Comparative physiological study on the development of primate brain : from Tupaia to Great Ape

• Project/Area Number: 19370100
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anthropology
• Research Institution: Kyoto University
• Principal Investigator: OISHI Takao Kyoto University, 霊長類研究所, 准教授 (40346036)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Keiko 岡山理科大学, 理学部, 教授 (90135616) ; HAYASHI Motoharu 日本医科大学, 医学部, 客員教授 (10027500)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 霊長類 / 発達加齢 / 脳 / 機能分子 / 性 / βアミロイド / ステロイド / MRI

Research Abstract

Following characteristics of development and aging process of primate brain were clarified : relationship of somatostatin and amyloid-beta 42 deposited in senile plaque, effects of steroid hormone administration during pregnancy on morphological and behavioral characteristics of neonatal macaque, synaptic mechanism of GnRH reactivation during puberty, regulatory mechanism of estrogen receptor ER-beta during and after menopause, sex-specific aging of gene expression in the brain, development of plasticity-related PKC substrates in the macaque motor cortex.

Research Products

• [Journal Article] Molecular characterization of the intercalated cell masses of the amygdale: implications for the relationship with the striatum. (2010)
  • Author(s): Kaoru T, Liu FC, Ishida M, Oishi T, Hayashi M, Kitagawa M, Shimoda K, Takahashi, H.
  • Journal Title: Neuroscience vol.166 Pages: 220-230
  • Peer Reviewed
• [Journal Article] Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. (2010)
  • Author(s): Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Kaneko T, Nakamura S
  • Journal Title: Nature Neuroscience Vol.13 Pages: 173-179
  • Peer Reviewed
• [Journal Article] Molecular characterization of the intercalated cell masses of the amygdala : implications for the relationship with the striatum (2010)
  • Author(s): Kaoru T, Liu FC, Ishida M, Oishi T, Hayashi M, Kitagawa M, Shimoda K, Takahashi H
  • Journal Title: Neuroscience 166 Pages: 220-230
  • Peer Reviewed
• [Journal Article] Age-related changes of elements in the tendons of the peroneus longus muscles in Thai, Japanese, and monkeys (2010)
  • Author(s): Tohno Y, Suwanahoy P, Tohno S, Sinthubua A, Azuma C, Nishiwaki F, Moriwake Y, Kumai T, Minami T, Laowatthanaphong S, Mahakkanukrauh P, Oishi T, Hayashi M
  • Journal Title: Biological Trace Element Research 133 Pages: 291-303
  • Peer Reviewed
• [Journal Article] Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells (2010)
  • Author(s): Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Kaneko T, Nakamura S
  • Journal Title: Nature Neuroscience 13 Pages: 173-179
  • Peer Reviewed
• [Journal Article] Increased expression of the growth-associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract. (2009)
  • Author(s): Higo N, Nishimura Y, Murata Y, Oishi T, Yoshino-Saito K, Takahashi M, Tsuboi F, Isa T
  • Journal Title: Journal of Comparative Neurolog Vol.516 Pages: 493-506
  • Peer Reviewed
• [Journal Article] A new aspect of the TrkB signaling pathway in neuronal plasticity. (2009)
  • Author(s): Ohira, K., Hayashi, M.
