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Central role of metastin/kisspeptin neurons in regulating reproductive function in mammals

Research Project

Project/Area Number 19380157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionNagoya University

Principal Investigator

TSUKAMURA Hiroko  Nagoya University, 大学院・生命農学研究科, 准教授 (00212051)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsメタスチン / キスペプチン / GPR54 / サージ / 黄体整形性ホルモン(LH) / エストロジェン / 視床下部弓状核(ARC) / 前腹側室周囲核(AVPV) / 性腺刺激ホルモン放出ホルモン(GnRH)
Research Abstract

Reproductive function is regulated by two modes (pulse and surge modes) of gonadotropin-releasing hormone (GnRH) secretion in mammals. The present study suggested that metastin/kisspeptin neurons distributed in the anteroventral paraventricular nucleus (AVPV) and hypothalamic arcuate nucleus (ARC) plays a key role in regulating surge and pulse modes of GnRH/gonadotropin release, respectively, and then follicular development and ovulation.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (149 results)

All 2010 2009 2008 2007 Other

All Journal Article (58 results) (of which Peer Reviewed: 32 results) Presentation (87 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Sexual Differentiation of Kisspeptin Neurons Responsible for Sex Difference in Gonadotropin Release in Rats.2010

    • Author(s)
      Tsukamura, H., Homma, T., Tomikawa, J., Uenoyama Y., Maeda, K.-I.
    • Journal Title

      Annals of the New York Academy of Sciences (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat.2010

    • Author(s)
      Wkabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, M., V., Clifton, K., D., Mori, Y., Tsukamura, H., Maeda, K.-I., Steiner, A., R., Okamura, H.
    • Journal Title

      Journal of Neuroscience 30(8)

      Pages: 3124-3132

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生周期とニューロペプチド(1)キスペプチン2010

    • Author(s)
      本間玲実、富川順子、上野山賀久、前多敬一郎、束村博子
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY vol.17,No.1

      Pages: 19-24

    • Related Report
      2009 Final Research Report
  • [Journal Article] 生殖機能調節の新しい視点3思春期/性成熟のタイミングを決定するキスペプチン/メタスチン2010

    • Author(s)
      上野山賀久、大蔵聡、束村博子、前多敬一郎
    • Journal Title

      産科と婦人科 vol.77(3)

      Pages: 259-263

    • Related Report
      2009 Final Research Report
  • [Journal Article] Kisspeptin/metastinと生殖機能制御2010

    • Author(s)
      冨川順子・上野山賀久・束村博子・前多敬一郎
    • Journal Title

      Annual Review糖尿病・代謝・内分泌2010

      Pages: 206-212

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sexual Differentiation of Kisspeptin Neurons Responsible for Sex Difference in Gonadotropin Release in Rats2010

    • Author(s)
      Tsukamura, H., Homma, T., Tomikawa, J., Uenoyama Y., Maeda, K.-I.
    • Journal Title

      Annals of the New York Academy of Sciences (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization and estrogen regulation of hypothalamic Kiss1 gene in the pig2010

    • Author(s)
      Tomikawa, J., Homma, T., Tajima, S., Shibata, T., Inamoto, Y., Takase, K., Inoue, N., Ohkura, S., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
    • Journal Title

      Biology of Reproduction (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat2010

    • Author(s)
      Wkabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, M., V., Clifton, K., D., Mori, Y., Tsukamura, H.Maeda, K.-I., Steiner, A., R., Okamura, H.
    • Journal Title

      Journal of Neuroscience 30(8)

      Pages: 3124-3132

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization and estrogen regulation of hypothalamic Kissl gene in the pig.2009

    • Author(s)
      Tomikawa, J., Homma, T., Tajiina, S., Shibata, T,, Inamoto, Y., Takase, K., Inoue, N., Ohkura, S., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
    • Journal Title

      Biology of Reproduction (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats.2009

    • Author(s)
      Homma, T., Sakakibara, M., Yamada, S., Kinoshita, M., Iwata, K., Tomikawa, J., Kanazawa, T., Matsui, H., Takatsu, Y., Ohtaki, T., Matsumoto, H., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
    • Journal Title

      Biology of Reproduction 81(6)

      Pages: 1216-25

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat.2009

    • Author(s)
      Ohkura, S., Takase, K., Matsuyama, S., Mogi, K., Ichimura, T., Wakabayashi, Y., Uenoyama, Y., Mori, Y., Steiner, R.A., Tsukamura, H., Maeda, K.-I., Okamura, H.
    • Journal Title

      Journal of Neuroendocrinology 21

      Pages: 813-821

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kisspeptin/metastin: A Key Molecule Controlling Two Modes of Gonadotrophin-releasing Hormone/Luteinising Hormone Release in Female Rats.2009

    • Author(s)
      Uenoyama Y, Tsukamura H, Maeda K.-I.
    • Journal Title

      Journal of Neuroendocrinology 21(4)

      Pages: 299-304

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats2009

    • Author(s)
      Ohkura, S., Uenoyama, Y., Yamada, S., Homma, T., Takase, K., Inoue, N., Maeda, K.-I., Tsukamura, H.
    • Journal Title

      Peptides 30(1)

      Pages: 49-56

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible Role of Oestrogen in Pubertal Increase of Kissl/Kisspeptin Expression in Discrete Hypothalamic Areas of Female Rats.2009

    • Author(s)
      Takase, K., Uenoyama, Y., Inoue, N,, Matsui, H., Yamada, S., Shimizu, M., Homma, T., Tomikawa, J., Kanda, S., Matsumoto, H., Oka, Y., Tsukamura, H., Maeda, K.-I.
    • Journal Title

      Journal of Neuroendocrinology. 21(6)

      Pages: 527-37

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potencies of centrally-or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats.2009

