| Project/Area Number |
19390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMADA Kiyofumi Nagoya University, 医学部附属病院, 教授 (30303639)
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| Co-Investigator(Kenkyū-buntansha) |
永井 拓 名古屋大学, 大学院・医学系研究科, 講師 (10377426)
溝口 博之 名古屋大学, 環境医学研究所, 助教 (70402568)
田熊 一浩 金沢大学, 自然科学研究科, 准教授 (90289025)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
MIZOGUCHI Hiroyuki 名古屋大学, 環境医学研究所, 助教 (70402568)
TAKUMA Kazuhiro 大阪大学, 大学院・薬学研究科, 准教授 (90289025)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 組織プラスミノーゲン活性化因子 / プラスミン / ドーパミン / 薬物依存 / 覚せい剤精神病 / 認知症 / ニコチン / メタンフェタミン / モルヒネ / ドーパミンD1受容体 / プロテインキナーゼA |
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| Research Abstract |
In the present study we investigated whether tissue plasminogen activator (tPA)-plasmin system was involved in the pathophysiology/pathogenesis of dopamine-related neuropsychiatric disorders, by using animal models for the diseases. Our findings suggest that tPA-plasmin may play a role in the development of methamphetamine dependence as well as methamphetamine-induced psychosis. Furthermore, it is indicated that the activation of dopamine D1 receptors leads to an increase in extracellular tPA activity and the dopamine D1 receptor-tPA signaling may play a role in memory formation.
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