Cl-homeodynamics and resulting GABA_A-receptor-mediated functional changes underlying the cortical developmental disorder induced by stress

• Project/Area Number: 19390058
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FUKUDA Atsuo Hamamatsu University School of Medicine, 医学部・生理学第一講座, 教授 (50254272)
• Co-Investigator(Kenkyū-buntansha): KUMADA Tatsurou 浜松医科大学, 医学部, 助教 (00402339) ; FURUKAWA Tomonori 浜松医科大学, 医学部, 助教 (60402369) ; MORISHIMA Toshitaka 浜松医科大学, 医学部, 助教 (60456548)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 細胞移動 / 母体ストレス / GABA / グルタミン酸 / 大脳皮質 / 皮質形成異常 / 線条体原基 / 神経発生 / クロライドトランスポーター / 皮質板細胞 / GABA細胞 / タウリン / てんかんモデル

Research Abstract

妊娠中の精神的ストレスが出生児の脳機能に与える影響が懸念されている。これらストレス脆弱性には臨界期が存在すると考えられる。そこで、神経細胞の種類と細胞発生時期を識別できるモデルマウスを作製し、母体ストレスあるいは出生直後の傷害ストレスが仔脳のGABA作用を撹乱し、細胞の分化・移動の障害を誘発することを明らかにした。さらに細胞種や分化・移動ステージでの感受性の差を解析し、母体ストレスや周産期脳傷害による発達障害の発生メカニズムを検討した。

Research Products

• [Journal Article] Dominant negative mutations inα-II spectrin cause early onset West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. (2010)
  • Author(s): Saitsu, H., Tohyama, J., Kumada, T., Egawa, K., Hamada, K., Okada, I., Mizuguchi, T., Osaka, H., Miyata, R., Furukawa, T., Haginoya, K., Hoshino, H., Goto, T., Hachiya, Y., Yamagata, T., Saitoh, S., Nagai, T., Nishiyama, K., Nishimura, A., Miyake, N., Komada, M., Hayashi, K., Hirai, S., Ogata, Kazuhiro., Kato, M., Fukuda, A., Matsumoto N.
  • Journal Title: Am. J. Human Genet. (in press)
  • Peer Reviewed
• [Journal Article] GABA imaging in brain slices using immobilized enzyme-linked photo analysis. (2010)
  • Author(s): Morishima, T., Uematsu, M., Furukawa, T., Yanagawa, Y., Fukuda, A., Yoshida, S.
  • Journal Title: Neurosci. Res (in press)
  • Peer Reviewed
• [Journal Article] Difference in binocularity and ocular dominance plasticity between GABAergic and excitatory cortical neurons. (2010)
  • Author(s): Kameyama, K., Sohya, K., Ebina, T., Fukuda, A., Yanagawa, Y., Tsumoto, T.
  • Journal Title: J. Neurosci 30 Pages: 1551-1559
  • Peer Reviewed
• [Journal Article] Difference in binocularity and ocular dominance plasticity between GABAergic and excitatory cortical neurons (2010)
  • Author(s): Kameyama, K., et al.
  • Journal Title: J.Neurosci. 30 Pages: 1551-1559
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 福田敦夫
  • Journal Title: 組織標本 (脳スライス) への各種イメージング法適用の実際(第18回メディカルホトニクスコース講習テキスト) Pages: 95-114
• [Journal Article] 動物モデルからヒトヘ (2009)
  • Author(s): 福田敦夫
  • Journal Title: ベビーサイエンス 8 Pages: 33-35
• [Journal Article] Glycine receptors mediate excitation of subplate neurons in neonatal rat cerebral cortex. (2008)
  • Author(s): Kilb, W., Hanganu, I.L., Okabe, A., Shimizu-Okabe, C., Fukuda, A., Luhmann, H.J.
  • Journal Title: J. Neurophysiol 100 Pages: 698-707
  • Peer Reviewed
• [Journal Article] Induction of amyloid βaccumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. (2008)
  • Author(s): Koyama, Y., Matsuzaki, S., Gomi, F., Yamada., K., Katayama, T., Sato, K., Kumada, T., Fukuda, A., Matsuda, S., Tano, Y., Tohyama, M.