    • Author(s)
      Pheng, V., Uenoyama, Y., Homma T., Inamoto Y., Takase K., Yoshizawa K., Isaka S., Watanabe T., Ohkura S., Tomikawa J., Maeda K.-I,, Tsukamura, H.
    • Journal Title

      Journal of Reproduction and Development 55

      Pages: 378-382

    • NAID

      10025194159

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat.2009

    • Author(s)
      Matsuyama, S., Ohkura, S., Iwata, K., Uenoyama, Y,, Tsukamura, H., Maeda, Kimura, K.
    • Journal Title

      Journal of Reproduction and Development 55

      Pages: 256-261

    • NAID

      10024942246

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] エストロゲンと視床下部-フィードバック機構の鍵を握るメタスチン/キスペプチンニューロンの役割2009

    • Author(s)
      東村博子・前多敬一郎
    • Journal Title

      産科と婦人科 vol.76,No.2

      Pages: 135-140

    • Related Report
      2009 Final Research Report
  • [Journal Article] Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH/LH surge system in male rats2009

    • Author(s)
      Homma, T., Sakakibara, M., Yamada, S., Kinoshita, M., Iwata, K., Tomikawa, J., Kanazawa, T., Matsui, H., Takatsu, Y., Ohtaki, T., Matsumoto, H., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
    • Journal Title

      Biology of Reproduction 81(6)

      Pages: 1216-1225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat2009

    • Author(s)
      Ohkura, S., Takase, K., Matsuyama, S., Mogi, K., Ichimura, T., Wakabayashi, Y., Uenoyama, Y., Mori, Y., Steiner, R.A., Tsukamura, H.Maeda, K.-I.Okamura, H.
    • Journal Title

      Journal of Reproduction and Development 21

      Pages: 813-821

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible Role of Oestrogen in Pubertal Increase of Kiss1/Kisspeptin Expression in Discrete Hypothalamic Areas of Female Rats2009

    • Author(s)
      Takase, K., Uenoyama, Y., Inoue N., Matsui, H., Yamada, S., Shimizu, M., Homma, T., Tomikawa, J., Kanda, S., Matsumoto, H., Oka, Y., Tsukamura, H., Maeda, K.-I.
    • Journal Title

      Journal of Neuroendocrinology 21(6)

      Pages: 527-537

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potencies of centrally- or peripherally-injected full-length kisspeptin or its C-terminal decapeptide on LH release in intact male rats2009

    • Author(s)
      Pheng, V., Uenoyama, Y., Homma T., Inamoto Y., Takase K., Yoshizawa K., Isaka S., Watanabe T., Ohkura S., Tomikawa J., Maeda K.-I., Tsukamura, H.
    • Journal Title

      Journal of Reproduction and Development 55

      Pages: 378-382

    • NAID

      10025194159

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible Role of Oestrogen in Pubertal Increase of Kissl/Kisspeptin Expression in Discrete Hypothalamic Areas of Female Rats.2009

    • Author(s)
      Takase K., Uenoyama Y., Inoue N., Matsui H., Yamada S., Shimizu M., Homma T., Tomikawa J., Kanda S., Matsumoto H., Oka Y., Tsukamura H ., Maeda K. -I.
    • Journal Title

      Journal of Neuroendocrinology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potencies of Centrally- or Peripherally-Injected Full-Length Kisspeptin or Its C-Terminal Decapeptide on LH Release in Intact Male Rats.2009

    • Author(s)
      Pheng, V., Uenoyama, Y., Homma T., Inamoto Y., Takase K., Yoshizawa K., Isaka S., Watanabe T., Ohkura S., Tomikawa J., Maeda K. -I., Tsukamura, H.
    • Journal Title

      Journal of Reproduction and Development (in press)

    • NAID

      10025194159

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Food Deprivation Induces Monocarboxylate Transporter 2 Expression in the Brainstem of Female Rat.2009

    • Author(s)
      Matsuyama S, Ohkura S, Iwata K, Uenoyama Y, Tsukamura H, Maeda K. -I, Kimura K.
    • Journal Title

      Journal of Reproduction and Developmexit. (in press)

    • NAID

      10024942246

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka lorvzias latipes).2008

    • Author(s)
      Kanda, S., Akazome, Y., Matsunaga, T., Yamamoto, N., Yamada, S., Tsukamura, H., Maeda, K.-I., Oka, Y.
    • Journal Title

      Endocrinology 149

      Pages: 2467-2476

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 視床下部-性腺軸のマスターレギュレーターとしてのメタスチン(キスペプチン)2008

    • Author(s)
      束村博子・上野山賀久・山田俊児・冨川順子・井上直子・大蔵聡・前多敬一郎
    • Journal Title

      ホルモンと臨床 Vol56,No.8

      Pages: 771-777

    • Related Report
      2009 Final Research Report
  • [Journal Article] メタスチン(キスペプチン)研究で生殖の謎を解く一応用の可能性も含めてー2008

    • Author(s)
      束村博子
    • Journal Title

      生物科学 第60巻,第1号

      Pages: 46-48

    • Related Report
      2009 Final Research Report
  • [Journal Article] 生殖を司る神経ペプチド, メタスチン(キスペプチン)2008

    • Author(s)
      束村博子・前多敬一郎
    • Journal Title

      成長発達 Vol15,No.3

      Pages: 1-4

    • NAID

      10024289582

    • Related Report
      2009 Final Research Report
  • [Journal Article] キスペプチン(メタスチン)による繁殖機能制御とその応用2008

    • Author(s)
      上野山賀久・束村博子・前多敬一郎
    • Journal Title

      週刊医学のあゆみ 第227巻11号

    • Related Report
      2009 Final Research Report
  • [Journal Article] 視床下部-下垂体-性腺軸のマスターレギュレーターとしてのメタスチン(キスペプチン)2008

