Verification of the relationship between fat cells and lymphangiogenesis by using a benign lymphangioma model
| Project/Area Number |
19390053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
EZAKI Taichi Tokyo Women's Medical University, 医学部, 教授 (10128259)
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| Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Shunichi 東京女子医科大学, 医学部, 助教 (70339000)
SHIMIZU Kazuhiko 東京女子医科大学, 医学部, 助教 (90385394)
KIKUTA Sachiko 東京女子医科大学, 医学部, 助教 (10367089)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAHARA Shuji 東京女子医科大学, 医学部, 助教 (40510235)
DESAKI Junzo 愛媛大学, 大学院・医学系研究科, 講師 (00036451)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | (N)細胞分化・組織形成 / リンパ管新生 / アジュバント / リンパ管腫 / 脂肪細胞 / 内皮細胞 / 中皮細胞 / 腹膜 / マウス |
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| Research Abstract |
In an adjuvant-induced lymphangioma model, we found that abdominal mesothelial cells and bone marrow-derived cells proliferated and transformed into fat storing cells in response to extrinsic mineral oil, and then, by fusing with each other, formed tubular structures which appeared to be morphologically and functionally immature lymphatic vessels. This suggests that mesothelium, fat cell and lymphatic endothelium may be interchangeable to each other depending on their local microenvironment.
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Report
(4 results)
Research Products
(72 results)