  • Journal Title: Invest. Ophthalmol. Visual Sci 49 Pages: 2376-2383
  • Peer Reviewed
• [Journal Article] De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. (2008)
  • Author(s): Saitsu, H., Kato, M., Mizuguchi, T., Hamada, K., Osaka, H., Tohyama, J., Uruno, K., Kumada, S., Nishiyama, K., Nishimura, A., Okada, I., Yoshimura, Y., Hirai, S., Kumada, T., Hayasaka, K., Fukuda, A., Ogata, K., Matsumoto, N.
  • Journal Title: Nat. Genet 40 Pages: 782-788
  • Peer Reviewed
• [Journal Article] De novo mutations in the gene encoding STXBP1(MUNC18-1) cause early infantile epileptic encephalopathy. (2008)
  • Author(s): Saitsu, H., et al.
  • Journal Title: Nat. Genet 40 Pages: 782-788
  • Peer Reviewed
• [Journal Article] Induction of amyloid β accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. (2008)
  • Author(s): Koyama, Y., et al.
  • Journal Title: Invest. Ophthalmol. Visual Sci. 49 Pages: 2376-2383
  • Peer Reviewed
• [Journal Article] Glycine receptors mediate excitation of subplate neuronsin neonatal rat cerebral cortex. (2008)
  • Author(s): Kilb, W., et al.
  • Journal Title: J. Neurophysiol. 100 Pages: 698-707
  • Peer Reviewed
• [Journal Article] Changes in the expression of cation-Clcotransporters, NKCC1 and KCC2, during cortical malformation induced by neonatal freeze-lesion. (2007)
  • Author(s): Shimizu-Okabe, C., Okabe, A., Kilb, W., Sato, K., Luhmann, H.J., Fukuda, A.
  • Journal Title: Neurosci. Res 59 Pages: 288-295
  • Peer Reviewed
• [Journal Article] Kinetic properties of Cl-uptake mediated by Na+-dependent K+-2Cl-cotransport in immature rat neocortical neurons. (2007)
  • Author(s): Achilles, K., Okabe, A., Ikeda, M., Shimizu-Okabe, C., Yamada, J., Fukuda, A., Luhmann, H.J., Kilb, W.
  • Journal Title: J. Neurosci 27 Pages: 8616-8627
  • Peer Reviewed
• [Journal Article] Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. (2007)
  • Author(s): Yamada, J., Furukawa, T., Ueno, S., Yamamoto, S., Fukuda, A.
  • Journal Title: Cereb. Cortex 17 Pages: 1782-1787
  • Peer Reviewed
• [Journal Article] Insertion ofα7 nicotinic receptors at neocortical layer V GABAergic synapses is induced by a benzodiazepine, midazolam. (2007)
  • Author(s): Yamamoto, S., Yamada, J., Ueno, S., Kubota, H., Furukawa, T., Yamamoto, S., Fukuda, A.
  • Journal Title: Cereb. Cortex 17 Pages: 653-660
  • Peer Reviewed
• [Journal Article] Molecular basis for the GABA_A receptor-mediated tonic inhibition in ratsomatosensory cortex (2007)
  • Author(s): Yamada, J., et. al.
  • Journal Title: Cereb.Cortex 17 Pages: 1782-1787
  • Peer Reviewed
• [Journal Article] Kinetic properties of Cl^-uptake mediated by Na^+-dependent K^+-2C1^-cotransport in immatnature rat neocortical neurons (2007)
  • Author(s): Achilles, K., et. al.
  • Journal Title: J.Neurosci. 27 Pages: 8616-8627
  • Peer Reviewed
• [Journal Article] Changes in the expression of cation-C1^- cotransporters,NKCC1 and KCC2,during cortical malformation induced by neonatal freeze-lesion (2007)
  • Author(s): Shimizu-Okabe, C., et. al.
  • Journal Title: Neurosci.Res. 59 Pages: 288-295
  • Peer Reviewed
• [Presentation] Chloride homeo-dynamics causing GABA modal shift during development and pathogenesis. (2010)
  • Author(s): Fukuda, A.