    • Author(s)
      束村博子・上野山賀久・山田俊児・冨川順子・井上直子・大蔵聡・前多敬一郎
    • Journal Title

      ホルモンと臨床 Vol.56、No.8

      Pages: 771-777

    • Related Report
      2009 Final Research Report
  • [Journal Article] メタスチン/キスペプチンー種を超えて生殖を司る神経ペプチドGnRHの上位にあって性腺刺激ホルモン分泌をコントロールする2008

    • Author(s)
      束村博子、上野山賀久、大蔵聡、前多敬一郎
    • Journal Title

      化学と生物 vol46、No.4

      Pages: 234-236

    • NAID

      10021177023

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes).2008

    • Author(s)
      Kanda, S., Akazome, Y., Matsunaga, T., Yamamoto, N., Yamada, S., Tsukamura. H., Maeda, K. -I., Oka, Y.
    • Journal Title

      Endoerinology 149

      Pages: 2467-2476

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paraventricular α 1- and α 2-adrenergic receptors mediate hindbrain lipoprivation-induced suppression of luteinizing hormone pulses in female rats.2008

    • Author(s)
      Sajapitak, S., Uenoyama, Y., Yamada, S., Kinoshita, M., Iwata, K., Bari, F. Y., I'Anson, H., Tsukamixra. H., Maeda, K. -I.
    • Journal Title

      Journal of Reproduction and Development 54

      Pages: 198-202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats.2008

    • Author(s)
      Uenoyama, Y., Tsukamura. H., Kinoshita, M., Yamada, S., Iwata, K., Pheng, V., Sajapitak, S., Sakakibara, M., Ohtaki, T., Matsumoto, H., Maeda, K. -I.
    • Journal Title

      Journal of Neuroendocrinology 20

      Pages: 626-631

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central lipoprivation-induced suppression of LH pulses is mediated by paraventrieular catecholaminergic inputs in femalerats.2008

    • Author(s)
      Sajapitak, S.
    • Journal Title

      Endocrinology

      Pages: 3016-3024

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oestrogen-Dependent Stimulation of Luteinising Hormone Release by Galanin-Like Peptide (GALP) in Female Rats.2008

    • Author(s)
      Uenoyama, Y.
    • Journal Title

      Journal of Neuroendocrinology (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Paraventricular al-and a 2-adrenergic receptors mediate hindbrain lipoprivation-induced suppression of luteinizing hormone pulses in female rats.2008

    • Author(s)
      Sajapitak, S.
    • Journal Title

      Journal of Reproduction and Development (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of kiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually-Dimorphic Kisspeptin neurons in Medaka (Oryzias latipes).2008

    • Author(s)
      Kanda, S.
    • Journal Title

      Endocrinology 149(in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats.2007

    • Author(s)
      Adachi, S., Yamada, S., Takatsu, S., Matsui, H., Kinoshita, M., Takase, K., Sugiura, H., Ohtaki, T., Matsumoto, H., Uenoyama, Y., Tsukamura, H., Inoue, K., Maeda, K.-I.
    • Journal Title

      Journal of Reproduction and Development 53

      Pages: 367-378

    • NAID

      10027328252

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of metastin-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats.2007

    • Author(s)
      Yamada, S., Uenoyama, Y., Kinoshita, M., Iwata, K., Takase, K., Matsui, H., Adachi, S., Inoue, K,, Maeda, K.-I., Tsukamura, H.
    • Journal Title

      Endocrinology 148

      Pages: 2226-2232

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metastin/kisspeptin and control of estrous cycle in rats.2007

    • Author(s)
      Maeda, K., Adachi, S., Inoue, K., Ohkura, S., Tsukamura, H.
    • Journal Title

      Reviews in Endocrine and Metabolic Disorders 8

      Pages: 21-29

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 繁殖メカニズムの中核ペプチド、メタスチン(キスペプチン)をめぐる新しい性腺刺激剤の可能性(その1)-2007

    • Author(s)
      前多敬一郎、上野山賀久、大蔵聡、束村博子
    • Journal Title

      家畜人工授精 241号

      Pages: 22-36

    • Related Report
      2009 Final Research Report
  • [Journal Article] メタスチン-特集中枢内分泌の最新知見とその異常-2007

    • Author(s)
      上野山賀久、束村博子、前多敬一郎
    • Journal Title

      産科と婦人科 vol.74No.8

      Pages: 898-903

    • NAID

      40015569533

    • Related Report
      2009 Final Research Report
  • [Journal Article] metastin(キスペプチンkisspeptin)とGnRH分泌2007

    • Author(s)
      前多敬一郎、束村博子
    • Journal Title

      日本比較内分泌学会ニュースJSCE- No.126

      Pages: 13-14

    • Related Report
      2009 Final Research Report
  • [Journal Article] )繁殖メカニズムの中核ペプチド、メタスチン(キスペプチン)をめぐる新しい性腺刺激剤の可能性(その2)2007

    • Author(s)
      前多敬一郎、上野山賀久、大蔵聡、束村博子
    • Journal Title

      -家畜人工授精- 242号

      Pages: 7-24

    • Related Report
      2009 Final Research Report
  • [Journal Article] 生理的GnRH放出因子2007

    • Author(s)
      前多敬一郎、束村博子
    • Journal Title

      メタスチン(キスペプチン)の基礎と応用-家畜診療- 54巻10号

      Pages: 589-594

    • Related Report
      2009 Final Research Report
  • [Journal Article] メタスチン(キスペプチン):新しい繁殖制御の可能性を秘めた神経ペプチド2007

    • Author(s)
      前多敬一郎、上野山賀久、束村博子、大蔵聡
    • Journal Title

      臨床獣医 vol25、No.11

      Pages: 62-65

    • Related Report
      2009 Final Research Report
  • [Journal Article] Metastin/kisspeptin and control of estrous cycle in rats.2007

