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Chemical biology of collagen toward drug development

Research Project

Project/Area Number 19390032
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionWaseda University

Principal Investigator

KOIDE Takaki  Waseda University, 理工学術院, 教授 (70322253)

Co-Investigator(Kenkyū-buntansha) KITAGAWA Kouki  新潟薬科大学, 薬学部, 教授 (60093853)
ASADA Shinichi  新潟薬科大学, 薬学部, 助教 (50424883)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords医薬分子設計 / ペプチド / コラーゲン / スクリーニング / タンパク質
Research Abstract

We have developed a facile high-throughput screening system to obtain inhibitors for collagen-protein interactions. By using this system, we obtained inhibitors for HSP47 (collagen-specific chaperone), GPVI (platelet collagen receptor), VWF (blood coagulation factor), and clostridial collagenase (exotoxin causing gas gangrene). Results obtained from a structure-activity relationship study of PEDF-binding peptides have implied involvement of heparan sulfate proteoglycans in PEDF's anti-angiogenic activity.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (45 results)

All 2011 2010 2009 2008 Other

All Journal Article (19 results) (of which Peer Reviewed: 17 results) Presentation (24 results) Remarks (2 results)

  • [Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010

    • Author(s)
      小出隆規
    • Journal Title

      生化学 82巻

      Pages: 474-483

    • NAID

      10026899828

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010

    • Author(s)
      Y.Nishikawa, Y.Takahara, S.Asada, A.Shigenaga, A.Otaka, K.Kitagawa, T.Koide
    • Journal Title

      Bioorg.Med.Chem. 18

      Pages: 3767-3775

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses2010

    • Author(s)
      C.M.Yamazaki, Y.Kadoya, K.Hozumi, H.Okano-Kosugi, S.Asada, K.Kitagawa, M.Nomizu, T.Koide
    • Journal Title

      Biomaterials 31

      Pages: 1925-1934

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010

    • Author(s)
      小出隆規
    • Journal Title

      生化学

      Volume: 82 Pages: 474-483

    • NAID

      10026899828

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010

    • Author(s)
      小出隆規
    • Journal Title

      生化学 82(印刷中)

    • NAID

      10026899828

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A collagen-like triple helical supramolecule that evokes integrin-dependent cell response2010

    • Author(s)
      C.M. Yamazaki, Y. Kadoya, K. Hozumi, H. Okano-Kosugi, S. Asada, K. Kitagawa, M. Nomizu, T. Koide
    • Journal Title

      Biomaterials 31

      Pages: 1925-1934

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] コラーゲン様三重らせんペプチドを利用した生化学研究2010

    • Author(s)
      小出隆規
    • Journal Title

      生化学 82(in press)

    • NAID

      10026899828

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A collagen-like triple helical supramolecule that evokes integrin-dependent cell response2010

    • Author(s)
      C.M.Yamazaki, T.Koide, et al.
    • Journal Title

      Biomaterials 31

      Pages: 1925-1934

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009

    • Author(s)
      H.Okano-Kosugi, O.Matsushita, S.Asada, A.B.Herr, K.Kitagawa, T.Koide
    • Journal Title

      Anal.Biochem. 394

      Pages: 125-131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Totally synthetic collagen-like gels by intermolecular folding of designed peptides, (Proceeding for 30th European Peptide Symposium)2009

    • Author(s)
      C.M.Yamazaki, S.Asada, K.Kitagawa, T.Koide
    • Journal Title

      Peptides 2008

      Pages: 458-459

    • Related Report
      2010 Final Research Report
  • [Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates2009

    • Author(s)
      S.T.L.Philominathan, T.Koide, K.Hamada, H.Yasui, S.Seifert, O.Matsushita, J.Sakon
    • Journal Title

      J.Biol.Chem. 284

      Pages: 10868-10876

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009

    • Author(s)
      H. Okano-Kosugi, O. Matsushita, S. Asada, A. B. Herr, K. Kitagawa, T. Koide
    • Journal Title

      Anal.Biochem. 394

      Pages: 125-131

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Unidirectional binding of clostridial collagenase to triple helical substrates2009

    • Author(s)
      S.T.L. Philominathan, T. Koide, K. Hamada, H. Yasui, S. Seifert, O. Matsushita, J. Sakon
    • Journal Title

      J.Biol.Chem. 284

      Pages: 10868-10876

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions2009

    • Author(s)
      H.Okano-Kosugi, T.Koide, et al.
    • Journal Title

      Anal.Biochem. 394

      Pages: 125-131

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] nidirectional binding of clostridial collagenase to triple helical substrates2009

    • Author(s)
      S. T. L. Philominathan, T. Koide, K. Hamada, et al
    • Journal Title

      J. Biol. Chem. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Totally synthetic collagen-like gels by intermoleoular folding of designed peptides.2009

    • Author(s)
      C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
    • Journal Title

      Peptides 2008

      Pages: 458-459

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides2008

    • Author(s)
      C.M.Yamazaki, S.Asada, K.Kitagawa, T.Koide
    • Journal Title

      Biopolymers(Peptide Science) 90

      Pages: 816-823

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Artificial collagen gels via self-assembly of de novo designed peptides2008

