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The new method to identify small molecules binding proteins by usingmutants and genome sequences

Research Project

Project/Area Number 19380066
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionTokyo University of Science

Principal Investigator

菅原 二三男  Tokyo University of Science, 理工学部, 教授 (30192123)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords受容体 / 結合タンパク質 / 遺伝子変異体 / ゲノム / ファージディスプレイ / QCM / 結合アミノ酸配列 / 標的分子 / 医薬結合タンパク質 / ファージディスプレイ法 / バイオインフォマティクス / 遺伝子変異株
Research Abstract

The present study aimed at the identification of the action new and in vivo target protein of the establishment of the new medicine receptivity evaluation method that used gene mutation Drosophila melanogaster and CPT that used it.
CPT-20-B connecting peptide (NSASRGGSQRGRGEH) is identified by using the T7 phage display method with crystal departure pendulum microbalance (QCM) device. This peptide sequencing showed each array and the homology of human HshnRNP A1 and Drosophila melanogaster DmHrb87F. CPT united from the bead pull-down examination that used HeLa cell meltable picture with HshnRNP A1. CPT made HshnRNP A1-GST united changing protein, did the QCM interaction analysis, and was HshnRNP A1 and was dissociation constant 82.7 nM.
As a result of the microbial sensitivity test, by gene loss Drosophila melanogaster, two Hrb87FKG02089 and Hrb87FBG02743 that was the DmHrb87F gene mutant showed CPT high receptivity compared with the wild strain. Topo I has working that cancels a super-coil of plasmid DNA. This topology change was observed under CPT and the HshnRNP A1 existence. CPT obstructed the topo I revitalization as reported. Moreover, hnRNP A1 also similarly obstructed the topo I revitalization. In addition, CPT has improved the topo I active inhibition to HshnRNP A1 under both existence.
HshnRNP A1 or DmHrb87F united from the above-mentioned result with CPT, and the possibility of adjusting the topo I revitalization was suggested.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (188 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (87 results) (of which Peer Reviewed: 46 results) Presentation (94 results) Book (3 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] A sulfoglycolipid beta-sulfoquinovosyldiacylglycerol (betaSQDG) binds to Met1-Arg95 region of murine DNA polymerase lambda (Mmpol lambda) and inhibits its nuclear transit.2010

    • Author(s)
      Takakusagi K, Takakusagi Y, Ohta K, Aoki S, Sugawara F, Sakaguchi K.
    • Journal Title

      Protein Eng Des Sel 23(2)

      Pages: 51-60

    • Related Report
      2009 Final Research Report
  • [Journal Article] A sulfoglycolipid beta-sulfoquinovosyldiacylglycerol(betaSQDG)binds to Met1-Arg95 region of murine DNA polymerase lambda(Mmpol lambda)and inhibits its nuclear transit2010

    • Author(s)
      Takakusagi K, Takakusagi Y, Ohta K, Aoki S, Sugawara F, Sakaguchi K.
    • Journal Title

      Protein Eng Des Sel 23

      Pages: 51-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain.2009

    • Author(s)
      Mizushina Y, Motoshima H, Yamaguchi Y, Takeuchi T, Hirano K, Sugawara F, Yoshida H.
    • Journal Title

      Mar Drugs 7(4)

      Pages: 624-39

    • Related Report
      2009 Final Research Report
  • [Journal Article] Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells.2009

    • Author(s)
      Takeuchi T, Takahashi N, Ishi K, Kusayanagi T, Kuramochi K, Sugawara F.
    • Journal Title

      Bioorg Med Chem 17(23),17(23)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.2009

    • Author(s)
      Kuramochi K, Fukudome K, Kuriyama I, Takeuchi T, Sato Y, Kamisuki S, Tsubaki K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem 17(20)

      Pages: 7227-38

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structure and activity relationship of monogalactosyl diacylglycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth.2009

    • Author(s)
      Matsui Y, Hada T, Maeda N, Sato Y, Yamaguchi Y, Takeuchi T, Takemura M, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y.
    • Journal Title

      Cancer Lett 283(1)

      Pages: 101-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases.2009

    • Author(s)
      Kimura T, Takeuchi T, Kumamoto-Yonezawa Y, Ohashi E, Ohmori H, Masutani C, Hanaoka F, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem 17(5)

      Pages: 1811-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] Chlorogenic acid facilitates root hair formation in lettuce seedlings.2009

    • Author(s)
      Narukawa M, Kanbara K, Tominaga Y, Aitani Y, Fukuda K, Kodama T, Murayama N, Nara Y, Arai T, Konno M, Kamisuki S, Sugawara F, Iwai M, Inoue Y.
    • Journal Title

      Plant Cell Physiol 50(3)

      Pages: 504-14

    • NAID

      10027338353

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device.2009

    • Author(s)
      Nishiyama K, Takakusagi Y, Kusayanagi T, Matsumoto Y, Habu S, Kuramochi K, Sugawara F, Sakaguchi K, Takahashi H, Natsugari H, Kobayashi S.
    • Journal Title

      Bioorg Med Chem 17(1)

      Pages: 195-202

    • Related Report
      2009 Final Research Report
  • [Journal Article] 3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain2009

    • Author(s)
      Mizushina Y, Motoshima H, Yamaguchi Y, Takeuchi T, Hirano K, Sugawara F, Yoshida H.
    • Journal Title

      Mar Drugs. 7

      Pages: 624-639

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and structure-activity relationships of dehydroalt enusin derivatives as selective DNA polymerase alpha inhibitors2009

    • Author(s)
      Kuramochi K, Fukudome K, Kuriyama I, Takeuchi T, Sato Y, Kamisuki S, Tsubaki K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. 15

      Pages: 7227-7238

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and activity relationship of monogalactosyl diacyl glycerols, which selectively inhibited in vitro mammalian replicative DNA polymerase activity and human cancer cell growth2009

    • Author(s)
      Matsui Y, Hada T, Maeda N, Sato Y, Yamaguchi Y, Takeuchi T, Takemura M, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y.
    • Journal Title

      Cancer Lett. 283

      Pages: 101-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells2009

    • Author(s)
      Takeuchi T, Takahashi N, Ishi K, Kusayanagi T, Kuramochi K, Sugawara F.
    • Journal Title

      Bioorg Med Chem. 17

      Pages: 8113-8122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases2009

    • Author(s)
      Kimura T, Takeuchi T, Kumamoto-Yonezawa Y, Ohashi E, Ohmori H, Masutani C, Hanaoka F, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. 17

      Pages: 1811-1816

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chlorogenic acid facilitates root hair formation in lettuce seedlings2009

    • Author(s)
      Narukawa M, Kanbara K, Tominaga Y, Aitani Y, Fukuda K, Kodama T, Murayama N, Nara Y, Arai T, Konno M, Kamisuki S, Sugawara F, Iwai M, Inoue Y.
    • Journal Title

      Plant Cell Physiol. 50

      Pages: 504-514

    • NAID

      10027338353

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of small-molecule/protein interactions by the T7 phage display strategy using a quartz-crystal microbalance device2009

    • Author(s)
      Takakusagi Y, Takakusagi K, Sugawara F, Sakaguchi K.
    • Journal Title

      タンパク質核酸酵素 54

      Pages: 1203-1209

    • NAID

      40016708059

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases.2009

    • Author(s)
      Kimura T, Takeuchi T, Kumamoto-Yonezawa Y, Ohashi E, Ohmori H, Masutani C, Hanaoka F, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. 1

