| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Research Abstract |
Type 2 diabetes, one of life style-related diseases and a member of metabolic syndrome, is increasing worldwide. Its main symptom is high blood glucose value. By constructing in vitro assay systems using cultured muscle cells and pancreatic β-cells, we have screened food components that have potentiality to stimulate glucose consumption and/or insulin secretion. Some food components such as soy isoflavones and grape stilbenoids were found to suppress increases in blood glucose levels and to improve impaired glucose tolerance in type 2 diabetic model mice. Modes of actions of these food components were clarified mainly at cellular levels.
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