| Project/Area Number |
19370104
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
生理人類学
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| Research Institution | Nagasaki University |
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Principal Investigator |
MAEDA Takahiro Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (40284674)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Kenichiro 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30039656)
AOYAGI Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80295071)
TAKAMURA Noboru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30295068)
YAMASAKI Hironori 長崎大学, 保健・医療推進センター, 准教授 (40346953)
KUSANO Yosuke 長崎ウエスレヤン大学, 現代社会学部, 教授 (70325637)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 生理的多型性 / ホモシステイン / 離島 / 動脈硬化 / メチレンテトラヒドロ葉酸還元酵素 / アディポネクチン / ヒストン脱アセチル化酵素 / 遺伝子多型 / 葉酸 / ホモシステイ / 生活習慣病 |
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| Research Abstract |
We conducted the investigation study related to arteriosclerosis in small remote islands with a population of less than 1,000 and large island with a population of about 40,000 in Goto islands, where the environmental factor was considered to be different. Comparing 205 inhabitants in small islands with 2,520 inhabitants in large island after adjustment for age and sex, plasma homocysteine concentration and carotid intima-media thickness was significantly higher in large island, and plasma folic acid concentration was significantly higher in small island. Because there was not a difference by areas regarding the genetic factor related to the metabolism of folic acid, it was suggested that the physiological polymorphism with acquired factor existed.
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