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Molecular Neuropharmacology on histamine system : From basic to clinical investigation on unsolved issues

Research Project

Project/Area Number 19390061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionTohoku University

Principal Investigator

YANAI Kazuhiko  Tohoku University, 大学院・医学系研究科, 教授 (50192787)

Co-Investigator(Kenkyū-buntansha) KURAMASU Atsuo  東北大学, 大学院・医学系研究科, 講師 (90302091)
SAKURAI Eiko  東北大学, 大学院・医学系研究科, 助教 (90153949)
WATANABE Takehiko  東北大学, 大学院・医学系研究科, 名誉教授 (70028356)
岡村 信行  東北大学, 大学院・医学系研究科, 助教 (40361076)
Co-Investigator(Renkei-kenkyūsha) OKAMURA Nobuyuki  東北大学, 大学院医学系研究科, 講師 (40361076)
TASHIRO Manabu  東北大学, サイクロトロンRIセンター, 准教授
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywordsヒスタミン / ヒスタミン受容体 / ヒスタミンH1受容体 / ヒスタミンH4受容体 / プロテオミクス / PET / 性差 / small GTPase Rho / Rac / ヒスタミンH2受容体 / Dynamin / internalization
Research Abstract

ヒスタミンH2、H4受容体のカルボキシル末端の機能と細胞内情報伝達機能について、プロテオミクスの技術を導入して研究を行った。H2、H4受容体C末端領域の結合タンパク質の同定をおこない、H4受容体C末端に結合した蛋白質としてsmall GTPase Rhoファミリー(Rac1、Rac2)を同定した。H2受容体については、C末に結合する蛋白質としてDynaminなど12種の蛋白を同定して、さらにDynaminに関してその機能を解析した。臨床研究として、ヒトのヒスタミン神経の性差について[^(11)C]Doxepinを用いてPET臨床研究を行った。帯状回、前頭葉、側頭葉など大脳皮質を中心に10-20%ほど女性はH1受容体量が多かった。さらに神経性食欲異常症では海馬において高いH1受容体量を示した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (73 results)

All 2009 2008 2007 Other

All Journal Article (35 results) (of which Peer Reviewed: 27 results) Presentation (33 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009

    • Author(s)
      Ogawa S, Yanai K, Watanabe T, Wang ZM, Akaike H, Ito Y, Akaike N
    • Journal Title

      Brain Res Bull 78(4-5)

      Pages: 189-194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls2009

    • Author(s)
      Nishino S, Sakurai E, Nevsimalova S, Yoshida Y, Watanabe T, Yanai K, Mignot E
    • Journal Title

      Sleep 32(2)

      Pages: 175-180

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased Brain Histamine H1 Receptor Binding in Patients with Anorexia Nervosa2009

    • Author(s)
      Yoshizawa M, Tashiro M, Fukudo S, Yanai K, Utsumi A, Kano M, Karahasi M, Endo Y, Morisita J, Sato Y, Adachi M, Itoh M, Hongo M
    • Journal Title

      Biol Psychiatry 65(4)

      Pages: 329-335

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中枢に移行しない第二世代抗ヒスタミン薬 : PETによる脳内移行性に関する研究2009

    • Author(s)
      谷内一彦, 田代学, 岡村信行
    • Journal Title

      西日本皮膚科 1巻1号

      Pages: 3-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] インペアード・パフォーマンス : 国際標準に基づく抗ヒスタミン薬の使用法2009

    • Author(s)
      谷内一彦, 田代学
    • Journal Title

      医薬ジャーナル 45

      Pages: 687-693

    • Related Report
      2008 Final Research Report
  • [Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009

    • Author(s)
      Ogawa S, Yanai K, et.al.
    • Journal Title

      Brain Res Bull. 78(4-5)

      Pages: 189-194

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls2009

    • Author(s)
      Nishino S, Yanai K, et.al.
    • Journal Title

      Sleep 32(2)

      Pages: 175-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Brain Histamine H1 Receptor Binding in Patients with Anorexia Nervosa2009

    • Author(s)
      Yoshizawa M, Yanai K, et.al.
    • Journal Title

      Biol Psychiatry 65(4)

      Pages: 329-335

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent2008

    • Author(s)
      Xu AJ, Kuramasu A, Maeda K, Kinoshita K, Takayanagi S, Fukushima Y, Watanabe T, Yanagisawa T, Sukegawa J, Yanai K
    • Journal Title

      J Neurochem 107

      Pages: 208-217

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blocking histamine H1 improves learning and mnemonic dysfunction in mice with social isolation plus repeated methamphetamine injection2008

    • Author(s)
      Jia F, Mobarakeh JI, Dai H, Kato M, Xu A, Okuda T, Sakurai E, Okamura N, Takahashi K, Yanai K
    • Journal Title

      J Pharmacol Sci 107(2)

      Pages: 167-174

    • NAID

      130000075818

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin2008

    • Author(s)
      Tashiro M, Duan X, Kato M, Miyake M, Watanuki S, Ishikawa Y, Funaki Y, Iwata R, Itoh M, Yanai K
    • Journal Title

      Br J Clin Pharmacol 65(6)

      Pages: 811-21

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression2008

    • Author(s)
      Maeda K, Haraguchi M, Kuramasu A, Sato T, Ariake K, Sakagami H, Kondo H, Yanai K, Fukunaga K, Yanagisawa T, Sukegawa J
    • Journal Title

      Biochem Biophys Res Commun 369(2)

      Pages: 603-608

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving2008

    • Author(s)
      Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K
    • Journal Title

      Hum Psychopharmacol 23(2)

      Pages: 139-150

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors2008

    • Author(s)
      Watanabe C, Orito T, Watanabe H, Mizoguchi H, Yonezawa A, Yanai K, Mobarakeh JI, Onodera K, Sakurada T, Sakurada S
    • Journal Title

      Eur J Pharmacol 581(1-2)

      Pages: 54-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease2008

    • Author(s)
      Okamura N, Funaki Y, Tashiro M, Kato M, Ishikawa Y, Maruyama M, Ishikawa H, Meguro K, Iwata R, Yanai K
    • Journal Title

      Br J Clin Pharmacol 65

      Pages: 472-479

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging amyloid pathology in the living brain2008

    • Author(s)
      Okamura N, Furumoto S, Arai H, Iwata R, Yanai K, Kudo Y
    • Journal Title

      Curr Med Imaging Rev 4

      Pages: 56-62

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 序にかえて「脳の核医学分子イメージング」2008

    • Author(s)
      谷内一彦, 須原哲也
    • Journal Title

      臨床放射線 53(7)

      Pages: 845-848

    • Related Report
      2008 Final Research Report
  • [Journal Article] 抗ヒスタミン薬のヒスタミンH1拮抗作用とインペアード・パフォーマンス2008

    • Author(s)
      谷内一彦, 田代学
    • Journal Title

      臨床免疫・アレルギー科 50(1)

      Pages: 46-51

    • Related Report
      2008 Final Research Report
  • [Journal Article] アレルギー性皮膚疾患におけるエビデンスに基づいた抗ヒスタミン薬の選択2008

    • Author(s)
      川島眞、江藤隆史、江畑俊哉、大谷道輝、片山一朗、幸野健, 瀧川雅浩, 田邉昇, 中川秀巳, 原田昭太郎, 古川福実 森川昭広 谷内一彦
    • Journal Title

      臨床皮膚科 62(1)

      Pages: 8-15

    • Related Report
      2008 Final Research Report
  • [Journal Article] The roles of histamine H(1)receptors on cognition.2008

    • Author(s)
      Yanai K, Dai H, Sakurai E, Watanabe T.
    • Journal Title

      Inflamm Res. Mar14;Epub(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression.2008

    • Author(s)
      Maeda K, Haraguchi M, Kuramasu A, Sato T, Ariake K, Sakagami H, Kondo H, Yanai K, Fukunaga K, Yanagisawa T, Sukegawa J.
    • Journal Title

      Biochem Biophys Res Commun. 369(2)

      Pages: 603-608

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a sedative antihistamine, D-chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving. 2008 Mar,;2008