      Pages: 1811-1816

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chlorogenic acid facilitates root hair formation in lettuce seedlings.2009

    • Author(s)
      Narukawa M, Kanbara K, Tominaga Y, Aitani Y, Fukuda K, Kodama T, Murayama N, Nara Y, Arai T, Konno M, Kamisuki S, Sugawara F, Iwai M, Inoue Y.
    • Journal Title

      Plant Cell Physiol. 50

      Pages: 504-514

    • NAID

      10027338353

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of trimannoside-recognizing peptide sequences from a T7 phage display screen using a QCM device.2009

    • Author(s)
      Nishiyama K, Takakusagi Y, Kusayanagi T, Matsumoto Y, Habu S, Kuramochi K, Sugawara F, Sakaguchi K, Takahashi H, Natsugari H, Kobayashi S.
    • Journal Title

      Bioorg Med Chem. 17

      Pages: 195-202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta.2008

    • Author(s)
      Mizushina Y, Manita D, Takeuchi T, Sugawara F, Kumamoto-Yonezawa Y, Matsui Y, Takemura M, Sasaki M, Yoshida H, Takikawa H.
    • Journal Title

      Molecules 14(1)

      Pages: 102-21

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells.2008

    • Author(s)
      Kuriyama I, Mizuno T, Fukudome K, Kuramochi K, Tsubaki K, Usui T, Imamoto N, Sakaguchi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Molecules 13(12)

      Pages: 2948-61

    • Related Report
      2009 Final Research Report
  • [Journal Article] Synthesis and biological activities of neoechinulin A derivatives: new aspects of structure-activity relationships for neoechinulin A.2008

    • Author(s)
      Kuramochi K, Ohnishi K, Fujieda S, Nakajima M, Saitoh Y, Watanabe N, Takeuchi T, Nakazaki A, Sugawara F, Arai T, Kobayashi S.
    • Journal Title

      Chem Pharm Bull 56(12)

      Pages: 1738-43

    • NAID

      110007004710

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of Small Molecule Binding Molecules by Affinity Purification Using a Specific Ligand Immobilized on PEGA Resin.2008

    • Author(s)
      Kuramochi K, Miyano Y, Enomoto Y, Takeuchi R, Ishi K, Takakusagi Y, Saitoh T, Fukudome K, Manita D, Takeda Y, Kobayashi S, Sakaguchi K, Sugawara F.
    • Journal Title

      Bioconjug Chem 19(12)

      Pages: 2417-26

    • Related Report
      2009 Final Research Report
  • [Journal Article] Synthesis of Neoechinulin A and Derivatives.2008

    • Author(s)
      Kuranochi K, Aoki T, Nakazaki A, Kamisuki S, Takeno M, Ohnishi K, Kimoto K, Watanabe N, Kamakura T, Arai T, Sugawara F, Kobayashi K.
    • Journal Title

      Synthesis 23

      Pages: 3810-18

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Journal Article] The specific inhibitory effect of demethoxydehydroaltenusin, a derivative of dehydroaltenusin, on mammalian DNA polymerase alpha.2008

    • Author(s)
      Kuriyama I, Fukudome K, Kamisuki S, Kuramochi K, Tsubaki K, Sakaguchi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Int J Mol Med 22(6)

      Pages: 793-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool.2008

    • Author(s)
      Takakusagi Y, Kuramochi K, Takagi M, Kusayanagi T, Manita D, Ozawa H, Iwakiri K, Takakusagi K, Miyano Y, Nakazaki A, Kobayashi S, Sugawara F, Sakaguchi K.
    • Journal Title

      Bioorg Med Chem 16(22)

      Pages: 9837-46

    • Related Report
      2009 Final Research Report
  • [Journal Article] Neoechinulin A protects PC12 cells against MPP+-induced cytotoxicity.2008

    • Author(s)
      Kajimura Y, Aoki T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T.
    • Journal Title

      J Antibiot (Tokyo) 61(5)

      Pages: 330-3

    • NAID

      10021927874

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device.2008

    • Author(s)
      Takakusagi Y, Kuroiwa Y, Sugawara F, Sakaguchi K.
    • Journal Title

      Bioorg Med Chem 52(3)

      Pages: 556-62

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of macrolide antibiotic-binding Human_p8 protein.2008

    • Author(s)
      Morimura T, Hashiba M, Kameda H, Takami M, Takahama H, Ohshige M, Sugawara F.
    • Journal Title

      J Antibiot (Tokyo) 61(5)

      Pages: 291-6

    • NAID

      10021927785

    • Related Report
      2009 Final Research Report
  • [Journal Article] A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage.2008

    • Author(s)
      Ishi K, Sugawara F.
    • Journal Title

      Biochem Pharmacol 75(9)

      Pages: 1743-50

    • Related Report
      2009 Final Research Report
  • [Journal Article] Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol, targeting angiogenesis.2008

    • Author(s)
      Mori Y, Sahara H, Matsumoto K, Takahashi N, Yamazaki T, Ohta K, Aoki S, Miura M, Sugawara F, Sakaguchi K, Sato N.
    • Journal Title

      Cancer Sci 99(5)

      Pages: 1063-70

    • NAID

      10024006631

    • Related Report
      2009 Final Research Report
  • [Journal Article] Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.2008

    • Author(s)
      Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S.
    • Journal Title

      Bioorg Med Chem 16(9)

      Pages: 5039-49

    • Related Report
      2009 Final Research Report
  • [Journal Article] Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.2008

    • Author(s)
      Nishida M, Ida N, Horio M, Takeuchi T, Kamisuki S, Murata H, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem 16(9)

      Pages: 5115-22

    • Related Report
      2009 Final Research Report
  • [Journal Article] The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Hada T, Maeda N, Sugawara F, Yoshida H, Fujita M.
    • Journal Title

      Biochimie 90(6)

      Pages: 947-56

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases beta and lambda from Talaromyces sp.2008

    • Author(s)
      Kimura T, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem 16(8)

      Pages: 4594-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      Int J Mol Med 21(3)

      Pages: 281-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] 1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae.2008

    • Author(s)
      Naganuma M, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem 16(6)

      Pages: 2939-44

    • Related Report
      2009 Final Research Report
  • [Journal Article] Coenzyme Q(10) as a potent compound that inhibits Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Yonezawa Y, Mizuno T, Yanagi K, Imamoto N, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      Biochim Biophys Acta 1780(2)

      Pages: 203-13

    • Related Report
      2009 Final Research Report
  • [Journal Article] The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta.2008

    • Author(s)
      Mizushina Y, Manita D, Takeuchi T, Sugawara F, Kumamoto-Yonezawa Y, Matsui Y, Takemura M, Sasaki M, Yoshida H, Takikawa
    • Journal Title

      Molecules 14

      Pages: 102-121

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of dehydroaltenusin-C12 derivative, a selective DNA polymerase alpha inhibitor, on DNA replication in cultured cells2008

    • Author(s)
      Kuriyama I, Mizuno T, Fukudome K, Kuramochi K, Tsubaki K, Usui T, Imamoto N, Sakaguchi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Molecules 13

      Pages: 2948-2961

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological activities of neoechinulin A derivatives : new aspects of structure-activity relationships for neoechinulin A2008

