Elucidation of the molecular system of skeletal formation using mouse andmedaka mutants of organogenesis

• Project/Area Number: 19370093
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: KUDO Akira Tokyo Institute of Technology, 大学院・生命理工学研究科, 教授 (70178002)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000); Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: トランスジェニックメダカ / メダカ突然変異体 / 骨格形成 / 破骨 / メダカ / 骨形成 / トランスジェニック / ペリオスチ / 心筋梗塞 / ペリオスチン

Research Abstract

種々のメダカ骨格異常変異体の原因遺伝子が解明され、脊椎動物共通の骨格形成システムが明らかになった。またメダカ変異体は、ヒト疾患モデルとして重要な実験動物であり、今後もその原因解明に利用できる。小型魚類でメカニカルストレス依存性の筋間中隔形成に働き、細胞外マトリックス蛋白であるぺリオスチンは、そのノックアウトマウスの解析から、切歯萌出、心筋梗塞時の心筋再生に機能することがわかった。従って、小型魚類とマウスを統合的に解析することによって、ぺリオスチンがメカニカルストレスによる組織再生に機能する分子であることが明らかになった。

Research Products

• [Journal Article] Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons (2009)
  • Author(s): Hibiya, K., Katsumoto, T., Kondo, T., Kitabayashi, I. and Kudo, A.
  • Journal Title: Dev. Biol.(Epub)
• [Journal Article] Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro (2009)
  • Author(s): Miyagoe-Suzuki, Y., Masubuchi, N., Miyamoto, K., Wada, MR. Yuasa, S., Saito, F., Matsumura, K., Kanesaki, H., Kudo, A., Manya, H., Endo, T. and Takeda, S.
  • Journal Title: Mech. Dev. 126 Pages: 107-116
• [Journal Article] Peiostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon. Journal of Histochemistry & Cytochemistry (2009)
  • Author(s): Kikuchi,Y., kashima, T.G., Nishiyama,T., Shimazu,K., Morishita,Y., Shimazaki,M., Kii,I., Horie,H., Nagai,H., Kudo, A.. And Fukayama,M.
  • Journal Title: 56 (8) Pages: 753-764
• [Journal Article] Gene expression and functional analysis of zebrafish larval fin fold regeneration (2009)
  • Author(s): Yoshinari,N., Ishida,T., Kudo, A. and Kawakami.A.
  • Journal Title: Dev. Bio. 325 Pages: 71-81
• [Journal Article] Periostin, a novel marker of intramembranous ossification, is ecpressed in fibrous dysplasia and in c-Fos-overexpressing bon lesions (2009)
  • Author(s): Kashima,T.G., Nishiyama,T., Shimazu,K., Shimazaki,M., Kii,I., Grigoriadis,A.E., Fukayama,M., and Kudo, A
  • Journal Title: Human Pathology 40 Pages: 226-237
• [Journal Article] Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons. (2009)
  • Author(s): Hibiya, K
  • Journal Title: Dev. Biol. Feb 27 Pages: 19254709-19254709
  • Peer Reviewed
• [Journal Article] Reduced proliferative activity of primary POMGnTl-null myoblasts in vitro. (2009)
  • Author(s): Miyagoe-Suzuki, Y.
  • Journal Title: Mech. Dev. 126 Pages: 107-116
  • Peer Reviewed
• [Journal Article] Peiostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon. (2009)
  • Author(s): Kikuchi, Y.
  • Journal Title: J Histochemistry & Cytochemistry 56(8) Pages: 753-764
  • Peer Reviewed
• [Journal Article] Gene expression and functional analysis of zebrafish larval fin fold regeneration . (2009)
  • Author(s): Yoshinari, N.
  • Journal Title: Dev. Bio. 325 Pages: 71-81
  • Peer Reviewed
• [Journal Article] Grigoriadis, A. E., Fukayama, M., Kudo, A. Periostin, a novel marker of intramembranous ossification, is ecpressed in fibrous dysplasia and in c-Fos-overexpressing bon lesions. (2009)
  • Author(s): Kashima, T. G.
  • Journal Title: Human Pathology 40 Pages: 226-237
  • Peer Reviewed
• [Journal Article] Mutation in the abcb7 gene causes abnormal iron and fatty acid metabolism in developing medaka fish (2008)
  • Author(s): iyake, A., Higashijima, S., Kobayashi, D., Narita, T., Jindo, T., Davin H. E. Setiamarga, D.H.E., Ohisa, S., Orihara, N., Hibiya, K., Konno, S., Sakaguchi, S., Horie, K., Imai, Y., Naruse, K., Kudo, A. and Takeda, H.
  • Journal Title: Dev. Growth Differ 50 Pages: 703-716
  • NAID: 10023963222
• [Journal Article] Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas (2008)
  • Author(s): Fukushima, N., Kikuchi, Y., Nishiyama, T., Kudo, A., and Fukayama, M.
  • Journal Title: Mod. Pathol 21 Pages: 1044-1053
• [Journal Article] The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function (2008)
  • Author(s): Itakura,T., Chandra, A., Yang, Z., Xue X.D., Wang, B., Kimura, W., Hikosaka, K., Inohaya, K., Kudo, A., Uezato, T., and Miura, N.
  • Journal Title: J. Biochem 143 Pages: 407-416
  • NAID: 10024908974
• [Journal Article] Function of Pax1 and Pax9 in the sclerotome of medaka fish (2008)
  • Author(s): Mise, T., Iijima, M., Inohaya, K., Kudo, A. and Wada, H.
  • Journal Title: Genesis 46 Pages: 185-192
• [Journal Article] Impaired capsule formation of tumors in periostin-null mice (2008)
  • Author(s): Shimazaki, M. and Kudo, A.
  • Journal Title: Biochem. Biophys. Res. Com. 342 Pages: 766-772
• [Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction (2008)
  • Author(s): Shimazaki, M., Nakamura, K., Kii, I., Kashima, T., Amizuka, N., Li, M., Saito, M., Fukuda, K., Nishiyama, T., Kitajima, S., Saga, Y., Fukayama, M., Sata, M., and Kudo, A.
  • Journal Title: J. Exp. Med. 205 Pages: 295-303
• [Journal Article] Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration (2008)
  • Author(s): Nakatani, Y., Nishidate, M., Fujita, M., Kawakami, A. and Kudo, A.
  • Journal Title: Dev. Growth Differ 50 Pages: 71-83
  • NAID: 10021095489
• [Journal Article] Expression of marker genes during otolith development in medaka (2008)
  • Author(s): Nemoto, Y., Chatani, M., Inohaya, K., Hiraki, Y. and Kudo, A.
  • Journal Title: Gene Exp. Patterns 8 Pages: 92-95
• [Journal Article] Bone marrow stromal cell lines having high potential for osteoclast-supporting activity express PPAR・1 and show a high potential for differentiation into adipocytes (2008)
  • Author(s): Takagi, K. and Kudo, A.
  • Journal Title: J Bone Miner. Metab. 26 Pages: 13-23
• [Journal Article] Mutation in the abcb7 gene causes abnormal iron and fatty acid metabolism in developing medaka fish. (2008)
  • Author(s): Miyake, A.
  • Journal Title: Dev. Growth Differ. 50 Pages: 703-716
  • Peer Reviewed
• [Journal Article] Periostin deposition in the stroma of invasive and intraductal neoplasms of the pancreas. (2008)
  • Author(s): Fukushima, N.
  • Journal Title: Mod. Pathol. 21 Pages: 1044-1053
  • Peer Reviewed
• [Journal Article] The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function (2008)
  • Author(s): Itakura, T.
  • Journal Title: J. Biochem 143 Pages: 407-416
  • Peer Reviewed
• [Journal Article] Function of Pax1 and Pax9 in the sclerotome of medaka fish. (2008)
  • Author(s): Mise, T.
  • Journal Title: Genesis 46 Pages: 185-192
  • Peer Reviewed
• [Journal Article] Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration (2008)
  • Author(s): Nakatani, Y.
