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Regulation of mesenchymal stem cell differentiation by growth hormone

Research Project

Project/Area Number 19380167
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

YAMANOUCHI Keitaro  The University of Tokyo, 大学院・農学生命科学研究科, 准教授 (70272440)

Co-Investigator(Kenkyū-buntansha) 田中 智  東京大学, 大学院・農学生命科学研究科, 准教授 (90242164)
Co-Investigator(Renkei-kenkyūsha) TANAKA Satoshi  東京大学, 大学院・農学生命科学研究科, 准教授 (90242164)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords成長ホルモン / 間葉系幹細胞 / 脂肪細胞 / 筋衛星細胞 / 骨芽細胞 / 骨髄 / 分化 / 骨
Research Abstract

Age-related decline in growth hormone (GH) secretion results in the loss of skeletal muscle (sarcopenia) and bone mass (osteopenia). The specific aim of the present research was to test, using human GH-transgenic rats whose GH secretion is severely suppressed, whether sarcopenia and osteopenia caused by lowered secretion/action of GH is related to the decrease in the differentiation potential of mesenchymal stem cells (MSC) in skeletal muscle and bone. The results obtained clearly indicated that GH plays a role in the maintenance of MSC function both in skeletal muscle and bone.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (12 results)

  • [Journal Article] Skeletal muscle growth defect in human growth hormone transgenic rat is accompanied by phenotypic changes in progenitor cells.2010

    • Author(s)
      Shibata S, Ueno C, Ito T, Yamanouchi K, Matsuwaki T, Nishihara M
    • Journal Title

      AGE 32

      Pages: 239-253

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for re-establishing satellite cell quiescence in vivo.2010

    • Author(s)
      Yamada M, Tatsumi R, Yamanouchi K, Hosoyama Y, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE
    • Journal Title

      Am J Physiol Cell Physiol 298

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skeletal Muscle Growth Defect in Human Growth Hormone Transgenic Rat is Accompanied by Phenotypic Changes in Progenitor Cells.2010

    • Author(s)
      Shibata S, et al.
    • Journal Title

      AGE 32(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degenerative muscle fiber accelerates adipogenesis of intramuscular cells via RhoA signaling pathway.2009

    • Author(s)
      Hosoyama T, Ishiguro N, Yamanouchi K, Nishihara M
    • Journal Title

      Differentiation 77

      Pages: 350-359

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Satellite cell differentiation in goat skeletal muscle single fiber culture.2009

    • Author(s)
      Yamanouchi K, Hosoyama T, Murakami Y, Nakano SI, Nishihara M
    • Journal Title

      J Reprod Dev 55

      Pages: 252-255

    • NAID

      10024942233

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Degenerative muscle fiber accelerates adipogenesis of intramuscularcells via RhoA signaling pathway2009

    • Author(s)
      Hosoyama T
    • Journal Title

      Differentiation 77

      Pages: 350-359

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Satellite cell differentiation in goat skeletal muscle single fiber culture2009

    • Author(s)
      Yamanouchi K
    • Journal Title

      J Reprod Dev 55(In press)

    • NAID

      10024942233

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo gene transfer of PPARγ is insufficient to induce adipogenesis in skeletal muscle.2008

    • Author(s)
      Ban A, Yamanouchi K, Matsuwaki T, Nishihara M
    • Journal Title

      J Vet Med Sci 70

      Pages: 761-767

    • NAID

      110006878922

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo gene transfer of PPARγ is insufficient to induce adipogenesis in skeletal muscle2008

    • Author(s)
      Ban A
    • Journal Title

      J Vet Med Sci 70

      Pages: 761-767

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myogenic and adipogenic properties of goat skeletal muscle stem cells.2007

    • Author(s)
      Yamanouchi K, Hosoyama T, Murakami Y, Nishihara M
    • Journal Title

      J Reprod Dev 53

      Pages: 51-58

    • NAID

      10027327027

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Both PPARγ and C/EBPα are sufficient to induce transdifferentiation of goat fetal myoblasts to adipocytes.2007

    • Author(s)
      Yamanouchi K, Ban A, Shibata S, Hosoyama T, Murakami Y, Nishihara M
    • Journal Title

