Exhaustive studies on filament forming proteins of molluskan muscle
| Project/Area Number |
19380119
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OCHIAI Yoshihiro The University of Tokyo, 大学院・農学生命科学研究科, 准教授 (50160891)
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| Co-Investigator(Kenkyū-buntansha) |
WATABE Shugo 東京大学, 大学院・農学生命科学研究科, 教授 (40111489)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | 軟体類 / 筋肉 / タンパク質 / フィラメント / 構造 / 軟体動物 / フィラメント形成 / 一次構造 / 立体構造 / ミオシン / フィラメント形成能 / 構造機能解析 |
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| Research Abstract |
Muscular filament-forming proteins, namely, myosin heavy chain, actin and tropomyosin from four species of mollusks (cephalopods) have been investigated. As for tropomyosin, those from other species were examined for their structural stability. Primary structure analysis based on cDNA cloning, phylogenetic analysis based on amino acid sequence, and functional and structural analysis based on tertiary structure simulation have revealed the specificity and uniqueness of those contractile proteins. The results obtained suggested that mollusks, especially cephalopods, have evolved protein related to muscle contraction to compensate for their specialized locomotion activities. On the other hand, the properties of myosin heavy chain, etc. would give important information for the effective utilization and processing of mollusks.
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Report
(4 results)
Research Products
(25 results)