    • Author(s)
      Maeda, K.
    • Journal Title

      Reviews in Endocrine and Metabolic Disorders 8

      Pages: 21-29

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 繁殖機能を制御するエネルギーセンサーとその応用の可能性2007

    • Author(s)
      岩田衣世
    • Journal Title

      Journal of Veterinary Medicine 60-6

      Pages: 455-460

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 繁殖メカニズムの中核ペプチド、メタスチン(キスペプチン)をめぐる新しい性腺刺激剤の可能性(その1)2007

    • Author(s)
      前多敬一郎
    • Journal Title

      家畜人工授精 241

      Pages: 22-36

    • Related Report
      2007 Annual Research Report
  • [Journal Article] メタスチン-特集 中枢内分泌の最新知見とその異常-2007

    • Author(s)
      上野山賀久
    • Journal Title

      産科と婦人科 74-8

      Pages: 898-903

    • Related Report
      2007 Annual Research Report
  • [Journal Article] metastin(キズペプチンkisspeptin)とGnRH分泌-2007

    • Author(s)
      前多敬一郎
    • Journal Title

      日本比較内分泌学会ニュースJSCE 126

      Pages: 13-14

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 繁殖メカニズムの中核ペプチド、メタスチン(キスペプチン)をめぐる新しい性腺刺激剤の可能性(その2)2007

    • Author(s)
      前多敬一郎
    • Journal Title

      家畜人工授精 242

      Pages: 7-24

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 生理的GnRH放出因子,メタスチン(キスペプチン)の基礎と応用2007

    • Author(s)
      前多敬一郎
    • Journal Title

      家畜診療 54-10

      Pages: 589-594

    • Related Report
      2007 Annual Research Report
  • [Journal Article] メタスチン(キスペプチン): 新しい繁殖制御の可能性を秘めた神経ペプチド2007

    • Author(s)
      前多敬一郎
    • Journal Title

      臨床獣医 25

      Pages: 62-65

    • Related Report
      2007 Annual Research Report
  • [Journal Article] メタスチン/キスペプチンー種を超えて生殖を司る神経ペプチドGnRHの上位にあって性腺刺激ホルモン分泌をコントロールする2007

    • Author(s)
      束村博子
    • Journal Title

      化学と生物 46-4

      Pages: 234-236

    • NAID

      10021177023

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats.2007

    • Author(s)
      Adachi, S.,
    • Journal Title

      Journal of Reproduction and Development 53

      Pages: 367-378

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Metastin (Kisspeptin-54)-GPR 54 Signaling in the Arcuate Nucleus-Median Eminence Region during Lactation in Rats.2007

    • Author(s)
      Yamada S.
    • Journal Title

      Endocrinology 148(5)

      Pages: 2226-2232

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Kisspeptin neurons responsible for animal reproduction: Surge vs. pulse modes of GnRH/LH secretion and its sex difference.2010

    • Author(s)
      Tsukamura H., Maeda K.I.
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] Kisspeptin neurons responsible for animal reproduction : Surge vs. pulse modes of GnRH/LH secretion and its sex difference2010

    • Author(s)
      束村博子, 前多敬一郎
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 種を越えて生殖を制御する神経ペプチド、メタスチン/キスペプチン2010

    • Author(s)
      束村博子
    • Organizer
      第18回生殖.発生毒性学東京セミナー
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2010-03-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 種を越えて生殖を制御する神経ペプチド、メタスチン/キスペプチン2010

    • Author(s)
      束村博子
    • Organizer
      第18回生殖・発生毒性学東京セミナー
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2010-03-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gonadotropin-releasing hormone pulse generator activity from the arcuate nucleus kisspeptin neurons in the goat hypothalamus2010

    • Author(s)
      Ohkura S., Wakabayashi Y., Uenoyama Y., Steiner R.A., Tsukamura H., Maeda K. I, Okamura H
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] Induction of ovulation by kisspeptin and its agonists in the musk shrew (Suncus murinus), a reflex ovulator2010

    • Author(s)
      Inoue N., Sasaki Y.,, Oishi S., Fujii N., Uenoyama Y., Yamamoto, N., Tsukamura H., Maeda K.I.
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of neonatal estrogen on brain kisspeptin expression in adult mice : possible role of estrogen receptor α2010

    • Author(s)
      吉田佳絵, 本間玲実, 稲本瑶子, 冨川順子, 上野山賀久, 前多敬一郎, 束村博子
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular characterization of Kiss1 gene in the pig2010

    • Author(s)
      冨川順子, 本間珠実, 田嶋茂行, 柴田貴子, 稲本瑶子, 大蔵聡, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] Acute trapping of peripubertal kisspeptin or leptin with antibodies to determine factors triggering the onset of puberty in female rats2010

    • Author(s)
      Uenoyama Y., Takase K., Hirata J., Tanaka A., Tsukamura H., Maeda K.I.
    • Organizer
      14th international Congress of Endocrinology
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2009 Annual Research Report
  • [Presentation] 種を越えて生殖を支配するメタスチン(キスペプチン)-応用の可能性を含めて-2009

    • Author(s)
      束村博子
    • Organizer
      第25回東日本家畜受精卵移植技術研究会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-12-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 種を越えて生殖を支配するメタスチン (キスペプチン) -応用の可能性を含めて-2009

    • Author(s)
      束村博子
    • Organizer
      第25回東日本家畜受精卵移植技術研究会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] "Phylogenetic Aspects of Neuropeptides- from Invertebrates to Humans". Metastin/kisspeptin neuron, a key player in mammalian reproduction2009

    • Author(s)
      束村博子
    • Organizer
      Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Yakushima Iwasaki Hotel
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Central metastin/kisspeptin in the regulation of luteinizing hormone secretion.2009

