Mechanism for CO_2 perception in the arterial chemoreceptors.
| Project/Area Number |
19380166
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Iwate University |
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Principal Investigator |
YAMAMOTO Yoshio Iwate University, 農学部, 教授 (10252123)
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| Co-Investigator(Kenkyū-buntansha) |
KIZAKI Keiichiro 岩手大学, 農学部, 准教授 (40337994)
YOSHIZAKI Katsuaki 秋田大学, 医学部, 教授 (90108936)
YAMADA Misuzu 岩手大学, 農学部, 准教授 (10414012)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 生体分子 / マイクロアレイ / 生理学 / シグナル伝達 / 獣医学 / エピジェネティクス / 化学受容 / 二酸化炭素 / 頚動脈小体 / 免疫組織化学 |
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| Research Abstract |
Arterial chemoreceptors, carotid and aortic bodies, sense arterial CO_2 as well as low oxygen. In the present study, rats exposed to hypercapnia, hypoxia and hypercapnic-hypoxia in order to analyze hypercapnic modulation of molecular expression in the carotid body. As a result, alteration of molecular expression in rats exposed hypercapnia shows lower effect than hypoxia. Furthermore, carbon dioxide delay the expression of some molecules that increased by hypoxia.
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Report
(4 results)
Research Products
(25 results)
