Functional analysis of molecular complex composed by CMV-resistance protein RCY1 and other host proteins

• Project/Area Number: 19380026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plant pathology
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Hideki Tohoku University, 大学院・農学研究科, 准教授 (20197164)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Nobuyuki 岩手大学, 農学部, 教授 (40191556) ; HASE Shu 東北大学, 大学院・農学研究科, 助教 (10261497)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2007: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
• Keywords: ウイルス抵抗性 / キュウリモザイクウイルス / 病害抵抗性遺伝子 / NB-LRRタンパク質 / 病害抵抗性遣伝子 / NB-LRRタンパク

Research Abstract

Resistance gene to CMV(Y), RCY1, encodes CC-NBS-LRR-containing protein. In this study, we analyzed the molecular aspect of a complex composed by RCY1 and other host proteins. In conclusion, (1) RCY1-conferred resistance to CMV(Y) required three structural domains : CC, NBS and LRR in RCY1 protein, (2) HR-cell death was induced by Agrobacterium-mediated transient expression of RCY1, but co-expression of all combination of CC, NBS and LRR domain proteins in plant cell did not induce not only the cell death but also molecular interaction among them, indicating that three domains are not able to act trans-complimentarily, (3) A protein with molecular weight of 43kDa and a NTPase containing 'GHKL'ATPase motif were identified as a RCY1-interacting proteins. These finding will give a new insight for understanding the function of RCY1 protein conferring the resistance to CMV(Y).

Research Products

• [Journal Article] CRT 1, a new player in R (resistance) gene-mediated immunity, implicates endosomes in defense signaling. (2010)
  • Author(s): Kang H.-G., Oh C.-S., Sato M., Katagiri F., Glazebrook J., Takahashi.H., Martin G., Klessig D.F.
  • Journal Title: Plant Cell 22 Pages: 918-936
  • Peer Reviewed
• [Journal Article] Large-scale analysis of full-length cDNAs from the tomato (Solanum lycopersicum) cultivarMicro-Tom, a reference system for the Solanaceae genomics. (2010)
  • Author(s): Aoki K., Yano Y., Suzuki A., Kawamura S.,Sakurai N., Suda K., Kurabayashi A., Suzuki T., Tsugane T., Watanabe M., Ooga K.,Torii M., Narita T., Shin-i T., Kohara Y.,Yamamoto N., Takahashi H., Watanabe Y.,Egusa M., Kodama M., Ichinose Y., Kilcuchi M., Fukushima S., Okabe A., Arie T.,Sato Y., Yazawa K., Satoh S., Omura T., Ezura H., Shibata D.
  • Journal Title: BMC Genomics 11 Pages: 210-210
  • Peer Reviewed
• [Journal Article] Distribution and expression of elicitin-like protein genes of the biocontrol agent Pythium oligandrum. (2010)
  • Author(s): Masunaka A, Sekiguchi H, Iakahashi.H., Takenaka S.
  • Journal Title: Journal of Phytopathology 158 Pages: 417-426
  • Peer Reviewed
• [Journal Article] Identification of a protein that interacts with LeATL6 ubiquitin-protein ligase E3 upregulated in tomato treated with elicitin-like cell wall proteins of Pythium oligandrum. (2010)
  • Author(s): Takahashi H., Hondo D., Hase S., Takenaka S
  • Journal Title: Journal of Phytopathology 158 Pages: 132-136
  • Peer Reviewed
• [Journal Article] CRT1, a new player in R(resistance)gene-mediated immunity, implicates endosomes in defense signaling. (2010)
  • Author(s): Kang, H.-G., et al.
  • Journal Title: Plant Cell Volume: 22 Pages: 918-936
  • Peer Reviewed
• [Journal Article] Distribution and expression of elicitin-like protein genes of the biocontrol agent Pythium oligandrum. (2010)
  • Author(s): Masunaka, A., et al.
  • Journal Title: Journal of Phytopathology Volume: 50 Pages: 924-934
  • Peer Reviewed
• [Journal Article] Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1, RAR1, NPR1 and JAR1. (2009)
  • Author(s): Kawamura Y., Takenaka S., Hase S., Kubota M., Ichinose Y., Kanayama Y., Nakaho K., Takahashi H.
