Identification of candidate genes for unique QTL affecting growth and obesity discovered from a genetic resource of the wild mouse
| Project/Area Number |
19380156
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIKAWA Akira Nagoya University, 大学院・生命農学研究科, 准教授 (20211724)
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| Co-Investigator(Kenkyū-buntansha) |
NAMIKAWA Takao 名古屋大学, 大学院・生命農学研究科, 特任教授 (70111838)
EBIHARA Shizufumi 名古屋大学, 大学院・生命農学研究科, 教授 (50135331)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2009: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | マウス / 成長 / 肥満 / QTL / 量的形質 / 候補遺伝子 / コンジェニック系統 |
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| Research Abstract |
We have previously discovered a new QTL for growth and obesity on mouse chromosome 2 from a gene pool of the wild mouse and have constructed a congenic strain carrying the QTL allele derived from the wild mouse. In this study, we developed many subcongenic strains with different introgressed intervals using the previously constructed congenic strain. Phenotypic characterization of the subcongenic strains developed and expression analyses of genes within the introgressed region revealed that four genes are most likely candidates for the obesity QTL.
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Report
(4 results)
Research Products
(25 results)
