Genomics based analysis of pathogenicity evolution of Staphylococcal aureus
| Project/Area Number |
19380173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Iwate University |
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Principal Investigator |
SHINAGAWA Kunihiro Iwate University, 農学部, 教授 (60133906)
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| Co-Investigator(Kenkyū-buntansha) |
OMOE KATSUHIKO 岩手大学, 農学部, 准教授 (60224309)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 獣医公衆衛生 / 食中毒 / 食品衛生学 / S. aureus / Stanhvlococcal enterotoxin / recombinant DNA / genome biology / diagnosis / pathogenicity islands / Staphylococcal enterotoxin |
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| Research Abstract |
Staphylococciのゲノム配列情報を解析し、ヒト食中毒原因毒素であるエンテロトキシン(SEs)遺伝子群を保有する可動性遺伝因子を検出・分類するLA-PCR/RFLP法を確立した。霊長類モデルを用いて新規なSE様毒素群SElsの嘔吐活性を解析し、何れも霊長類に対して嘔吐活性を有することを明らかにした。さらに、2種類の新型SEsについてその生物活性を詳細に解析し、SESおよびSETと命名した。
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Identification and characterization of two novel staphylococcal enterotoxins, types S and T. Infect2008
Author(s)
Ono, H. K., Omoe, K., Imanishi, K., Iwakabe, Y., Hu, D.-L., Kato, H., Saito, N., Nakane, A., Uchiyama, T., and Shinagawa, K.
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Journal Title
Immun 76
Pages: 4999-5005
Related Report
Peer Reviewed
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[Presentation] New SEB-encoding Staphylococcus aureus pathogenicity island2008
Author(s)
Omoe, K., Misu, H., Saito, M., Nukui, T., Hu, D.-L., Nakane, A., and Shinagawa, K.
Organizer
13th International Symposium on Staphylococci and Staphylococcal Infections
Place of Presentation
Cairns
Related Report
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