| Project/Area Number |
19380154
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
MIYAMOTO Akio Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 教授 (10192767)
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| Co-Investigator(Kenkyū-buntansha) |
清水 隆 帯広畜産大学, 大学院・畜産学研究科, 助教 (90375113)
松井 基純 帯広畜産大学, 畜産学部, 助教 (20374762)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takashi 国立大学法人帯広畜産大学, 畜産学部, 准教授 (90375113)
MATSUI Motozumi 国立大学法人帯広畜産大学, 畜産学部, 准教授 (20374762)
SHIRASUNA Koumei 国立大学法人帯広畜産大学, 畜産学部, 助教 (20552780)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 黄体 / 退行 / PGF_<2α> / 血管機能 / データベース / ウシ / PGF2α |
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| Research Abstract |
Establishment of pregnancy is a basic phenomenon for the conserved strategy of species. In mammals, progesterone released from the corpus luteum has an essential key to establish pregnancy. The aim of the present study is to elucidate molecular mechanisms of development and regression of the bovine corpus luteum, and to give the new vision of the developing technologies for improvement of conception rate in the cow. From the results of the present study, we clearly showed that PGF_<2α>, a luteolytic factor, starts the luteolytic cascade within 5 minutes after intramascular injection in the cow, and PGF_<2α> stimulates luteolytic mediators within the corpus luteum. Addktionally, we showed the delay of luteolysis due to functional suppression of luteolytic mediators such as NOS, endothelin or angiotensin II.
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