    • Author(s)
      Kuramochi K, Ohnishi K, Fujieda S, Nakajima M, Saitoh Y, Watanabe N, Takeuchi T, Nakazaki A, Sugawara F, Arai T, Kobayashi S.
    • Journal Title

      Chem Pharm Bull(Tokyo). 56

      Pages: 1738-1743

    • NAID

      110007004710

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Small Molecule Binding Molecules by Affinity Purification Using a Specific Ligand Immobilized on PEGA Resin2008

    • Author(s)
      Kuramochi K, Miyano Y, Enomoto Y, Takeuchi R, Ishi K, Takakusagi Y, Saitoh T, Fukudome K, Manita D, Takeda Y, Kobayashi S, Sakaguchi K, Sugawara F.
    • Journal Title

      Bioconjug Chem. 19

      Pages: 2417-2426

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The specific inhibitory effect of demethoxydehydroaltenusin, a derivative of dehydroaltenusin, on mammalian DNA polymerase alpha.2008

    • Author(s)
      Kuriyama I, Fukudome K, Kamisuki S, Kuramochi K, Tsubaki K, Sakaguchi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Int J Mol Med. 22

      Pages: 793-799

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool2008

    • Author(s)
      Takakusagi Y, Kuramochi K, Takagi M, Kusayanagi T, Manita D, Ozawa H, Iwakiri K, Takakusagi K, Miyano Y, Nakazaki A, Kobayashi S, Sugawara F, Sakaguchi K
    • Journal Title

      Bioorg Med Chem. 16

      Pages: 9837-9846

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neoechinulin A protects PC12 cells against MPP+-induced cytotoxicity2008

    • Author(s)
      Kajimura Y, Aoki T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T.
    • Journal Title

      J Antibiot (Tokyo). 61

      Pages: 291-296

    • NAID

      10021927874

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a methotrexate-binding peptide from a T7 phage display screen using a QCM device.2008

    • Author(s)
      Takakusagi Y, Kuroiwa Y, Sugawara F, Sakaguchi K
    • Journal Title

      Bioorg Med Chem. 52

      Pages: 556-562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of macrolide antibiotic-binding Human_p8 protein.2008

    • Author(s)
      Morimura T, Hashiba M, Kameda H, Takami M, Takahama H, Ohshige M, Sugawara F.
    • Journal Title

      J Antibiot (Tokyo). 61

      Pages: 291-296

    • NAID

      10021927785

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.2008

    • Author(s)
      Saitoh T, Kuramochi K, Imai T, Takata KI, Takehara M, Kobayashi S, Sakaguchi K, Sugawara F.
    • Journal Title

      Bioorg Med Chem. 16

      Pages: 5815-5825

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage.2008

    • Author(s)
      Ishi K, Sugawara F.
    • Journal Title

      Biochem Pharmacol. 75

      Pages: 1743-1750

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol, targeting angiogenesis.2008

    • Author(s)
      Mori Y, Sahara H, Matsumoto K, Takahashi N, Yamazaki T, Ohta K, Aoki S, MiuraM, Sugawara F, SakaguchiK, Sato N.
    • Journal Title

      Cancer Sci. 99

      Pages: 1063-1970

    • NAID

      10024006631

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses and applications of fluorescent and biotinylated epolactaene derivatives : Epolactaene and its derivative induce disulfide formation.2008

    • Author(s)
      Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S
    • Journal Title

      Bioorg Med Chem. 16

      Pages: 5039-5049

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.2008

    • Author(s)
      Nishida M, Ida N, Horio M, Takeuchi T, Kamisuki S, Murata H, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      v Bioorg Med Chem. 16

      Pages: 5115-5122

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory action of SQDG (sulfoquinovosyl diacylglycerol) from spinach on Cdtl-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Hada T, Maeda N, Sugawara F, Yoshida H, Fujita M.
    • Journal Title

      Biochimie 90

      Pages: 947-956

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases beta and lambda from Talaromyces sp.2008

    • Author(s)
      Kimura T, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. 16

      Pages: 4594-4599

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      Int J Mol Med. 21

      Pages: 281-290

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae.2008

    • Author(s)
      Naganuma M, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. 2 16

      Pages: 2939-2944

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme Q(10) as a potent compound that inhibits Cdtl-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Yonezawa Y, Mizuno T, Yanagi K, Imamoto N, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      Biochim Biophys Acta. 1780

      Pages: 203-213

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibitory action of SQDG(sulfoquinovosyl diacylglycerol)from spinach on Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Hada T, Maeda N, Sugawara F, Yoshida H, Fujita M.
    • Journal Title

      Biochimie Mar 4(印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel azaphilones, kasanosins A and B, which are specific in hibitors of eukaryotic DNA polymerases beta and lambda from Talaromyces sp.2008

    • Author(s)
      Kimura T, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. Feb 15(印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      Int J Mol Med. 21(印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coenzyme Q(10) as a potent compound that inhibits Cdt1-geminin interaction.2008

    • Author(s)
      Mizushina Y, Takeuchi T, Takakusagi Y, Yonezawa Y, Mizuno T, Yanagi K, Imamoto N, Sugawara F, Sakaguchi K, Yoshida H, Fujita M.
    • Journal Title

      Biochim Biophys Acta 1780(印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae.2008

    • Author(s)
      Naganuma M, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. Dec 25

      Pages: 2939-44

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases.2007

    • Author(s)
      Nakamura R, Takeuchi R, Kuramochi K, Mizushina Y, Ishimaru C, Takakusagi Y, Takemura M, Kobayashi S, Yoshida H, Sugawara F, Sakaguchi K.
    • Journal Title

      Org Biomol Chem 5(24)

      Pages: 3912-21

    • Related Report
      2009 Final Research Report
  • [Journal Article] Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin.2007

    • Author(s)
      Aoki S, Morohashi K, Sunoki T, Kuramochi K, Kobayashi S, Sugawara F.
    • Journal Title

      Bioconjug Chem 18(6)

      Pages: 1981-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death.2007

    • Author(s)
      Kimoto K, Aoki T, Shibata Y, Kamisuki S, Sugawara F, Kuramochi K, Nakazaki A, Kobayashi S, Kuroiwa K, Watanabe N, Arai T.
    • Journal Title

      J Antibiot (Tokyo) 60(10)

      Pages: 614-21

    • NAID

      10019777394

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of C10 biotinylated camptothecin (CPT-10-B) binding peptides using T7 phage display screen on a QCM device.2007

    • Author(s)
      Takakusagi Y, Takakusagi K, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K.
    • Journal Title

      Bioorg Med Chem 15(24)

      Pages: 7590-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] An approach to evaluate two-electron reduction of 9, 10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress.2007

    • Author(s)
      Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y.
    • Journal Title

      Free Radic Biol Med 43(5)

      Pages: 789-99

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of a new immunosuppressive agent, beta-SQAG9, in swine kidney transplantation.2007

    • Author(s)
      Tanaka T, Kitamura H, Sahara H, Imai A, Itoh Y, Honma I, Sato E, Kobayashi K, Maeda T, Takenouchi M, Ohta K, Sugawara F, Sakaguchi K, Ando A, Inoko H, Sato N, Tsukamoto T.
    • Journal Title

      Transpl Immunol 18(1)

      Pages: 67-71

    • Related Report
      2009 Final Research Report
  • [Journal Article] Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase.2007

    • Author(s)
      Mizushina Y, Dairaku I, Yanaka N, Takeuchi T, Ishimaru C, Sugawara F, Yoshida H, Kato N.
    • Journal Title