  • Journal Title: Current Neuropharmacology Vol.7 Pages: 276-285
  • Peer Reviewed
• [Journal Article] Distribution and progression of amyloid-beta deposit in the amygdala of the aged macaque monkey, and parallets with zinc distribution. (2009)
  • Author(s): Ichinohe, N., Hayashi, M., Wakabayashi, K., Rockl, K. S
  • Journal Title: Neuroscience Vol.159 Pages: 1374-1383
  • Peer Reviewed
• [Journal Article] 神経系の可塑性-霊長類の皮質脊髄路, 運動野損傷からの運動機能回復. (2009)
  • Author(s): 大石高生
  • Journal Title: Clinical Neuroscience Vol.27 Pages: 277-286
• [Journal Article] Increased expression of the growth-associated protein 43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract (2009)
  • Author(s): Higo N, Nishimura Y, Murata Y, Oishi T, Yoshino-Saito K, Takahashi M, Tsuboi F, Isa T
  • Journal Title: Journal of Comparative Neurology 516 Pages: 493-506
  • Peer Reviewed
• [Journal Article] A new aspect of the TrkB signaling pathway in neuronal plasticity (2009)
  • Author(s): Ohira, K., Hayashi, M
  • Journal Title: Current Neuropharmacology 7 Pages: 276-285
  • Peer Reviewed
• [Journal Article] Distribution and progression of amyloid-beta deposit in the amygdala of the aged macaque monkey, and parallets with zinc distribution (2009)
  • Author(s): Ichinohe, N., Hayashi, M., Wakabayashi, K., Rockland, K.S
  • Journal Title: Neuroscience 159 Pages: 1374-1383
  • Peer Reviewed
• [Journal Article] 神経系の可塑性 ―霊長類の皮質脊髄路, 運動野損傷からの運動機能回復 (2009)
  • Author(s): 大石高生
  • Journal Title: Clinical Neuroscience 27 Pages: 994-997
• [Journal Article] Seasonal and reproductive variation in body condition in captive female Japanese macaques (Macaca fuscata) (2009)
  • Author(s): Garcia C, Huffman M, Shimizu K
  • Journal Title: American Journal of Primatology 72 Pages: 277-286
  • Peer Reviewed
• [Journal Article] Distribution and progession of amyloid- βdeposits in the amygdala of the aged macaque monkey, and parallels with zinc distribution. (2009)
  • Author(s): Ichinohe, N.
  • Journal Title: Neuroscience 159 Pages: 1374-1383
  • Peer Reviewed
• [Journal Article] 尿および糞を用いたサル類の非侵襲的ホルモン測定法とその応用. (2009)
  • Author(s): 清水慶子
  • Journal Title: 霊長類研究 24 Pages: 367-384
  • Peer Reviewed
• [Journal Article] Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2. (2008)
  • Author(s): Takahashi K, Liu FC, Oishi T, Mori T, Higo N, Hayashi M, Hirokawa K, Takahashi H
  • Journal Title: Journal of Comparative Neurology 509(2) Pages: 180-189
  • Peer Reviewed
• [Journal Article] Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys. (2008)
  • Author(s): Murata Y, Higo N, Oishi T, Yamashita A, Matsuda K, Hayashi M, Yamane S.
  • Journal Title: Journal of Neurophysiology Vol.99 Pages: 773-786
  • Peer Reviewed
• [Journal Article] Neuroactive molecules in the brain of nonhuman primates and their therapeutic application to neurodegenerative disorders. (2008)
  • Author(s): Hayashi M
  • Journal Title: Central Nervous System Agents in Medicinal Chemistry No.8 Pages: 220-228
  • Peer Reviewed
• [Journal Article] Age-related changes of elements in the coronary arteries of monkeys in comparison with those of humans. (2008)
  • Author(s): Tohno, Y.
  • Journal Title: Biological Trace Element Research 125 Pages: 141-153
  • Peer Reviewed
• [Journal Article] Expression of FoxP2 in the developing monkey forebrain : comparison with the expression of the genes FOXP1, PBX3, and MEIS2. (2008)
  • Author(s): Takahashi, K.
  • Journal Title: Journal of Comparative Neurology 509 Pages: 180-189
  • Peer Reviewed
• [Journal Article] Neuroactive molecules in the brain or nonhuman primates and their therapeutic application to neurodegenerative disorders. (2008)
  • Author(s): Hayashi, M.
  • Journal Title: Nervous System Agents in Medicinal Chemistry 8 Pages: 220-228
  • Peer Reviewed
• [Journal Article] Reproductive hormones and the ovarian cycle in macaques. (2008)
  • Author(s): Keiko Shimizu
  • Journal Title: Journal of Mammailan Ova Research 25 Pages: 122-126
  • NAID: 10024486436
  • Peer Reviewed
• [Journal Article] Expression of protein kinase-C substrate mRNA in the motor cortex of adult and infant macaque monkeys. (2007)
  • Author(s): Higo N, Oishi T, Yamashita A, Murata Y, Matsuda K, Hayashi M.
  • Journal Title: Brain Research Vol.1171 Pages: 30-41
  • Peer Reviewed
• [Journal Article] Tyrosine hydroxylase (TH)-and aromatic-L-amino acid decarboxylase (AADC)-immunoreactive neurons of the common marmoset (Callithrix jacchus) brain: an immunohistochemical analysis. (2007)
  • Author(s): Karasawa N, Hayashi M, Yamada K, Nagatsu I, Iwasa M, Takeuchi T, Uematsu M, Watanabe K, Onozuka M.
