Molecular basis of pathogenicity of classical swine fever virus -Mechanism of down regulation of innate immunity in the cells and pigs infected with classical swine fever virus-
| Project/Area Number |
19380170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAKODA Yoshihiro Hokkaido University, 大学院・獣医学研究科, 准教授 (40333637)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Hiroshi 日本獣医生命科学大学, 獣医学部, 講師 (10440067)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 豚コレラウイルス / 病原性 / 自然免疫 / ペスチウイルス / 宿主 |
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| Research Abstract |
To assess the molecular basis of classical swine fever virus, the mechanism of down regulation of innate immunity mediated by type-1 interferon was analyzed using mutant viruses constructed by reverse genetics. Critical amino acids of N^<pro> protein for the control of type-1 interferon production were determined and it was concluded that the down regulation of innate immunity mediated by type-1 interferon was one of the important factors for the pathogenicity of classical swine fever virus in pigs.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro2009
Author(s)
Ruggli, N., Summerfield, A., Fiebach, A.R., Guzylack-Piriou, L., Bauhofer, O., Lamm, C.G., Waltersperger, S., Matsuno, K., Liu, L., Gerber, M., Choi, K.H., Hofmann, M.A., Sakoda, Y., Tratschin, J. D
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Journal Title
J. Virol 83
Pages: 817-829
Related Report
Peer Reviewed
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[Journal Article] Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus2008
Author(s)
Kameyama, K., Sakoda, Y., Matsuno, K., Ito, A., Tajima, M., Nakamura, S., Kida, H
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Journal Title
Microbiol. Immunol 52
Pages: 277-282
NAID
Related Report
Peer Reviewed
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[Journal Article] Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation2007
Author(s)
Bauhofer, O., Summerfield, A., Sakoda, Y., Tratschin, J.D., Hofmann, M.A., Ruggli, N
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Journal Title
J. Virol 81
Pages: 3087-3096
Related Report
Peer Reviewed
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