| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
This project aims to identify regulators of MAPK signaling using fission yeast S. pombe as a model organism. We identified negative regulators of Pmk1 MAPK, such as ptc1+, ptc3+, encoding PP2Cs, and ecm33+, encoding a cell surface protein. We also identified targets of Pmk1 including the Atf1 transcription factor and the Nrd1 RNA-binding protein. We also demonstrated feedback mechanisms involving these regulators of Pmk1 MAPK and identified several compounds with potent MAPK inhibitory action.
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