    • Author(s)
      Tashiro M, Sakurada Y, Mochizuki H, Horikawa E, Maruyama M, Okamura N, Watanuki S, Arai H, Itoh M, Yanai K.
    • Journal Title

      Hum Psychopharmacol. Hum Psychopharmacol. 23(2)

      Pages: 139-150

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the binding characteristics of [(18)F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H(3) receptor2007

    • Author(s)
      Funaki Y, Sato K, Kato M, Ishikawa Y, Iwata R, Yanai K
    • Journal Title

      Nucl Med Biol 34(8)

      Pages: 981-987

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain activity associated with dual-task management differs depending on the combinations of response modalities2007

    • Author(s)
      Mochizuki H, Tashiro M, Gyoba J, Suzuki M, Okamura N, Itoh M, Yanai K
    • Journal Title

      Brain Res 1172C

      Pages: 82-92

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit2007

    • Author(s)
      Murakami M, Nakagawasai O, Yanai K, Nunoki K, Tan-No K, Tadano T, Iijima T
    • Journal Title

      Brain Res 1160

      Pages: 102-112

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between alexithymia and hypersensitivity to visceral stimulation in human2007

    • Author(s)
      Kano M, Hamaguchi T, Itoh M, Yanai K, Fukudo S
    • Journal Title

      Pain 132(3)

      Pages: 252-263

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural correlates of perceptual difference between itching and pain: A human fMRI study2007

    • Author(s)
      Mochizuki H, Sadato H, Saito D. N., Toyoda H, Tashiro M, Okamura N, Yanai K
    • Journal Title

      Neuroimage 36

      Pages: 706-717

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors2007

    • Author(s)
      Dai H, Kaneko K, Kato H, Fujii S, Jing Y, Sakurai E, Kato M, Okamura N, Kuramasu A, Yanai K
    • Journal Title

      Neuroscience Research 57(2)

      Pages: 306-313

    • NAID

      10021189206

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In Vivo Evaluation of P-Glycoprotein Modulation of 8 PET Radioligands Used Clinically2007

    • Author(s)
      Ishiwata K, Kawamura K, Yanai K, Hendrikse H.N
    • Journal Title

      J Nucl Med 48

      Pages: 81-87

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in the development of amyloid imaging agents2007

    • Author(s)
      Furumoto S, Okamura N, Iwata R, Yanai K, Arai H, Kudo Y
    • Journal Title

      Curr Top Med Chem 7(18)

      Pages: 1773-1789

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The physiological and pathophysiological roles of neuronal histamine: An insight from human PET studies2007

    • Author(s)
      Yanai K, Tashiro M
    • Journal Title

      Pharmacology & Therapeutics 113

      Pages: 1-15

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳内に移行する抗ヒスタミン薬の小児に与える影響2007

    • Author(s)
      谷内一彦、岡村信行、田代学
    • Journal Title

      小児科 48(10)

      Pages: 1435-1443

    • NAID

      40015635049

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] PETによる分子・機能イメージングを組み合わせた脳機能研究2007

    • Author(s)
      鈴木美穂, 岡村信行, 谷内一彦
    • Journal Title

      認知神経科学 9(1)

      Pages: 62-65

    • Related Report
      2008 Final Research Report
  • [Journal Article] 抗アレルギー薬、抗精神病薬、抗うつ薬のヒスタミンH1拮抗作用と認知機能2007

    • Author(s)
      谷内一彦、加藤元久
    • Journal Title

      脳21 解説「脳とくすり」 10(1)

      Pages: 85-90

    • Related Report
      2008 Final Research Report
  • [Journal Article] ヒスタミン受容体の分子イメージング2007

    • Author(s)
      田代学、谷内一彦
    • Journal Title

      BRAIN AND NERVE 59(3)

      Pages: 221-231

    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular PET imaging in Alzheimer disease: From basic development to clinical application2009

    • Author(s)
      Yanai K, Okamura N
    • Organizer
      4th Japan-China Joint Meeting of Basic and Clinical Pharmacology
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗ヒスタミン薬の最新科学 : インペアード・パフォーマンスを中心に2009