  • Journal Title: Plant Cell Physiology 50 Pages: 924-934
  • NAID: 10027340081
  • Peer Reviewed
• [Journal Article] Spermine signaling plays as significant role in the defense response of Arabidopsis thaliana to cucumber mosaic virus. (2009)
  • Author(s): Mitsuya Y., Takahashi Y., Berberich T., Miyazaki A., Matsumura H., Iakahashi H, Terauchi R., Kusano, T.
  • Journal Title: Journal of Plant Physiology 166 Pages: 626-643
  • Peer Reviewed
• [Journal Article] Spermine signaling in defense reaction against avirulent viral pathogen in Arabidopsis thaliana. (2009)
  • Author(s): Sagor G.H.M., Cong R.-Z., Berberich T., Takahashi H., Takahashi Y., Kusano T.
  • Journal Title: Plant Signaling & Behavior 4 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Apple latent spherical virus vectors for reliable and effective virus-induced gene silencing among a broad range of plants including tobacco, tomato (2009)
  • Author(s): Igarashi A., Yamagata K., Sugai T., Takahashi Y., Sugawara E., Tamura A., Yaegashi H., Yamagishi N., Takahashi T., Isogai M., Iakahashi H., Ybshikawa N
  • Journal Title: Arabidopsis Arabidopsis thaliana cucurbits, and legumes. Virology 386 Pages: 407-416
  • Peer Reviewed
• [Journal Article] INF l Elicitin activates jasmonic acid- and ethylene-mediated signalling pathways and induces resistance to bacterial wilt disease in tomato. (2009)
  • Author(s): Kawamura Y., Hase S., Takenaka S., Kanayama Y., Yoshioka H., Kamoun S., Iakahashi H
  • Journal Title: Journal of Phytopathology 157 Pages: 287-297
  • Peer Reviewed
• [Journal Article] Visualization of Ralstonia solanacearum cells during biocontrol of bacterial wilt disease in tomato with Pythium oligandrum. (2009)
  • Author(s): Masunaka A., Nakaho K., Sakai M.
  • Journal Title: Journal of General Plant Pathology 75 Pages: 181-287
  • Peer Reviewed
• [Journal Article] Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1_ RAR1_ NPR1 and JAR1. (2009)
  • Author(s): Kawamura, Y., et al.
  • Journal Title: Plant Cell Physiology Volume: 50 Pages: 924-934
  • Peer Reviewed
• [Journal Article] Spermine signaling play as significant role in the defense response of Arabidopsis thaliana to cucumber mosaic virus. (2009)
  • Author(s): Mitsuya, Y., et al.
  • Journal Title: Journal of Plant Physiology Volume: 166 Pages: 626-643
  • Peer Reviewed
• [Journal Article] Spermine signaling in defense reaction against avirulent viral pathogen in Arabidopsis thaliana. (2009)
  • Author(s): Sagor, G.H.M., et al.
  • Journal Title: Plant Signaling & Behavior Volume: 4 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Apple latent spherical virus vectors for reliable and effective virus-induced gene silencing among a broad range of plants including tobacco. tomato. Arabidopsis thaliana. cucurbits. and leeumes. (2009)
  • Author(s): Igarashi, A., et al.
  • Journal Title: Virology Volume: 386 Pages: 407-416
  • Peer Reviewed
• [Journal Article] INF1 Elicitin activates jasmonic acid- and ethylene-mediated signalling pathways and induces resistance to bacterial wilt disease in tomato. (2009)
  • Author(s): Kawamura, Y., et al.
  • Journal Title: Journal of Phytopathology Volume: 157 Pages: 287-297
  • Peer Reviewed
• [Journal Article] Visualization of Ralstonia solanacearum cells during biocontrol of bacterial wilt disease in tomato with Pythium oligandrum. (2009)
  • Author(s): Masunaka, A., et al.
  • Journal Title: Journal of General Plant Pathology Volume: 75 Pages: 281-287
  • Peer Reviewed
• [Journal Article] Spermine signaling plays a significant role in the defense response of Arabidopsis thaliana to cucumber mosaic virus (2009)
  • Author(s): Mitsuya, Y., et.al.
