Novel roles of lysolipid receptors as mediators of lipoprotein actions and proton sensors

• Project/Area Number: 19390015
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Gunma University
• Principal Investigator: OKAJIMA Fumikazu Gunma University, 生体調節研究所, 教授 (30142748)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2007: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
• Keywords: 脂質シグナル分子 / リポ蛋白質 / pH / G蛋白共役受容体 / スフィンゴシン1-リン酸 / リボ蛋白質 / 細胞外pH / 血管平滑筋細胞 / 骨芽細胞 / マクロファージ / TDAG8 / 高密度リポ蛋白質 / S1P1受容体 / 低密度リポ蛋白質 / リゾホスファチジン酸 / プロトン感知性受容体 / GPR4

Research Abstract

リゾ脂質性G蛋白質共役受容体をリポ蛋白質作用の仲介機能ならびに細胞外pHセンサー機能という新しい視点から解析した。その結果、血管内皮細胞や平滑筋細胞における様々なリポ蛋白質作用がスフィンゴシン1-リン酸受容体やリゾホスファチジン酸受容体を介していること、また、細胞外pH低下による骨芽細胞のCOX-2発現におけるOGR1受容体の役割などを明らかにした。

Research Products

• [Journal Article] Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Pro-Inflammatory Cytokine Production In Peritoneal Macrophages (2009)
  • Author(s): Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato K, Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, Okajima F
  • Journal Title: J Immunol 182 Pages: 3243-3251
  • Peer Reviewed
• [Journal Article] LPA_1 receptors mediate stimulation, whereas LPA_2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites (2009)
  • Author(s): Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, Okajima F
  • Journal Title: Carcinogenesis 30 Pages: 457-465
  • Peer Reviewed
• [Journal Article] Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells (2009)
  • Author(s): Komachi M, Damirin A, Malchinkhuu E, Mogi C, Tobo M, Ohta H, Sato K, Tomura H, Okajima F.
  • Journal Title: Vasc Pharmacol 50 Pages: 178-184
  • Peer Reviewed
• [Journal Article] Anti-atherogenic actions ohigh-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B type I (2009)
  • Author(s): Okajima F, Sato K, Kimura T
  • Journal Title: Endocrine J (in press)
  • Peer Reviewed
• [Journal Article] Anti-atherogenic actions of high-density lipoprotein through sphingosine 1-phosphate receptors and scavenger receptor class B tvne I. (2009)
  • Author(s): Okajima F, Sato K, and Kimura T:
  • Journal Title: Endocrine J (印刷中)
  • Peer Reviewed
• [Journal Article] Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cells. (2009)
  • Author(s): Komachi M, Damirin A, Malchinkhuu E, Mogi C, Tobo M, Ohta H, Sato K, Tomura H, and Okajima F
  • Journal Title: Vasc Pharmacol 50 Pages: 178-184
  • Peer Reviewed
• [Journal Article] LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malinnant ascites. (2009)
  • Author(s): Komachi M, Tomura H, Malchinkhuu E, Tobo M, Mogi C, Yamada T, Kimura T, Kuwabara A, Ohta H, Im DS, Kurose H, Takeyoshi I, Sato K, and Okajima F
  • Journal Title: Carcinogenesis 30 Pages: 457-465
  • Peer Reviewed
• [Journal Article] Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Pro-Inflammatory Cytokine Production In Peritoneal Macrophages. (2009)
  • Author(s): Mogi C, Tobo M, Tomura H, Murata N, He XD, Sato &Kimura T, Ishizuka T, Sasaki T, Sato T, Kihara Y, Ishii S, Harada A, and Okaiima F
  • Journal Title: J Immunol 182 Pages: 3243-3251
  • Peer Reviewed
• [Journal Article] S1P2 receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN (2008)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Kurose H and Okajima F.
  • Journal Title: Biochem Biophys Res Commun 366 Pages: 963-968
  • Peer Reviewed
• [Journal Article] Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma (2008)
  • Author(s): Aoki H, Hisada T, Ishizuka T, Utsugi M, Kawata T, Shimizu Y, Okajima F,Dobashi K, Mori M
  • Journal Title: Biochem Biophys Res Commun 367 Pages: 509-515
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line (2008)
  • Author(s): Tomura H, Wang JQ, Liu JP, Komachi M, Damirin A, Mogi C, Tobo M, Noch I H Tamoto K, Im DS, Sato K, Okajima F.
