• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism for CO_2 perception in the arterial chemoreceptors.

Research Project

Project/Area Number 19380166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionIwate University

Principal Investigator

YAMAMOTO Yoshio  Iwate University, 農学部, 教授 (10252123)

Co-Investigator(Kenkyū-buntansha) KIZAKI Keiichiro  岩手大学, 農学部, 准教授 (40337994)
YOSHIZAKI Katsuaki  秋田大学, 医学部, 教授 (90108936)
YAMADA Misuzu  岩手大学, 農学部, 准教授 (10414012)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords生体分子 / マイクロアレイ / 生理学 / シグナル伝達 / 獣医学 / エピジェネティクス / 化学受容 / 二酸化炭素 / 頚動脈小体 / 免疫組織化学
Research Abstract

Arterial chemoreceptors, carotid and aortic bodies, sense arterial CO_2 as well as low oxygen. In the present study, rats exposed to hypercapnia, hypoxia and hypercapnic-hypoxia in order to analyze hypercapnic modulation of molecular expression in the carotid body. As a result, alteration of molecular expression in rats exposed hypercapnia shows lower effect than hypoxia. Furthermore, carbon dioxide delay the expression of some molecules that increased by hypoxia.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (18 results)

  • [Journal Article] Short-term hypoxia increases tyrosine hydroxylase immunoreactivity in rat carotid body2010

    • Author(s)
      Kato K., Yamaguchi-Yamada, M., Yamamoto Y.
    • Journal Title

      Histochemistry and Cell Biology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells2009

    • Author(s)
      Yamamoto, Y., Hatakeyama, T., Taniguchi, K.
    • Journal Title

      Neurosci.Lett. 454

      Pages: 129-133

    • NAID

      120001613599

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells2009

    • Author(s)
      Yamamoto Y., et.al.
    • Journal Title

      Neurosci. Lett (掲載決定)

    • NAID

      120001613599

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of inwardly rectifying K^+ channels in the carotid body of rat2008

    • Author(s)
      Yamamoto, Y., Ishikawa, R., Omoe, K., Taniguchi, K.
    • Journal Title

      Histol.Histopath 23

      Pages: 799-806

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of inwardly rectifying K^+ channels in the carotic body of rat2008

    • Author(s)
      Yamamoto Y., et.al.
    • Journal Title

      Histol. Histopath 23

      Pages: 799-806

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical Distribution of Inwardly Rectifying K+ Channels in the Medulla oblongata of the Rat2008

    • Author(s)
      Yamamoto Y., et. al.
    • Journal Title

      J. Vet. Med. Sci. 70

      Pages: 265-271

    • NAID

      130000447010

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of inwardly rectifying K^+ channels in the carotid body of rat2008

    • Author(s)
      Yamamoto Y., et. al.
    • Journal Title

      Histol. Histopath. 23(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低酸素および高二酸化炭素暴露によるラット頚動脈小体における tyrosine hydroxylase の免疫組織化学的変化2010

    • Author(s)
      若井淳, 山田美鈴, 山本欣郎
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      日本獣医生命科学大学, 東京
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 低酸素暴露によるラット頚動脈小体におけるドーパミン-β-水酸化酵素の発現増強2010

    • Author(s)
      加藤弘毅, 山田美鈴, 山本欣郎
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県民会館, 盛岡
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 低酸素および高二酸化炭素暴露によるラット頚動脈小体におけるtyrosine hydroxylaseの免疫組織化学的変化2010

    • Author(s)
      若井淳, 木崎景一郎, 山田美鈴, 山本欣郎
    • Organizer
      第149回日本獣医学会学術集会
    • Place of Presentation
      日本獣医生命科学大学(武蔵野市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素暴露によるラット頚動脈小体におけるドーパミン-β-水酸化酵素の発現増強.2010

    • Author(s)
      加藤弘毅, 山田美鈴, 山本欣郎
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県民会館(盛岡市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素暴露によるラット頚動脈小体の低酸素適応関連分子の初期発現変化と二酸化炭素の影響2009