  • Journal Title: Dev. Growth Differ 50 Pages: 71-83
  • Peer Reviewed
• [Journal Article] Impaired capsule formation of tumors in periostin-null mice. (2008)
  • Author(s): Shimazaki, M.
  • Journal Title: Biochem. Biophys. Res. Com. 367 Pages: 736-742
  • Peer Reviewed
• [Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction. (2008)
  • Author(s): Shimazaki, M.
  • Journal Title: J. Exp. Med. 205 Pages: 295-303
  • Peer Reviewed
• [Journal Article] Migration of mesenchymal cell fated to blastema is necessary for fish fin regeneration. (2008)
  • Author(s): Nakatani, Y.
  • Journal Title: Dev. Growth Differ. 50 Pages: 71-83
  • Peer Reviewed
• [Journal Article] Expression of marker genes during otolith development in medaka. (2008)
  • Author(s): Nemoto, Y.
  • Journal Title: Gene Exp. Patterns 8 Pages: 92-95
  • Peer Reviewed
• [Journal Article] Bone marrow stromal cell lines having high potential for osteoclast-supporting activity express PPARγ1 and show a high potential for differentiation into adipocytes. (2008)
  • Author(s): Takagi, K.
  • Journal Title: J Bone Miner. Metab. 1.26. Pages: 13-23
  • Peer Reviewed
• [Journal Article] Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates to bone defects on rat calvariae (2007)
  • Author(s): Kojima, T., Freitas, P.H.L., Ubaidus, S., Suzuki, A., Li, M., Yoshizawa, M., Oda, K., Maeda, T., Kudo, A., Saito, C. and Amizuka, N.
  • Journal Title: Biomedical Res. 28 Pages: 219-229
• [Journal Article] The teleost intervertebral region acts as a growth center of the centrum : In vivo visualization of osteoblasts and their progenitors in transgenic fish (2007)
  • Author(s): Inohaya, K., Takano, Y. and Kudo, A.
  • Journal Title: Developmental Dynamics 236 Pages: 3031-3046
• [Journal Article] Identification of novel markers expressed during fin regeneration by microarray analysis in Medaka fish (2007)
  • Author(s): Nishidate, M., Nakatani, Y., Kudo, A. and Kawakami, A.
  • Journal Title: Developmental Dynamics 236 Pages: 2685-2693
• [Journal Article] Histological examinations on the bone regeneration achieved by combining grafting with hydroxyapatite and thermoplastic bioresorbable plates (2007)
  • Author(s): Kojima, T., Amizuka, N., Suzuki, A., Freitas, P.H., Yoshizawa, M., Kudo, A., Saito, C. and Maeda, T.
  • Journal Title: J Bone Miner. Metab. 25 Pages: 361-373
  • NAID: 10024125348
• [Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells (2007)
  • Author(s): Kondo, S., Shukunami, C., Morioka, Y., Matsumoto, N., Takahashi, R., Oh, J., Atsumi, T., Umezawa, A., Kudo, A., Kitamura, H., Hiraki, Y. and Noda, M.
  • Journal Title: J. Cell Sci. 120 Pages: 849-857
• [Journal Article] Cellular and molecular processes of regeneration, with special emphasis on fish fins (review) Dev. (2007)
  • Author(s): Nakatani, Y., Kawakami, A. and Kudo, A.
  • Journal Title: Growth Differ 49 Pages: 145-154
• [Journal Article] GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen (2007)
  • Author(s): Moriyama, A., Kii, I., Sunabori, T., Kurihara, S., Takayama, I. Shimazaki, M., Tanabe, H., Oginuma, M., Fukayama, M., Matsuzaki, Y., Saga, Y., and Kudo, A.
  • Journal Title: Genesis 45 Pages: 90-100
• [Journal Article] Multinucleate osteoclasts in medaka as evidence of active bone remodeling (2007)
  • Author(s): Nemoto, Y., Higuchi, K., Baba, O., Kudo, A. and Takano, Y
  • Journal Title: Bone^+(+ : equal correspondence) 40 Pages: 399-408
• [Journal Article] Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates to bone defects on rat calvariae. (2007)
  • Author(s): Kojima, T.,
  • Journal Title: Biomedical Res. 28 Pages: 219-229
  • Peer Reviewed
• [Journal Article] The teleost intervertebral region acts as a growth center of the centrum: In vivo visualization of osteoblasts and their progenitors in transg enic fish. (2007)
  • Author(s): Inohaya, K.