  • Journal Title: Acta Hitstochemistry and Cytochemistry Vol.40 Pages: 83-92
  • NAID: 110006633418
  • Peer Reviewed
• [Journal Article] Seasonal variation in fecal testosterone levels in free-ranging male Japanese macaques. (2007)
  • Author(s): Muroyama Y, Shimizu K, Sugiura H.
  • Journal Title: American Journal of Primatology 69(6) Pages: 603-610
  • NAID: 130006996211
  • Peer Reviewed
• [Journal Article] Differentially expressed genes among motor and prefrontal areas of macaque neocortex. (2007)
  • Author(s): Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T.
  • Journal Title: Biochemical and Biophysical Research Communications 362(3) Pages: 665-669
  • Peer Reviewed
• [Journal Article] Urinary Prostate-Specific Antigen Is a Noninvasive Indicator of Sexual Development in Male Children. (2007)
  • Author(s): Sato I, Yoshikawa A, Shimizu K, Ishiwari A, Mukai T.
  • Journal Title: Journal of Andrology Vol.28 Pages: 150-154
  • Peer Reviewed
• [Presentation] Gene expression analysis of motor-related areas of the monkey neocortex during recovery from corticospinal tract lesion (2009)
  • Author(s): Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Yoshino-Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2009-10-10
• [Presentation] Changes in regional brain activities involved in recovery of dexterous hand movements after lesion of the primary motor cortex : PET study with macaque monkeys (2009)
  • Author(s): Murata Y, Higo N, Nishimura Y, Oishi T, Tsukada H, Isa T, Onoe H
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2009-10-10
• [Presentation] Selective expression of SPP1 in the corticospinal neurons of highly dexterous primate species (2009)
  • Author(s): Yamamoto T, Sato A, Higo N, Nishimura Y, Oishi T, Murata Y, Onoe H, Yoshino-Saito K, Isa T, Kojima T
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: シカゴ、米国
  • Year and Date: 2009-10-10
• [Presentation] Parvalbumin/GABA cells in the monkey cerebral cortex : gap junctions, chandelier- and basket-terminals (2009)
  • Author(s): Yamashita, A, Taira, M., Oishi, T., Hayashi, M
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Quantitative inter-segmental and inter-laminar comparison of corticospinal projections from the hand area of the primary motor cortex of macaque monkeys (2009)
  • Author(s): Yoshino-Saito K, Nishimura Y, Oishi T, Isa T
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Changes in regional brain activities involved in functional recovery after primary motor cortex lesion : PET study with macaque monkeys (2009)
  • Author(s): Murata Y, Higo N, Nishimura Y, Oishi T, Tsukada H, Isa T, Onoe H
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Ischemia-induced neurogenesis of neocortical progenitor cells (2009)
  • Author(s): Ohira K, Furuta T, Hioki H, Nakamura K, Kuramoto E, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Keneko T, Nakamura S
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Selective SPP1 expression in amyotrophic lateral sclerosis-vulnerable motor neurons of the macaque monkey (2009)
  • Author(s): Yamamoto T, Sato A, Higo N, Nishimura Y, Oishi T, Murata Y, Yoshino-Saito K, Isa T, Kojima T
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Gene expression analysis of motor-related areas of the monkey neocortex during recovery from corticospinal tract lesion (2009)
  • Author(s): Sato A, Nishimura Y, Oishi T, Higo N, Murata Y, Onoe H, Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Flybrain Neuron Database, a comprehensive online database of the Drosophila brain neurons (2009)
  • Author(s): Shinomiya K, Matsuda K, Oishi T, Ito K
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Presentation] Ischemia-induced neurogenesis of endogenous progenitor cells in the neocortex (2009)
  • Author(s): Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Shimizu
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-30
• [Presentation] Up-regulation of estrogen receptor beta in the menopausal monkey hippocampus is not a direct response (2009)
  • Author(s): Higaki S, Takumi K, Shimizu K, Oishi T, Hayashi M
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] Web-based 3D Biological Image Database. (2008)
  • Author(s): Takao Oishi
  • Organizer: The 2nd International Symposium of the Biodiversity Global COE Project
  • Place of Presentation: 京都市
  • Year and Date: 2008-11-21
• [Presentation] Up-regulation of estrogen receptor in the menopausal monkey brains is not direct response to deficit in gonadal estrogen (2008)
  • Author(s): Sayuri Higaki
  • Organizer: The 2nd International Symposium of the Biodiversity Global COE Project
  • Place of Presentation: 京都市
  • Year and Date: 2008-11-21
• [Presentation] Web-based MRI Brain image database system. (2008)
  • Author(s): Keiji Matsuda
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington D. C.