      Biochimie 89(5)

      Pages: 581-90

    • Related Report
      2009 Final Research Report
  • [Journal Article] Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp.2007

    • Author(s)
      Kamisuki S, Ishimaru C, Onoda K, Kuriyama I, Ida N, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem 15(9)

      Pages: 3109-14

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sulfoglycolipids as candidate antiangiogenic radiosensitizers2007

    • Author(s)
      Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K.
    • Journal Title

      Anticancer Drugs 18(1)

      Pages: 1-5

    • Related Report
      2009 Final Research Report
  • [Journal Article] Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53.2007

    • Author(s)
      Iijima H, Kasai N, Chiku H, Takeuchi T, Kuramochi K, Hanashima S, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y.
    • Journal Title

      Int J Mol Med 19(1)

      Pages: 41-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.2007

    • Author(s)
      Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N, Mizushina Y.
    • Journal Title

      Biochem Biophys Res Commun 352(2)

      Pages: 390-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] Chemical properties of fatty acid derivatives as inhibitors of DNA polymerases.2007

    • Author(s)
      Nakamura R, Takeuchi R, Kuramochi K, Mizushina Y, Ishimaru C, Takakusagi Y, Takemura M, Kobayashi S, Yoshida H, Sugawara F, Sakaguchi K.
    • Journal Title

      Org Biomol Chem. 5

      Pages: 3912-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin.2007

    • Author(s)
      Aoki S, Morohashi K, Sunoki T, Kuramochi K, Kobayashi S, Sugawara F.
    • Journal Title

      Bioconjug Chem. 18

      Pages: 1981-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death.2007

    • Author(s)
      Kimoto K, Aoki T, Shibata Y, Kamisuki S, Sugawara F, Kuramochi K, Nakazaki A, Kobayashi S, Kuroiwa K, Watanabe N, Arai T.
    • Journal Title

      J Antibiot(Tokyo). 60

      Pages: 614-21

    • NAID

      10019777394

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of C10 biotinylated camptothecin(CPT-10-B) binding peptides using T7 phage display screen on a QCM device.2007

    • Author(s)
      Takakusagi Y, Takakusagi K, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K.
    • Journal Title

      Bioorg Med Chem. 15

      Pages: 7590-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic DNA polymerase I activity and cell growth of Escherichia coli.2007

    • Author(s)
      Furukawa T, Nishida M, Hada T, Kuramochi K, Sugawara F, Kobayashi S, Iijima H, Shimada H, Yoshida H, Mizushina Y.
    • Journal Title

      J Oleo Sci. 56

      Pages: 43-7

    • NAID

      130000055536

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An approach to evaluate two-electron reduction of 9, 10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress.2007

    • Author(s)
      Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y.
    • Journal Title

      Free Radic Biol Med. 43

      Pages: 789-99

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a new immunosuppressive agent, beta-SQAG9, in swine kidney transplantation.2007

    • Author(s)
      Tanaka T, Kitamura H, Sahara H, Imai A, Itoh Y, Honma I, Sato E, Kobayashi K, Maeda T, Takenouchi M, Ohta K, Sugawara F, Sakaguchi K, Ando A, Inoko H, Sato N, Tsukamoto T.
    • Journal Title

      Transpl Immunol. 18

      Pages: 67-71

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory action of polyunsaturated fatty acids on IMP dehy drogenase.2007

    • Author(s)
      Mizushina Y, Dairaku I, Yanaka N, Takeuchi T, Ishimaru C, Sugawara F, Yoshida H, Kato N.
    • Journal Title

      Biochimie. 89

      Pages: 581-90

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp.2007

    • Author(s)
      Kamisuki S, Ishimaru C, Onoda K, Kuriyama I, Ida N, Sugawara F, Yoshida H, Mizushina Y.
    • Journal Title

      Bioorg Med Chem. 15

      Pages: 3109-14

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulfoglycolipids as candidate antiangiogenic radiosensitizers.2007

    • Author(s)
      Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K.
    • Journal Title

      Anticancer Drugs. 18

      Pages: 1-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of a glycolipid, sulfoquinovosyl diacylglycerol, with the DNA binding activity of p53.2007

    • Author(s)
      Iijima H, Kasai N, Chiku H, Takeuchi T, Kuramochi K, Hanashima S, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y
    • Journal Title

      Int J Mol Med. 19

      Pages: 41-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha.2007

    • Author(s)
      Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K, Sugawara F, Yoshida H, Sato N, Mizushina Y.
    • Journal Title

      Biochem Biophys Res Commun. 352

      Pages: 390-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of sulfoquinovosyl diacylglycerol on prokaryotic DNA polymerase I activity and cell growth of Escherichia coli.2006

    • Author(s)
      Furukawa T, Nishida M, Hada T, Kuramochi K, Sugawara F, Kobayashi S, Iijima H, Shimada H, Yoshida H, Mizushina Y.
    • Journal Title

      J Oleo Sci 56(1)

      Pages: 43-7

    • NAID

      130000055536

    • Related Report
      2009 Final Research Report
  • [Journal Article] Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.

    • Author(s)
      Saitoh T, Kuramochi K, Imai T, Takata KI, Takehara M, Kobayashi S, Sakaguchi K, Sugawara F.
    • Journal Title

      Bioorg Med Chem 16(10)

      Pages: 5815-25

    • Related Report
      2009 Final Research Report
  • [Presentation] 線虫ガレクチンLEC-6による糖鎖認識機構解明のための分子プローブの合成及びその評価2010

    • Author(s)
      西山和沙, 山田篤, 草柳友恵, 松本勇記, 高草木洋一, 菅原二三男, 坂口謙吾, 小林進, 武内智春, 笠井献一, 夏苅英昭, 高橋秀依
    • Organizer
      日本薬学会第130年会
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] エポラクタエン及び誘導体の化学と生物:全合成から作用機構解析2010

    • Author(s)
      倉持幸司, 椿一典, 水品善之, 菅原二三男, 池北雅彦, 小林進
    • Organizer
      第4回連携大学院セミナー京都「先端バイオイメージングと基盤技術」
    • Year and Date
      2010-01-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] YファミリーDNAポリメラーゼ選択的阻害剤:Penicilliol A, Penicilliol B2009

    • Author(s)
      水品善之, 木村拓馬, 竹内倫文, 米澤裕子, 大橋英治, 大森治夫, 益谷央豪, 花岡文雄, 吉田弘美, 菅原二三男, 坂口謙吾
    • Organizer
      第32回日本分子生物学会
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] T7 PD法による低分子化合物とタンパク質の相互作用の検出: QCM装置とRELICサーバーの利用がもたらす実用性と可能性2009

    • Author(s)
      高草木洋一, 高草木香織, 菅原二三男, 坂口謙吾
    • Organizer
      第32回日本分子生物学会
    • Year and Date
      2009-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 含硫糖脂質SQAGのhVEGF165結合領域の同定及び結合様式の解明2009

    • Author(s)
      高草木香織, 高草木洋一, 松本勇記, 鷹見美穂子, 井田紀子, 青木仁子, 村田寛, 太田慶祐, 菅原二三男, 坂口謙吾
    • Organizer
      第32回日本分子生物学会
    • Year and Date
      2009-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法を用いて同定したアンジオモチンとロキシスロマイシンの相互作用の検証2009