  • Organizer: FENS/ Hertie WINTER SCHOOL 2010 Obergurgl
  • Place of Presentation: Austria
• [Presentation] Chloride homeo-dynamics causing GABA modal shift during development and pathogenesis (2010)
  • Author(s): 福田敦夫
  • Organizer: FENS/Hertie WINTER SCHOOL 2010
  • Place of Presentation: obergurgl
• [Presentation] 幼少時の麻酔暴露による脳障害と脳発達過程の興奮性GABA作用. (2009)
  • Author(s): 福田敦夫
  • Organizer: 第29回日本臨床麻酔学会大会
  • Place of Presentation: 浜松
• [Presentation] Endogenous taurine tonically activates GABAA receptors in embryonic mouse neocortex. (2009)
  • Author(s): Fukuda, A., Furukawa, T., Morishima, T., Kumada, T.
  • Organizer: The 40th NIPS International Symposium: International Joint Symposium 2009 "Physiology of Anion Transport" and "Cell Volume Regulation"(PAT-CVR, 2009)
  • Place of Presentation: Okazaki
• [Presentation] Physiological significance of taurine-mediated Cl- conductances during corticogenesis. In Symposium, "Modulation of brain development by paracrine activation of Clconductances. " (2009)
  • Author(s): Fukuda, A.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Cl- mediated GABA release from Bergmann glia in developing cerebellar cortex. In Symposium, "Modulation of brain development by paracrine activation of Cl- conductances. " (2009)
  • Author(s): Yoshida, S., Morishima, T., Okochi, K., Takayama, C., Yanagawa, Y., Fukuda, A.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Ionotropic GABA receptors control neuronal migration in neonatal rat cerebral cortex. (2009)
  • Author(s): Luhmann, H.J., Kilb, W., Fukuda, A.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Physiological roles of taurine-mediated tonic GABAA-receptor activation in corticogenesis. (2009)
  • Author(s): Fukuda, A.
  • Organizer: The 2nd International Symposium Topical Problems of Biophotonics-2009
  • Place of Presentation: Nizhny Novgorod
• [Presentation] Ambient GABA and taurine during corticogenesis. (2009)
  • Author(s): Fukuda, A., Furukawa, T., Morishima, T., Kumada, T.
  • Organizer: 2009 IUPS, International Conference of Physiological Science and 8th Korea-Japan Joint Symposium, Busan
  • Place of Presentation: Korea
• [Presentation] 母体ストレスが及ぼすマウス胎仔大脳皮質形成の異常 (2009)
  • Author(s): 内田琢, 他
  • Organizer: 第36回日本脳科学大会
  • Place of Presentation: 金沢
• [Presentation] Physiological roles of taurine-mediated tonic GABA_A-receptor activation in corticogenesis (2009)
  • Author(s): 福田敦夫
  • Organizer: The 2nd International Symposium Topical Problems of Biophotonics-2009
  • Place of Presentation: Nizhny Novgorod
• [Presentation] Maternal stress decreased the generation of the GABAergic but not pyramidal neurons in the cerebral cortex (2009)
  • Author(s): 内田琢, et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Role of [Ca^<2+>]_i and [Cl-]_i alterations in distinct pattern of glioblastoma cell migration (2009)
  • Author(s): 熊田竜郎, et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Temporal release of GABA from Bergmann glia accelerates granule cell precursors (GCPs) proliferation during rat cerebellar cortex development (2009)
  • Author(s): 森島寿貴, et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] The effect of ambient GABA and taurine on cortical plate cells in developing cortex (2009)
  • Author(s): 古川智範, et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Peculiar accumulation of GABAergic and glutamatergic neuronsat the early stage of freeze lesion-induced microgyrus in mice (2009)
  • Author(s): Wang, T., et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Physiological significance of taurine-mediated Cl^- conductances during corticogenesis. In Symposium, "Modulation of brain development by paracrine activation of Cl^- conductances (2009)
  • Author(s): 福田敦夫
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Cl^- mediated GABA release from Bergmann glia in developing cerebellar cortex. In Symposium, "Modulation of brain development by paracrine activation of Cl^- conductances (2009)
  • Author(s): Yoshida, S., et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Astrocytic responses to GABA spill-over by interneuron firings in CA1 stratum lacunosum-moleculare (SLM) (2009)
  • Author(s): 江川潔, et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Ionotropic GABA receptors control neuronal migration in neonatal rat cerebral cortex (2009)
  • Author(s): Luhmann, H.J., et al.