  • Year and Date: 2008-11-19
• [Presentation] Changes in regional brain activities involved in recovery of dexterous hand movements after lesion of the primary motor cortex : PET study with a macaque monkey. (2008)
  • Author(s): Yumi Murata
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington D. C
  • Year and Date: 2008-11-17
• [Presentation] Gene expression analysis of motor-related areas of the monkey neocortex during recovery from corticospinal tract lesion. (2008)
  • Author(s): Akira Sato
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington D. C.
  • Year and Date: 2008-11-17
• [Presentation] SPP1 is selectively expressed in large pyramidal neurons in layer V of the macaque sensorimotor cortex. (2008)
  • Author(s): Noriyuki Higo
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington D. C.
  • Year and Date: 2008-11-15
• [Presentation] Evolving life history traits : the influence of environment and nutrition on three populations of Japanese macaque (Macaca fuscata). (2008)
  • Author(s): A. C. Chalmers
  • Organizer: 22nd International Primatological society
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2008-08-08
• [Presentation] Timing of sexual activity in relation to female ovarian cycle in captive Japanese macaques (Macaca fuscata). (2008)
  • Author(s): C. Garcia
  • Organizer: 22nd International Primatological society
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2008-08-08
• [Presentation] Time course of changes in plasma inhibin B level in male Japanese macaques (Macaca fuscata). (2008)
  • Author(s): Mariko Itoh
  • Organizer: 22nd International Primatological society
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2008-08-06
• [Presentation] Contraception for population control in macaques. (2008)
  • Author(s): K. Shimizu
  • Organizer: 22nd International Primatological society
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 2008-08-06
• [Presentation] Amyloid β-immunoreactive structures in the brain of aged tree shrews. (2008)
  • Author(s): Yamashita, A.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] 皮質脊髄路損傷後の回復過程におけるサル大脳新皮質運動関連領野の網羅的遺伝子発現解析. (2008)
  • Author(s): 佐藤明
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Up-regulation of estrogen receptor in the menopausal monkey brains is not direct response to deficit in gonadal estrogen. (2008)
  • Author(s): Higaki S, Takumi K, Shimizu K, Oishi T, Hayashi M
  • Organizer: The 2nd International Symposium of the Biodiversity Global COE Project
  • Place of Presentation: 京都市
• [Presentation] Amyloidβ-immunoreactive structures in the brain of aged tree shrews. (2008)
  • Author(s): Yamashita A, Fuchs E, Taira M, Hayashi M
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 胎生期マカクザルにおけるアンドロゲン曝露. (2008)
  • Author(s): 清水慶子, 伊藤麻里子, 託見健, 桧垣小百合, 国枝匠, 毛利恵子, 林基治
  • Organizer: 第24回日本霊長類学会大会
  • Place of Presentation: 東京
• [Presentation] Characterization of GAP-43 immunoreactive structures from the viewpoint of neurotransmitters in the anterior horn of the monkey spinal cord. (2007)
  • Author(s): Oishi T, Higo N, Yamashita A, Murata Y, Matsuda K, Hayashi M.
  • Organizer: 第37回北米神経科学学会
  • Place of Presentation: San Diego, USA
• [Presentation] メスニホンザルにおける血中IGF-1の季節変動. (2007)
  • Author(s): 託見健, 伊藤麻里子, 清水慶子, 林基治
  • Organizer: 第23回日本霊長類学会大会
  • Place of Presentation: 彦根
• [Book] 「生き物たちのつづれ織り」第1巻 (2008)
  • Author(s): 林基治
  • Publisher: 中村印刷株式会社
• [Book] 霊長類進化の科学(京都大学霊長類研究所編) (2007)
  • Author(s): 林基治
  • Publisher: 京都大学学術出版会
• [Book] 霊長類進化の科学(京都大学霊長類研究所編) (2007)
  • Author(s): 大石高生
  • Publisher: 京都大学学術出版会
• [Book] 霊長類進化の科学(京都大学霊長類研究所編) (2007)
  • Author(s): 清水慶子
  • Publisher: 都大学学術出版会
• [Remarks] 大石高生(2009)第32回日本神経科学大会市民公開講座企画運営、名古屋