    • Author(s)
      鈴木愛こ, 高草木洋一, 渡辺まどか, 松本勇記, 戸井崎絢, 鈴木孝洋, 菅原二三男, 小林進, 坂口謙吾
    • Organizer
      第32回日本分子生物学会
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] エポラクタエン及び誘導体のチオール反応性2009

    • Author(s)
      倉持幸司, 椿一典, 水品善之, 菅原二三男, 池北雅彦, 小林進
    • Organizer
      日本農芸化学会関西支部例会
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] カバノアナタケから同定された新規化合物DDTCTの細胞増殖抑制効果2009

    • Author(s)
      望月万里, 森田明典, 羽染芳宗, 井田紀子, 村田寛, 船津修, 菅原二三男, 池北雅彦
    • Organizer
      第82回日本生化学会大会
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] X-family DNAポリメラーゼによる生物多様性の調節2009

    • Author(s)
      小寺啓文, 武内亮, 半澤直人, 内山幸伸, 美和秀胤, 菅原二三男, 坂口謙吾
    • Organizer
      第11回日本進化学会大会
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Self-assembled monolayer (SAM) of small organic molecule for efficient random-peptide phage display selection using a cuvette type quartz-crystal microbalance2009

    • Author(s)
      Takakusagi Y, Suzuki A, Sugawara F, Kobayashi S, Sakaguchi K
    • Organizer
      (QCM) device ICCE-17
    • Year and Date
      2009-07-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Camptothecins : Inhibition of the E-prostanoid receptor subtype 12009

    • Author(s)
      Takakusagi Y, Manita D, Okado M, Nakayama M, Takakusagi K, Sugawara F, Sakaguchi K
    • Organizer
      (EP1) signaling pathways and its' mechanistic aspects The 50th Anniversary Meeting of the American Society of Pharmacognosy
    • Year and Date
      2009-06-27
    • Related Report
      2009 Final Research Report
  • [Presentation] QCM-phage display: Identification of doxorubicin-binding protein (part III)2009

    • Author(s)
      Kusayanagi T, Takakusagi Y, Takeuchi T, Sakaguchi K, Sugawara F
    • Organizer
      The 50th Anniversary Meeting of the American Society of Pharmacognosy
    • Year and Date
      2009-06-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 海洋天然物SQAGによるDNA polymerase lambdaの阻害様式の解明2009

    • Author(s)
      高草木香織, 太田慶祐, 高草木洋一, 青木仁子, 菅原二三男, 坂口謙吾
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Year and Date
      2009-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] ニガウリ由来のmonoacylgalactosyl diacylglycerol (MGDG)のDNAポリメラーゼ阻害活性とヒト癌増殖抑制活性2009

    • Author(s)
      松井由樹, 羽田尚彦, 佐藤義大, 山口素弘, 竹内倫文, 坂口謙吾, 菅原二三男, 水品義之, 吉田弘美
    • Organizer
      日本農芸化学会2009年度(平成21年度)大会
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 浜辺に生息する苔に寄生する真菌(Penicillium deleae)ユリアの新規物質peniciliol AおよびBの生理活性2009

    • Author(s)
      水品義之, 木村拓馬, 竹内倫文, 菅原二三男
    • Organizer
      日本農芸化学会2009年度(平成21年度)大会
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法を用いたタンパク質間相互作用阻害剤の探索法の改良2009

    • Author(s)
      齊藤雄己, 真仁田大輔, 菅原二三男
    • Organizer
      日本農芸化学会2009年度(平成21年度)大会
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] クルクミン誘導体の抗炎症作用2009

    • Author(s)
      西田真之, 吉田優, 東健, 福留啓志, 清水恭平, 竹内倫文, 大澤俊彦, 菅原二三男, 水品義之, 吉田弘美
    • Organizer
      日本農芸化学会2009年度(平成21年度)大会
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] トリマンノース由来の分子プローブの合成とQCM-PD-SAM法を用いた結合ペプチドの同定2009

    • Author(s)
      西山和沙, 高草木洋一, 草柳友恵, 松本勇記, 羽生紫織, 倉持幸司, 菅原二三男, 坂口謙吾, 高橋秀依, 夏苅英昭, 小林進
    • Organizer
      日本薬学会第129年会
    • Year and Date
      2009-03-26
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Antitumor Antibiotic Fostriecin Targets Cystein-269 of the Protein Phosphatase 2A Catalitic Subunit in Mammailan Cells with a Covalent Bond.2009

    • Author(s)
      Toshifumi Takeuchi, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Developement of Phage Display with Quartz Crystal Microbalance Method.2009

    • Author(s)
      Tomoe Kusayanagi, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] A Facile Method to inhibit Protein-Protein Interactions with Phage Display Method.2009

    • Author(s)
      Takeki Saitoh, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Isolation of Natural Products (2)2009

    • Author(s)
      Yoshihiro Sato, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Synthesis of Natural Products (1): The Radio Sensitizer SQ series.2009

    • Author(s)
      Hiroshi Murata, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Sinthesis of Natural Products (2): Bioactive Compounds.2009

    • Author(s)
      Hiroaki Ishii, Kyohei Shimizu, Satomi Shimura, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-16
    • Related Report
      2009 Final Research Report
  • [Presentation] New Screening Methods for Protein-Protein Interaction Inhibitors Based on FRET and Phage Display.2009

    • Author(s)
      Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-15
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Isolation of Natural Products (1)2009

    • Author(s)
      Takuma Kimura, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Year and Date
      2009-03-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Self-assembled monolayer(SAM)of small organic molecule for efficient random-peptide phage display selection using a cuvette type quartz-crystal microbalance(QCM)device2009

    • Author(s)
      高草木洋一, 鈴木愛こ, 菅原二三男, 小林進, 坂口謙吾
    • Organizer
      ICCE-17
    • Place of Presentation
      Honolulu, HI
    • Related Report
      2009 Annual Research Report
  • [Presentation] Camptothecins : Inhibition of the E-prostanoid receptor subtype 1(EP1)signaling pathways and its' mechanistic aspects2009

    • Author(s)
      Takakusagi Y, Manita D, Okado M, Nakayama M, Takakusagi K, Sugawara F, Sakaguchi K
    • Organizer
      The 50th Anniversary Meeting of the American Society of Pharmacognosy
    • Place of Presentation
      Honolulu, HI
    • Related Report
      2009 Annual Research Report
  • [Presentation] QCM-phage display : Identification of doxorubicin-binding protein(part III)2009

    • Author(s)
      草柳友恵, 高草木洋一, 武内智春, 坂口謙吾, 菅原二三男
    • Organizer
      The 50th Anniversary Meeting of the American Society of Pharmacognosy
    • Place of Presentation
      Honolulu, HI
    • Related Report
      2009 Annual Research Report
  • [Presentation] 海洋天然物SQAGによるDNA polymerase lambda の阻害様式の解明2009

    • Author(s)
      高草木香織, 太田慶祐, 高草木洋一, 青木仁子, 菅原二三男, 坂口謙吾
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸市産業振興センター
    • Related Report
      2009 Annual Research Report
  • [Presentation] クルクミン誘導体の抗炎症作用2009

    • Author(s)
      西田真之, 古田優, 東健, 福留啓志, 清水恭平, 竹内倫文, 大澤俊彦, 菅原二三男, 水品義之, 吉田弘美
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡・マリンメッセ福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] T7ファージディスプレイ法を用いたタンパク質問相互作用阻害剤の探索法の改良2009

