| Project/Area Number |
19380162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KON Yasuhiro Hokkaido University, 大学院・獣医学研究科, 教授 (10178402)
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| Co-Investigator(Kenkyū-buntansha) |
ENDOH Daiji 酪農学園大学, 獣医学部, 教授 (40168828)
SASAKI Nobuya 北海道大学, 大学院・獣医学研究科, 准教授 (20302614)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Keywords | マウス / 精巣 / 卵巣 / 始原生殖細胞 / 精巣内卵細胞 / 性決定因子 / セルトリ細胞 / 透明帯 / 卵細胞 / MRLマウス / 減数分裂 / 原始卵胞 / 受精 / SYCP3 / Sry / MRL / MpJ / CAGリピート / 自己免疫疾患 / 減数分裂中期特異的アポトーシス / Exol |
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| Research Abstract |
The oocytes exist in seminiferous tubules of male MRL mice. As a result of the analysis, the testicular oocytes had several similar developmental dynamics, morphological characteristics, and functions to the ovarian oocytes. In the male MRL, the summaries are the following ; 1) the meiosis has already begun during embryogenesis, 2) sry mutation, male sex-determining factor was related with appearance of testicular oocytes, and 3) testicular oocytes have an ability for sperm acceptance. These results suggest an important finding that develop a new reproductive biology by the concept having an exchangeable availability of primordial germ cells from male to female.
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