| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
The mode of action of beetle-defensin derived peptides against Trypanosoma brucei brucei was revealed that the peptides attack cellular membrane of the parasites. We developed multi-functional materials on which the defensin derived peptides were covalently bound on the surface.
We purified an anti-trypanosomal substance from Bombyx pupae. Surprisingly, the active substance was identified as riboflavin, known as vitamin B2. Oral administration of riboflavin significantly delayed death of trypanosome-infected mice and proliferation of parasites. However, intravenous or intraperitoneal injection of riboflavin did not affect mortality and proliferation of parasites.
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