  • Journal Title: Journal of Plant Physiology (印刷中)
  • Peer Reviewed
• [Journal Article] INF1 elicitin activates jasmonic acid- and ethylene-mediated signaling pathways and induces resistance to bacterial wilt disease in tomato (2009)
  • Author(s): Kawamura, Y., et.al.
  • Journal Title: Journal of Phytopathology (印刷中)
  • Peer Reviewed
• [Journal Article] Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1, RAR1, IVPRI, and JAR1 (2009)
  • Author(s): Kawamura, Y., et.al.
  • Journal Title: Plant Cell Physiology (印刷中)
  • Peer Reviewed
• [Journal Article] High-level expression of a virus resistance gene (2008)
  • Author(s): Sekine K-T., Kawakami S., Kubota M., Ichinose Y., Shah J., Kang H-G., Klessig D.F., Takahashi H.
  • Journal Title: RCYl confers extreme resistance to Cucumber mosaic virus in Arabidopsis thaliana. Molecular Plant-Microbe Interaction Molecular Plant-Microbe Interaction 21 Pages: 1398-1407
  • Peer Reviewed
• [Journal Article] Overexpression of the Arabidopsis thaliana EDSS gene enhances resistance to vimses. (2008)
  • Author(s): Ishihara T., Sekine K.-T., Hase S., Kanayama Y., Seo S., Ohashi Y., Kusano T.,Shibata D., Shah J., Takahashi H.
  • Journal Title: Plant Biology 10 Pages: 451-461
  • Peer Reviewed
• [Journal Article] Veinal necrosis induced by Turnip mosaic virus infection in Arabidopsis is a form of defense response accompanying HR-like cell death. (2008)
  • Author(s): Kim B., Masuta C., Matsuura H., Takahashi H., Inukai T.
  • Journal Title: Molecular Plant-Microbe Interactions 321 Pages: 260-268
  • Peer Reviewed
• [Journal Article] Colonization of Pythium oligandrum in the tomato rhizosphere for biological control of bacterial wilt disease analyzed by real-time PCR and confocal laser-scanning microscopy. (2008)
  • Author(s): Takenaka S., Sekiguchi H., Nakaho K., Tojo M., Masunaka A., Takahashi H.
  • Journal Title: Phytopathology 98 Pages: 187-195
  • Peer Reviewed
• [Journal Article] Jasmonic acid signaling is required for bacterial wild disease resistance induced by biocontrol agent Pythium oligandrum in tomato. (2008)
  • Author(s): Hase S., Takahashi S., Takenaka S., Nakaho K., Arie T., Seo S., Ohashi Y., Takahashi H.
  • Journal Title: Plant Pathology 57 Pages: 870-876
  • Peer Reviewed
• [Journal Article] High-level expression of a virus resistance gene, RCY1 confers extreme resistance to Cucumber mosaic virus in Arabidopsis thaliana (2008)
  • Author(s): Sekine, K-T., et.al.
  • Journal Title: Molecular Plant-Microbe Interaction 21 Pages: 1398-1407
  • Peer Reviewed
• [Journal Article] Overexpression of the Arabidopsis thaliana EDS5 gene enhances resistance to viruses. (2008)
  • Author(s): Ishihara, T., et. al.
  • Journal Title: Plant Biology (in press)
  • Peer Reviewed
• [Journal Article] Jasmonic acid signaling is required for bacterial wild disease resistance induced by biocontrol agent Pythium oligandrum in tomato. (2008)
  • Author(s): Hase, S., et. al.
  • Journal Title: Plant Pathology (in press)
  • Peer Reviewed
• [Journal Article] Veinal necrosis induced by Turnip mosaic virus infection in Arabidopsis is a form of defense response accompanying HR-like cell death. (2008)
  • Author(s): Kim, B., et. al.
  • Journal Title: Molecular Plant Microbe Interactions 21 Pages: 260-268
  • Peer Reviewed
• [Journal Article] Colonization of Pythium oligandrum in the tomato rhizosphere for biocontrol of bacterial wilt disease analyzed by real-time PCR and confocal laser scanning microscopy. (2008)
  • Author(s): Takenaka, S., et. al.
