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Development and application of high-throughput screening method for drug-seeds discovery in Chinese traditional medicines

Research Project

Project/Area Number 19390013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionMukogawa Women's University

Principal Investigator

HAGINAKA Jun  Mukogawa Women's University, 薬学部, 教授 (20164759)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords分子インプリントポリマー / 中国伝承薬 / 創薬シード / ハイスループットスクリーニング / 分子インプリント / 分子インプ
Research Abstract

An antibody can specifically recognize an antigen. A molecularly imprinted polymer, which is a synthetic antibody (artificial antibody), can specifically recognize a target compound, too. In this study, artificial antibodies for matrine and oxymatrine have been prepared to extract matrine, oxymatrine and their structurally related compound(s) in Chinese traditional medicines (TCMs). Furthermore, an artificial antibody for curcumine has been prepared to extract curcumine and its structurally related compound(s) in TCMs. The obtained results indicate that these antibodies work very well for specific extraction of the target compounds in TCMs.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (26 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization2010

    • Author(s)
      Yueqi Liu, Kaori Hoshina, Jun Haginaka
    • Journal Title

      Talanta 80

      Pages: 1713-1718

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization2010

    • Author(s)
      Yueqi Liu
    • Journal Title

      Talanta 80

      Pages: 1713-1718

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecularly imprinted polymers as affinity-based separation media for sample preparation2009

    • Author(s)
      Jun Haginaka
    • Journal Title

      J. Sep. Sci 32

      Pages: 1548-1565

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecularly imprinted polymers as affinity-based separation media for sample preparation2009

    • Author(s)
      Jun Haginaka
    • Journal Title

      J.Sep. Sci. 32

      Pages: 1548-1565

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine2008

    • Author(s)
      Jun Haginaka, Aya Futagami
    • Journal Title

      J. Chromatogr. A 1185

      Pages: 258-262

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monodispersed, molecularly imprinted polymers as affinity-based chromatography media2008

    • Author(s)
      Jun Haginaka
    • Journal Title

      J. Chromatogr. B 866

      Pages: 3-13

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uniformly-sized, molecularly imprinted polymers for (-)-epigallocatechin gallate,-epicatechin gallate and-gallocatechin gallate by multi-step swelling and polymerization method2007

    • Author(s)
      Jun Haginaka, Hiromi Tabo, Masaki Ichitani, Takanobu Takihara, Akio Sugimoto, Haruyo Sambe
    • Journal Title

      J. Chromatogr. A 1156

      Pages: 45-50

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecularly imprinted polymers for triazine herbicides prepared by multi-step swelling and polymerization method. Their application to the determination of methylthiotriazine herbicides in river water2007

    • Author(s)
      Haruyo Sambe, Kaori Hoshina, Jun Haginaka
    • Journal Title

      J. Chromatogr. A 1152

      Pages: 130-137

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecularly imprinted polymers for triazine herbicides prepared by multi-step swelline and polymerization method.Their application to the determination of methylthiotriazine herbicides in river water2007

    • Author(s)
      Haruyo Sambe
    • Journal Title

      J.Chromatogr.A 1152

      Pages: 130-137

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unifbmly-sized,molecularly imprinted polymers for(-)-epigallocatechin gallate,-epicatechin gallate and-gallocatechin gallate by multi-step swelling and polymerization method2007

    • Author(s)
      Jun Hagianka
    • Journal Title

      J.Chromatogr.A 1156

      Pages: 45-50

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 粒子経の均一な分子インプリントポリマーを活用した分析2007

    • Author(s)
      萩中 淳
    • Journal Title

      臨床化学 36

      Pages: 101-107

    • Related Report
      2007 Annual Research Report
  • [Presentation] (S)-ナプロキセンに対する磁性分子インプリントポリマーの調製と応用2010

    • Author(s)
      船谷典子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 沈殿重合法によるクルクミンおよびナプロキセンに対する分子インプリントポリマーの調製:形状, 保持能および分子認識能に対する機能性モノマーの影響2010

    • Author(s)
      北畠智子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 沈殿重合法によるクルクミンおよびナプロキセンに対する分子インプリントポリマーの調製:形状,保持能および分子認識能に対する機能性モノマーの影響2010

    • Author(s)
      北畠智子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] アフィニティーを利用した液体クロマトグラフィー用充填剤の開発と応用2009

    • Author(s)
      Jun Haginaka
    • Organizer
      第20回クロマトグラフィー科学会議
    • Place of Presentation
      東京
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecularly Imprinted Microspheres for Separation of Drug Enantiomers2009

    • Author(s)
      Jun Haginaka
    • Organizer
      The 24th International Symposium on Microscale Bioseparations
    • Place of Presentation
      大連、中国
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecularly Imprinted Polymers for Pharmaceutical and Bioanalytical Applications2009

    • Author(s)
      Jun Haginaka
    • Organizer
      21st International Symposium on Pharmaceutical and Biomedical Analysis
    • Place of Presentation
      オーランド、米国
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 医薬品分析のための液体クロマトグラフィー用高機能充填剤の開発と応用2009

