| Project/Area Number |
19390033
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
OGRA Yasumitsu Chiba University, 薬学部, 教授 (40292677)
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| Co-Investigator(Kenkyū-buntansha) |
YAWATA Ayako 昭和薬科大学, 薬学部, 助教 (00384636)
SUZUKI Noriyuki 千葉大学, 大学院・薬学研究院, 准教授 (10376379)
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| Research Collaborator |
ENCINAR Jorge ruiz University of Oviedo (Spain), Lecturer
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | セレン / メタロミクス / スペシエーション / カラシナ / セレノ糖 / ICP-MS / 生物循環 / メタロイド / セレノアミノ酸 / セイヨウカラシナ / テルル / 銅 / 活性酸素 / セレン糖 / シロイヌナズナ / セレノホモランチオニン / メタロミク |
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| Research Abstract |
Selenium (Se) shows ambivalent characteristics in animals and plants. It is an essential element in animals but becomes severely toxic when the amount ingested exceeds the required level. Meanwhile, Se is not essential in plants although some plants are Se hyperaccumulators. Thus, Se may be circulated in biosphere. In the study, we obtained the results for the mechanisms underlying the Se metabolism in animals and plants, the distinguish between Se and tellurium in animals and plants, the novel approach for metal/metalloid metabolism by the combination techniques of molecular biology, speciation and elemental imaging as shown below.
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