| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Research Abstract |
To develop practical synthetic method of polycyclic heterocycles such as tetrahydroisoquinolines and oxindoles, which are very important as biologically active drug-templates, several metal-catalyzed reactions of 2-alkynylbenzylamines and carbamoyl chlorides bearing an alkene or diene moiety were investigated with In(OTf)_3, AuCl・PPh3/AgNTf_2, and Pd(dba)_2. Consequently, we have succeeded in the formal synthesis of epieburnamonine and isoelacomine as well as the construction of the core structures of ecteinascidin 743 and vincorine.
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