    • Author(s)
      Tsukamura, H., Maeda, K.I.
    • Organizer
      36th International Congress of Physiolgical Sciences
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-08-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Central metastin/kisspeptin in the regulation of luteinizing hormone secretion2009

    • Author(s)
      束村博子, 前多敬一郎
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 女性の脳、男性の脳2009

    • Author(s)
      束村博子
    • Organizer
      名古屋市西生涯学習センター平成21年度前期定期講座 <女性セミナー> 豊かな学び、楽しい出会い
    • Place of Presentation
      名古屋市西生涯学習センター
    • Year and Date
      2009-05-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生殖を制御するペプチド:メタスチン/キスペプチン2009

    • Author(s)
      .東村博子
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県民会館
    • Year and Date
      2009-04-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 生殖を制御するペプチド : メタスチン/キスペプチン2009

    • Author(s)
      束村博子
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県民会館・前橋商工会議所
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生殖を制御する神経ペプチド, メタスチン/キスペプチン2009

    • Author(s)
      束村博子、前多敬一郎
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Phylogenetic Aspects of Neuropeptides- from Invertebrates to Humans2009

    • Author(s)
      Tsukamura, H.
    • Organizer
      Metastin/kisspeptin neuron, a key player in mammalian reproduction. Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Yakushima Iwasaki Hotel (Yakushima).
    • Related Report
      2009 Final Research Report
  • [Presentation] Neurokinin B as a Cotransmitter in Kisspeptin Neurons in the Regulation of Pulsatile GnRH Secretion2009

    • Author(s)
      若林嘉浩, 中田友明, 村田健, 大蔵聡, Navarro VM, 森裕司, 束村博子, 前多敬一郎, Steiner RA, 岡村裕昭
    • Organizer
      The 39th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Functional Significance of Dynorphin as a Cotransmitter in Kisspeptin Neurons in the Regulation of Pulsatile GnRH Secretion2009

    • Author(s)
      大蔵聡, 若林嘉浩, 中田友明, 村田健, Navarro VM, 森裕司, 束村博子, 前多敬一郎, Steiner RA, 岡村裕昭
    • Organizer
      The 39th annual meeting of the Society for Neuro science
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification and characterization of Kiss1 gene in pigs2009

    • Author(s)
      Tomikawa, J., Homma, T., Tajima, S., Shibata, T., Yamamoto, N., Uenoyama, Y., Ohkura, S., Tsukamura, H., Maeda, K.-I.
    • Organizer
      The 39th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ketone body is an orexigenic signal associated with diabetic hyperphagia in rats2009

    • Author(s)
      Iwata, K., Kinoshita, M., Yamada, S., Uenoyama, Y., Tsukamura, H.Maeda, K.-I.
    • Organizer
      The 39th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Absence of neonatal sex steroids rescues anteroventral periventricular kisspeptin neurons and GnRH/LH surge system in male rats2009

    • Author(s)
      Homma, T., Sakakibar, M., Yamada, S.,, Kinoshita, M., Iwata, K., Tomikawa, J., Kanazawa, T., Uenoyama, Y., Maeda, K.-I. Tsukamura, H.
    • Organizer
      The 39th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Potencies of full-length kisspeptin or its C-terminal decapeptide on luteinizing hormone release in intact male rats2009

    • Author(s)
      Uenoyama, Y., Pheng, V., Homma, T., Inamoto, Y., Yoshizawa-Kumagaye, K., Isaka, S., Watanabe, T.X., Maeda, K.-I., Tsukamura, H.
    • Organizer
      The 39th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] ブタ卵巣におけるキスペプチン発現の解析2009

    • Author(s)
      井上直子, 平野隆之, 岡村裕昭, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      琉球大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] スンクスの脳におけるGnRH神経細胞の分布とLHおよびFSH遺伝子のクローニング2009

    • Author(s)
      佐々木有希, 山本直之, 上野山賀久, 束村博子, 前多敬一郎, 井上直子
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] ブタ卵胞顆粒層細胞におけるKiss1ならびにGpr54 mRNA発現の解析2009

    • Author(s)
      井上直子, 平野隆之, 岡村裕昭, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] シバヤギ弓状核キスペプチンニューロン神経活動に対する Neurokinin Bの作用2009

    • Author(s)
      若林嘉浩, 中田友明, 村田健, 大蔵聡, Navarro VM, 森裕司, 束村博子, 前多敬一郎, Steiner RA, 岡村裕昭
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] シバヤギ弓状核キスペプチンニューロン神経活動の制御における Dynorphin Aの役割2009

    • Author(s)
      大蔵聡, 若林嘉浩, 中田友明, 村田健, Navarro VM, 森裕司, 束村博子, 前多敬一郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホルスタイン種経産牛へのキスペプチン末梢投与による黄体形成ホルモン分泌刺激効果2009

    • Author(s)
      勝野伸吾, 大蔵聡, 佐藤精, 大橋秀一, 小林一雄, 難波陽介, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] 黄体期の黒毛和種雌ウシにおけるウシ型キスペプチン-10の性腺刺激ホルモン分泌刺激効果の検討2009

    • Author(s)
      難波陽介, 金沢哲広, 上野山賀久, 束村博子, 前多敬一郎, 大蔵聡
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] 視床下部弓状核キスペプチンニューロンの破壊がLHパルスに及ぼす影響2009

    • Author(s)
      岩田衣世, 大蔵聡, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラットにおいて新生仔期の精巣由来の性ステロイドは前腹側室周囲核 (AVPV) のキスペプチン発現を特異的に脱雌化させる2009

    • Author(s)
      本間玲実, 岩田衣世, 冨川順子, 上野山賀久, 前多敬一郎, 束村博子
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] ブタ Kiss cDNAのクローニングと発現解析2009