    • Author(s)
      萩中淳
    • Organizer
      日本分析化学会第58年会
    • Place of Presentation
      札幌
    • Year and Date
      2009-09-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] クルクミンに対する分子インプリントポリマーの調製とウコン中のクルクミン関連物質の分析への適用2009

    • Author(s)
      北畠智子
    • Organizer
      第70回分析化学討論会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 分子インプリントポリマーによる苦参中のマトリンおよびオキシマトリンの選択的分析2009

    • Author(s)
      船谷典子
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecularly imprinted polymers as affinity extraction media2009

    • Author(s)
      Jun Haginaka
    • Organizer
      20th International Symposium on Pharmaceutical and Biomedical Analysis
    • Place of Presentation
      アグラ、インド
    • Year and Date
      2009-03-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecularly imprinted polymers as affinity extraction media2009

    • Author(s)
      Jun Haginaka
    • Organizer
      20^<th> International Symposium on Pharmaceutical and Biomedical Analysis
    • Place of Presentation
      アグラ、インド
    • Year and Date
      2009-03-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecularly imprinted polymers as affinity media2008

    • Author(s)
      Jun Haginaka
    • Organizer
      33rd International Symposium on High Performance Liquid Phase Separations
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] マトリンおよびオキシマトリンに対する分子インプリントポリマーの調製並びに苦参中の主成分の選択的分取への適用2008

    • Author(s)
      船谷典子
    • Organizer
      日本分析化学会第57年会
    • Place of Presentation
      博多
    • Year and Date
      2008-09-10
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Monodispersed, molecularly imprinted polymers for pharmaceutical, biomedical and environmental analysis2008

    • Author(s)
      Jun Haginaka
    • Organizer
      5th International Workshop on Molecularly Imprinted Polymers
    • Place of Presentation
      神戸
    • Year and Date
      2008-09-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Monodispersed, molecularly imprinted polymers for pharmaceutical, biomedical and environmental analysis2008

    • Author(s)
      Jun Haginaka
    • Organizer
      5^<th> International Workshop on Molecularly Imprinted Polymers
    • Place of Presentation
      神戸
    • Year and Date
      2008-09-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] マトリンに対する分子インプリントポリマーの調製および苦参中のマトリンの選択的分取への適用2008

    • Author(s)
      船谷典子
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 2-アリルプロピオン酸誘導体に対する分子インプリントポリマー:保持能および分子認識能に対する架橋剤および希釈剤の影響2008

    • Author(s)
      田保 裕美
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 浸透制限型-分子インプリントポリマーを用いる環境水中の抗てんかん薬の高選択的分析法の開発2008

    • Author(s)
      保科 香織
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗てんかん薬のための浸透制限型-分子インプリントポリマ-の調製とその環境分析への適用2008

    • Author(s)
      保科 香織
    • Organizer
      フィジカル・ファーマフォーラム2008
    • Place of Presentation
      東京
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Preparation of monodispersed, molecularly imprinted polymers for cinchonidine by precipitation polymerization2007

    • Author(s)
      Yueqi Liu
    • Organizer
      第18回クロマトグラフィー科学会
    • Place of Presentation
      函館
    • Year and Date
      2007-11-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Preparation of Monodispersed,Molecularly Imprinted Polymers for Cinchonidine by Precipitation Polymerization2007

    • Author(s)
      Yueqi Liu
    • Organizer
      第18回クロマトグラフィー科学会
    • Place of Presentation
      函館
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 2-アリルプロピオン酸誘導体に対する分子インプリントポリマー:保持能および分子認識能に対する架橋剤の影響2007

    • Author(s)
      田保 裕美
    • Organizer
      日本分析化学会第56年会
    • Place of Presentation
      徳島
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルファ剤の分析のための浸透制限型-分子インプリントポリマーの調製と評価2007

    • Author(s)
      保科 香織
    • Organizer
      第20回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      八王子
    • Year and Date
      2007-07-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] The use of uniformly-sized molecularly imprinted polymers for solid-phase extraction2007

    • Author(s)
      Jun Haginaka
    • Organizer
      31st International Symposium on High Performance Liquid Phase Separations
    • Place of Presentation
      ゲント、ベルギー
    • Year and Date
      2007-06-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Uniformly-sized molecularly imprinted polymers as affinity-based chromatographic media2007

    • Author(s)
      Jun Haginaka
    • Organizer
      30th International Symposium on Capillary Chromatography
    • Place of Presentation
      大連、中国
    • Year and Date
      2007-06-06
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Preparation of molecularly imprinted polymers for(R)-nilvadipine and its application to efficient enantioseparation of nilvadipine2007

    • Author(s)
      Aya Futagami
    • Organizer
      PSWC 2007
    • Place of Presentation
      アムステルダム、オランダ
    • Year and Date
      2007-04-22
    • Related Report
      2007 Annual Research Report
  • [Book] 新しい地平をひらく分析手法の最前線2009

    • Author(s)
      萩中淳
    • Publisher
      化学同人
    • Related Report
      2009 Final Research Report
  • [Book] 分子インプリントポジマーを用いた分子認識2009

    • Author(s)
      萩中淳
    • Total Pages
      5
    • Publisher
      化学同人
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://ph.mukogawa-u.ac.jp/~bunseki/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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