Basic research on anti-trypanosomal drug discovery using bioactive substances derived from insect
| Project/Area Number |
19380068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
ISHIBASHI Jun National Institute of Agrobiological Sciences, 生体防御研究ユニット, ユニット長 (20391576)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | トリパノソーマ / ディフェンシン / 細胞膜 / リン脂質 / 固定化 / カイコ / リボフラビン / 経口投与 / タイワンカブトムシ / タカサゴシロアリ / 昆虫ディフェンシン改変ペプチド / 生理活性物質 / 抗トリパノソーマ薬 / 代謝 / 酸性リン脂質 / 改変ペプチド / 脱分極 / 抗トリパノソーマ活性物質 |
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| Research Abstract |
The mode of action of beetle-defensin derived peptides against Trypanosoma brucei brucei was revealed that the peptides attack cellular membrane of the parasites. We developed multi-functional materials on which the defensin derived peptides were covalently bound on the surface.
We purified an anti-trypanosomal substance from Bombyx pupae. Surprisingly, the active substance was identified as riboflavin, known as vitamin B2. Oral administration of riboflavin significantly delayed death of trypanosome-infected mice and proliferation of parasites. However, intravenous or intraperitoneal injection of riboflavin did not affect mortality and proliferation of parasites.
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Report
(6 results)
Research Products
(21 results)
