Regulation of life style-related diseases by phytochemicals

• Project/Area Number: 19380072
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: YAGASAKI Kazumi Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (20166474)
• Co-Investigator(Kenkyū-buntansha): MIURA Yutaka 東京農工大学, 大学院・共生科学技術研究院, 准教授 (10219595)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
• Keywords: 食品機能学 / 生活習慣病 / 糖尿病 / ポリフェノール / 栄養学 / ファイトケミカル / 食品因子 / シグナル伝達 / 農林水産物 / 培養細胞 / 食品 / 代謝症候群 / 筋管細胞 / 膵臓β細胞 / インスリン / グルコース

Research Abstract

Type 2 diabetes, one of life style-related diseases and a member of metabolic syndrome, is increasing worldwide. Its main symptom is high blood glucose value. By constructing in vitro assay systems using cultured muscle cells and pancreatic β-cells, we have screened food components that have potentiality to stimulate glucose consumption and/or insulin secretion. Some food components such as soy isoflavones and grape stilbenoids were found to suppress increases in blood glucose levels and to improve impaired glucose tolerance in type 2 diabetic model mice. Modes of actions of these food components were clarified mainly at cellular levels.

Research Products

• [Journal Article] 病態モデルによる食品因子の作用に関する栄養学的・食理学的研究 (2009)
  • Author(s): 矢ヶ崎一三
  • Journal Title: 日本栄養・食糧学会誌 62巻 Pages: 61-74
  • NAID: 10024794686
  • Peer Reviewed
• [Journal Article] 病態モデルによる食品因子の作用に関する栄養学的・食理学的研究 (2009)
  • Author(s): 矢ヶ崎一三
  • Journal Title: 日本栄養・食糧学会誌 62 Pages: 61-74
  • NAID: 10024794686
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 矢ヶ崎一三
  • Journal Title: 種子の科学とバイオテクノロジー(「コーヒーとその成分の食理機能」担当)(学会出版センター) Pages: 283-290
• [Journal Article] 病態モデルによる食品因子の作用に関する栄養学的・食理学的研究 (2009)
  • Author(s): 矢ヶ崎 一三
  • Journal Title: 日本栄養・食糧学会誌 62 Pages: 61-74
  • NAID: 10024794686
  • Peer Reviewed
• [Presentation] 糖代謝に対するコーヒー成分の作用 (2010)
  • Author(s): 森田淳一, ほか
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京大学(駒場)
  • Year and Date: 2010-03-29
• [Presentation] 糖代謝に対するコーヒー成分の作用 (2010)
  • Author(s): 森田淳一
  • Organizer: 日本農芸化学会2020年度大会
  • Place of Presentation: 東京大学・駒場キャンパス
  • Year and Date: 2010-03-29
• [Presentation] Nutrients and non-nutrients that regulate life style-related diseases (2009)
  • Author(s): Kazumi Yagasaki
  • Organizer: 4th Nutrition Industry Forum
  • Place of Presentation: Beijing, P.R. China
  • Year and Date: 2009-12-08
• [Presentation] Nutrients and non-nutrients that regulate lifestyle-related dieases (2009)
  • Author(s): Kazumi Yagasaki
  • Organizer: 4^<th> Nutrition Industry Forum
  • Place of Presentation: 人民大会堂 北京 中国
  • Year and Date: 2009-12-08
• [Presentation] Bromacology: Pharmacological aspects of nutrients and non-nutrients (2009)
  • Author(s): Kazumi Yagasaki
  • Organizer: International Symposium and Annual Meeting of the Korean Society of Food Science and Nutrition
  • Place of Presentation: Changwon T & E Center, Gyeongnam, Korea
  • Year and Date: 2009-11-06
• [Presentation] Bromacology : Pharmacological aspects of nutrients and non-nutrients (2009)
  • Author(s): Kazumi Yagasaki
  • Organizer: Korean Society of Food Science and Nutrition
  • Place of Presentation: Changwon T&E Center, Gyeongnam, Korea
  • Year and Date: 2009-11-06
• [Presentation] Anti-diabetic action of resveratrol in vitro and in vivo (2009)
  • Author(s): Miki Minakawa, et. al.
  • Organizer: 19th International Congress of Nutrition
  • Place of Presentation: BITEK, Bangkok, Thailand
  • Year and Date: 2009-10-07
• [Presentation] Anti-diabetic action of resveratrol in vitro and in vivo. (2009)
  • Author(s): 皆川身記
  • Organizer: 19^<th> International Congress of Nutrition
  • Place of Presentation: BITEK, Bangkok, Thailand
  • Year and Date: 2009-10-07
• [Presentation] esveratrol (RES)による糖代謝促進作用機構 (2009)
  • Author(s): 皆川身記, ほか
  • Organizer: 日本栄養・食糧学会関東支部シンポジウム
  • Place of Presentation: 日本大学(藤沢)
  • Year and Date: 2009-09-19
• [Presentation] レスベラトロールによる血糖値抑制作用および作用機構 (2009)
  • Author(s): 皆川身記, ほか
  • Organizer: 日本栄養・食糧学会第63回大会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2009-05-22
• [Presentation] レスベラトロールによる血糖値抑制作用および作用機構 (2009)
  • Author(s): 皆川身記
  • Organizer: 日本栄養・食糧学会第63回大会
  • Place of Presentation: 長崎ブリックホール(長崎)
  • Year and Date: 2009-05-22
• [Presentation] 細胞培養系および2型糖尿病モデルマウスにおける大豆イソフラボンの作用 (2009)
  • Author(s): 長岡真聡, ほか
  • Organizer: 日本農芸化学会2009年度大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-03-29
• [Presentation] Hypoglycemic action of resveratrol in vitro and in vivo (2008)
  • Author(s): Miki Minakawa, et. al.
  • Organizer: 21st International and Annual Meeting of the Japanese Association of Animal Cell Technology
  • Place of Presentation: Fukuoka International Congress Center
  • Year and Date: 2008-11-27
• [Presentation] Hypoglycemic effects of resveratrol in vitro and in vivo. (2008)
  • Author(s): 皆川身記
  • Organizer: 第21回日本動物細胞工学会国際大会(JAACT 2008)
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-11-27
• [Presentation] Anti-diabetic functions of genistein, daidzein and equol in vitro and in vivo. (2008)
  • Author(s): 長岡真聡
  • Organizer: 第21回日本動物細胞工学会国際大会(JAACT 2008)
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-11-27
• [Presentation] Anti-diabetic functions of genistein, daidzein and equol in vitro and in vivo (2008)
  • Author(s): Masato Nagaoka, et. al.
  • Organizer: 21st International and Annual Meeting of the Japanese Association of Animal Cell Technology
  • Place of Presentation: Fukuoka International Congress Center
  • Year and Date: 2008-11-26
• [Presentation] Effects of daidzein and equol on glucose uptake by cultured myotubes and on blood glucose in KK-Ay/Ta mice (2008)
  • Author(s): Masato Nagaoka, et. al.
  • Organizer: 24th International Conference on Polyphenols
  • Place of Presentation: University of Salamanca, Salamanca, Spain
  • Year and Date: 2008-07-08
• [Presentation] ダイゼインの体内動態と肝癌細胞の増殖・浸潤に対する作用 (2008)
  • Author(s): 矢ヶ崎一三
  • Organizer: 日本農芸化学会2008年度大会
  • Place of Presentation: 名古屋・名城大学
  • Year and Date: 2008-03-28
• [Presentation] Effects of daidzein and equol on glucose uptake by cultured L6 myotubes and on blood glucose in K. K-Ay/Ta mice. (2008)
  • Author(s): 矢ヶ崎 一三
  • Organizer: 第24回国際ポリフェノール会議(ICP 2008)
  • Place of Presentation: サラマンカ大学、スペイン
• [Book] 種子の科学とバイオテクノロジー(「コーヒーとその成分の食理機能」) (2009)
  • Author(s): 矢ヶ崎一三
  • Publisher: 学会出版センター
• [Remarks]
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• [Remarks]
  • URL: http://kenkyu-web.tuat.ac.jp/Profiles/2/0000169/profile.html
• [Remarks]
  • URL: http://kenkyu-web.tuat.ac.jp/Profi1es/2/0000169/profi1e.html
• [Remarks]
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