    • Author(s)
      C.M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
    • Journal Title

      Biopolymers (Peptide Science) 90

      Pages: 816-823

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides2008

    • Author(s)
      C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
    • Journal Title

      Biopolyniers (Peptide Science) 90

      Pages: 816-823

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] シスプラチン誘導体はコラーゲンのin vitro線維化を阻害する2011

    • Author(s)
      小出隆規
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Final Research Report
  • [Presentation] シスプラチン誘導体はコラーゲンのin vitro線維化を阻害する2011

    • Author(s)
      小出隆規
    • Organizer
      日本薬学会 第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surface-modifiable two-dimentional films containing the collagen-like triple-helical peptides2010

    • Author(s)
      Shunsuke Matsui
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Collagen-like peptide supramolecules that regulate cell adhesion2010

    • Author(s)
      小出隆規
    • Organizer
      31'st European Peptide Symposium
    • Place of Presentation
      Copenhagen
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Elucidation of sequence-specific collagen recognition mechanisms by anti-angiogenic factor ; pigment epithelium-derived factor2010

    • Author(s)
      Atsushi Sekiya
    • Organizer
      31'st European Peptide Symposium
    • Place of Presentation
      Copenhagen
    • Year and Date
      2010-09-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Elucidation of sequence-specific collagen recognition mechanisms by anti-angiogenic factor pigment epithelium-derived factor2010

    • Author(s)
      Atsushi Sekiya
    • Organizer
      31st European Peptide Symposium
    • Place of Presentation
      Copenhagen
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生阻害活性を示す色素上皮由来因子(PEDF)の配列特異的なコラーゲン認識機構解明2010

    • Author(s)
      関谷敦志
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究大会合同学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2010-08-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管新生阻害活性を示す色素上皮由来因子(PEDF)の配列特異的なコラーゲン認識機構解明2010

    • Author(s)
      関谷敦志
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究大会 合同学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] コラーゲンの線維化を阻害する低分子量化合物の探索2010

    • Author(s)
      全田未悠
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究大会合同学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2010-08-19
    • Related Report
      2010 Final Research Report
  • [Presentation] コラーゲンの線維化を阻害する低分子量化合物の探索2010

    • Author(s)
      全田未悠
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究大会 合同学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2010-08-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 色素上皮由来因子(PEDF)の配列特異的なコラーゲン認識とその意義2010

    • Author(s)
      小出隆規
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 色素上皮由来因子 (PEDF) の配列特異的なコラーゲン認識とその意義2010

    • Author(s)
      小出隆規, ら
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Development of artificial collagen that controls receptor-specific cell adhesion2009

    • Author(s)
      C.M.Yamazaki
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-04
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 色素上皮由来因子(PEDF)による特異的なコラーゲン認識2009

    • Author(s)
      関谷敦志
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 色素上皮由来因子 (PEDF) による特異的なコラーゲン認識2009

    • Author(s)
      関谷敦志, 小出隆規, ら
    • Organizer
      第82回に本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 色素上皮由来因子(PEDF)による特異的なコラーゲン認識2009

    • Author(s)
      関谷敦志, 小出隆規, ら
    • Organizer
      第82回に本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] A 384-plate screening of the compounds that ingibit collagen-protein interactions2009

    • Author(s)
      H.Kosugi
    • Organizer
      8th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      横須賀
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] A 384-plate screening of the compounds that inhibit collagen-protein interactions2009

    • Author(s)
      H. Kosugi, S. Asada, K. Kitagawa, T. Koide, et al.
    • Organizer
      8th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      横須賀
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] Integrin-dependent cell adhesion to the peptide-based artificial collagen2009

    • Author(s)
      C.M.Yamazaki
    • Organizer
      8th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      横須賀
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Integrin-dependent cell adhesin to the peptide-based artificial collagen2009

    • Author(s)
      C.M.Yamazaki, T.Koide, et al.
    • Organizer
      8th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      横須賀
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Totally synthetic collagen-like gels by intermolecular folding of designed peptides2008

    • Author(s)
      C.M. Yamazaki, S. Asada, K. Kitagawa, T. Koide
    • Organizer
      30th European Peptide Symposium
    • Place of Presentation
      ヘルシンキ
    • Year and Date
      2008-09-04
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] コラーゲン3重らせん上に存在するタンパク質結合配列の探索2008

    • Author(s)
      小杉日登美
    • Organizer
      第55回マトリックス研究会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report 2008 Annual Research Report
  • [Presentation] Totally synthetic collagen-like gels by intermolecular folding of designed peptides2008

    • Author(s)
      C.M.Yamazaki
    • Organizer
      30th European Peptide Symposium
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2010 Final Research Report
  • [Presentation] Totally synthetic collagen-like gels by intermoleoular folding of designed peptides2008

    • Author(s)
      Chisato M. Yamazaki, Shinichi Asada, Kouki Kitagawa, Takaki Koide
    • Organizer
      30th European Peptide Symposium
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.chem.waseda.ac.jp/koide/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.chem.waseda.ac.jp/koide/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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