Alternative mechanisms of gene regulation for pharmacokinetics related genes

Research Project

Project/Area Number	19390044
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Medical pharmacy
Research Institution	Kyushu University
Principal Investigator	HIGUCHI Shun Kyushu University, 大学院・薬学研究院, 教授 (40218699)
Co-Investigator(Kenkyū-buntansha)	IEIRI Ichiro 九州大学, 大学院・薬学研究院, 准教授 (60253473) HIROTA Takeshi 九州大学, 大学院・薬学研究院, 助教 (80423573)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2007: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Keywords	コピーナンバー多型 / miRNA / インプリンティング / CYP3A4 / MDR1 / 発現制御 / SNPs / エピジェネティックス
Research Abstract	In this study, we focused on copy number variation, microRNA and genome imprinting. Copy number was increased in human tumor tissues compared to normal counter parts. Dihydropyrimidine dehydrogenase was repressed by some miRNAs. Inter-individual difference in human organic cation transporter was responsible for loss of imprinting.

Report

(4 results)