  • Journal Title: J Bone Miner Res 23 Pages: 1129-1139
  • Peer Reviewed
• [Journal Article] Induction of Scavenger Receptor Class B Type I is Critical for Simvastatin Enhancement of High-Density Lipoprotein-induced Anti-Inflammatory Actions in Endothelial Cells (2008)
  • Author(s): Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, Okajima F
  • Journal Title: J Immunol 181 Pages: 7332-7340
  • Peer Reviewed
• [Journal Article] (*Corresponding author) Stimulatory Role of Lysophosphatidic Acid in COX-2 Induction by Synovial Fluid of Patients with Rheumatoid Arthritis in Fibroblast-like Synovial Cells (2008)
  • Author(s): Nochi H, Tomura H, Tobo M,Tanaka N, Sato K, Shinozaki T, Kobayashi T, Takagish I K, Ohta H, Okajima F*, Tamoto K
  • Journal Title: J Immunol 181 Pages: 5111-5119
  • Peer Reviewed
• [Journal Article] S1P2 receptors mediate inhibition of glioma cell migration through Rhosignaling nathways indenendent of PTEN. (2008)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H and Okaiima F
  • Journal Title: Biochem Biophys Res Commun. 366 Pages: 963-968
  • Peer Reviewed
• [Journal Article] Resolvin El dampens airway inflammation and hyperresponsiveness in a murine model of asthma. (2008)
  • Author(s): Aoki H, Hisada T, Ishizuka T, Utsugi M, Kawata T, Shimizu Y, Okajima F, Dobashi K, Mori M.
  • Journal Title: Biochem Biophys Res Commun. 367 Pages: 509-515
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line. (2008)
  • Author(s): Tomura H, Wang JQ, Liu JP, Komachi M, Damirin A, Mogi C, Tobo M, Mochi H, Tamoto K. Im DS. Sato K. and Okaiima F.
  • Journal Title: J Bone Miner Res. 23 Pages: 1129-1139
  • Peer Reviewed
• [Journal Article] Stimulatory Role of Lysophosphatidic Acid in COX-2 Induction by Synovial Fluid of Patients with Rheumatoid Arthritis in Fibroblast-like Synovial Cells. (2008)
  • Author(s): Nochi H, Tomura H, Tobo M, Tanaka N, Sato K, Shinozaki T, Kobayashi T, Takagishi K, Ohta H, Okajima F, and Tamoto K
  • Journal Title: J Immunol 181 Pages: 5111-5119
  • Peer Reviewed
• [Journal Article] Induction of Scavenger Receptor Class B Type I is Critical for Simvastatin Enhancement of High-Density Lipoprotein-induced Anti-Inflammatory Actions in endothelial Cells. (2008)
  • Author(s): Kimura T, Mogi C, Tomura H, Kuwabara A, Im DS, Sato K, Kurose H, Murakami M, and Okajima F
  • Journal Title: J Immunol 181 Pages: 7332-7340
  • Peer Reviewed
• [Journal Article] SlP2 receptors mediate inhibition of glioma cell migration through Rho signalilg pathways independent of PTEN. (2008)
  • Author(s): Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H and Okajima F.
  • Journal Title: Biochem Biophys Res Commun・ 366 Pages: 963-968
  • Peer Reviewed
• [Journal Article] Resolvin El dampens airway inflammation and hyperresponsiveness in a mu rine model of asthma. (2008)
  • Author(s): Aoki H, Hisada T, IshiZuka T, Utsugi M, Kawata T, Shimizu Y, Okajima F, Dobashi K, Mori M.
  • Journal Title: Biochem Biophys Res Commun. 367 Pages: 509-515
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression and prostaglandin E2 production in responseto acidic pH through OGRI in a human osteoblastic cell line. (2008)
  • Author(s): Tomura H, Wang JQ, Liu JP, Komachi M, Damirin A, Mogi C, Tobo M, Mochi H, Tamoto K, Im DS, Sato K, and Okajima F.