    • Author(s)
      若井淳, 木崎景一郎, 山田美鈴, 山本欣郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取市民会館, 鳥取
    • Year and Date
      2009-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] ラット中枢神経系における低酸素刺激によるエリスロポイエチン-mRNA発現亢進2009

    • Author(s)
      山田美鈴, 若井淳, 山本欣郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取市民会館, 鳥取
    • Year and Date
      2009-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 低酸素暴露によるラット頚動脈小体の低酸素適応関連分子の初期発現変化と二酸化炭素の影響.2009

    • Author(s)
      若井淳, 木崎景一郎, 山田美鈴, 出本欣郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取市民会館(鳥取市)
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット中枢神経系における低酸素刺激によるエリスロポイエチン-mRNA発現亢進.2009

    • Author(s)
      山田美鈴, 若井淳, 山本欣郎
    • Organizer
      第148回日本獣医学会学術集会
    • Place of Presentation
      鳥取市民会館(鳥取市)
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Carbon dioxide suppresses hypoxia-enhanced expression of TH and VEGF mRNA in the rat carotid body2009

    • Author(s)
      Wakai, J., Yamaguchi-Yamada, M., Yamamoto, Y.
    • Organizer
      6th Congress of the International Society for Autonomic Neuroscience
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2009-09-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Carbon dioxide suppresses hypoxia-enhanced expression of TH and VEGF mRNA in the rat carotid body.2009

    • Author(s)
      Wakai, J., Yamaguchi-Yamada, M., Yamamoto, Y.
    • Organizer
      6th Congress of the International Society for Autonomic Neuroscience
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Altered expression of erythropoietin mRNA in the central nervous system of hypoxic rats2009

    • Author(s)
      Yamada, M., Yamamoto, Y., Wakai, J., Kato, K.
    • Organizer
      36th International Congress of Physiological Sciences, August
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-08-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Altered expression of erythropoietin mRNA in the central nervous system of hypoxic rats.2009

    • Author(s)
      Yamada, M., Yamamoto, Y., Wakai, J., Kato, K.
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素および高二酸化炭素暴露によるラット頚動脈小体の vascular endothelial growth factor および tyrosine hydroxylase mRNAの発現変化2009

    • Author(s)
      若井淳, 加藤弘毅, 木崎景一郎, 山田美鈴, 山本欣郎
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター, 宇都宮
    • Year and Date
      2009-04-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 低酸素および高二酸化炭素暴露によるラット頚動脈小体のvascular endothelial growth factorおよびtyrosine hydroxylase mRNAの発現変化.2009

    • Author(s)
      若井淳, 加藤弘毅, 木崎景一郎, 山田美鈴, 山本欣郎
    • Organizer
      第147回日本獣医学会学術集会
    • Place of Presentation
      栃木県総合文化センター(宇都宮市)
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素刺激によるラット中枢神経系でのエリスロポイエチン-mRNA発現変化2008

    • Author(s)
      山田美鈴, 若井淳, 加藤弘毅, 山本欣郎
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      ワールドコンベンションセンター・サミット, 宮崎
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 低酸素刺激によるラット中枢神経系でのエリスロポイエチン-mRNA発現変化2008

    • Author(s)
      山田美鈴, ほか
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      宮崎県宮崎市, ワールドコンベンションセンターサミット
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高CO2刺激によるラット頚動脈小体における炭酸脱水素酵素mRNAの発現変化2008

    • Author(s)
      若井淳, 山田美鈴, 西田利穂, 山本欣郎
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      麻布大学, 相模原
    • Year and Date
      2008-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 高CO_2刺激によるラット頚動脈小体における炭酸脱水素酵素mRNAの発現変化2008

    • Author(s)
      若井淳、山田美鈴、西田利穂、山本欣郎
    • Organizer
      第145回日本獣医学会学術集会
    • Place of Presentation
      神奈川県相模原市 麻布大学
    • Year and Date
      2008-03-30
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi