Analysis of malfunction of the hippocampus in depression and diabetes

• Project/Area Number: 19390019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: MATSUKI Norio The University of Tokyo, 大学院・薬学系研究科, 教授 (70126168)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2007: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 海馬 / 扁桃体 / 青斑核 / シナプス可塑性 / ストレス / カンナビノイド受容体 / シナプス伝達 / 求心性迷走神経

Research Abstract

海馬は記憶・学習に重要な役割を果たしていることはよく知られているが、海馬内回路に比べて海馬外からの調節機構解明は進んでいなかった。本研究において、後部扁桃体基底核および青斑核の活性化がそれぞれ海馬内のシャッファー側枝-CA1野錐体細胞、嗅内皮質-CA3野錐体細胞のシナプス伝達にダイナミックに影響することを示した。また、前者はストレスに対する感受性が高いことも明らかになり、うつ病との関連が示唆される。また、末梢刺激により海馬機能が影響され、それが糖尿病でも低下していることを明らかにした。さらに、新しいうつ病モデル動物としてコルヒチン投与動物を解析した。残念ながらうつ病モデル動物動物とはならない結果であったが、逆に、抗うつ薬の作用機序として歯状回顆粒細胞の新生や生存は関係ないことが示された。

Research Products

• [Journal Article] Differential Involvement of Cell Cycle Reactivation between Striatal and Cortical Neurons in Cell Death Induced by 3-Nitropropionic Acid (2008)
  • Author(s): Akashiba, H., Y. Ikegaya, N. Nishiyama and N. Matsuki.
  • Journal Title: J.Biol.Chem. 283 Pages: 6594-6606
  • Peer Reviewed
• [Journal Article] Oseltamivir enhances hippocampal network synchronization (2008)
  • Author(s): Usami, A., Sasaki, T., Satoh, N., Akiba, T., Yokoshima, S., Fukuyama, T., Yamatsugu, K., Kanai, M., Shibasaki, M., Matsuki, N., and Ikegaya, Y.
  • Journal Title: J. Pharmacol. Sci. 106 Pages: 649-662
  • NAID: 10024320224
  • Peer Reviewed
• [Journal Article] Ethanol enhances reactivated fear memories (2008)
  • Author(s): Nomura, H. and N. Matsuki.
  • Journal Title: Neuropsychopharmacol. advance online publication, February 20, 2008 33 Pages: 2912-2921
  • NAID: 10021950651
  • Peer Reviewed
• [Journal Article] Long-range axonal calcium sweep induces axon retraction (2008)
  • Author(s): Yamada, R. X., T. Sasaki, J. Ichikawa, R. Koyama, N. Matsuki and Y. Ikegaya
  • Journal Title: J. Neurosci. 28 Pages: 4613-4618
  • Peer Reviewed
• [Journal Article] Spontaneous plasticity of multineuronal activity patterns in activated hippocampal networks (2008)
  • Author(s): Usami, A., Matsuki, N. and Ikegaya, Y.
  • Journal Title: Neural Plascit 108969
  • Peer Reviewed
• [Journal Article] Protein Kinase CK2 Modulates Synaptic NMDA Receptors and Synaptic Plasticity in the Hippocampus (2008)
  • Author(s): Kimura, R. and N. Matsuki.
  • Journal Title: J. Physiol. 586 Pages: 3195-3206
  • Peer Reviewed
• [Journal Article] Early-life status epilepticus induces ectopic granule cells in adult mice dentate gyrus (2008)
  • Author(s): Muramatsu, R., Y. Ikegaya, N. Matsuki and R. Koyama
  • Journal Title: Exp. Neurol. 211 Pages: 503-510
  • Peer Reviewed
• [Journal Article] Fast and accurate detection of action potentials from somatic calcium fluctuations (2008)
  • Author(s): Sasaki, T., N. Takahashi, N. Matsuki and Y. Ikegaya
  • Journal Title: J. Neurophysiol. 100 Pages: 1668-1676
  • Peer Reviewed
• [Journal Article] Protein Kinase CK2 Modulates Synaptic NMDA Receptors and Synaptic Plasticity in the Hippocampus. (2008)
  • Author(s): Kimura, R. and N. Matsuki
  • Journal Title: J. Physiol. 586 Pages: 3195-3206
  • Peer Reviewed
• [Journal Article] Ethanol enhances reactivated fear memories (2008)
  • Author(s): Hiroshi Nomura, Norio Matsuki
  • Journal Title: Neuropsychopharmacology 33 Pages: 2912-2921
  • NAID: 10021950651
  • Peer Reviewed
• [Journal Article] Differential involvement of cell cycle reactivation between striatal and cortical neurons in cell death. induced by 3-nitropropionic acid. (2008)
  • Author(s): Akashiba, H., Ikegaya Y., Nishiyama, N. and Matsuki, N.
  • Journal Title: J. Biol. Chem. 283 Pages: 6594-6606
  • Peer Reviewed
• [Journal Article] Early-life status epilepticus induces ectopic granule cells in adult mice dentate gyrus. (2008)
  • Author(s): Muramatsu R., Ikegaya, Y., Matsuki, N. and Koyama, R.
  • Journal Title: Exp. Neurol. 211 Pages: 503-510
  • Peer Reviewed
• [Journal Article] Long-range axonal calcium sweep induces axon retraction. (2008)
  • Author(s): Yamada, R. X., Sasaki, T., Ichikawa, J., Koyama, R., Matsuki, N. and Ikegaya, Y.
  • Journal Title: J. Neurosci 28 Pages: 4613-4618
  • Peer Reviewed
• [Journal Article] Fast and accurate detection of action potentials from somatic calcium fluctuations. (2008)
  • Author(s): Sasaki, T., Takahashi, N., Matsuki,N. and Ikegaya, Y.
  • Journal Title: J. Neurophysiol. 102 Pages: 1668-1676
  • Peer Reviewed
• [Journal Article] Single spike detection with a genetic calcium sensor. (2008)
  • Author(s): Mizunuma, M., Seki, M., Usami, A. and Ikegaya, Y.
  • Journal Title: Cell Science 5 Pages: 34-39
  • Peer Reviewed
• [Journal Article] Oseltamivir enhances hippocampal network synchronization. (2008)
  • Author(s): Usami A, Sasaki T, satoh N, Akiba T, Yokoshima S, Fukuyama T, Yamatsugu K, Kanai M, Shibasaki M, Matsuki N, Ikegaya Y.
  • Journal Title: J. Pharmacol. Sci. 106 Pages: 659-662
  • NAID: 10024320224
  • Peer Reviewed
• [Journal Article] Differential Involvement of Cell Cycle Reactivation between Striatal and Cortical Neurons in Cell Death Induced by3-Nitroroionic Acid. (2008)
  • Author(s): H.Akashiba, Yikegaya, N.Nishiama and N.Matsuki
  • Journal Title: J.Biol.Chem 283 Pages: 6594-6606
  • Peer Reviewed
• [Journal Article] Metastability of active CA3 networks (2007)
  • Author(s): Sasaki, T., N. Matsuki and Y. Ikegaya
  • Journal Title: J. Neurosci. 27 Pages: 517-528
  • Peer Reviewed
• [Journal Article] Transnitrosation of thiols from aliphatic N-nitrosamines : S-Nitrosation and indirect generation of nitric oxide (2007)
  • Author(s): Yanagimoto, T., T. Toyoda, N. Matsuki, Y. Makino, S. Uchiyama and T. Ohwada
  • Journal Title: J. Am. Chem. Soc. 129 Pages: 736-737
  • Peer Reviewed
• [Journal Article] β-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrophic factor release from dentate gyrus granule cells (2007)
  • Author(s): Sato, K., T. Akashi, N. Matsuki, Y. Ohno and K. Nakazawa
  • Journal Title: Brain Res 1150 Pages: 108-120
  • Peer Reviewed
• [Journal Article] Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice. Biol (2007)
  • Author(s): Hama, K., J. Aoki, A. Inoue, T. Endo, T.Amano, R. Motoki, M. Kanai, X. Ye, J. Chun, N. Matsuki, H. Suzuki, M. Shibasaki and H. Arai
  • Journal Title: Reproduction 77 Pages: 954-959
  • Peer Reviewed
• [Journal Article] A low-cost method for brain slice cultures (2007)
  • Author(s): Ichikawa J., Yamada R.X., Muramatsu R., Ikegaya, Y., Matsuki, N. and Koyama, R.
  • Journal Title: J. Pharmacol. Sci. 104 Pages: 191-194
  • NAID: 10024314561
  • Peer Reviewed
• [Journal Article] Cryopreservation of granule cells from postnatal rat hippocampus (2007)
  • Author(s): Ichikawa J., Yamada R.X., Muramatsu R., Ikegaya, Y., Matsuki, N., Koyama, R.
  • Journal Title: J. Pharmacol. Sci. 104 Pages: 387-391
  • NAID: 10024315397
  • Peer Reviewed
• [Journal Article] Neonatally born granule cells numerically dominate adult mice dentate gyrus (2007)
  • Author(s): Muramatsu R., Ikegaya, Y., N. Matsuki, N. and Koyama, R
  • Journal Title: Neuroscience 148 Pages: 593-598
  • Peer Reviewed
• [Journal Article] Active hippocampal networks undergo spontaneous synaptic modification (2007)
  • Author(s): Tsukamoto-Yasui, M., Sasaki, T., Matsumoto, W., Hasegawa, A., Toyoda, T., Usami, A., Kubota, Y., Ochiai, T., Hori T., Matsuki, N. and Ikegaya, Y
  • Journal Title: PLoS One 2(11) Pages: 1250-1250
  • Peer Reviewed
• [Journal Article] Watching neuronal circuit dynamics through functional multineuron calcium imaging (fMCI) (2007)
  • Author(s): Takahashi N, Sasaki T, Usami A, Matsuki N, Ikegaya Y.
  • Journal Title: Neurosci Res 58 Pages: 219-225
  • NAID: 10024415427
  • Peer Reviewed
• [Journal Article] Contextual learning induces an increase in the number of hippocampal CA1 neurons expressing high levels of BDNF (2007)
  • Author(s): Chen J, Kitanishi T, Ikeda T, Matsuki N, Yamada MK.
  • Journal Title: Neurobiol Learn Mem 88 Pages: 409-15
  • Peer Reviewed
• [Journal Article] Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration (2007)
  • Author(s): Ueyama C, Akashiba H, Nakayama K, Nakayama KI, Nishiyama N, Matsuki N.
  • Journal Title: Neuroreport 18 Pages: 1781-1785
  • Peer Reviewed
• [Journal Article] Contextual learning in duces an increase in the number ofhiocamal CAl neurons exressinhi levels of BDNF (2007)
  • Author(s): J.Chen, ら
  • Journal Title: Neurobiol Learn Mem 88 Pages: 409-415
  • Peer Reviewed
• [Journal Article] Neonatally born granule cells numericall ydominate adult mice dentate gyrus (2007)
  • Author(s): R.Muramatsu, ら
  • Journal Title: Neuroscience 148 Pages: 593-598
  • Peer Reviewed
• [Journal Article] Metastability of active CA3 networks (2007)
  • Author(s): Sasaki, T., N.Matsuki and Ylkeaa
  • Journal Title: J.Neurosci 27 Pages: 517-528
  • Peer Reviewed
• [Journal Article] Transnitrosation of thiols from aliphatic N-nitrosamines:S-Nitrosation and indirect eneration of nitric oxide (2007)
  • Author(s): T.Yanagimoto, ら
  • Journal Title: J.Am.Chem.Soc 129 Pages: 736-737
  • Peer Reviewed
• [Journal Article] β-Estradiol induces synaptogenesis in the hippocampus by enhancing brain-derived neurotrohic factor release from dentate sanule cells (2007)
  • Author(s): K.Sato, ら
  • Journal Title: Brain Res 1150 Pages: 108-120
  • Peer Reviewed
• [Journal Article] A low-cost method fbr brain slice cultures (2007)
  • Author(s): R.Koyama, ら
  • Journal Title: J.Pharmacol.Sci 104 Pages: 191-194
  • Peer Reviewed
• [Journal Article] Cryopreservation of granule cells from postnatal rat hippocampus (2007)
  • Author(s): J.Ichikawa ら
  • Journal Title: J.Pharmacol.Sci 104 Pages: 387-391
  • Peer Reviewed
• [Journal Article] Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration (2007)
  • Author(s): C.Ueyama, ら
  • Journal Title: Neurorepolt 18 Pages: 1781-1785
  • Peer Reviewed
