
  • Peer Reviewed
• [Presentation] Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex (2009)
  • Author(s): Tohru Ishitani, Tomoko Hirao, Maho Suzuki, Miho Isoda, Shizuka Ishitani, Kenichi Harigaya, Motoo Kitagawa, Kunihiro Matsumoto, Motoyuki Itoh
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: パシィフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] agged-NotchシグナルはNotochord細胞の分化・運命決定を通じて、周囲組織のパターン形成活性と体軸支持構造形成を調節する (2009)
  • Author(s): 盛田良子、山本麻衣、溝口貴正、磯田美帆、松本邦弘、米村重信、川上浩一、伊藤素行
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: パシィフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Jagged1b is required to maintain prosensory domain independent of Notch signaling during lateral line development in zebrafish (2009)
  • Author(s): Miho Isoda, Makiko Tsutsumi, Kunihiro Matsumoto, Motoyuki Itoh
  • Organizer: 第42回日本発生生物学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-29
• [Presentation] Jagged-NotchシグナルはNotochord細胞の運命決定を通じて、周囲組織のパターン形成活性と体軸支持構造形成を調節する (2009)
  • Author(s): 盛田良子、山本麻衣、溝口貴正、磯田美帆、松本邦弘、米村重信、川上浩一、伊藤素行
  • Organizer: 第15回小型魚類研究会
  • Place of Presentation: 名古屋大学
• [Presentation] Jagged-Notch signaling regulates cell fate decisions during notochord development in zebrafish (2009)
  • Author(s): 伊藤素行
  • Organizer: 4th Asia-Oceania zebrafish meeting
  • Place of Presentation: 済州jeju island, phoenix island resort., KOREA
• [Presentation] Jagged-Notch signaling regulates notochord morphogenesis and vertebral patterning in zebrafish (2009)
  • Author(s): Mai Yamamoto, , Kunihiro Matsumoto, Shigenobu Yonemura, Koichi Kawakami, , Motoyuki Itoh
  • Organizer: Third Strategic Conference of Zebrafish Investigators
  • Place of Presentation: Asilomar, California, USA
• [Presentation] Nemo-like kinaseはNotchシグナルを阻害し、神経分化を制御する (2008)
  • Author(s): 石谷太、平尾智子、鈴木真帆、磯田美帆、北川元生、松本邦弘、伊藤素行
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-11
• [Presentation] 側線の発生過程におけるJagged1bの機能解析 (2008)
  • Author(s): 磯田美帆、堤真紀子、松本邦弘、伊藤素行
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-10
• [Presentation] Functional Analysis of Jagged1b in Lateral Line Development (2008)
  • Author(s): Miho Isoda, Makiko Tsutsumi, Kunihiro Matsumoto, Motoyuki Itoh
  • Organizer: 第14回小型魚類研究会
  • Place of Presentation: 自然科学研究機構岡崎コンファレンスセンター
  • Year and Date: 2008-09-20
• [Presentation] 側線の発生過程におけるJagged1bの機能解析 (2008)
  • Author(s): 磯田美帆, 堤真紀子, 松本邦弘, 伊藤素行
  • Organizer: 第3回Notch研究会若手の会
  • Place of Presentation: 国立遺伝学研究所
  • Year and Date: 2008-07-18
• [Presentation] Jagged-Notch signaling is involved in zebrafish notochord development (2008)
  • Author(s): Mai Yamamoto, , Kunihiro Matsumoto, Shigenobu Yonemura, Koichi Kawakami, , Motoyuki Itoh
  • Organizer: 8th International Meeting on Zebrafish Development and Genetics
  • Place of Presentation: Madison, WI, USA(poster presentation)
  • Year and Date: 2008-06-27
• [Presentation] Jagged-Notch signaling is involved in zebrafish notochord development (2008)
  • Author(s): Mai Yamamoto, , Kunihiro Matsumoto, Shigenobu Yonemura Motoyuki Itoh
  • Organizer: 第41日本発生生物学会年会
  • Place of Presentation: 徳島郷土文化会館
  • Year and Date: 2008-05-28
• [Presentation] Mib-Jagged-NotchシグナルによるNotochord形成の制御機構 (2007)
  • Author(s): 山本麻衣、米村重信、松本邦弘、伊藤素行
  • Organizer: 第30回分子生物学会
  • Place of Presentation: パシィフィコ横浜
  • Year and Date: 2007-12-13
• [Presentation] Mib-Jagged-NotchシグナルによるNotochord形成の制御機構 (2007)
  • Author(s): 山本 麻衣
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-13
• [Presentation] Notch signaling controls lateral line development in zebrafish (2007)
  • Author(s): Motoyuki Itoh, Miho Isoda, Makiko Tsutsumi
  • Organizer: 第30回分子生物学会
  • Place of Presentation: パシィフィコ横浜
  • Year and Date: 2007-12-12
• [Presentation] Notch signaling controls lateral line development in zebrafish (2007)
  • Author(s): Makiko Tsutsumi、Miho Isoda, 、Motoyuki Itoh
  • Organizer: 第47回ASCB meeting
  • Place of Presentation: washington DC. USA
  • Year and Date: 2007-12-03
• [Presentation] Nemo-like kinase promotes neurogenesis by blocking Notch-signaling (2007)
  • Author(s): Tohru Ishitani, Tomoko Hirao, Maho Suzuki, Miho Isoda, Kunihiro Matsumoto, Motoyuki Itoh
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-29
• [Presentation] Regulation of the vertebrate axonal development by Nemo-like kinase (2007)
  • Author(s): Tohru Ishitani, Kunihiro Matsumoto, Motoyuki Itoh
  • Organizer: 2nd Strategic conference of zebrafish investigators
  • Place of Presentation: Asilomar, USA
• [Remarks]
  • URL: http://www.iar.nagoya-u.ac.jp/tenure/itoh/itoh.html
• [Remarks]
  • URL: http://www.bio.nagoya-u.ac.jp/index2.html
• [Remarks]
  • URL: http://www.bio.nagoya-u.ac.jp/index2.html