    • Author(s)
      冨川順子, 本間珠実, 田嶋茂行, 柴田貴子, 稲本瑶子, 上野山賀久, 大蔵聡, 束村博子, 前多敬一郎
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス前腹側室周囲核 (AVPV) キスペプチンニューロンにおけるBaxを介したアポトーシス2009

    • Author(s)
      金沢哲広, 本間玲実, 冨川順子, 上野山賀久, 前多敬一郎, 束村博子
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生仔期エストロジェン投与が成熟マウス脳内キスペプチン発現に及ぼす影響 : エストロジェン受容体αの関与の可能性2009

    • Author(s)
      吉田佳絵, 本間玲実, 稲本瑶子, 冨川順子, 上野山賀久, 前多敬一郎, 束村博子
    • Organizer
      第102回日本繁殖生物学会大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳領域得意的なKiss1コンディショナルK0マウス作製二向けた Kiss-floxed マウスの作出2009

    • Author(s)
      平嶋昂, 富川順子, 今村拓也, 三寳誠, 冨田江一, 平林真澄, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第24回日本下垂体研究会
    • Place of Presentation
      古牧温泉青森屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス初期胚の発生におけるKiss1発現とその機能2009

    • Author(s)
      深沼達也, 後藤哲平, 冨川順子, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第24回日本下垂体研究会
    • Place of Presentation
      古牧温泉青森屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] ブタKiss1 cDNAのクローニングと視床下部での発現分布の解析2009

    • Author(s)
      冨川順子, 本間玲実, 田嶋茂行, 柴田貴子, 稲本瑶子, 上野山賀久, 大蔵聡, 束村博子, 前多敬一郎
    • Organizer
      第24回日本下垂体研究会
    • Place of Presentation
      古牧温泉青森屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] Localization of kisspeptin and gonadotropin-releasing hormone (GnRH) in developing ovarian follicles of pigs and goats2009

    • Author(s)
      井上直子, 平野隆之, 上野山賀久, 束村博子, 岡村裕昭, 前多敬一郎
    • Organizer
      Society for the Study of Reproduction 42st Annual Meeting
    • Place of Presentation
      Pittsburgh, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレスによる生殖機能抑制の神経内分泌メカニズム2008

    • Author(s)
      束村博子
    • Organizer
      日本アンドロロジー学会第27回学術大会ならびに総会および第13回精子形成・精巣毒性研究会共同開催学会
    • Place of Presentation
      京都市先斗町歌舞練場
    • Year and Date
      2008-07-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of kisspeptin(metastin)-GPR54 system in regulating surge- and pulse-modes of GnRH/gonadotorpin release in rats Role of kisspeptin(metastin)-GPR54 system in regulating surge- and pulse-modes of GnRH/gonadotorpin release in rats.2008

    • Author(s)
      Tsukamura, H., Homma, T., Yamada, S., Inamoto, Y., Inoue, N., Ohkura, S., Uenoyama, Y., Maeda, K.I.
    • Organizer
      1st world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN.
    • Related Report
      2009 Final Research Report
  • [Presentation] 生殖を司る神経ペプチド、メタスチン/キスペプチン2008

    • Author(s)
      束村博子
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of metastin/kisspeptin neurons in Sex difference of LH secretion in the rat2008

    • Author(s)
      Tsukamura, H.
    • Organizer
      Grant-in-Aid for Scientific Research on Priority Areas 'Mechanism of Sex Differentiation' from The Ministry of Education, Culture, Sports, Science and Technology, Japan
    • Place of Presentation
      JAL Resort Sea Hawk Hotel Fukuoka.
    • Related Report
      2009 Final Research Report
  • [Presentation] Metasthl/kisspeptin neurons:Amissing link for mechanis.2008

    • Author(s)
      上野山賀久、束村博子、前多敬一郎
    • Organizer
      第4回日本繁殖生物学会・韓国繁殖生物学会合同シンポジウム
    • Place of Presentation
      ソウル
    • Related Report
      2009 Final Research Report
  • [Presentation] Metastin/kisspeptin-GPR54 system regulating reproductive functions in mammals.2008

    • Author(s)
      Tsukamura, H., Yamada, S., Homma, T., Inamoto, Y., Uenoyama, Y., Ohkura, S., Inoue, N., Maeda, K. -I.
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      Sheraton Keauhou Bay Resort & Spa Kailua-Kona, Hawaii
    • Related Report
      2009 Final Research Report
  • [Presentation] メタスチン(キスペプチン)によるゴナドトロピン分泌制御機構2008

    • Author(s)
      前多敬一郎、上野山賀久、大蔵聡、岡村裕昭、束村博子
    • Organizer
      第81回日本内分泌学会学術総会
    • Place of Presentation
      ホテル青森・青森市文化会館
    • Related Report
      2009 Final Research Report
  • [Presentation] DECREASED GONADAL ACTIVITIES BY ACTIVE IMMUNIZATION AGAINST KISSPEPTIN IN RATS.2008

    • Author(s)
      Uenoyama, Y., Inoue, N., Hasegawa, K., Tomikawa, J., Tsukamura, H., Maeda, K. I.
    • Organizer
      1^<st> world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN
    • Related Report
      2008 Annual Research Report
  • [Presentation] MOLECUKLAR AND PHYSIOLOGIC CHARACTERIZATION OF THE PORCINE KISS1 GENE AND PEPTIDE2008

    • Author(s)
      Tomikawa, J., Tajima, S., Shibata, T., Ohkiara, S., Uenoyama, Y., Tsukamura, H. . Maeda, K. I.
    • Organizer
      1^<st> world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN
    • Related Report
      2008 Annual Research Report
  • [Presentation] GONADORTOPIN-RELEASING HORMONE PULSE GENERATOR ACTIVITY IN CLOSE PROXIMITY TO THE ARCUATE KISSPEPTIN NEURONS IN THE GOAT.2008