  • Journal Title: J Bone Miner Res. 23 Pages: 1129-1139
  • Peer Reviewed
• [Journal Article] Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells (2007)
  • Author(s): Damirin A, Tomura H, Komachi M, Liu JP, Mogi C, Tobo M, Wang JQ, Kimura T, Kuwabara A, Yamazaki Y, Ohta H, Im DS, Sato K, Okajima F.
  • Journal Title: Am J Physiol Heart Circ Physiol 292
  • Peer Reviewed
• [Journal Article] Previously postulated "ligand-independent" signaling of GPR4 is mediatedproton-sensing mechanisms (2007)
  • Author(s): Tobo M, Tomura H, Mogi C, Wang JQ, Liu JP, Komachi M, Damirin A, Kimura K, Murata N, Kurose H, Sato K, Okajima F
  • Journal Title: Cell Signal 19 Pages: 1745-1753
  • Peer Reviewed
• [Journal Article] Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes (2007)
  • Author(s): Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F
  • Journal Title: J Neurochem 103 Pages: 2610-2619
  • Peer Reviewed
• [Journal Article] HDL-like lipoproteins in cerebrospinal fluid affect neural cell activity through lipoprotein-associated sphingosine 1-phosphate (2007)
  • Author(s): Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F
  • Journal Title: Biochem Biophys Res Commun 359 Pages: 649-654
  • Peer Reviewed
• [Journal Article] Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts (2007)
  • Author(s): Chang YJ, Kim YL, Lee YK, Sacket SJ, Kim K, Kim HL, Han M, Bae YS, Okajima F, Im DS
  • Journal Title: Prostaglandins Other Lipid Mediat 83 Pages: 268-276
  • Peer Reviewed
• [Journal Article] Role of lipoprotein-associated lysophospholipids in migratory actlvlty of coronary artery smooth muscle cells. (2007)
  • Author(s): Damirin A, Tomura H, Komachi M, Liu JP, Mogi C, Tobo M, Wang JQ, Kimura T, Kuwabara A, Yamazaki Y, Ohta H, Im DS, Sato K, Okajima F.
  • Journal Title: Am J Physiol Heart Circ Physiol. 292
  • Peer Reviewed
• [Journal Article] Previously postulated"ligand-independent"signaling of GPR4 is mediated throughprpton-sensing mechanisms. (2007)
  • Author(s): Tobo M, Tomura H, Mogl C, Wang. JQ, Liu JP, Komachi M Dammn A Kmura T, Murata N, Kurose H, Sato K, Okajima F.
  • Journal Title: Cell SignaL 19 Pages: 1745-1753
  • Peer Reviewed
• [Journal Article] Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPAreceptors in C6 glioma and L2071 fibroblasts. (2007)
  • Author(s): Chang YJ, Kim YL, Lee YK, Sacket SJ, Kim K, Kim HL, Han M, Bae YS, Okajima F, Im DS.
  • Journal Title: Prostaglandins Other Lipid Mediat. 292 Pages: 649-654
  • Peer Reviewed
• [Journal Article] HDL-like lipoproteins in cerebrospinal fiuid affect neural cell activity through lipoprotein-associated sphingosine l-phosphate. (2007)
  • Author(s): Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F.
  • Journal Title: Biochem Biophys Res Commun. 292 Pages: 649-654
  • Peer Reviewed
• [Journal Article] Critical role of ABCAI transporter in sphingosine l-phosphate release fromastrocytes. (2007)
  • Author(s): Sato K, Malchinkhuu E, Horiuchi Y, Mogi C, Tomura H, Tosaka M, Yoshimoto Y, Kuwabara A, Okajima F.
