| Project/Area Number |
19390028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HASHIMOTO Yuichi The University of Tokyo, 分子細胞生物学研究所, 教授 (90164798)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hisayoshi 東京大学, 分子細胞生物学研究所, 助教 (80225531)
NOGUCHI Tomomi 東京大学, 分子細胞生物学研究所, 技術職員 (20401284)
AOYAMA Hiroshi 東京大学, 分子細胞生物学研究所, 助教 (40374699)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 医薬分子機能学 / 生物応答調節剤創製法 / 生理活性物質 / フォールディング / 核内受容体 / テンプレート / サリドマイド / 細胞内局在 / 構造展開 / ロドプシン / 抗ウイルス剤 / ケミカルジェネティクス / 化合部物ライブラリー / 生物応答調節 / 構造活性相関 / 肝臓X受容体 / 核内受容体リガンド / 抗アンドロゲン / ジフェニルペンタン / PPAR / 酵素阻害剤 |
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| Research Abstract |
Two approaches, named multi-template approach (focusing on three dimensional structure of the scaffold and its receptor) and dramatype approach (focusing on conformational change, time-dependent presence, trafficking, and/or stability of the receptor), have been proposed for the methodology to create various categories of biologically active compounds, including nuclear receptor ligands and thalidomide-related derivatives. Some unique active compounds were made commercially available as reagents.
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