  • Journal Title: Phytopathology 98 Pages: 187-195
  • Peer Reviewed
• [Journal Article] Up-regulation of LeATL6 that encodes a fungal elicitor-responsive ubiquitin ligase induces jasmonic acid-dependent proteinase inhibitor gene expression in tomato. (2007)
  • Author(s): Hondo D., Hase S., Kanayama Y., Yoshikawa N., Takenaka S., Takahashi H.
  • Journal Title: Molecular Plant-Microbe Interactions 20 Pages: 72-81
  • Peer Reviewed
• [Journal Article] Identification of a novel Cyst/His2-type zinc-finger protein as a component of a spermine-signaling pathway in tobacco. (2007)
  • Author(s): Mitsuya Y., Takahashi Y., Uehara Y., Berberich T-, Miyazaki A., Takahashi H, Kusano T.
  • Journal Title: Journal of Plant Physiology 164 Pages: 785-793
  • Peer Reviewed
• [Journal Article] Characterization of virus-induced gene silencing in tobacco plants infected with apple latent spherical virus. (2007)
  • Author(s): Yaegashi H., Yamatsuta T., Takahashi T., Li C., Isogai M. Kobori T., Ohki S., Yoshikawa N.
  • Journal Title: Archives of Virology 152 Pages: 1893-1849
  • Peer Reviewed
• [Journal Article] Analysis ofthe spatial distribution of identical and two distinct virus populations differently labeled with cyan and yellow fluorescent proteins in coinfected plants (2007)
  • Author(s): Takahashi T., Sugawara T., Yamatsuta T.,Isogai M., Natsuaki T., Yoshikawa N.
  • Journal Title: Phytopathology 97 Pages: 1200-1206
  • Peer Reviewed
• [Journal Article] Characterization of virus-induced gene silencing in tobacco plants infected with apple latent spherical virus. (2007)
  • Author(s): Yaegashi, H., et. al.
  • Journal Title: Archives of Virology 152 Pages: 1893-1849
  • Peer Reviewed
• [Journal Article] Analysis of the spatial distribution of identical and two distinct virus populations differently labeled with cyan and yellow fluorescent proteins in coinfected plants. (2007)
  • Author(s): Takahashi, T., et. al.
  • Journal Title: Phytopathology 97 Pages: 1200-1206
  • Peer Reviewed
• [Presentation] キュウリモザイクウイルス抵抗性遺伝子RCY1を導入したNicotiana benthamianaの作出とウイルス感染に対する応答 (2010)
  • Author(s): 高橋英樹, ら
  • Organizer: 平成22年度日本植物病理学会大会
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-04-18
• [Presentation] Defense system induced by elicitin-like proteins of biocontrol agent Pythium oligandrum (2010)
  • Author(s): Takahashi, H., Takenaka S.
  • Organizer: 10^<th> Japan-USA Scientific Seminar
  • Place of Presentation: Oregon State University, Corvallis, USA
  • Year and Date: 2010-01-27
• [Presentation] Defense system induced by elicitin-like proteins of biocontrol agent Pythium oligandrum. (2010)
  • Author(s): Takahashi H., Takenaka, S.
