| Project/Area Number |
19390052
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIBATA Yosaburo Kyushu University, 大学院・医学研究院, 教授 (90037482)
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| Co-Investigator(Kenkyū-buntansha) |
INAI Tetsuchro 九州大学, 大学院・医学研究院, 准教授 (00264044)
HROSE Eiji 九州大学, 大学院・医学研究院, 助教 (40380620)
IIDA Hroh 九州大学, 大学院・農学研究院, 教授 (70150399)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | パネキシン / 心臓 / 筋肉 / ゼブラフィッシュ / コネキシン / ギャップ結合 / 免疫組織化学 / Pannexin / Connexin / 解剖学 / 細胞・組織 / 遺伝子 / 蛋白質 |
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| Research Abstract |
GAP junction mediates the excitation propagation and synchronized contraction of the muscle cells in the heart. GAP junction is conposed of connexin molecules. Pannexin is the homologue of connexin. We isolated three pannexin fanily genes frommodel lower vertebrate, zebrafish and determined the spatio-tenporal expression profiles of zebrafish pannexins (ZPanxs). ZPanx2 is expressed in the heart at beat-initiation stage, in the skeletal muscles at the free-swimming stage, and later, in the vessels at imnature fast blood flowstage. These results indicate the role of ZPanx2 in functional maturation processes of the muscle, rather than in determination or differentiation processes.
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