      J Reprod Dev 53

      Pages: 563-572

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 18α-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.2007

    • Author(s)
      Yamanouchi K, Yada E, Ishiguro N, Nishihara M
    • Journal Title

      Cell Physiol Biochem 20

      Pages: 781-790

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myogenic and adipogenic properties of goat skeletal muscle stem cells2007

    • Author(s)
      Yamanouchi K
    • Journal Title

      J Reprod Dev 53

      Pages: 51-58

    • NAID

      10027327027

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Both PPARγ and C/EBPα are sufficient to induce transdifferentiation of goat fetal myoblasts to adipocytes2007

    • Author(s)
      Yamanouchi K
    • Journal Title

      J Reprod Dev 53

      Pages: 563-572

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 18α-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis2007

    • Author(s)
      Yamanouchi K
    • Journal Title

      Cell Physiol Biochem 20

      Pages: 781-790

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨量低下を示す成長ホルモン(GH)分泌低下モデルラットに対するGH投与の効果2010

    • Author(s)
      藤井崇博, 中野真一, 松脇貴志, 山内啓太郎, 西原真杉
    • Organizer
      第149回日本獣医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 成長ホルモン分泌低下モデルラットにおける骨量低下メカニズムの解析2009

    • Author(s)
      藤井崇博, 村上要介, 松脇貴志, 山内啓太郎, 西原真杉
    • Organizer
      第148回日本獣医学会
    • Place of Presentation
      鳥取
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 骨格筋前駆細胞/幹細胞の脂肪分化2009

    • Author(s)
      山内啓太郎
    • Organizer
      第17回日本運動生理学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-26
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 成長ホルモン分泌低下症モデルラットを用いた成長ホルモンによる骨髄間質細胞の分化制御機構の解明2009

    • Author(s)
      藤井崇博, 山内啓太郎, 松脇貴志, 西原真杉
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 骨格筋由来高脂肪分化細胞クローンの樹立と筋・脂肪分化能の解析2007

    • Author(s)
      村上要介、矢田英理香、細山徹、山内啓太郎、西原真杉
    • Organizer
      第108回日本畜産学会
    • Place of Presentation
      岡山
    • Year and Date
      2007-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Adipogenic differentiation of skeletal muscle progenitor/stem cells.2007

    • Author(s)
      Yamanouchi K
    • Organizer
      University of Wisconsin-Madison
    • Place of Presentation
      Madison WI, USA
    • Year and Date
      2007-07-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Skeletal muscle fibers affect lineage specification of satellite cells through RhoA signaling pathway.2007

    • Author(s)
      Hosoyama T, Ishiguro N, Murakami Y, Yamanouchi K, Nishihara M
    • Organizer
      FASEB summer research conference "Skeletal Muscle and Stem Cells"
    • Place of Presentation
      Indian Wells CA, USA
    • Year and Date
      2007-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Cloning and characterization of highly adipogenic cells derived from rat skeletal muscle.2007

    • Author(s)
      Murakami Y, Yada E, Hosoyama T, Yamanouchi K, Nishihara M
    • Organizer
      FASEB summer research conference "Skeletal Muscle and Stem Cells"
    • Place of Presentation
      Indian Wells CA, USA
    • Year and Date
      2007-07-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Skeletal muscle fibers affect lineage specification of satellite cells through RhoA signaling pathway2007

    • Author(s)
      Hosoyama T
    • Organizer
      FASEB summer research conference "Skeletal Muscle and Stem Cells"
    • Place of Presentation
      Indian Wells CA, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cloning and characterization of highly adipogenic cells derived from rat skeletal muscle2007

    • Author(s)
      Murakami Y
    • Organizer
      FASEB summer research conference "Skeletal Muscle and Stem Cells"
    • Place of Presentation
      Indian Wells CA, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Adipogenic differentiation of skeletal muscle progenitor/stem cells2007

    • Author(s)
      Yamanouchi K
    • Organizer
      University of Wisconsin-Madison (invited seminar)
    • Place of Presentation
      Madison WI, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨格筋由来高脂肪分化細胞クローンの樹立と筋・脂肪分化能の解析2007

    • Author(s)
      村上要介
    • Organizer
      第108回 日本畜産学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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