  • Organizer: The 36th International Congress of Physiological Sciences (IUPS 2009)
  • Place of Presentation: Kyoto
• [Presentation] Cl^- ontogeny of Cl^- homeostasis in mouse hypoglossal nucleus (2009)
  • Author(s): Okabe, A., et al.
  • Organizer: The 11th Oxford Conference
  • Place of Presentation: Nara
• [Presentation] Endogenous taurine tonically activates GABAA receptors in embryonic mouse neocortex (2009)
  • Author(s): 福田敦夫, et al.
  • Organizer: The 40th NIPS International Symposium : International Joint Symposium 2009 "Physiology of Anion Transport" and "Cell Volume Regulation" (PAT-CVR 2009)
  • Place of Presentation: Okazaki
• [Presentation] Temporal release of GABA regulates granule cell precursors (GCPs) proliferation during rat cerebellar cortical development (2009)
  • Author(s): 森島寿貴, et al.
  • Organizer: The 40th NIPS International Symposium : International Joint Symposium 2009 "Physiology of Anion Transport" and "Cell Volume Regulation" (PAT-CVR 2009)
  • Place of Presentation: Okazaki
• [Presentation] [Ca^<2+>]_i and [Cl^-]_i alterations in migrating glioblastoma cells (2009)
  • Author(s): 熊田竜郎, et al.
  • Organizer: The 40th NIPS International Symposium : International Joint Symposium 2009 "Physiology of Anion Transport" and "Cell Volume Regulation" (PAT-CVR 2009)
  • Place of Presentation: Okazaki
• [Presentation] Neurogenesis of GABAergic interneurons but not of cortical plate cells in the fetal cerebral cortex was decreased by maternal stress (2009)
  • Author(s): 内田琢, et al.
  • Organizer: The 40th NIPS International Symposium : International Joint Symposium 2009 "Physiology of Anion Transport" and "Cell Volume Regulation" (PAT-CVR 2009)
  • Place of Presentation: Okazaki
• [Presentation] Astrocytic responses to GABA spill-over from synaptic clefts and their functional role for regulating extracellular Cl^- in hippocampus (2009)
  • Author(s): 江川潔, et al.
  • Organizer: The 40th NIPS International Symposium : International Joint Symposium 2009 "Physiology of Anion Transport" and "Cell Volume Regulation" (PAT-CVR 2009)
  • Place of Presentation: Okazaki
• [Presentation] GABAが小脳皮質形成期の外顆粒細胞層で一時的にバークマングリアから放出され顆粒細胞前駆体の増殖に関与している (2009)
  • Author(s): 森島寿貴, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 発達期大脳皮質におけるタウリンGABAA受容体を介した役割 (2009)
  • Author(s): 古川智範, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 発達期の小脳皮質でのGABA放出は細胞外のCl^-とグルタミン酸によって調節されている (2009)
  • Author(s): 丸山圭, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 胎仔大脳皮質抑制性神経細胞の細胞新生が母体ストレスによって抑制される (2009)
  • Author(s): 内田琢, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] CA1網状分子層におけるアストロサイトの介在ニューロン連続発火に対する応答 (2009)
  • Author(s): 江川潔, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] グリオブラストーマ細胞の移動時で見られる特徴的な様式におけるクロライド輸送の役割 (2009)
  • Author(s): 熊田竜郎, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Temporal release of GABA from Bergman glia(BG) regulates granule cell precursors (GCPs) proliferation during rat cerebellar cortical development (2009)
  • Author(s): 森島寿貴, et al.
  • Organizer: The 9th Hamamatsu-Kyungpook Joint Symposium
  • Place of Presentation: Busan
• [Presentation] 海馬CA1アストロサイトにおけるGABAカレントと細胞内Cl^-濃度変化 (2009)
  • Author(s): 江川潔, 他
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
• [Presentation] 幼少時の麻酔暴露による脳障害と脳発達過程の興奮性GABA作用 (2009)
  • Author(s): 福田敦夫
  • Organizer: 第29回日本臨床麻酔学会大会
  • Place of Presentation: 浜松
• [Presentation] TRPM7チャネルを介する神経細胞の亜鉛毒性 (2009)
  • Author(s): 井上浩一, 他
  • Organizer: 第56回中部日本生理学会
  • Place of Presentation: 金沢
• [Presentation] Ambient GABA and taurine during corticogenesis. (2009)
  • Author(s): Fukuda, A
  • Organizer: 2009 IUPS, International Conference of Physiological Science and 8th Korea-Japan Joint Symposium
  • Place of Presentation: Busan
• [Presentation] てんかん病態の新しい仮説としての能動的Cl^-ホメオスタシス (2008)
  • Author(s): 福田敦夫
  • Organizer: 第14回漆山てんかん懇話会
  • Place of Presentation: 静岡
  • Year and Date: 2008-06-14
• [Presentation] Changes in KCC2 and NKCC1 expressions in spinal nucleus and ganglion of the trigeminal nerve in a rat model of trigeminal neuropathic pain. (2008)
  • Author(s): Fukuda, A., Wei, B., Furukawa, T., Kumada, T., Sato, K.
