Analysis of a novel NFkB inhibitor deficient mouse as a model for atopic dermatisis

• Project/Area Number: 19380164
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Hokkaido University
• Principal Investigator: MORIMATSU Masami Hokkaido University, 遺伝子病制御研究所, 准教授 (70241370)
• Co-Investigator(Kenkyū-buntansha): TOMIOKA Yukiko 北海道大学, 遺伝子病制御研究所, 助教 (50374674) ; OMOE Katsuhiko 岩手大学, 農学部, 教授 (60224309) ; KANO Kiyoshi 東京大学, 農学生命化学研究科, 助教 (40312516) ; MAEDA Sadatoshi 岐阜大学, 応用生物科学部, 准教授 (50377694)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: NFkB / IkB / アトピー性皮膚炎 / 疾患モデル

Research Abstract

MAIL (molecule possessing ankyrin-repeats induced by LPS) is a nuclear IkappaB protein that is also termed inhibitor of nuclear factor kappaB (IkappaB) zeta. We generated Mail-deficient mice that appeared to develop atopic dermatitis (AD). In this study, we tried to rescue embryonic lethality of the mice. We investigated expression and function of MAIL in the skin to elucidate its role in AD. Possible interactions of Mail with some genes were also investigated.

Research Products

• [Journal Article] Discoidin domain receptor 2 (DDR2) is required for maintenance of spermatogenesis in male mice、Mol (2010)
  • Author(s): Kano, K, Kitamura, A, Matsuwaki, T, Morimatsu, M, Naito, K
  • Journal Title: Mol. Reprod. Dev 77巻 Pages: 29-37
  • Peer Reviewed
• [Journal Article] Discoidin domain receptor 2(DDR2)is required for maintenance of spermatogenesis in male mice. (2010)
  • Author(s): Kano, Kiyoshi, ら
  • Journal Title: Mol.Reprod. Dev. 77 Pages: 29-37
  • Peer Reviewed
• [Journal Article] Fusion protein consisting of the first immunoglobulin-like domain of porcine nectin-1 and Fc portion of human IgG1 provides a marked resistance against pseudorabies virus infection to transgenic mice (2009)
  • Author(s): Tomioka, Y, Morimatsu, M, Amagai, K, Kuramochi, M, Watanabe, Y, Kouda, S, Wada, T, Kuboki, N, Ono, E
  • Journal Title: Microbiol. Immunol 53巻 Pages: 8-15
  • NAID: 10026403895
  • Peer Reviewed
• [Journal Article] A fusion protein consisting of the first immunoglobulin-like domain of porcine nectin-1 and Fc portion of human IgG1 provides a marked resistance against pseudorabies virus infection to the transgenic mice (2008)
  • Author(s): Tomioka, Yukiko, ら
  • Journal Title: Microbiol. Immunol. 53 Pages: 8-15
  • NAID: 10026403895
  • Peer Reviewed
• [Journal Article] Novel variations and loss of heterozygosity of BRCA2 in canine mammary tumors (2008)
  • Author(s): Yoshikawa, Yasunaga, ら
  • Journal Title: Am. J. Vet. Res. 69 Pages: 1323-1328
  • Peer Reviewed
• [Journal Article] Cerebellar pathology in transgenic mice expressing the pseudorabies virus immediate-early protein IEl80
  • Author(s): Tomioka, Yukiko, ら
  • Journal Title: Eur. J. Neurosci. (In press)
  • Peer Reviewed
• [Journal Article] Novel variations and loss of heterozygosity of BRCA2 in canine mammary tumors
  • Author(s): Yoshikawa, Yasunaga, ら
  • Journal Title: Am. J. Vet. Res. (印刷中)(In press)
  • Peer Reviewed
• [Presentation] Mutation analysis of unclassified variants in the C-terminal RAD51-binding region of BRCA2/FANCD1 (2008)
  • Author(s): Yoshikawa, Y., ら
  • Organizer: The Twentieth Annual Fanconi Anemia Research Fund Scientific Symposium
  • Place of Presentation: 米国オレゴン州ユージン市
  • Year and Date: 2008-10-04
• [Presentation] he International Ataxia-Telangiectasia Workshop (2008)
  • Author(s): Yoshikawa, Y., ら
  • Organizer: The International Ataxia-Telangiectasia Workshop
  • Place of Presentation: 大津市
  • Year and Date: 2008-04-22