Dioxin-induced imprinting of sexual immaturity and its mechanism
| Project/Area Number |
19390034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMADA Hideyuki Kyushu University, 大学院・薬学研究院, 教授 (40142351)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Yuji 九州大学, 大学院・薬学研究院, 准教授 (90253468)
ISHIDA Takumi 九州大学, 大学院・薬学研究院, 助教 (10301342)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | ダイオキシン / 胎児 / 性腺ステロイドホルモン / 脳下垂体ホルモン / 後世代影響 / ステロイドホルモン / 性未成熟 / インプリンティング / 下垂体 / 性腺刺激ホルモン / 視床下部 / メタボローム解析 / 胎児期特異性 / 性差 / 性行動障害 / 内分泌攪乱 / 性ステロイド合成酵素 |
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| Research Abstract |
The effects of maternal exposure to 2,3,7,8-tetra- chlorodibenzo- p-dioxin (TCDD), an environmental pollutant, on fetal maturation were studied in rats. The fetuses exposed to TCDD showed not only a reduction in the expression of gonadal proteins necessary for sex-steroid syntheses, but also impaired activity in sexual behaviors at adulthood. We also obtained evidence that above damages are due to a TCDD-produced reduction in fetal pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior.2009
Author(s)
1 Takeda, T., Matsumoto, Y., Koga, T., Mutoh, J., Nishimura, Y., Shimazoe, T., Ishii, Y., Ishida, T., Yamada, H.
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Journal Title
J. Pharmacol. Exp. Ther. 929
Pages: 1091-1099
Related Report
Peer Reviewed
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