Isolation and identification of CD81 as a novel target for treatment of rheumatoid arthritis.
| Project/Area Number |
19390026
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Shujitsu University |
|---|
Principal Investigator |
中西 徹 Shujitsu University, 薬学部, 教授 (30243463)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
森 宏樹 就実大学, 薬学部, 助教 (40388989)
中島 利博 医療法人さわらび会福祉村病院長寿医学研究所, 研究員 (90260752)
浅沼 幹人 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00273970)
新井 佑志 (新井 祐志) 京都府立医科大学, 医学部, 助教 (50347449)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | CD81 / リウマチ / シノビオリン / 滑膜細胞 / DNAチップ |
|---|
| Research Abstract |
Quantitative PCR and reporter gene system showed that the stimulation of CD81 on cell surface of SW982 cells directly induced the expression of synoviolin. When siRNA of CD81 introduced into the joints of RA-model rats, this siRNA teageting CD81 ameliorated RA in these rats.
|
Report
(4 results)
Research Products
(19 results)
