|Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
We have developed a facile high-throughput screening system to obtain inhibitors for collagen-protein interactions. By using this system, we obtained inhibitors for HSP47 (collagen-specific chaperone), GPVI (platelet collagen receptor), VWF (blood coagulation factor), and clostridial collagenase (exotoxin causing gas gangrene). Results obtained from a structure-activity relationship study of PEDF-binding peptides have implied involvement of heparan sulfate proteoglycans in PEDF's anti-angiogenic activity.