  • Journal Title: J Neurochem. 103 Pages: 2610-2619
  • Peer Reviewed
• [Presentation] グリオーマのにおける低分子量Gタンパク質とPTENの役割 (2008)
  • Author(s): 佐藤幸市、マルチンフ・エンフゾル、岡島史和
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] Role of TDAG8 in Extracellular Acidification-induced Inhibition of Pro-inflammatory Cytokine Production in Peritoneal Macrophages (2008)
  • Author(s): Mogi, C., Tobo, M., Tomura, H., Murata, N., He, XD, Sato, K., Harada, A., Okajima, F
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 細胞外pHの低下に伴うヒト気管支平滑筋細胞からのインターロイキン6の産生は、OGR1受容体を介して引き起こされる (2008)
  • Author(s): 戸村秀明、一文字功、石塚全、小町麻由美、当房雅之、佐藤幸市、茂木千尋、森昌朋、岡島史和
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 細胞外pHの低下はOGR1受容体を介してヒト大動脈平滑筋細胞におけるシクロゲナーゼ-2の発現誘導とプロスタサイクリン産生の増加を引き起こす (2008)
  • Author(s): 劉進朋、戸村秀明、小町麻由美、当房雅之、佐藤幸市、茂木千尋、岡島史和
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 細胞1を介してヒト気管支平滑筋細胞からIL-6を産生させる (2008)
  • Author(s): 一文字功、石塚全、久田剛志、青木悠、森昌明、岡島史和
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] スフィンゴシン1-リン酸の細胞外放出とABCA1トランスポーター (2008)
  • Author(s): 岡島史和、木村孝穂、戸村秀明、佐藤幸市
  • Organizer: 第50回脂質生化学会
  • Place of Presentation: 徳島県郷土文化会館(徳島)
• [Presentation] ABCA1トランスポーターによる血漿リポ蛋白質産生とスフィンゴシン1-リン酸の動態調節 (2008)
  • Author(s): 佐藤幸市、マルチンフ エンフゾル、岡島史和
  • Organizer: 第50回脂質生化学会
  • Place of Presentation: 徳島県郷土文化会館(徳島)
• [Presentation] 膵臓がん細胞の遊走におけるリゾホスファチジン酸受容体サブタイプの役割 (2008)
  • Author(s): 小町麻由美、戸村秀明、岡島史和
  • Organizer: 第50回脂質生化学会
  • Place of Presentation: 徳島県郷土文化会館(徳島)
• [Presentation] ヒト骨芽細胞における細胞外pHの低下に伴うCOX-2発現誘導・PGE2産生とOGR1受容体の関連解析 (2008)
  • Author(s): 戸村秀明、劉進朋、当房雅之、Doon-Soon Im、茂木千尋、岡島史和
  • Organizer: 第50回脂質生化学会
  • Place of Presentation: 徳島県郷土文化会館(徳島)
• [Presentation] Enhacement of High-densityLipoprotein-induced Anti-Inflammatory Actions in Endothelial Cells by Simvastatin-induced expression of Scavenger Receptor Class B Type I (2008)
  • Author(s): Kimura, T., Okajima, F., and Murakami, M.
  • Organizer: The 72^<st> Annual Scientific Meeting of the Japansese Circulation Society
  • Place of Presentation: Fukuoka
• [Presentation] 膵臓がん細胞の遊走におけるLPA受容の役体割分担 (2008)
  • Author(s): 小町麻由美、戸村秀明、岡島史和
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] S1P isPTEN-dependent pathway in S1P2 receptor-mediated inhibitory action on glioma cell migration (2008)
  • Author(s): Malchinkhuu, E., Sato, K., and Okajima, F
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Acidic pH Induced Cyclooxygenase-2 Expression and Prostaglandin E2 Production through Ovarian cancer G-protein-coupled receptor 1(OGR1)in Human Osteoblasts (2008)
  • Author(s): Hideaki Tomura, Jin-peng Liu, Mayumi Komachi, Wang Ju Qiang, Masayuki Tobo Hiromi Nochi, Koichi Tamoto, Alatangaole Damirin, Koichi Sato, Chihiro Mogi, and Fumikazu Okajima
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] ABCA1トランスポーターによる血漿リボ蛋白質産生とスフィンゴシン1-リン酸の動態調節 (2008)
  • Author(s): 佐藤幸市、マルチンフエンフゾル、岡島史和
  • Organizer: 第50回日本脂質生化学会
  • Place of Presentation: 徳島県郷土文化会(徳島)
• [Presentation] 膵臓がん細胞の遊走におけるリゾホスファチジン酸受容体サブタイプの役割 (2008)
  • Author(s): 小町麻由美、戸村秀明、岡島史和
  • Organizer: 第50回日本脂質生化学会
  • Place of Presentation: 徳島県郷土文化会(徳島)
• [Presentation] ヒト骨芽細胞における細胞外pHの低下に伴うCOX-2発現誘導・PGE2 産生とOGRl受容体の関連解析 (2008)
  • Author(s): 戸村秀明、劉進朋、当房雅之、Doon-Soon Im、茂木千尋、岡島史和
  • Organizer: 第50回日本脂質生化学会
  • Place of Presentation: 徳島県郷土文化会(徳島)
• [Presentation] Isoproterenol-induced Rap1B and Tumor Suppressor PTEN-dependent Signaling in Down-regulation of Glioma Cell Invasion Stimulated by Lysophosphatidic Acid. (2008)
  • Author(s): Malchinkhuu E,Sato K,and Okajima F.