  • Organizer: The 6th Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
• [Presentation] The Cl- homeo-dynamics modulates GABA actions and hence the neural network dynamics. (2008)
  • Author(s): Fukuda, A.
  • Organizer: ISTC-RIKEN BSI workshop (44th Japan Workshop): Bridging non-linear dynamics with cellular and molecular neuroscience
  • Place of Presentation: Wako
• [Presentation] 大脳皮質形成異常モデルのmicrogyrus形成過程におけるGABA細胞移動 (2008)
  • Author(s): 福田敦夫
  • Organizer: 第35回日本脳科学会
  • Place of Presentation: 東京
• [Presentation] 三叉神経痛モデルの三叉神経脊髄路核と神経節におけるKCC2とNKCC1の発現変化 (2008)
  • Author(s): 福田敦夫
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] グリオーマ細胞の移動時における時空間的な[Cl^-]_iの変化 (2008)
  • Author(s): 熊田竜郎
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 小脳皮質形成期の外顆粒細胞層で一時的にGABAが放出される (2008)
  • Author(s): 森島寿貴
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] GAD67-GFP knock inマウスを用いた母体ストレス動物の作成 (2008)
  • Author(s): 内田琢
  • Organizer: 第31回本神経科学大会
  • Place of Presentation: 東京
• [Presentation] マウスの多小脳回モデルである凍結損傷で誘発した微小脳回における異常な皮質形成 (2008)
  • Author(s): 王天英
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 発達期大脳皮質における細胞外タウリンのGABA_A, 受容体を介する影響 (2008)
  • Author(s): 古川智範
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] 海馬CAlアストロサイトにおけるGABA応答カレントと細胞内Cl-濃度変化 (2008)
  • Author(s): 江川潔
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Changes in KCC2 and NKCC1 expressions in spinal nucleus and ganglion of the trigeminal nerve in a rat model of trigeminal neuropathic pain. (2008)
  • Author(s): Fukuda, A
  • Organizer: The 6th Forum of European Neuroscience.
  • Place of Presentation: Geneva
• [Presentation] 皮質凍結損傷で誘発したマウス微小脳回の形成期におけるGABA作動性ニューロンの集積 (2008)
  • Author(s): 王天英
  • Organizer: 第55回中部日本生理学会
  • Place of Presentation: 長久手
• [Presentation] 海馬CAlアストロサイトにおけるGABA応答カレントと細胞内Cl-濃度変化 (2008)
  • Author(s): 江川潔
  • Organizer: 第55回中部日本生理学会
  • Place of Presentation: 長久手
• [Presentation] The Cl^- homeo-dynamics modulates CABA actions and hence the neural network dynamics (2008)
  • Author(s): Fukuda, A.