    • Author(s)
      齊藤雄己, 真仁田大輔, 菅原二三男
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡・マリンメッセ福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] 浜辺に生息する苔に寄生する真菌(Penicillium deleae)ユリアの新規物質peniciliol AおよびBの生理活性2009

    • Author(s)
      水品義之, 木村拓馬, 竹内倫文, 菅原二三男
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡・マリンメッセ福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニガウリ由来のmonoacylgalactosyl diacylglycerol (MGDG)のDNAポリメラーゼ阻害活性とヒト癌増殖抑制活性2009

    • Author(s)
      松井由樹, 羽田尚彦, 佐藤義大, 山口素弘, 竹内倫文, 坂口謙吾, 菅原二三男, 水品義之, 吉田弘美
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡・マリンメッセ福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synthesis of Natural Products(1) : The Radio Sensitizer SQ series.2009

    • Author(s)
      Hiroshi Murata, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Place of Presentation
      東京・ホテルエドモント
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sinthesis of Natural Products(2) : Bioactive Compounds.2009

    • Author(s)
      Hiroaki Ishii, Kyohei Shimizu, Satomi Shimura, Fumio Sugawara
    • Organizer
      3rd Tokyo Uiniversity of Science Interanational Collaboration Workshop
    • Place of Presentation
      東京・ホテルエドモント
    • Related Report
      2008 Annual Research Report
  • [Presentation] QCM T7ファージディスプレイ法:新規ドキソルビシン結合タンパク質の探索2008

    • Author(s)
      草柳友恵, 倉持幸司, 高草木洋一, 菅原二三男
    • Organizer
      (第二報)先端科学セミナー京都ケミカルバイオロジーシンポジウム
    • Year and Date
      2008-12-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗腫瘍活性物質カンプトテシンの新規作用標的タンパク質の探索2008

    • Author(s)
      真仁田大輔, 高草木洋一, 倉持幸司, 菅原二三男
    • Organizer
      先端科学セミナー京都ケミカルバイオロジーシンポジウム
    • Year and Date
      2008-12-15
    • Related Report
      2009 Final Research Report
  • [Presentation] 固相合成用樹脂を利用した結合タンパク質探索2008

    • Author(s)
      榎本好宏, 倉持幸司, 宮野友香, 石一智, 高草木洋一, 斉藤雄己, 小林進, 坂口謙吾, 菅原二三男
    • Organizer
      先端科学セミナー京都ケミカルバイオロジーシンポジウム
    • Year and Date
      2008-12-15
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法を用いたリダイフェンBの新規標的タンパク質の探索2008

    • Author(s)
      九十田千子, 高草木洋一, 今井孝彦, 椎名勇, 坂口謙吾, 池北雅彦, 菅原二三男
    • Organizer
      先端科学セミナー京都ケミカルバイオロジーシンポジウム
    • Year and Date
      2008-12-15
    • Related Report
      2009 Final Research Report
  • [Presentation] QCM T7 ファージディスプレイ法 : 新規ドキソルビシン結合タンパク質の探索(第二報)2008

    • Author(s)
      草柳友恵, 倉持幸司, 高草木洋一, 菅原二三男
    • Organizer
      先端科学セミナー京都ケミカルバイオロジーシンポジウム
    • Place of Presentation
      京都府立大学
    • Year and Date
      2008-12-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗腫瘍活性物質カンプトテシンの新規作用標的タンパク質の探索2008

    • Author(s)
      真仁田大輔, 高草木洋一, 倉持幸司, 菅原二三男
    • Organizer
      先端科学セミナー京都 ケミカルバイオロジーシンポジウム
    • Place of Presentation
      京都府立大学
    • Year and Date
      2008-12-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 固相合成用樹脂を利用した結合タンパク質探索2008

    • Author(s)
      榎本好宏, 倉持幸司, 宮野友香, 石一智, 高草木洋一, 斉藤雄己, 小林進, 坂口謙吾, 菅原二三男
    • Organizer
      先端科学セミナー京都 ケミカルバイオロジーシンポジウム
    • Place of Presentation
      京都府立大学
    • Year and Date
      2008-12-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] T7ファージディスプレイ法を用いたリダイフェンBの新規標的タンパク質の探索2008

    • Author(s)
      九十田千子, 高草木洋一, 今井孝彦, 椎名勇, 坂口謙吾, 池北雅彦, 菅原二三男
    • Organizer
      先端科学セミナー京都 ケミカルバイオロジーシンポジウム
    • Place of Presentation
      京都府立大学
    • Year and Date
      2008-12-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] カバノアナタケから同定されたDDTCTの細胞増殖抑制効果2008

    • Author(s)
      望月万里, 森田明典, 羽染芳宗, 井田紀子, 村田寛, 船津修, 菅原二三男, 池北雅彦
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Year and Date
      2008-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] クルクミンとその誘導体による炎症抑制効果2008

    • Author(s)
      西田真之, 吉田優, 東健, 福留啓志, 竹内倫文, 倉持幸司, 菅原二三男, 坂口謙吾, 吉田弘美, 水品善之
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] T7 phage display法を用いたロキシスロマイシン結合タンパク質の探索2008

    • Author(s)
      鈴木愛こ, 高草木洋一, 渡邊まどか, 松本勇記, 菅原二三男, 坂口謙吾
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7 phage display法を用いたPFOS結合タンパク質の探索2008

    • Author(s)
      岡戸真実, 宮野友香, 崎元一平, 志村聡美, 草柳友恵, 武内亮, 高草木香織, 松本勇記, 中崎敦夫, 竹内倫文, 倉持幸司, 高草木洋一, 太田慶祐, 三浦雅彦, 小林進, 菅原二三男, 坂口謙吾
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] QCM T7ファージディスプレイ法:新規ドキソルビシン結合タンパク質の探索2008

    • Author(s)
      草柳友恵, 真仁田大輔, 岩切佳那子, 倉持幸司, 高草木洋一, 中崎敦夫, 小林進, 坂口謙吾, 菅原二三男
    • Organizer
      (第一報)第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] CBP501によるG2チェックポイント阻害作用の詳細についての研究2008

    • Author(s)
      松本勇記, 高草木洋一, 新藤陽介, 高草木香織, 小谷野祐希, 佐藤仁志, 河邊拓己, 菅原二三男, 坂口謙吾
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Year and Date
      2008-12-09
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 糖鎖認識機能解明のための分子プローブの合成2008

    • Author(s)
      西山和沙, 草柳友恵, 松本勇記, 高草木洋一, 倉持幸司, 菅原二三男, 坂口謙吾, 高橋秀依, 夏苅英昭, 小林進
    • Organizer
      反応と合成の進歩シンポジウム
    • Year and Date
      2008-11-04
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] T7ファージディスプレイ法を用いたBrz-2001とチトクロムP450 DWF4の結合解析2008

    • Author(s)
      真仁田大輔, 草柳友恵, 高草本洋一, 倉持幸司, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京学術総合センター
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] T7ファージディスプレイ法を用いたBrz-2001とチトクロムP450 DWF4の結合解析2008

    • Author(s)
      真仁田大輔, 草柳友恵, 高草木洋一, 倉持幸司, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Year and Date
      2008-05-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 医薬小分子結合タンパク質の同定を目的としたワンサイクルT7ファージディスプレイ法の研究2008