  • Journal Title: Developmental Dynamics. 236 Pages: 3031-3046
  • Peer Reviewed
• [Journal Article] Identification of novel markers expressed during finregeneration by microarray analysis in Medaka fish. (2007)
  • Author(s): Nishidate, M.
  • Journal Title: Developmental Dynamics. 236 Pages: 2685-2693
  • Peer Reviewed
• [Journal Article] Histological examinations on the bone regeneration achieved by combining grafting with hydroxyapatite and thermoplastic bioresorbable plates. (2007)
  • Author(s): Kojima, T.
  • Journal Title: J Bone Miner. Metab. 25 Pages: 361-373
  • Peer Reviewed
• [Journal Article] Dual effects of the membrane-anchored MMP regulator RECK on chondrogenic differentiation of ATDC5 cells. (2007)
  • Author(s): Kondo, S.
  • Journal Title: J. Cell Sci. 120 Pages: 849-857
  • Peer Reviewed
• [Journal Article] Cellular and molecular processes of regeneration, with special emphasis on fish fins (review) (2007)
  • Author(s): Nakatani, Y.
  • Journal Title: Dev. Growth Differ. 49 Pages: 145-154
• [Journal Article] GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen. (2007)
  • Author(s): Moriyama, A.
  • Journal Title: Genesis 45 Pages: 90-100
  • Peer Reviewed
• [Journal Article] Multinucleate osteoclasts in medaka as evidence of active bone remodeling. (2007)
  • Author(s): Nemoto, Y.
  • Journal Title: Bone 40 Pages: 399-408
  • Peer Reviewed
• [Presentation] Characterization of Mutations Affecting Embryonic Hematopoiesis in the Medaka. (2008)
  • Author(s): Akemi Moriyama
  • Organizer: 生命時空間ネットワーク進化型教育研究拠点 第1回国際公開シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-03-03
• [Presentation] Characterization of the medaka mutant that displays abnorm alities in craniofacial skeleton and fin ray (2008)
  • Author(s): Kenta Hibiya
  • Organizer: 生命時空間ネットワーク進化型教育研究拠点 第1回国際公開シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-03-03
• [Presentation] Characterization of the medaka mutant which displays abnor malities in vertebral body (2008)
  • Author(s): Satoshi Ohisa
  • Organizer: 生命時空間ネットワーク進化型教育研究拠点 第1回国際公開シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-03-03
• [Presentation] The role of periostin in cutaneous wound healing (2008)
  • Author(s): Takashi Nishiyama
  • Organizer: 生命時空間ネットワーク進化型教育研究拠点 第1回国際公開シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-03-03
• [Presentation] Periostin is essential for cardiac healing after acute myocardial infarction. (2008)
  • Author(s): Masashi Shimazaki
  • Organizer: 生命時空間ネットワーク進化型教育研究拠点 第1回国際公開シンポジウム
  • Place of Presentation: 東京工業大学
  • Year and Date: 2008-03-03
• [Presentation] 小型魚類を用いた骨代謝研究 宇宙基礎医学研究に用いるべき最適なモデル生物に関するワークショップ (2008)
  • Author(s): 工藤明、高野吉郎
  • Organizer: 第15回宇宙医学研究推進分科会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-11
• [Presentation] 小型魚類を用いた骨代謝研究 (2008)
  • Author(s): 工藤明
  • Organizer: 第15回宇宙医学研究推進分科会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-11
• [Presentation] 心室の拍動不全メダカ変異体hozuki(hoz)におけるストレスに依存した心筋細胞増殖機構の解析BMB2008 (2008)
  • Author(s): 種田悠佑、今野さやか、牧野伸司、福田恵一、工藤明、川上厚志
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] 神経型一酸化窒素合成酵素はAktシグナルを介して筋肥大の進行を制御しているBMB2008 (2008)
  • Author(s): 伊藤尚基、Ampong, B.N., 工藤明、鈴木友子武田伸一
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] In-vivo imaging for osteoclasts in medaka, showing the evidence of bone modeling (2008)
  • Author(s): Chatani, M., Inohaya, K., Kudo, A.