    • Author(s)
      谷内一彦
    • Organizer
      日本薬理学会
    • Place of Presentation
      日本薬理学会・横浜
    • Year and Date
      2009-03-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗ヒスタミン薬の最新科学 : インペアード・パフォーマンスを中心に2009

    • Author(s)
      谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 高速液体クロマトグラフィーを用いた簡便なヒスタミンと1-メチルヒスタミンの同時定量2009

    • Author(s)
      井筒敏恵, 櫻井映子, 及川綾子, 瀧野奈緒子, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト脳内ヒスタミンH1受容体の男女差 : PET研究2009

    • Author(s)
      加藤元久、田代学、吉沢正彦, 張冬頴, 岡村信行, 福土審, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンH3受容体に結合し発現量を制御するタンパク質の新たな同定2009

    • Author(s)
      高柳詩織、木下和樹、佐藤岳哉、前田恵、原口満也、谷内一彦、福永浩司、柳澤輝行、助川淳
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳スライスからの内因性モノアミン同時遊離測定法の開発 : ヒスタミン受容体遺伝子ノックアウトマウスへの応用2009

    • Author(s)
      張冬頴, 櫻井映子, 瀧野奈緒子, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンH3受容体の細胞表面発現調節2009

    • Author(s)
      助川淳, 木下和樹, 高柳詩織, 佐藤岳哉, 前田恵, 原口満也, 谷内一彦, 福永浩司, 柳澤輝行
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 規制薬物誘発の異常行動とヒスタミン神経2009

    • Author(s)
      瀧野奈緒子, 櫻井映子, 岩村樹憲, 谷内一彦
    • Organizer
      第82回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 鎮静性抗ヒスタミン薬による認知機能低下と運転への影響2008

    • Author(s)
      谷内一彦
    • Organizer
      第17回日本交通医学工学研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-23
    • Related Report
      2008 Final Research Report
  • [Presentation] Molecular PET imaging of acetylcholine esterase, histamine H1 receptor and amyloid deposits in Alzheimer disease2008

    • Author(s)
      Okamura N, Yanai K
    • Organizer
      13th International Conference on Biomedical Engineering(ICBME2008)
    • Place of Presentation
      シンガポール
    • Related Report
      2008 Final Research Report
  • [Presentation] 薬理学から見た理想的な抗ヒスタミン薬とは?2008

    • Author(s)
      谷内一彦
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 中枢ヒスタミン受容体の規制薬物誘発行動異常への関与2008

    • Author(s)
      瀧野奈緒子, 櫻井映子, 奥田友宏, 岩村樹憲, 谷内一彦
    • Organizer
      第38回日本精神神経薬理学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of methamphetamine on locomotor sensitization and conditioned place preference in histamine receptor deficient mice2008

    • Author(s)
      Takino N, Sakurai E, Iwamura T, Yanai K
    • Organizer
      XI Workshop on apoptosis in biology and medicine
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンH2受容体カルボキシ末端に結合する蛋白質の同定と機能解析2008

    • Author(s)
      谷内一彦, 徐阿晶, 櫻井映子, 倉増敦朗
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] PET evaluation of sedative properties of antihistamines2008

    • Author(s)
      K. Yanai, N. Okamura, M. Tashiro
    • Organizer
      World Conference on Clinical Pharmacology and Therapeutics
    • Place of Presentation
      カナダ・ケベック
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳内ヒスタミン神経機能イメージング2008

    • Author(s)
      谷内一彦, 岡村信行, 田代学
    • Organizer
      第31回日本神経科学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Sedation and impaired performance by antihistamines: PET measurements of H1 receptor occupancy2008

    • Author(s)
      K. Yanai
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] カゼインキナーゼIIはヒトヒスタミンH4受容体カルボキシ末端に結合する2008

    • Author(s)
      軽部雅崇, 若林深恵, 倉増敦朗, 谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンH3受容体カルボキシ末端はGi蛋白質を介するシグナリングに必要である2008

    • Author(s)
      倉増敦朗、助川淳、佐藤岳哉、櫻井映子、渡邉建彦、柳澤輝行、谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] MDMA、5-MeO-DIPT、メタアンフェタミンの慢性投与による逆耐性形成と場所嗜好性2008