  • Organizer: ISTC-RIKEN BSI workshop
  • Place of Presentation: Wako
• [Presentation] 三叉神経痛モデルラットにおける痛覚過敏とCl-トランスポーター発現変化の相関 (2008)
  • Author(s): 福田 敦夫
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 移動中のグリオブラストーマ細胞における[Ca^<2+>]_iと[C1^-]_iの変動の役割 (2008)
  • Author(s): 熊田 竜郎
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 大脳皮質発達期におけるGABA_A受容体を介した細胞外タウリンの作用 (2008)
  • Author(s): 古川 智範
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 小脳皮質形成期の外穎粒細胞層で一時的にGABAが放出される (2008)
  • Author(s): 森島 寿貴
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] AD67-GFP knock in マウスを用いた母体ストレスモデル動物の作成 (2008)
  • Author(s): 内田 琢
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 海馬CA1アストロサイトにおけるGABAカレントと細胞内C1^-濃度変化 (2008)
  • Author(s): 江川 潔
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] マウス大脳新皮質における凍結損傷法により誘発されたmicrogyrusの皮質形成 (2008)
  • Author(s): 王 天栄
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 脳神経細胞の応答の多様性を調べる研究方法と課題. (2007)
  • Author(s): 福田敦夫
  • Organizer: メディカルイノベーションフォーラム2007 HAMAMATSU
  • Place of Presentation: 浜松
  • Year and Date: 2007-11-20
• [Presentation] 脳神経細胞の応答の多様性を調べる研究方法と課題 (2007)
  • Author(s): 福田 敦夫
  • Organizer: メディカルイノベーションフォーラム
  • Place of Presentation: 浜松
  • Year and Date: 2007-11-20
• [Presentation] Rat facial hyperalgesia induced by the trigeminal nerve constriction is associated with changes in Cltransporters expression in the spinal nucleus and the ganglion. (2007)
  • Author(s): Fukuda, A., Wei, B., Furukawa, T., Kumada, T., Okabe, A., Ohno, K., Sato, K.
  • Organizer: The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Sendai
• [Presentation] 塩素イオンはどのように脳の機能を変えるか? (2007)
  • Author(s): 福田敦夫
  • Organizer: 第12回静岡健康・長寿学術フォーラム
  • Place of Presentation: 静岡
• [Presentation] Modal shift of the tonic GABAA receptor-mediated conductance during neocortical development, "Mechanisms and functional significance of tonic GABAA receptor mediated conductance. (2007)
  • Author(s): Atsuo Fukuda
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 三叉神経痛モデルラットにおける痛覚過敏とC1曹トランスポーター発現変化の相関 (2007)
  • Author(s): 福田 敦夫
  • Organizer: 日本脳科学会大会
  • Place of Presentation: 出雲
• [Presentation] Modal shift of the tonic GABA_A receptor-mediated conductance during neocortical development (2007)
  • Author(s): Fukuda, A.
  • Organizer: 日本神経科学大会シンポジウム
  • Place of Presentation: 横浜
• [Presentation] 移動中のグリオブラストーマ細胞における[Ca^?2+?]_i と[C1^-]_iの変動解析 (2007)
  • Author(s): 熊田 竜郎
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 発達期大脳皮質における細胞外タウリンのGABA_A受容体を介する役割 (2007)
  • Author(s): 古川 智範
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 入力損傷のある三叉神経核におけるクロライド恒常性変化関連遺伝子 (2007)
  • Author(s): 魏 兵
  • Organizer: 日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 塩素イオンはどのように脳の機能を変えるか (2007)
  • Author(s): 福田 敦夫
  • Organizer: 静岡健康・長寿学術フォーラム
  • Place of Presentation: 静岡
• [Presentation] Transition of GABA releasing pattern modulates the tone of granule cell development,migration or proliferation (2007)
  • Author(s): Morishima, T.
  • Organizer: Annual Meeting, Society for Neuroscience
  • Place of Presentation: San Diego,CA
• [Presentation] Rat facial hyperalgesia induced by the trigeminal nerve constriction is associated with changes in C1^- transporters expression in the spinal nucleus and the ganglion (2007)
  • Author(s): Fukuda, A.
  • Organizer: The 7th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: 仙台
• [Book] 組織標本(脳スライス)への各種イメージング法適用の実際(第18回メディカルホトニクスコース講習テキスト) (2009)
  • Author(s): 福田敦夫
• [Book] 動物モデルからヒトへ(ベビーサイエンス) (2008)
  • Author(s): 福田敦夫
• [Book] 組織標本(脳スライス)への各種イメージング法適用の実際(第17回メディカルホトニクスコース講習テキスト) (2008)
  • Author(s): 福田敦夫
• [Book] 組織標本(脳スライス)への各種イメージング法適用の実際(第16回メディカルホトニクスコース講習テキスト) (2007)
  • Author(s): 福田敦夫
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/w1a/phys1/index-j.html
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/wla/physl/index-j.html
• [Remarks]
  • URL: http://www2.hama-mcd.ac.jp/wla/physl/index-j.html