  • Organizer: The 8th international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, US
• [Presentation] Characterization of the medaka mutant which displays abnormalities in hematopoiesis (2008)
  • Author(s): Moriyama, A., Ohisa, Satoshi, Kudo, A.
  • Organizer: The 8^<th>international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Characterization of the medaka mutant which displays abnormalities in vertebral body (2008)
  • Author(s): Ohisa, S., Inohaya, K., Kawakami, A., Kudo, A.
  • Organizer: The 8^<th>international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Positional cloning rebeals the brpf1 locus in the medaka mutant which displays craniofacial homeosis (2008)
  • Author(s): Hibiya, K., Inohaya, K., Kawakami, A., Kudo, A.
  • Organizer: The 8^<th>international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Identification and functional analysis of regeneration-associated molecules using the fin-fold regeneration model in juvenile zebrafish (2008)
  • Author(s): Kawakami, A., Ishida, T., Yoshinari, N., Kudo, A.
  • Organizer: The 8^<th>international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Vertebral bone formation inMdeaka メダカ脊椎骨形成 (2008)
  • Author(s): 工藤明
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Characterization of the medaka mutant which displays abnormalities in vertebral body (2008)
  • Author(s): Satoshi Ohisa, Keiji Inohaya, Atsushi Kawakami, Yoshiro Takano, Akira Kudo
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Gene expression and functional analysis of zebrafish larval fin-fold regenerationゼブラフィッシュ正中膜ひれ再生における遺伝子プロファイリングと関連分子機能の解析 (2008)
  • Author(s): Takashi Ishida, Nozomi Yoshinari, Akira Kudo, Atsushi Kawakami
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 岡崎
• [Presentation] Analyses by mutants and bone specific transgenic Medaka (2008)
  • Author(s): Kudo, A.Bone formation in Medaka
  • Organizer: The 54^<th>NIBB Conference
  • Place of Presentation: Durham, USA
• [Presentation] Bone formation in Medaka : Analyses by mutants and bone specific transgenic Medaka (2008)
  • Author(s): Kudo, A
  • Organizer: The fourth aquatic animal models of human disease conference
  • Place of Presentation: Durham, USA
• [Presentation] Periostin is essential for cardiac healing after acute myocardial infarction (2008)
  • Author(s): Shimazaki, M., Nakamura, K., Kii, I., Sata, M. and Kudo, A.
  • Organizer: Keystone symposia on cellular biology
  • Place of Presentation: Vancouver, USA
• [Presentation] 歯周組織の恒常性維持に必要な細胞外マトリックスタンパク質、ペリオスチンの分子機能解析 (2008)
  • Author(s): 高山一成
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] ゼブラフィッシュのひれ再生におけるJun/JNKシグナルによる細胞増殖の活性化機構 (2008)
  • Author(s): 石田高志
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 神経型一酸化窒素合成酵素はAktシグナルを介して筋肥大の進行を制御している (2008)
  • Author(s): 伊藤尚基
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 心室の拍動不全メダカ変異体hozuki (hoz)におけるストレスに依存した心筋細胞増殖機構の解析 (2008)
  • Author(s): 種田悠佑
  • Organizer: BMB2008
  • Place of Presentation: 神戸
• [Presentation] 脊椎骨融合を示すダルマメダカ変異体の原因遺伝子の解明 (2008)
  • Author(s): 猪早敬二
  • Organizer: 動物学会
  • Place of Presentation: 福岡
• [Presentation] Identification and functional analysis of regeneration-associated molecules using the fin-fold regeneration model in juvenile zebrafish (2008)
  • Author(s): Kawakami, A.