  • Organizer: An AACR Special Conference in Cancer Research Joint Metastasis Research Society-AACR Conference on Metastasis
  • Place of Presentation: The Fairmont Hotel Vancouver Vancouver, BC, Canada
• [Presentation] 新規抗炎症脂質メディエーターResolvinE1のTh2系疾患モデルベの作用 (2008)
  • Author(s): 青木悠、久田剛志、川田忠嘉、古賀康彦、宇津木光克、梗谷典子、石塚全、岡島史和、土橋邦生、森昌明
  • Organizer: 第58回日本アレルギ一学会秋季学術大会、
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] ヒト好塩基球のIgEを介するIL-8産生 (2008)
  • Author(s): 石塚全、岡島史和、松崎晋一、今井久雄、久田剛志、古賀康彦、川田忠嘉、岩崎靖樹、柳谷典子、土橋邦生、森、昌明
  • Organizer: 第58回日本アレルギ一学会秋季学術大会、
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] 細胞外pH低下はOGR1を介してヒトメ気管支平滑筋細胞からIL-6を産生 (2008)
  • Author(s): 一文字功、石塚全、久田剛志青木悠、森昌明、岡島史和
  • Organizer: 第58回日本アレルギ一学会秋季学術大会、
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] LPA受容体を介したヒト気道上皮細胞におけるRANTES産生抑制機序 (2008)
  • Author(s): 松崎晋一、石塚全、川田忠嘉、宇津木光克砂長則明、久田剛志、土橋邦生、岡島史和、森昌明
  • Organizer: 第58回日本アレルギ一学会秋季学術大会、
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] プロスタノイドによるマウス肥満細胞からのLTC4産生抑制作用 (2008)
  • Author(s): 関香織、石塚全、川田忠嘉、宇津木光克、古賀康彦、久田剛志、土橋邦生、岡島史和、森昌明
  • Organizer: 第58回日本アレルギ一学会秋季学術大会、
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] グリオーマの遊走抑制シグナルにおける低分子量Gタンパク質とPTENの役割 (2008)
  • Author(s): 佐藤幸市、マルチンフ・エンフゾル、岡島史和
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 細胞外pHの低下はOGR1受容体を介してヒト大動脈平滑細胞におけるシクロゲナーゼー2の発現誘導とプロスタサイクリン産生の増加を引き起こす (2008)
  • Author(s): 戸村秀明、一文字功、石塚全、小町麻由美、当房雅之、佐藤幸市、茂木千尋、森昌朋、岡島史和
  • Organizer: 第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] Roles of lipoproteins as carriers of sphingosine 1-phophate (2007)
  • Author(s): Okajima, F
  • Organizer: Pusan National University College of Medicine
  • Place of Presentation: Pusan, Korea
  • Year and Date: 2007-10-30
• [Presentation] Roles of lipoproteins as carriers of sphingosine 1-phosphate (2007)
  • Author(s): Okajima, F
  • Organizer: College of Pharmacy, Pusan National University
  • Place of Presentation: Pusan, Korea
  • Year and Date: 2007-10-29
• [Presentation] リポ蛋白質作用におけるスフィンゴシン1-リン酸受容体とスカベンジャー受容体の役割 (2007)
  • Author(s): 岡島史和
  • Organizer: 第6回生体機能研究会
  • Place of Presentation: 箱根プリンスホテル
  • Year and Date: 2007-09-22
• [Presentation] Roles of lipoproteins as carriers of lysolipids (2007)
  • Author(s): Oka jima, F
  • Organizer: 2007 FASEB Summer Research Conferences
  • Place of Presentation: Tucson, Arizona
• [Presentation] ヒト臍帯静脈内皮細胞における高密度リポ蛋白質HDLの接着分子発現抑制作用~HDL受容体SR-BIとS1P受容体の役割 (2007)
  • Author(s): 木村孝穂、戸村秀明、桑原敦志、茂木千尋、佐藤幸市、村上正巳、岡島史和
  • Organizer: 第49回日本脂質生化学会
  • Place of Presentation: 北海道大学、学術交流会館(札幌)
• [Presentation] Spingosine 1-phosphatisoproterenol negatively but differently regulate LPA-induced migration in human glioma cells (2007)
  • Author(s): Malchinkhuu Enkhzol, 佐藤幸市、岡島史和
  • Organizer: 第49回日本脂質生化学会
  • Place of Presentation: 北海道大学、学術交流会館(札幌)
• [Presentation] Role of sphingosine l-phosphate receptors and SR-BI in HDL-induced inhibition of adhesion molecule exression in endothelial cells (2007)
  • Author(s): Kimura T, Murakami M, and Okajima F.
