| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Research Abstract |
(1) We have found that the extent of chirality transfer in [2,3]-Wittig rearrangement employing a chiral β-substituted allyl benzyl carbanion can be used as a tool for evalulation of the effect of substituents on the configurational stability of a chiral carbanion through a double bond.
(2) Treatment of (R, Z)-3-(tert-butyldimethylsilyl)-1-cyano-3-hydroxyprop-1-enyl carbamate with a catalytic amount of a base afforded (S, E)-3-(tert-butyldimethylsilyloxy)-1-cyanoallyl diisopropyl- carbamate, showing that S_E2'-type reaction of allylsilicates proceeds in an anti-mode fashion. The overall process is equivalent to trapping of an enantioenriched C-chiral carbanion at α-position of nitrile group in up to 77% ee.
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