The elucidation of the physiological polymorphism related to arteriosclerosis by the approach method from genetic and acquired factor
| Project/Area Number |
19370104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
生理人類学
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| Research Institution | Nagasaki University |
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Principal Investigator |
MAEDA Takahiro Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (40284674)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Kenichiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30039656)
AOYAGI Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80295071)
TAKAMURA Noboru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30295068)
YAMASAKI Hironori 長崎大学, 保健・医療推進センター, 准教授 (40346953)
KUSANO Yosuke 長崎ウエスレヤン大学, 現代社会学部, 教授 (70325637)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 生理的多型性 / ホモシステイン / 離島 / 動脈硬化 / メチレンテトラヒドロ葉酸還元酵素 / アディポネクチン / ヒストン脱アセチル化酵素 / 遺伝子多型 / 葉酸 / ホモシステイ / 生活習慣病 |
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| Research Abstract |
We conducted the investigation study related to arteriosclerosis in small remote islands with a population of less than 1,000 and large island with a population of about 40,000 in Goto islands, where the environmental factor was considered to be different. Comparing 205 inhabitants in small islands with 2,520 inhabitants in large island after adjustment for age and sex, plasma homocysteine concentration and carotid intima-media thickness was significantly higher in large island, and plasma folic acid concentration was significantly higher in small island. Because there was not a difference by areas regarding the genetic factor related to the metabolism of folic acid, it was suggested that the physiological polymorphism with acquired factor existed.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma.2009
Author(s)
Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K
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Journal Title
Biomed Chromatogr 23
Pages: 935-939
Related Report
Peer Reviewed
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[Journal Article] Thyroid function is associated with carotid intima-media thickness in euthyroid subjects.2009
Author(s)
Takamura N, Akilzhanova A, Hayashida N, Kadota K, Yamasaki H, Usa T, Nakazato M, Maeda T, Ozono Y, Aoyagi K, Kadota K
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Availability of cardio-ankle vascular index (CAVI) as a screening tool for atherosclerosis.2008
Author(s)
Takamura N, Aoyagi K, Yamasaki H, Usa T, Nakazato M, Maeda T, Wada M, Nakashima K, Ishibashi K,, Abe K, Takeshima F, Ozono Y
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Determinants of plasma homocysteine levels and carotid intima-media thickness in Japanese.2007
Author(s)
Takamura N, Abe Y, Nakazato M, Maeda T, Wada M, Nakashima K, Kusano Y, Aoyagi K, Mori S, Sugahara K, Uemura A, Yamada Y, Uzihara K, Hayashida H, Ideguchi T, Ishibashi K, Nakazato M
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Journal Title
Asia Pac J Clin Nutr 16
Pages: 698-703
Related Report
Peer Reviewed
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[Presentation] :本邦における赤血球中葉酸濃度と血清ホモシステイン、動脈硬化との関連2009
Author(s)
中里未央, 坂本大地, 高村昇, 門田耕一郎, 中島憲一郎, 青柳潔, 大園恵幸, 山崎浩則, 前田隆浩, 田村庸信, Kelley Johnston, 中尾郁子, 吉谷清光
Organizer
第17回日本総合診療医学会
Place of Presentation
福岡
Year and Date
2009-03-01
Related Report
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[Presentation] Urinary cystatin C as a biomarker for detecting early renal dysfunction in the general populations.2009
Author(s)
Obata Y, Furusu A, Yamashita H, Nishino T, Nakazato M, Miyazaki M, Takamura N, Maeda T, Ozono Y, Kohno S
Organizer
World Congress of Nephrology 2009
Place of Presentation
Milan, Italy
Related Report
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[Presentation] Physiological polymorphism of arteriosclerosis on a remote Japanese island.2008
Author(s)
Kusano Y, Nakazato M, Ishibashi K, Takamura N, Nakashima K, Yamasaki H, Oozono Y, Kuwahara K, Nakamura H, Aoyagi K, Maeda T
Organizer
9th International Congress of Physiological Anthropology
Place of Presentation
Delft, The Netherlands
Related Report
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[Presentation] An association between plasma homocysteine concentration and methylenetetrahydrofolate reductase gene C677T polymorphism on a remote island.2007
Author(s)
Nakazato M, Kadota K, Takamura N, Sekitani M, Yamasaki H, Mukae H, Nakashima K, Aoyagi K, Maeda T
Organizer
6th Conference on Homocysteine Metabolism, World Congress on Hyperhomocysteinemia
Place of Presentation
Saarbruecken, Germany
Year and Date
2007-06-08
Related Report
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