| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Research Abstract |
The effects of maternal exposure to 2,3,7,8-tetra- chlorodibenzo- p-dioxin (TCDD), an environmental pollutant, on fetal maturation were studied in rats. The fetuses exposed to TCDD showed not only a reduction in the expression of gonadal proteins necessary for sex-steroid syntheses, but also impaired activity in sexual behaviors at adulthood. We also obtained evidence that above damages are due to a TCDD-produced reduction in fetal pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone.
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