| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
|
|---|
| Research Abstract |
We succeeded in the cDNA cloning and preparations of active recombinants of high mannose N-glycan-specific algal lectins thatcan be grouped into three types (Type I～III) based on the recognition moiety within the branched oligomannosides of the N-glycans. Furthermore,we newly isolated and characterized the lectins, which belong to type I, from the three cultivated species of edible seaweeds. We found that the type I～III lectins had the anti-HIV activity and inhibitory activity against the growth of the cultured cells which are derived from human colonic cancer. These lectins were also useful to separate easily the high mannose N-glyans to each other from their mixture.
|