    • Author(s)
      Ohkura, S., Takase, K., Uenoyama, Y., Tsukamura, H., Maeda, K. I., Okamura, H.
    • Organizer
      1^<st> world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN
    • Related Report
      2008 Annual Research Report
  • [Presentation] KISSPEPTIN FIBERS DIRECTLY CONTACT WITH GONADOTROPIN-RELEASING HORMONE FIBERS IN THE MEDIAN EMINENCE OF FEMALE RATS.2008

    • Author(s)
      Inoue, N., Pheng, V., Inamoto, Y., Uenoyama, Y., Tsukamura, H., Ichikawa, M., Maeda, K. I.
    • Organizer
      1^<st> world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN
    • Related Report
      2008 Annual Research Report
  • [Presentation] KISSPEPTIN AND ATEROID-SENSITIVE SEXUALLY DIMORPHIC KISSPEPTIN NEURONS IN MEDAKA(ORYZIAS LATIPES)2008

    • Author(s)
      Kanda, S., Akazome, Y., Matsunaga, T., Yamamoto, N., Yamada, S., Tsukamura. H., Maeda, K. I., Oka, Y.
    • Organizer
      1^<st> world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of KISSPEPTIN (METASTIN) -GPR54 System in Regulating Surge- and Pulse-Modes of GnRH/GONADOTORP IN RELEASE IN RATS.2008

    • Author(s)
      Tsukamura, H., Homma, T., Yamada, S., Inamoto, Y., Inoue, N., Ohkura, S., Uenoyama, Y., Maeda, K. I.
    • Organizer
      1^<st> world conference on kisspeptin signaling in the brain
    • Place of Presentation
      CORDOBA SPAIN
    • Related Report
      2008 Annual Research Report
  • [Presentation] 雌ラツトにおける新生仔期のエストロジェン長期投与はパルス状LH分泌の抑制と弓_状メタスチンニューロン核のの減少を引き起こす2008

    • Author(s)
      稲本瑶子, 本間玲実, 上野山賀久, 前田麻希, 山田俊児, 井上直子, 大蔵聡, 前多敬一郎, 束村博子
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] 交尾排卵動物スンクスにおけるメタスチンの排卵誘起効果2008

    • Author(s)
      井上直子, 上野山賀久, 大蔵聡, 束村博子, 前多敬一郎
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] 雌ブタヘのkisspeptin-10静脈内投与による黄体形成ホルモン分泌刺激効果2008

    • Author(s)
      田島茂行, 柴田貴子, 河野建夫, 難波陽介, 大蔵聡, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウシKiss-1遺伝子の同定および視床下部におけるメクスチンニューロンの局在2008

    • Author(s)
      若林嘉浩, 大蔵聡, 上野山賀久, 高瀬健志, 束村博子, 前多敬一郎, 岡村裕昭
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヤギおよびブタ卵巣におけるメタスチンの局在2008

    • Author(s)
      平野隆之, 岡村裕昭, 上野山賀久, 束村博子, 前多敬一郎, 井上直子
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットにおけるメタスチン/キスペプチンに対する能動免疫による性腺機能の低下2008

    • Author(s)
      上野山賀久, 井上直子, 長谷川浩一, 冨川順子, 東村博子, 前多敬一郎
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄体形成ホルモン(LH)サージを制御するメタスチンニューロンの性差をもたらす新生仔期の性ステロイド2008

    • Author(s)
      本間玲実, 榊原基嗣, 岩田良香, 前田麻希, 山田俊児, 稲本瑶子, 上野山賀久, 前多敬一郎, 束村博子
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生殖と摂食の制御に関わる脳内のエネルギーシグナル物質, ケトン体2008

    • Author(s)
      岩田衣世, 木下美香, 須崎直樹, 佐藤弘明, 上野山賀久, 束村博子, 前多敬一郎
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] 未成熟雌ラツトにおける脳内メタスチン発現と黄体形成ホルモン(LH)分泌にたいするエストロジェンの抑制作用2008

    • Author(s)
      上野山賀久, 高瀬健志, 清水基道, 束村博子, 前多敬一郎
    • Organizer
      第101回日本繁殖生物学会大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Related Report
      2008 Annual Research Report
  • [Presentation] シバヤギ視床下部弓状核のメタスチンニューロンはGnRHパルス発生機構に関与する2008

    • Author(s)
      大蔵聡, 高瀬健志, 松山秀一, 茂木一孝, 市丸徹, 上野山賀久, 森裕司, 束村博子, 前多敬一郎, 岡村裕昭
    • Organizer
      第35回日本神経内分泌学会第23回日本下垂体研究会合同学術集会
    • Place of Presentation
      政策研究大学院大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] Metastin/kisspeptin-GPR54 system regulating reproductive functions in mammals.2008

    • Author(s)
      束村博子, 山田俊児, 本間玲実, 稲本瑶子, 上野山賀久, 大蔵聡, 井上直子, 前多敬一郎
    • Organizer
      世界合同繁殖生物学会議
    • Place of Presentation
      コナ、ハワイ
    • Related Report
      2008 Annual Research Report
  • [Presentation] The absence in the neonatal androgen is essential for the presence of anteroventral periventricular metastin neurons and GnRH/LH surge system in the adult2008

    • Author(s)
      Homma, T., Uenoyaraa, Y., Maeda, M., Yamada, S., Iwata, K., Maeda, K. -I., Tsukamura. H.
    • Organizer
      世界合同繁殖生物学会議
    • Place of Presentation
      コナ、ハワイ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prolonged neonatal exposure to estrogen inhibits pulsatile LH release and estrous cyclicity in female rats probably via disruption of the arcuate metastin/kisspeptin neurons.2008

