Roles of membrane microdomains in fertilization and activation of development
| Project/Area Number |
19370094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
SATO Ken-ichi Kyoto Sangyo University, 工学部, 教授 (30235337)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 受精 / シグナル伝達 / 細胞膜マイクロドメイン / Src / ウロプラキンIII / 初期発生 / 生殖細胞 / 配偶子間相互作用 / 卵活性化 / モデル生物 |
|---|
| Research Abstract |
On uroplakin III (UPIII), its mechanism for localization to the membrane microdomain and for negative regulation of Src. 2)Phosphorylation of hnRNP K and its physiological relevance to translational control of maternal mRNAs. 3) PI3-kinase and Akt as important components for fertilization signaling. 4)Molecular function of ARISX as a carbohydrate-containing protein. 5)Molecular mechanism of an enzymatic regulation of phospholipase Cζ, a sperm factor in mammals, that involves partial proteolysis. 6) Importance of tyrosine phosphorylation of Stat3 in human melanoma cell lines.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Expression, phosphorylation, and mRNA-binding of heterogeneous nuclear ribonucleo-protein K in Xenopus oocytes, eggs, and early embryos.2008
Author(s)
Iwasaki T, Koretomo Y, Fukuda T, Paronetto MP, Sette C, Fukami Y, Sato K.
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Journal Title
Dev Growth Differ 50
Pages: 23-40
NAID
Related Report
Peer Reviewed
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[Presentation] ゼノパス初期発生におけるhnRNP K結合mRNAの発現解析2009
Author(s)
Tetsushi Iwasaki, A.K.M.Mahbub Hasan, Sho Iguchi, Gunay Mammadova, Alexander A.Tokmakov, Ken-ichi Sato, Yasuo Fukami
Organizer
第32回日本分子生物学会年会
Place of Presentation
横浜、パシフィコ横浜
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