  • Organizer: 10/^<th> US-Japan Science Seminar, "Genome-enabled integration of research in plant-pathogen systems"
  • Place of Presentation: オレゴン、アメリカ合衆国
• [Presentation] キュウリモザイクウイルス抵抗性遺伝子RCY1を導入したNicotiana benthamianaの作出とウイルス感染に対する応答 (2010)
  • Author(s): 高橋英樹・庄子紘美・安藤杉尋・竹下稔・鈴木匡・増田税
  • Organizer: 平成22年度日本植物病理学会大会
  • Place of Presentation: 京都、日本
• [Presentation] 外被タンパク質にアミノ酸変異を導入したキュウリモザイクウイルス(CMV)感染トマトにおける病徴発現の解析 (2010)
  • Author(s): 関拓真・安藤杉尋・高橋英樹
  • Organizer: 平成22年度日本植物病理学会大会
  • Place of Presentation: 京都、日本
• [Presentation] キュウリモザイクウイルス抵抗性遺伝子RcY1導入Nicotiana benthamianaとCMVベクターによるVIGSシステムの構築とRCYI-CMV抵抗性シグナル伝達系解析への利用 (2010)
  • Author(s): 庄子紘美・安藤杉尋・竹下稔・鈴木匡・増田税・高橋英樹
  • Organizer: 平成22年度日本植物病理学会大会
  • Place of Presentation: 京都、日本
• [Presentation] キュウリモザイクウイルス抵抗性遺伝子RCY1を導入したシロイヌナズナエコタイプDi-17における乾燥ストレス耐性と矮化形態を制御する遺伝子のマッピング (2009)
  • Author(s): 高橋英樹, ら
  • Organizer: 平成21年度日本植物病理学会大会
  • Place of Presentation: 山形大学(山形市)
  • Year and Date: 2009-03-27
• [Presentation] Characterization of NON-RCYI-RESISTANCE (NRR) locus required for RCYI-conferred resistance to Cucumber mosaic virus in Arabidopsis. XIV. (2009)
  • Author(s): Takahashi H., Kang H.-G., Klessig D.F.
  • Organizer: International Congress of Molecular Plant-Microbe Interaction(MPMI 2009)
  • Place of Presentation: ケベック、カナダ
• [Presentation] キュウリモザイクウイルス抵抗性遺伝子RCY1を導入したシロイヌナズナエコタイプDi-17における乾燥ストレス耐性と矯化形態を制御する遺伝子のマッピング (2009)
  • Author(s): 高橋英樹・Kang, H.-G.-Klessig, D.F.
  • Organizer: 平成21年度日本植物病理学会大会
  • Place of Presentation: 山形、日本
• [Presentation] キュウリモザイクウイルス抵抗性の強度を決定する抵抗性遺伝子産物RCY1の蓄積量 (2008)
  • Author(s): 関根健太郎, ら
  • Organizer: 平成20年度日本植物病理学会大会
  • Place of Presentation: 島根県松江市
  • Year and Date: 2008-04-24
• [Presentation] GFPレポーターを用いたキュウリモザイクウイルス抵抗性におけるサリチル酸シグナル伝達系活性化の解析 (2008)
  • Author(s): 甲斐朝湖, ら
  • Organizer: 平成20年度日本植物病理学会大会
  • Place of Presentation: 島根県松江市
  • Year and Date: 2008-04-24
• [Presentation] キュウリモザイクウイルス抵抗性遺伝子RCY1を過剰発現するシロイヌナズナエコタイプDi-17における非生物ストレス耐性の付与 (2008)
  • Author(s): 高橋英樹・Kang, H.-G.-Klessig, D.F.
  • Organizer: 平成20年度日本植物病理学会東北部会
  • Place of Presentation: 盛岡、日本
• [Presentation] GFPレポーターを用いたキュウリモザイクウイルス抵抗性におけるサリチル酸シグナル伝達系活性化の解析 (2008)
  • Author(s): 甲斐朝湖・関根健太郎・河村陽子・長谷修・山下真生・富田啓文・高橋英樹
  • Organizer: 平成20年度日本植物病理学会大会
  • Place of Presentation: 松江、日本
• [Presentation] キュウリモザイクウイルス抵抗性の強度を決定する抵抗性遺伝子産物RCY1の蓄積量 (2008)
  • Author(s): 関根健太郎・石原岳明・川上さやか・長谷修・高橋英樹
  • Organizer: 平成20年度日本植物病理学会大会
  • Place of Presentation: 松江、日本
• [Presentation] キュウリモザイクウイルス高度抵抗性を誘導する抵抗性遺伝子RCY1の高レベル発現 (2007)
  • Author(s): 関根健太郎, ら
  • Organizer: 平成19年度日本植物病理学会大会
  • Place of Presentation: 宇都宮大学農学部
  • Year and Date: 2007-03-29
• [Presentation] キュウリモザイクウイルスサイレンシングベクターを用いたトマトACD2の解析 (2007)
  • Author(s): 石原岳明, ら
  • Organizer: 平成19年度日本植物病理学会大会
  • Place of Presentation: 宇都宮大学農学部
  • Year and Date: 2007-03-29
• [Presentation] WRKY33過剰発現シロイヌナズナのキュウリモザイクウイルスに対する応答 (2007)
  • Author(s): 小山内朋絵, ら
  • Organizer: 平成19年度日本植物病理学会大会
  • Place of Presentation: 宇都宮大学農学部
  • Year and Date: 2007-03-29
• [Presentation] High-level expression of a resistance gene, RCYI confers extreme resistance to Cucumber mosaic virus. XIII. (2007)
  • Author(s): Sekine K.-T., Kawakami S., Hase S., Shah J., Takahashi H.
