| Project/Area Number |
19380176
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
SHIMODA Minoru Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (50154323)
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| Co-Investigator(Kenkyū-buntansha) |
IWASAKI Toshiro 東京農工大学, 大学院・共生科学技術研究院, 教授 (50262754)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 治療 / 薬物動態 / 薬物間相互作用 / 消炎ステロイド / イヌ / 酵素阻害 / CYP3A / キニジン / プレドニゾロン / ヒドロコルチゾン / 血漿タンパク結合 / CYP活性 / ラット / α_1酸性糖タンパク / 肝マイクロソーム |
|---|
| Research Abstract |
In this study we examined possible pharmacokinetic drug-drug interaction by corticosteroid treatment in dogs. As a result, predonisolone, triamucinolone and hydrocortisone affected oxidative metabolism and the levels of drug binding protein in plasma. These corticosteroids may, therefore, result in adverse effects of some drugs, which are co-medicated, through altering biotransformation rate and distribution of the co-medicated drugs.
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