    • Author(s)
      草柳友恵, 高木真奈美, 真仁田大輔, 岩切佳那子, 倉持幸司, 高草木洋一, 中崎敦夫, 小林進, 坂口謙吾, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Year and Date
      2008-05-19
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 糖認識機能解明のための分子プローブの合成2008

    • Author(s)
      西山和沙, 草柳友恵, 高草木洋一, 倉持幸司, 菅原二三男, 坂口謙吾, 武内智春, 笠井献一, 高橋秀依, 夏苅英昭, 小林進
    • Organizer
      第55回有機合成化学協会関東支部シンポジウム
    • Year and Date
      2008-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7 ファージディスプレイ法によるポドフィロトキシンの新規結合タンパク質の探索と同定2008

    • Author(s)
      斉藤 雄己、倉持 幸司、今井 孝彦、高田 慶一、菅原 二三男
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] T7 phage display法による抗腫瘍性抗生物質PD 113,271結合タンパク質の探索2008

    • Author(s)
      今井 孝彦、竹内 倫文、石 一智、斉藤 雄己、倉持 幸司、菅原 二三男
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワンステップT7ファージディスプレイ法による医薬小分子の結合タンパク質の同定2008

    • Author(s)
      草柳 友恵、高木 真奈美、真仁田 大輔、岩切 佳那子、倉持 幸司、高草木 洋一、中崎 敦夫、小林 進、坂口 謙吾、菅原 二三男
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] T7ファージディスプレイ法によるドキソルビシン標的タンパク質の探索および酵母を用いた生物活性評価法の研究2008

    • Author(s)
      真仁田 大輔、小柳 邦生、高橋 徳行、今井 孝彦、石 一智、倉持 幸司、菅原 二三男
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多価不飽和脂肪酸はIMPデヒドロゲナーゼを阻害する2008

    • Author(s)
      水品 善之、矢中 規之、Han, Yunkyung、竹内 倫文、石丸 千里、菅原 二三男、吉田 弘美、加藤 範久
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] トリマンノース由来の分子プローブの合成とQCM-PD法による結合ペプチドの探索2008

    • Author(s)
      西山和沙, 草柳友恵, 高草木洋一, 倉持幸司, 菅原二三男, 坂口謙吾, 高橋秀依, 夏苅英昭, 小林進
    • Organizer
      日本薬学会128年会
    • Year and Date
      2008-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] クルクミン誘導体の抗炎症作用の解析2008

    • Author(s)
      西田 真之、吉田 優、東 健、大澤 俊彦、福留 啓志、竹内 倫文、倉持 幸司、菅原 二三男、水品 善之、吉田 弘美
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名城大学
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワンステップT7ファージディスプレイ法による医薬小分子の結合タンパク質の同定2008

    • Author(s)
      草柳友恵, 高木真奈美1, 真仁田大輔, 岩切佳那子, 倉持幸司, 高草木洋一, 中崎敦夫, 小林進, 坂口謙吾, 菅原二三男
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] クルクミン誘導体の抗炎症作用の解析2008

    • Author(s)
      西田真之, 吉田優, 東健, 大澤俊彦, 福留啓志, 竹内倫文, 倉持幸司, 菅原二三男, 水品善之, 吉田弘美
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法によるポドフィロトキシンの新規結合タンパク質の探索と同定2008

    • Author(s)
      斉藤雄己, 倉持幸司, 今井孝彦, 高田慶一, 菅原二三男
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] T7 phage display法による抗腫瘍性抗生物質PD 113, 271結合タンパク質の探索2008

    • Author(s)
      今井孝彦, 竹内倫文, 石一智, 斉藤雄己, 倉持幸司, 菅原二三男
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法によるドキソルビシン標的タンパク質の探索および酵母を用いた生物活性評価法の研究2008

    • Author(s)
      真仁田大輔, 小柳邦生, 高橋徳行, 今井孝彦, 石一智, 倉持幸司, 菅原二三男
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 多価不飽和脂肪酸はIMPデヒドロゲナーゼを阻害する2008

    • Author(s)
      水品善之, 矢中規之, Han, Yunkyung, 竹内倫文, 石丸千里, 菅原二三男, 吉田弘美, 加藤範久
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] キイロショウジョウバエによる医薬標的分子の評価2008

    • Author(s)
      真仁田大輔, 高草木洋一, 松本勇記, 高田和徳, 坂口謙吾, 菅原二三男
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] T7 phage display 法を用いたロキシスロマイシン結合タンパク質の探索2008

    • Author(s)
      鈴木愛子, 高草木洋一, 渡邊まどか, 松本勇記, 菅原二三男, 坂口謙吾
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] T7 phage display 法を用いたPFOS結合タンパク質の探索2008

    • Author(s)
      岡戸真実, 宮野友香, 崎元一平, 志村聡美, 草柳友恵, 武内亮, 高草本香織, 松本勇記, 中崎敦夫, 竹内倫文, 倉持幸司, 高草木洋一, 太田慶祐, 三浦雅彦, 小林進, 菅原二三男, 坂口謙吾
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] QCM T7 ファージディスプレイ法 : 新規ドキソルビシン結合タンパク質の探索(第一報)2008

    • Author(s)
      草柳友恵, 真仁田大輔, 岩切佳那子, 倉持幸司, 高草木洋一, 中崎敦夫, 小林進, 坂口謙吾, 菅原二三男
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖認識機能解明のための分子プローブの合成2008

    • Author(s)
      西山和沙, 草柳友恵, 高草木洋一, 倉持幸司, 菅原二三男, 坂口謙吾, 武内智春, 笠井献一, 高橋秀依, 夏苅英昭, 小林 進
    • Organizer
      第55回有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      野田市・東京理科大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] Target Identification: Affinithy Selection and Phage Display2008

    • Author(s)
      Fumio Sugawara
    • Organizer
      Zhang Synposium for Drug Discovery.
    • Place of Presentation
      Antigua
    • Related Report
      2007 Annual Research Report
  • [Presentation] カバノアナタケから同定された新規アポトーシス誘導物質DDTCTの作用機構2007

    • Author(s)
      望月万里, 森田明典, 羽染芳宗, 井田紀子, 村田寛, 船津修, 菅原二三男, 池北雅彦
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-14
    • Related Report
      2009 Final Research Report
  • [Presentation] ニンニク由来の含硫黄物質群のDNAポリメラーゼ分子種選択的阻害活性とヒト癌細胞増殖抑制活性BMB20072007

    • Author(s)
      西田真之, 羽田尚彦, 吉田英生, 木元貴士, 倉持幸司, 菅原二三男, 米澤裕子, 栗山磯子, 坂口謙吾, 吉田弘美, 水品善之
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 低分子化合物の高性能な標的探索を可能とするファージディスプレイ法の確立BMB20072007

    • Author(s)
      高草木洋一, 高木真奈美, 草柳友恵, 倉持幸司, 宮野友香, 高草木香織, 菅原二三男, 小林進, 坂口謙吾
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] EFFECTS OF DNA POLYMERASE ALPHA POISON DEHYDROALTENUSIN ON THE FISSION YEAST SCHIZOSACCHAROMYCES POMBE BMB20072007

    • Author(s)
      栗山磯子, 紙透伸治, 菅原二三男, 吉田弘美, 水品善之, 野口英史
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] カバノアナタケから同定された新規アポトーシス誘導物質DDTCTの作用機構BMB20072007

    • Author(s)
      望月万里, 森田明典, 羽染芳宗, 井田紀子, 村田寛, 船津修, 菅原二三男, 池北雅彦
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 固相有機合成用樹脂を用いたアフィニティービーズの標的タンパク質探索への応用BMB20072007

