Development of microbial catalyst catalyzing high shikimate production from quinate
| Project/Area Number |
19380050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
ADACHI Osao Yamaguchi University, 名誉教授 (20027189)
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| Co-Investigator(Kenkyū-buntansha) |
AKAKABE Yoshihiko 山口大学, 農学部, 准教授 (20274186)
SHINAGAWA Emiko 宇部工業高等専門学校, 物質工学科, 教授 (20116726)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 酢酸菌 / 酸化発酵 / シキミ酸 / コーヒー麹 / タミフル / キナ酸の製造 / シキミ酸の製造 / コーヒー粕麹 / 固定化触媒 |
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| Research Abstract |
A novel strategy preparing high shikimic acid with high efficiency with developed microbial enzymes from fungi and acetic acid bacteria has finally completed during three years of investigation supported by this grant. Coffee pulp koji facilitated strong formation of chlorogenic acid hydrolase and yielded quinic acid from coffee pulp easier than any other methods so far reported. Quinic acid was converted by two enzyme systems of acetic acid bacteria, oxidative fermentation of 3-dehydroshikimate from quinic acid and asymmetric reduction yielding shikimic acid from 3-dehydroshikimate were so successful. The fruitful outcomes in this project must help people from pandemic flu through plentiful supply of Tamiflu synthesized from shikimic acid provided in this project.
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Report
(4 results)
Research Products
(36 results)