  • Organizer: The 8^<th> international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Positional cloning rebeals the brpf1 locus in the medaka mutant which displays craniofacial homeosis. (2008)
  • Author(s): Hibiya, K.
  • Organizer: The 8^<th> international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Characterization of the medaka mutant which displays abnormalities in vertebral body. (2008)
  • Author(s): Ohisa, S.
  • Organizer: The 8^<th> international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Ohisa, Satoshi, Kudo, A. : Characterization of the medaka mutant which displays abnormalities in hematopoiesis. (2008)
  • Author(s): Moriyama, A.
  • Organizer: The 8^<th> international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] Inohaya, K., Kudo, A. : In-vivo imaging for osteoclasts in medaka, showing the evidence of bone modeling. (2008)
  • Author(s): Chatani, M.
  • Organizer: The 8^<th> international meeting on zebrafish development and genetics
  • Place of Presentation: Madison, USA
• [Presentation] In vivo imaging for osteoclasts in medaka, showing the evidence of bone modeling (2008)
  • Author(s): Masahiro Chatani
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Characterization of the medaka mutant which displays abnor malities in hematopoiesis (2008)
  • Author(s): Akemi Moriyama
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Analysis of the Dharma-Medaka mutant, which shows a defect in formation and/or maintenance of intervertebral region (2008)
  • Author(s): Keiji Inohaya
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Transcriptional regulation of the hox family genes with brpf1 is required for the establishment of pharyngeal segmental identity in medaka (2008)
  • Author(s): Kenta Hibiya
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Gene expression and functional analysis of zebrafish larval fin-fold regeneration ゼブラフィッシュ正中膜ひれ再生における遺伝子プロファイリングと関連分子機能の解析 (2008)
  • Author(s): Takashi Ishida
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Characterization of the medaka mutant which displays abnor malities in vertebral body (2008)
  • Author(s): Satoshi Ohisa
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Vertebral bone formation in Mdeaka メダカ脊椎骨形成 (2008)
  • Author(s): 工藤明
  • Organizer: 第41回日本発生生物学会
  • Place of Presentation: 徳島
• [Presentation] Periostin is essential for cardiac healing after acute myocardial infarction. (2008)
  • Author(s): Shimazaki, M.
  • Organizer: Keystone symposia on cellular biology
  • Place of Presentation: Vancouver, USA
• [Presentation] Bone formation in Medaka: Analyses by mutants and bone specific transgenic Medaka. (2008)
  • Author(s): Kudo, A.
  • Organizer: The fourth aquatic animal models of human disease conference
  • Place of Presentation: Durham, USA
• [Presentation] Bone formation in Medaka: Modeling of vertebral bone. (2008)
  • Author(s): Kudo, A.
  • Organizer: The 54th NIBB Conference
  • Place of Presentation: 岡崎
• [Presentation] 疾患モデルとしてのメダカ : 突然変異体の解析とアレイによるヒレ再生の解析 (2007)
  • Author(s): 工藤明
  • Organizer: 第13回動物遺伝育種シンポジウム「動物ゲノム解析と新たな家畜育種戦略」
  • Place of Presentation: つくば
  • Year and Date: 2007-11-25
• [Presentation] 疾患モデルとしてのメダカ:突然変異体の解析とアレイによるヒレ再生の解析 (2007)
  • Author(s): 工藤 明
  • Organizer: 第13回動物遺伝育種シンポジウム「動物ゲノム解析と新たな家畜育種戦略」
  • Place of Presentation: つくば
  • Year and Date: 2007-11-25
• [Presentation] Different cell types in the regeneration niche and the involvement of JNK signaling during zebrafish fin regeneration. (2007)
  • Author(s): Ishida, T.
  • Organizer: Toin international symposium on biomedical engineering 2007 (BME 07)
  • Place of Presentation: 桐蔭横浜大学
  • Year and Date: 2007-11-02
• [Presentation] Toward the molecular mechanism of tissue regeneration using fish fin model (2007)
  • Author(s): Kawakami, A.