    • Author(s)
      瀧野奈緒子, 櫻井映子, 岩村樹憲, 谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンH3受容体の細胞表面発現に対する細胞内クロライドチャネルの影響2008

    • Author(s)
      原口満也, 前田恵, 倉増敦朗, 佐藤岳哉, 谷内一彦, 福永浩司, 柳澤輝行, 助川淳
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 低分子量G蛋白質RacはヒスタミンH4受容体C末端に結合する2008

    • Author(s)
      若林深恵, 倉増敦朗, 谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンH2受容体カルボキシ末端に結合する蛋白質の同定と機能解析2008

    • Author(s)
      徐阿晶, 倉増敦朗, 前田恵, 福嶋康, 渡辺建彦, 柳澤輝行, 助川淳, 谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミン受容体遺伝子欠損がマウスの行動変化に及ぼす影響2008

    • Author(s)
      櫻井映子, 倉増敦朗, 岡村信行, 谷内一彦
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Sedation and impaired performance by antihistamines: PET measurements of H1 receptor occupancy2007

    • Author(s)
      Kazuhiko Yanai
    • Organizer
      World Allergy Congress 2007
    • Place of Presentation
      タイ、バンコク
    • Year and Date
      2007-12-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 分子イメージング法の創薬科学へのインパクト2007

    • Author(s)
      谷内一彦
    • Organizer
      ゲノム創薬フォーラムキーテクノロジー
    • Year and Date
      2007-09-10
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミンによる痒みの脳内メカニズム研究 : fMRI2007

    • Author(s)
      谷内一彦, 望月秀紀, 岡村信行, 加藤元久, 櫻井映子, 定藤規弘
    • Organizer
      第11回日本ヒスタミン学会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] Sedation and impaired performance by antihistamines : PET measurements of H1 receptor occupancy2007

    • Author(s)
      Kazuhiko Yanai
    • Organizer
      World Allergy Congress
    • Place of Presentation
      バンコク・タイ
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗アレルギー薬のヒスタミンH1拮抗作用とインペアード・パフォーマンス2007

    • Author(s)
      谷内一彦
    • Organizer
      第57回日本アレルギー学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] C11-Donepezilを用いたアセチルコリンエステラーゼの分子イメージング2007

    • Author(s)
      谷内一彦, 岡村信行, 加藤元久, 船木善仁, 荒井啓行, 目黒謙一, 岩田錬
    • Organizer
      日本神経精神薬理学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] 最新の薬理学から見た抗ヒスタミン薬の適切な使用法2007

    • Author(s)
      谷内一彦
    • Organizer
      第30回日本プライマリー・ケア学会
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of histamine receptors on cognition2007

    • Author(s)
      Kazuhiko Yanai, Hongmei Dai, Eiko Sakurai, Takehiko Watanabe
    • Organizer
      European Histamine Research Society
    • Place of Presentation
      フローレンス・イタリア
    • Related Report
      2008 Final Research Report
  • [Book] Inflamm Res2009

    • Author(s)
      Sakurai E, Sakurai E, Watanabe T, Yanai K
    • Publisher
      Uptake of L-histidine and histamine biosynthesis at the blood-brain barrier
    • Related Report
      2008 Final Research Report
  • [Book] Inflamm Res2009

    • Author(s)
      Sakurai E, Kuramasu A, Watanabe T, Yanai K
    • Publisher
      Multiple histamine receptor gene knockout mice and their phenotypes
    • Related Report
      2008 Final Research Report
  • [Book] "Nano-Biomedical Engineering 2009 : Proceedings of the Tohoku University Global Centre of Excellence Programme" (Editor : Takami Yamaguchi)2009

    • Author(s)
      Yanai K, Okamura N, Iwata R, Tashiro M.
    • Total Pages
      469
    • Publisher
      Molecular imaging and its application to drug development at Tohoku University.
    • Related Report
      2008 Annual Research Report
  • [Book] Inflamm Res2008

    • Author(s)
      Yanai K, Dai H, Sakurai E, Watanabe T
    • Publisher
      The roles of histamine H1 receptors on cognition
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.med.tohoku.ac.jp/room/126/japanese.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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