  • Organizer: International Congress of Molecular Plant-Microbe Interaction(MPMI 2007)
  • Place of Presentation: ソレント、イタリア
• [Presentation] WRKY33 negatively regulates the resistance to R CYI-mediated resistance to Cucumber mosaic virus in Arabidopsis thaliana. XIII. (2007)
  • Author(s): Osanai T., Sekine K.-T., Ishihara T., Kawakami S., Hase S, Takahashi H.
  • Organizer: International Congress of Molecular Plant-Microbe Interaction(MPMI2007)
  • Place of Presentation: ソレント、イタリア
• [Presentation] INF 1 treatment activates the j asmonic acid-mediated signaling pathway and induces resistance to Ralstonia solanacearum in tomato. XIII. (2007)
  • Author(s): Kawamura Y., Hase S., Yoshioka H., Takenaka S., Takahashi H.
  • Organizer: International Congress of Molecular Plant-Microbe Interaction(MPMI 2007)
  • Place of Presentation: ソレント、イタリア
• [Presentation] Functional analysis of LeATL6 encoding fungal glycoprotein elicitor-responsive ubiquitin ligase in tomato. XIII. (2007)
  • Author(s): Takahashi H., Hondo D., Hase S., Takenaka, S.
  • Organizer: International Congress of Molecular Plant-Microbe Interaction(MPMI 2007)
  • Place of Presentation: ソレント、イタリア
• [Presentation] Molecular mechanism for RCYI conferred resistance to Cucumbermosaic virus in Arabidopsis thaliana. (2007)
  • Author(s): 高橋英樹
  • Organizer: KCIST 2007Symposium on Molecular Host-Parasite Interactions
  • Place of Presentation: 済州島、韓国
• [Book] In 10th Japan-USA Scientific Seminar St Paul, Minnesota, USA (Eds. T.Walpert, T. Shiraishim, K. Akimitsu and J. Glazebrook)("Defense system induced by elicitin-like proteins of biocontrol agent Pythium oligandrum". Genome-enabled integration of research in plant-pathogen systems) (2010)
  • Author(s): Takahashi, H., Takenaka S.
  • Publisher: APS Press(in press)
• [Book] 植物病理学(眞山滋志・難波成任編)(抵抗性発現に関わる遺伝子制御) (2010)
  • Author(s): 高橋英樹
  • Publisher: 文英堂
• [Book] 「抵抗性発現に関わる遺伝子制御」植物病理学(眞山滋志・難波成任 編) (2010)
  • Author(s): 高橋英樹
  • Publisher: 文英堂
• [Book] 微生物と植物の相互作用一病害と生物防除-(百町満朗・対馬誠也編)(遺伝子発現からみた誘導抵抗の全体像)(第2章2-1) (2009)
  • Author(s): 高橋英樹・竹中重仁
  • Publisher: ソフトサイエンス社
• [Book] 微生物の病原性と植物の防御応答(上田一郎編著)(キュウリモザイクウイルス抵抗性におけるシグナル伝達機構) (2007)
  • Author(s): 高橋英樹
  • Publisher: 北海道大学出版会
• [Book] 微生物の病原性と植物の防御応答 (2007)
  • Author(s): 高橋英樹
  • Publisher: 北海道大学出版会
• [Book] ウイルス研究の現在と展望(蛋白質核酸酵素) (2007)
  • Author(s): 増田 税・高橋英樹
  • Publisher: 共立出版