Unique response of hippocampal zinc in recognition and stress and prevention of stress-induced neuropsychological diseases
| Project/Area Number |
19390035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
武田 厚司 University of Shizuoka, 薬学部, 准教授 (90145714)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 亜鉛 / 海馬 / 学習 / 記憶 / シナプス可塑性 / 長期増強 / ストレス / 精神障害 / 学習・記憶 / グルタミン酸 / 記憶・学習 / CAI / 開口放出 |
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| Research Abstract |
Long-term potentiation (LTP) is known as a cellular mechanism of memory formation. In the hippocampus, Zn^<2+> attenuates mossy fiber LTP, while potentiated CA1 LTP. On the other hand, the stressful environment changes synaptic plasticity and memory formation. When rats were subjected to acute stress, zinc homeostasis in the extracellular compartment was significantly changed in the hippocampus. This change may attenuate LTP in the hippocampus. The present study suggests that Zn^<2+> signaling modulates LTP in the hippocampus.
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Report
(4 results)
Research Products
(126 results)