    • Author(s)
      宮野友香, 倉持幸司, 武内亮, 榎本好宏, 草柳友恵, 高草木洋一, 中崎敦夫, 小林進, 菅原二三男, 坂口謙吾
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] High-throughput and High-accuracy Drug-Target Identifications2007

    • Author(s)
      Fumio Sugawara, Yoichi Takakusaghi, Kouji Kuramochi
    • Organizer
      The 4th Takeda Science Foundation Symposium on PharmaScience: On the Fronthiers of Chemical Biology
    • Year and Date
      2007-12-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Down regulation of Tie-2 gene in vivo by novel anti-tumor agent SQAG targeting antiangionesis2007

    • Author(s)
      Yoko Mori, Hiroeki Sahara, Kayo Matsumoto, Nobuaki Takahashi, Takayuki Yamazaki, Keisuke Ohta, Satoko Aoki, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, Noriyuki Sato
    • Organizer
      第66回日本癌学会学術総会
    • Year and Date
      2007-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of cyclosporin A binding protein CSBP that plays a critical role in hepatitis C virus genome replication2007

    • Author(s)
      Hiroeki Sahara, Kengo Morohashi, Koichi Watashi, Yoko Mori, Kazuki Iwabata, Wataru Tsutae, Hiroki Miyashita, Kokichi Kikuchi, Kunitada Shimotohno, Kengo Sakaguchi, Noriyuki Sato, Fumio Sugawara
    • Organizer
      第66回日本癌学会学術総会
    • Year and Date
      2007-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗腫瘍抗生物質fostriecinはプロテインフォスファターゼ2AのCys269-Lys283領域と共有結合する2007

    • Author(s)
      竹内倫文, 高橋徳行, 石一智, 倉持幸司, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会
    • Year and Date
      2007-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法お用いたポドフィロトキシン結合タンパク質の探索2007

    • Author(s)
      斉藤雄己, 倉持幸司, 高田慶一, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会
    • Year and Date
      2007-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] ファージディスプレイ法を用いたneoechinulin Aが活性作用を示す際のターゲットタンパク及び、neoechinulin A生合成に関る遺伝子の探索2007

    • Author(s)
      堀内桃子, 竹野正洋, 倉持幸司, 菅原二三男, 鎌倉高志
    • Organizer
      日本ケミカルバイオロジー研究会
    • Year and Date
      2007-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法によるカンプトテシンの新規分子標的hEP1受容体細胞内第3ループの同定2007

    • Author(s)
      高草木洋一, 太田慶祐, 倉持幸司, 高草木香織, 小林進, 菅原二三男, 坂口謙吾
    • Organizer
      日本ケミカルバイオロジー研究会
    • Year and Date
      2007-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法によるメトトレキサートの新規結合タンパク質の探索2007

    • Author(s)
      黒岩祐貴, 高草木洋一, 倉持幸司, 今井孝彦, 伊藤一明, 吉田充輝, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会
    • Year and Date
      2007-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法によるトラニラスト結合タンパク質の同定2007

    • Author(s)
      平山智子, 高草木洋一, 石一智, 倉持幸司, 竹内倫文, 菅原二三男
    • Organizer
      日本ケミカルバイオロジー研究会
    • Year and Date
      2007-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 有機合成用樹脂をアフィニティー担体として利用したファージディスプレイ法2007

    • Author(s)
      榎本好宏, 倉持幸司, 一智, 新井威史, 菅原二三男
    • Organizer
      日本農芸化学会2007年度大会
    • Year and Date
      2007-03-25
    • Related Report
      2009 Final Research Report
  • [Presentation] T7ファージディスプレイ法によるポドフィロトキシンの新規結合タンパク質の探索2007

    • Author(s)
      斉藤雄己, 高田慶一, 倉持幸司, 菅原二三男
    • Organizer
      日本農芸化学会2007年度大会
    • Year and Date
      2007-03-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Aspergione A及びBの提出構造式の訂正と2007

    • Author(s)
      倉持幸司, 齊藤史代, 中崎敦夫, 高橋徳行, 水品善之, 小林進, 菅原二三男
    • Organizer
      Pseudodeflectusinの生物活性日本農芸化学会2007年度大会
    • Year and Date
      2007-03-25
    • Related Report
      2009 Final Research Report
  • [Presentation] T7 phage display法を用いたインターフェロン-α結合タンパク質の探索2007

    • Author(s)
      今井孝彦, 斉藤雄己, 石一智, 倉持幸司, 渡士幸一, 佐原弘益, 下遠野邦忠, 菅原二三男
    • Organizer
      日本農芸化学会2007年度大会
    • Year and Date
      2007-03-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Target Identificaiton of Small Drug Molecules2007

    • Author(s)
      Fumio Sugawara
    • Organizer
      5th International Drug Discovery Symposium
    • Place of Presentation
      Shanghai
    • Related Report
      2007 Annual Research Report
  • [Book] Handbook of Nutritional Biochemistry : Genomics2009

    • Author(s)
      Yoshiyuki Mizushina,, Kengo Sakaguchi, Fumio Sugawara, Hiromi Yoshida
    • Total Pages
      538
    • Publisher
      INHIBITORY MECHANISM OF LONGER CHAIN FATTY ACIDS ON MAMMALIAN DNA POLYMERASE B ACTIVITY
    • Related Report
      2009 Annual Research Report
  • [Book] クラーク分子生物学2008

    • Author(s)
      田沼精一,菅原二三男, 他
    • Total Pages
      860
    • Publisher
      丸善
    • Related Report
      2009 Final Research Report
  • [Book] クラーク 分子生物学2008

    • Author(s)
      田沼精一, 菅原二三男, 他
    • Total Pages
      860
    • Publisher
      丸善
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 腫瘍滞留性を有する化合物2009

    • Inventor(s)
      太田慶祐三浦雅彦坂口謙吾菅原二三男村田博石間正浩
    • Industrial Property Rights Holder
      東洋水産株式会社
    • Filing Date
      2009-01-20
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規なスルホン酸化糖誘導およびその医薬としての使用2009

    • Inventor(s)
      太田慶祐三浦雅彦坂口謙吾菅原二三男佐藤昇志佐原弘益高橋延昭森陽子山崎隆之正木和好村田博
    • Industrial Property Rights Holder
      東洋水産株式会社
    • Filing Date
      2009-01-19
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] シクロスポリンA結合タンパク質2008

    • Inventor(s)
      佐原弘益森陽子高橋延昭佐藤昇志菅原二三男坂口謙吾諸橋謙吾岩端一樹渡士幸一下遠野邦忠菊地浩吉傅亘宮下広樹
    • Industrial Property Rights Holder
      北海道公立大學学校法人札幌医科大学, 学校法人東京理科大学, 国立大学法人京都大学, 株式会社イムノ・ダイアグノスティク・ラボラトリー
    • Filing Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 新規なスルホン酸化誘導体およびその医薬としての使用2007

    • Inventor(s)
      太田慶祐、三浦雅彦、坂口健吾、菅原二三男、佐藤昇志、佐原広益、高橋延昭、森陽子、山崎隆之、正木和好
    • Industrial Property Rights Holder
      東京医科歯科大学, 札幌医科大学、東洋水産(株)
    • Industrial Property Number
      2007-190120
    • Filing Date
      2007-07-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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