  • Organizer: Toin international symposium on biomedical engineering 2007 (BME 07)
  • Place of Presentation: 桐蔭横浜大学
  • Year and Date: 2007-11-02
• [Presentation] メダカの世界 : ゲノム・再生・宇宙 (2007)
  • Author(s): 工藤明
  • Organizer: ゲノムひろば2007
  • Place of Presentation: 大阪
• [Presentation] 骨・歯の力学的負荷に機能する再生蛋白、ペリオスチン (2007)
  • Author(s): 工藤明
  • Organizer: 第49回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 北海道大学
• [Presentation] ペリオスチンは力学的負荷依存的骨形成に必須である (2007)
  • Author(s): 中川一樹
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学学会大会合同大会
  • Place of Presentation: 横浜
• [Presentation] 椎間板領域の発生に異常を示すダルマメダカ変異体 (2007)
  • Author(s): 猪早 敬二
  • Organizer: 動物学会第78回大会
  • Place of Presentation: 弘前大学
• [Presentation] メダカ骨格形成突然変異体の解析 (2007)
  • Author(s): 大久 敬
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東大
• [Presentation] メダカ骨格異常変異体の原因遺伝子同定とその解析 (2007)
  • Author(s): 日比谷健太
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東大
• [Presentation] 椎間板領域の発生に異常を示すダルマメダカ変異体の解析 (2007)
  • Author(s): 猪早 敬二
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東大
• [Presentation] 破骨細胞特異的トランスジェニックメダカをin-vivoにおける破骨細胞の動態解析 (2007)
  • Author(s): 茶谷昌宏
  • Organizer: 第13回小型魚類研究会
  • Place of Presentation: 東大
• [Presentation] ヒトペリオスチンは線維性骨異形成症に発現し、そのコラーゲン線維形成に関与する。 (2007)
  • Author(s): 西山尚志
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] ペリオスチンによって安定化されるフィヒブロネクチンマトリックスは、メカニカルストレス感知機構を担う (2007)
  • Author(s): 喜井勲
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] 破骨細胞が特異的に光るトランスジェニックメダカを用いたin vivoにおける破骨細胞の動態解析 (2007)
  • Author(s): 茶谷昌宏
  • Organizer: 第25回日本骨代謝学会
  • Place of Presentation: 大阪
• [Presentation] The Dharma-medaka mutant is defective in formation and/or maintenance of intervertebral region. (2007)
  • Author(s): Inohaya, K.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Cadherin-11 stabilizes FGF Receptor 1 during craniofacial skeletal development in mice. (2007)
  • Author(s): Kii, I.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Characterization of the medaka mutant which displays abnormalities in vertebral body. (2007)
  • Author(s): Ohisa, S.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Characterization of the medaka mutant that displays abnormalities in craniofacial skeleton and fin ray. (2007)
  • Author(s): Hibiya, K.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Different cell types in the regeneration niche and the involvement of JNK signaling during zebrafish fin regeneration (2007)
  • Author(s): Ishida T.
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] 左右性形成に異常を示すメダカ突然変異体abecobeの解析 (2007)
  • Author(s): 加村啓一郎
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Presentation] Regeneration of fish fin (2007)
  • Author(s): Yuki Nakatani
  • Organizer: 第40回日本発生生物学会第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
• [Book] 心筋梗塞を修復するタンパク質、ペリオスチンの機能解明、細胞工学27(06) (2008)
  • Author(s): 島崎雅司、工藤明
  • Publisher: 秀潤社
• [Book] ペリオスチンと歯根膜・骨外膜、Clinical Calcium(Vo.17, No.2) (2007)
  • Author(s): 喜井勲、工藤明
  • Publisher: 医薬ジャーナル社
• [Book] ペリオスチンと歯根膜・骨外膜Clinical Calcium (2007)
  • Author(s): 喜井勲
  • Total Pages: 166
  • Publisher: 医薬ジャーナル社
• [Patent(Industrial Property Rights)] 心筋壊死を伴う疾患の治療薬及び検査薬 (2008)
  • Inventor(s): 工藤明
  • Industrial Property Rights Holder: 東京工業大学・三菱メディエンス
  • Industrial Property Number: 2008-187851
  • Filing Date: 2008-07-18