• [Journal Article] Watching neuronal circuit dynamics through functional multineuroncalcium iming(fMCI) (2007)
  • Author(s): N.Takahashi, ら
  • Journal Title: Neurosci.Res 58 Pages: 219-225
  • Peer Reviewed
• [Presentation] 乳幼児期における海馬神経回路の形成機構の解明-難治性てんかんの新たな治療戦略 (2009)
  • Author(s): 小山隆太
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-03-18
• [Presentation] Representation of fear memory in lateral amygdala (2008)
  • Author(s): Hiroshi Nomura
  • Organizer: Society for Neuroscience2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-19
• [Presentation] Coherent synaptic inputs between synchronized neuron pairs. (2008)
  • Author(s): Naoya Takahashi
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-19
• [Presentation] Evoked neuronal activity patterns are linked to spontaneously generated network activity. (2008)
  • Author(s): Atsushi Usami
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-19
• [Presentation] Acute and coordinated spine reorganization in behaviorally activated neurons. (2008)
  • Author(s): Takuma Kitanishi
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-19
• [Presentation] Representation of fear memory in lateral amygdala (2008)
  • Author(s): Hiroshi Nomura
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C.
  • Year and Date: 2008-11-19
• [Presentation] Coherent synaptic inputs between synchronized neuron pairs. (2008)
  • Author(s): Naoya Takahashi
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C.
  • Year and Date: 2008-11-19
• [Presentation] Evoked neuronal activity patterns are linked to spontaneously generated network activity. (2008)
  • Author(s): Atsushi Usami
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C
  • Year and Date: 2008-11-19
• [Presentation] Acute and coordinated spine reorganization in behaviorally activated neurons. (2008)
  • Author(s): Takuma Kitanishi
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C.
  • Year and Date: 2008-11-19
• [Presentation] GABA-induced KCC2 regulates the development of primary dendrites from dentate granule cells. (2008)
  • Author(s): Junya Ichikawa
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-18
• [Presentation] Neuronal hyperactivity regulates the persistence of basal dendrites from den t ate granule cells : time-lapse confocal analysis using organotypic slice cultures. (2008)
  • Author(s): Soichiro Nakahara
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-18
• [Presentation] GABA-induced KCC2 regulates the development of primary dendrites from dentate granule cells. (2008)
  • Author(s): Junya Ichikawa
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C.
  • Year and Date: 2008-11-18
• [Presentation] Neuronal hyperactivity regulates the persistence of basal dendrites from dentate granule cells: time-lapse confocal analysis using organotypic slice cultures. (2008)
  • Author(s): Soichiro Nakahara
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C.
  • Year and Date: 2008-11-18
• [Presentation] The relationship between Arc/Arg3.1 expression and neuronal activities (2008)
  • Author(s): Takeshi Toyoda
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D.C.
  • Year and Date: 2008-11-17
• [Presentation] The relationship between Arc/Arg3.1 expression and neuronal activities (2008)
  • Author(s): Takeshi Toyoda
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington, D. C.