    • Author(s)
      Inamoto, Y., Homma, T., Uenoyama, Y., Maeda, M., Yamada, S., Inoue, N., Ohkura, S., Maeda, K. -I., Tsukamura. H.
    • Organizer
      世界合同繁殖生物学会議
    • Place of Presentation
      コナ、ハワイ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Brain ketone body sensing involved in the suppression of pulsatile luteinizing hormone release in female rats2008

    • Author(s)
      Iwata, K., Kinoshita, M., Susaki, N., Homma, T., Tsukamura. H., Maeda, K. -I.
    • Organizer
      世界合同繁殖生物学会議
    • Place of Presentation
      コナ、ハワイ
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄体形成ホルモン(LH)サージを誘起するエストロジェンの正のフィードバックを仲介するメタスチンニューロンの役割2008

    • Author(s)
      束村博子
    • Organizer
      日本畜産学会
    • Place of Presentation
      常磐大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 性成熟のタイミングを制御するメタスチンの発現調節機構2008

    • Author(s)
      上野山賀久
    • Organizer
      日本畜産学会
    • Place of Presentation
      常磐大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄体形成ホルモン(LH)分泌の性差をもたらすメタスチン/キスペプチンニューロンの役割2007

    • Author(s)
      束村博子、足立幸香、上野山賀久、井上金治、前多敬一郎
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京国際ファーラム
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 黄体形成ホルモン(LH)分泌の性差をもたらすメタスチンニューロンの役割2007

    • Author(s)
      束村博子、足立幸香、山田俊児、本間玲実、上野由賀久、井上金治、前多敬一郎
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 性成熟のタイミングを制御するメタスチン/キスペプチン2007

    • Author(s)
      上野山賀久
    • Organizer
      第80回日本内分泌学会学術総会
    • Place of Presentation
      東京国際ファーラム
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒトメタスチン活性ペプチド(キスペプチンン10)は去勢雄ウシのLH分泌を促進する2007

    • Author(s)
      大蔵聡
    • Organizer
      日本下垂体研究会第22回学術集会
    • Place of Presentation
      湘南国際村センター国際会議場
    • Related Report
      2007 Annual Research Report
  • [Presentation] Morphological basis for the regulation of GnRH release by metastin/kisspeptin neurons in the female rat brain2007

    • Author(s)
      Vutha Pheng
    • Organizer
      日本下垂体研究会第22回学術集会
    • Place of Presentation
      湘南国際村センター国際会議場
    • Related Report
      2007 Annual Research Report
  • [Presentation] Metastin/Kisspeptin Neuronal Projection in the Brain of Female Rats2007

    • Author(s)
      Vutha Pheng
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] 視床下部弓状核メタスチンニューロンの黄体形成ホルモンサージの成立における役割について2007

    • Author(s)
      前多敬一郎
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] 雌ラットの黄体形成ホルモン分泌におよぼすGalanin-like Peptideの影響2007

    • Author(s)
      上野山賀久
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] シバヤギメタスチンニューロンに対するエストロジェン作用の形態学的解析2007

    • Author(s)
      岡村裕昭
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] シバヤギ視床下部弓状核のメタスチンニューロンにおける多ニューロン発火活動の一過性上昇は黄体形成ホルモンのパルス状分泌に同期する2007

    • Author(s)
      茂木一孝
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] パルス状GnRH/LH分泌成立機構におけるメタスチンニューロンの役割2007

    • Author(s)
      稲本瑶子
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] 性成熟期のラット脳内におけるKiSS-1 mRNA発現の増加なエストロジェンにより制御される2007

    • Author(s)
      清水基道
    • Organizer
      第100回日本繁殖生物学会大会・第12回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京大学農学部キャンパス・弥生講堂
    • Related Report
      2007 Annual Research Report
  • [Presentation] Stimulatory effect of galanin-like peptide (GALP) on luteinizing hormone release in female rats2007

    • Author(s)
      Y. UENOYAMA
    • Organizer
      Neuroscience 2007, the Socciety's 37th annual meeting
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of arcuate metastin/kisspeptin neurons in regulation of pulsatile GnRH/LH secretion in the female rat2007

    • Author(s)
      Y. INAMOTO
    • Organizer
      Neuroscience 2007, the Socciety's 37th annual meeting
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of metastin/kisspeptin, a product of Kiss-1 gene, in the goat hypothalamus2007

    • Author(s)
      K. TAKASE
    • Organizer
      Neuroscience 2007, the Socciety's 37th annual meeting
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] Possible neuronal projections of the two populations of metastin/kisspeptin neurons in female rats2007

    • Author(s)
      V. PHENG
    • Organizer
      Neuroscience 2007, the Socciety's 37th annual meeting
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] 黄体形成ホルモン(LH)サージを誘起するエストロジェンの正のフィードバックを仲介するメタスチンニューロンの役割

    • Author(s)
      束村博子、本間玲実、前田麻希、山田俊児、上野山賀久、前多敬一郎
    • Organizer
      日本畜産学会第109回大会
    • Place of Presentation
      常磐大学
    • Related Report
      2009 Final Research Report
  • [Book] 家畜の文化2009

    • Author(s)
      前多敬一郎・束村博子
    • Publisher
      岩波書店
    • Related Report
      2009 Final Research Report
  • [Book] バイオテクノロジーと家畜"「ヒトと動物の関係学」第2巻「家畜の文化」2009

    • Author(s)
      前多敬一郎, 束村博子
    • Total Pages
      20
    • Publisher
      岩波書店
    • Related Report
      2008 Annual Research Report
  • [Book] 生殖機能の神経内分泌メカニズムー内分泌と生命現象〜シリーズ21世紀の動物科学〜2007

    • Author(s)
      束村博子
    • Total Pages
      36
    • Publisher
      培風館
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.agr.nagoya-u.ac.jp/~hanshoku/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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