  • Organizer: The 71^stAnnual Scientific Meeting of the Japansese Circulation Society
  • Place of Presentation: Kobe
• [Presentation] ヒト膀帯静脈内皮細胞における高密度リボ蛋白質HDLの接着分子発現抑制作用〜HDL受容体SR-BIとSIP受容体の役割 (2007)
  • Author(s): 木村 孝穂, 戸村 秀明, 桑原 敦志, 茂木 千尋, 佐藤 幸市, 村上 正巳, 岡島 史和
  • Organizer: 第49回日本脂質生化学会
  • Place of Presentation: 北海道大学、学術交流会館(札幌)
• [Presentation] Spingosine l-phosphate and isoproterenol negatively but differently regulate LPA-induced migration in human glioma cells (2007)
  • Author(s): Malchinkhuu Enkhzol, 佐藤 幸市, 岡島 史和
  • Organizer: 第49回日本脂質生化学会
  • Place of Presentation: 北海道大学、学術交流会館(札幌)
• [Presentation] Roles of lipoproteins as carriers of lysolipids (2007)
  • Author(s): Fumikazu Okajima
  • Organizer: 2007FASEB Summer Research Conferences:Lysophospholipid Mediators in Health and Disease
  • Place of Presentation: Tucson,Arizona
• [Presentation] EP3アゴニスト(ONO-AE-248)によるマウス肥満細胞のロイコトリエンC4産生抑制作用 (2007)
  • Author(s): 関香 織, 石塚 全, 川田 忠嘉, 宇津木 光克, 清水 泰生, 久田 剛志, 土橋 邦生, 岡島 史和, 森 昌朋
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] LPA受容体-Rhoを介したヒト気道上皮細胞からのRANTES産生抑制効果 (2007)
  • Author(s): 松崎 晋一, 石塚 全, 川田 忠嘉, 青 木遥、宇津木 光克, 小野 昭浩, 清水 泰生, 久田 剛志, 土橋 邦生, 岡島 史和, 森 昌朋
  • Organizer: 第57回日本アレルギー学会秋季学術大会
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] 膵臓がん細包の遊走におけるLPA受容体の役割分担 (2007)
  • Author(s): 小町 麻由美, 戸村 秀明, 岡島 史和
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] SlP is unlikely to utilize PTEN-dependent pathway in SlP2 receptor-mediated inhibitory action on glioma cell migration (2007)
  • Author(s): Enkhzol Malchinkhuu, KoichiSato and Fumikazu Okajima
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Presentation] Acidic pH Induced Cyclooxygenase-2 Expression and Prostaglandin E2 Production through Ovarian cancer G-protein-coupled receptor l(OGR1) in Human Osteoblasts7 (2007)
  • Author(s): Hideaki Tbmura, Jin-peng Liu, Mayumi Komachi, Wang Ju Qiang, Masayuki Tobo, Hhiromi Nochi, Koichi Tamoto, Alatang aole Damirin, Koichi Sato, Chihiro Mogi, and Fumikazu Okajima
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会大会合同大会BMB2007
  • Place of Presentation: 横浜(パシフィコ横浜)
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jo/lab/signal/index.html
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/signal/index.html