  • Year and Date: 2008-11-17
• [Presentation] 脳深部位における血管イメージング (2008)
  • Author(s): 久我奈穂子
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-10
• [Presentation] 海馬多シナプス回路における情報演算の短期的および長期的可塑性 (2008)
  • Author(s): 木村梨絵
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 経験依存的に活動した神経細胞におけるスパインの可塑性 (2008)
  • Author(s): 北西卓磨
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 嗅内皮質-海馬CA1ペアから単シナプス結合をパッチクランプ記録する (2008)
  • Author(s): 佐々木拓哉
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] GABAによる海馬顆粒細胞の移動異常 (2008)
  • Author(s): 小山隆太
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 海馬苔状線維における神経活動依存的なミトコンドリアの分布 (2008)
  • Author(s): 中原聡一郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] Netrin-1による神経活動依存的な海馬苔状線維の軸索誘導 (2008)
  • Author(s): 村松里衣子
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 歯状回顆粒細胞成熟における胎生期ストレスの影響 (2008)
  • Author(s): 田村誠
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] GABAによる海馬顆粒細胞の移動異常 (2008)
  • Author(s): 小山隆太
  • Organizer: 第31回目本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 扁桃体および青斑核活動による海馬シナプス可塑性の調節 (2008)
  • Author(s): 松木則夫
  • Organizer: 第85回日本生理学会年会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2008-03-26
• [Presentation] 扁桃体および青斑核活動による海馬シナプス可塑性の調節 (2008)
  • Author(s): 松木 則夫
  • Organizer: 第85回目本生理学会年会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2008-03-26
• [Presentation] ASK1ノックアウトマウスの行動的特徴 (2008)
  • Author(s): 熊倉かれん
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] 経済的な脳スライス培養法 (2008)
  • Author(s): 佐々木拓哉
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] 扁桃体における恐怖記憶の表現 (2008)
  • Author(s): 野村洋
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] 海馬における経験依存的なシナプス構造の可塑性 (2008)
  • Author(s): 北西卓磨
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] Arc/Arg3.1の発現と神経細胞の活動の関係 (2008)
  • Author(s): 豊田雄
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] ASKIノックアウトマウスの行動的特徴 (2008)
  • Author(s): 熊倉 かれん
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] ArG/Arg3.1の発現と神経細胞の活動の関係 (2008)
  • Author(s): 豊田 雄
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-19
• [Presentation] 後部扁桃体基底核-腹側海馬CA1経路と海馬Schaffer側枝-CA1経路間のシナプスの相互調節 (2008)
  • Author(s): 松山皓治
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 海馬苔状線維のNetrin-1依存性誘引の細胞内cAMP量による制御 (2008)
  • Author(s): 村松里衣子
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 軸索分枝形成におけるミトコンドリアの局在解析 (2008)
  • Author(s): 中原聡一郎
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] オセルタミビルは海馬回路に同期発火を惹起する (2008)
  • Author(s): 宇佐美篤
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 神経ネットワーク活動のイメージング : 次世代の薬理スクリーニング系を目指して (2008)
  • Author(s): 高橋直矢
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 海馬多シナプス応答のイメージング : 次世代の薬理スクリーニングを目指して (2008)
  • Author(s): 木村梨絵
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] アストロサイトのカルシウム動態の大規模なイメージング (2008)
  • Author(s): 長谷川彩子
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 覚醒下マウスにおけるパッチクランプ記録 (2008)
  • Author(s): 松本渉
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] スプライシング機構をターゲットとした脊髄小脳変性症6型の治療戦略の確立 (2008)
  • Author(s): 赤芝洋紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 後部扁桃体基底核ー腹側海馬CA1経路と海馬Schaffer側枝ーCA1経路間のシナプスの相互調節 (2008)
  • Author(s): 松山 皓治
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 神経ネットワーク活動のイメージング:次世代の薬理スクリーニング系を目指して (2008)
  • Author(s): 高橋 直矢
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 海馬多シナプス応答のイメージング:次世代の薬理スクリーニングを目指して (2008)
  • Author(s): 木村 梨絵
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-03-18
• [Presentation] 覚醒下マウスにおけるパッチクランプ記録 (2008)
  • Author(s): 松本 渉
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 第81回日本薬理学会年会
  • Year and Date: 2008-03-18
• [Presentation] 細胞体による軸索伸長の遠隔制御 (2007)
  • Author(s): 池谷裕二
  • Organizer: Neuro2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] Modulation of hippocampal synaptic plasticities by the activities of the amygdala (2007)
  • Author(s): Norio Matsuki
  • Organizer: Neuro2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] アストロサイトのセルアセンブリ (2007)
  • Author(s): 長谷川彩子
  • Organizer: Neuro2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] グルタミン酸による海馬新生顆粒細胞の分化 (2007)
  • Author(s): 市川淳也, GABA
  • Organizer: Neuro2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] ネトリン-1による海馬苔状線維の順行性投射機構の維持 (2007)
  • Author(s): 村松里衣子
  • Organizer: Neuro2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10
• [Presentation] GABA、グルタミン酸による海馬新生穎粒細胞の分化 (2007)
  • Author(s): 市川 淳也
  • Organizer: Neuro2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-09-10