| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Research Abstract |
To know the neurotoxic mechanism induced by domoic acid (DA ; amnesic shellfish poison), we administered DA to male mice by intraperitoneal injection. We found subacute impairment of contextual memory and delayed cued memory loss by using fear conditioning test. Although we never detect histopathological damages, i.e. neural death, neurofibrillary tangles, neural loss, we found the effects on synapse by immunohistochemical study in hippocampus of mice. Furthermore, we found the influences on axonal guidance signal pathway and synaptic function in hippocampus of mice by molecular analysis using percellome methods.
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