Quantitative analysis of pain response in isolated spinal cord and cultured dorsal root ganglion cell
| Project/Area Number |
19380163
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
ITO Shigeo Hokkaido University, 大学院・獣医学研究科, 教授 (40109509)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OTSUGURO Ken-ichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2007: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
|
|---|
| Keywords | バニロイド受容体 / TRPV1チャネル / 背根神経節細胞 / 新生仔ラット脊髄 / ヒスタミン / 5-ヒドロキシトリプタミン / アデノシン / 腸管神経叢細胞 / 新生ラット脊髄標本 / リポポリサッカライド / 腸管神経細胞 / 後根神経 / ブラジキニン / 低酸素刺激 / TPRV1チャネル / 痛覚過敏 / 後根神経節 / 5-hydroxytryptamine / カプサイシンン |
|---|
| Research Abstract |
We found that vanilloid receptor (TRPV1) channels, being key proteins for pain generation, were activated by mustard oil or methylsalicylate in addition to a vanilloid compound such as capsaicin and that the opening of the channels was controlled by extracellular Na^+ ions. It was demonstrated that histamine and 5-hydroxy- tryptamine, which were released at inflammation sites, augmented pain due to TRPV1 channel activation through respective receptors for these amines, and that adenosine release was associated with the analgesic action in response to hypercapnia.
|
Report
(4 results)
Research Products
(66 results)
-
-
-
-
-
-
[Journal Article] Amelioration of amemia in the ICGN mouse, a renal anemia model, with a subcutaneous bolus injection of erythropoietin a dsorbed to hydroxyapatite matrix.2009
Author(s)
Nagasaki k, Ikoma T, Katsuda S, Tonegawa T, Tanaka J, Ohyama M, Hayashida K, Nakamura T, Sato H, Ito S, Sasaki N, Agui T
-
Journal Title
Journal of Veterinary Medical Science 71(10)
Pages: 1365-1371
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4, 5-Bisphosphate2008
Author(s)
Otsuguro K, Tang J, Tang Y, Xiao R, Freichel M, Tsvilovskyy V, Ito S, Flockerzi V, Zhu MX, Zholos AV
-
Journal Title
The Journal of Biological Chemistry 283
Pages: 10026-10036
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
